Technical Limitations of the C1q Single-Antigen Bead Assay to Detect Complement Binding HLA-Specific Antibodies.

scientific article

Technical Limitations of the C1q Single-Antigen Bead Assay to Detect Complement Binding HLA-Specific Antibodies. is …
instance of (P31):
scholarly articleQ13442814

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P356DOI10.1097/TP.0000000000001270
P932PMC publication ID5457814
P698PubMed publication ID27306532

P50authorVasilis KosmoliaptsisQ42539358
Dermot MallonQ58210208
P2093author name stringJ Andrew Bradley
Craig J Taylor
Sarah Peacock
Graham Knighton
Jessie Martin
P2860cites workComplement is activated by IgG hexamers assembled at the cell surfaceQ30409381
Transplantation: Complementing donor-specific antibody testingQ33877558
Preexisting donor-specific HLA antibodies predict outcome in kidney transplantationQ34124202
Detection of C3d-binding donor-specific anti-HLA antibodies at diagnosis of humoral rejection predicts renal graft loss.Q35027253
IgG Donor-Specific Anti-Human HLA Antibody Subclasses and Kidney Allograft Antibody-Mediated InjuryQ36417907
The complement-mediated prozone effect in the Luminex single-antigen bead assay and its impact on HLA antibody determination in patient seraQ38036750
Detection of alloantibody-mediated complement activation: A diagnostic advance in monitoring kidney transplant rejection?Q38539302
Class I HLA folding and antigen presentation in beta 2-microglobulin-defective Daudi cellsQ39876473
The epitope recognized by pan-HLA class I-reactive monoclonal antibody W6/32 and its relationship to unusual stability of the HLA-B27/beta2-microglobulin complexQ40771639
Assessing Antibody Strength: Comparison of MFI, C1q, and Titer Information.Q40990548
The prevalence and clinical significance of C1q-binding donor-specific anti-HLA antibodies early and late after kidney transplantationQ41150961
Association of Kidney Graft Loss With De Novo Produced Donor-Specific and Non-Donor-Specific HLA Antibodies Detected by Single Antigen Testing.Q41228171
HLA-A- and HLA-B-specific monoclonal antibodies reactive with free heavy chains in western blots, in formalin-fixed, paraffin-embedded tissue sections and in cryo-immuno-electron microscopyQ41635879
Production of monoclonal antibodies to group A erythrocytes, HLA and other human cell surface antigens-new tools for genetic analysisQ42802250
False-positive reactions against HLA class II molecules detected in Luminex single-antigen bead assaysQ42854881
Improved Luminex-based human leukocyte antigen-specific antibody screening using dithiothreitol-treated seraQ43266315
The significance of pretransplant donor-specific antibodies reactive with intact or denatured human leucocyte antigen in kidney transplantationQ43419051
HLA antibody specification using single-antigen beads--a technical solution for the prozone effectQ43914521
The role of immunoglobulin-G subclasses and C1q in de novo HLA-DQ donor-specific antibody kidney transplantation outcomesQ44174433
Influence of test technique on sensitization status of patients on the kidney transplant waiting listQ44371693
Naturally occurring interference in Luminex assays for HLA-specific antibodies: characteristics and resolutionQ45185527
Systematic comparison of four cell- and Luminex-based methods for assessment of complement-activating HLA antibodiesQ45332005
Detection of immunoglobulin G human leukocyte antigen-specific alloantibodies in renal transplant patients using single-antigen-beads is compromised by the presence of immunoglobulin M human leukocyte antigen-specific alloantibodiesQ46081845
Complement-binding anti-HLA antibodies and kidney-allograft survivalQ46141053
Relevance of different antibody detection methods for the prediction of antibody-mediated rejection and deceased-donor kidney allograft survival.Q47989446
Novel C1q assay reveals a clinically relevant subset of human leukocyte antigen antibodies independent of immunoglobulin G strength on single antigen beads.Q50618048
Antibodies against denatured HLA class II molecules detected in luminex-single antigen assay.Q50855051
Post-transplant development of C1q-positive HLA antibodies and kidney graft survival.Q51841126
Deciphering complement interference in anti-human leukocyte antigen antibody detection with flow beads assays.Q53032138
C1q Binding Activity of De Novo Donor-specific HLA Antibodies in Renal Transplant Recipients With and Without Antibody-mediated Rejection.Q53225887
Denatured class I human leukocyte antigen antibodies in sensitized kidney recipients: prevalence, relevance, and impact on organ allocation.Q53256332
Single human leukocyte antigen flow cytometry beads for accurate identification of human leukocyte antigen antibody specificities.Q53659700
Pretransplant Donor-Specific HLA Class-I and -II Antibodies Are Associated With an Increased Risk for Kidney Graft FailureQ60182181
Tools for human leukocyte antigen antibody detection and their application to transplanting sensitized patientsQ81774381
Complement-fixing donor-specific antibodies identified by a novel C1q assay are associated with allograft lossQ82554497
C1q-Fixing Human Leukocyte Antigen Antibodies Are Specific for Predicting Transplant Glomerulopathy and Late Graft Failure After Kidney TransplantationQ82659907
Baseline donor-specific antibody levels and outcomes in positive crossmatch kidney transplantationQ82732578
Preformed complement-activating low-level donor-specific antibody predicts early antibody-mediated rejection in renal allograftsQ85575440
The complement interference phenomenon as a cause for sharp fluctuations of serum anti-HLA antibody strength in kidney transplant patientsQ85963365
Complement component C3 activation: the leading cause of the prozone phenomenon affecting HLA antibody detection on single-antigen beadsQ87427905
Determinants of C1q binding in the single antigen bead assayQ88058283
Questioning the added value of Luminex single antigen beads to detect C1q binding donor HLA-specific antibodiesQ88058291
P433issue6
P407language of work or nameEnglishQ1860
P304page(s)1206-1214
P577publication date2017-06-01
P1433published inTransplantationQ15730500
P1476titleTechnical Limitations of the C1q Single-Antigen Bead Assay to Detect Complement Binding HLA-Specific Antibodies
P478volume101

Reverse relations

cites work (P2860)
Q39445381Application, technical issues, and interpretation of C1q for graft outcome
Q59807564Clinical impact of complement (C1q, C3d) binding De Novo donor-specific HLA antibody in kidney transplant recipients
Q47646739Complement (C1q) Binding De Novo Donor Specific Antibodies and Cardiac-Allograft Vasculopathy in Pediatric Heart Transplant Recipients
Q28075921Detection of HLA Antibodies in Organ Transplant Recipients - Triumphs and Challenges of the Solid Phase Bead Assay
Q93035787EDTA Treatment for Overcoming the Prozone Effect and for Predicting C1q Binding in HLA Antibody Testing
Q91936201Human Leucocyte Antigen Sensitisation and Its Impact on Transfusion Practice
Q91837466Immune Algorithm Optimization for Organ Transplantation in Poland
Q59807111Predicting Humoral Alloimmunity from Differences in Donor and Recipient HLA Surface Electrostatic Potential
Q30397251The Humoral Theory of Transplantation: Epitope Analysis and the Pathogenicity of HLA Antibodies

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