ENU mutagenesis identifies mice with morbid obesity and severe hyperinsulinemia caused by a novel mutation in leptin

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ENU mutagenesis identifies mice with morbid obesity and severe hyperinsulinemia caused by a novel mutation in leptin is …
instance of (P31):
scholarly articleQ13442814

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P819ADS bibcode2010PLoSO...515333H
P356DOI10.1371/JOURNAL.PONE.0015333
P932PMC publication ID3000341
P698PubMed publication ID21151569
P5875ResearchGate publication ID49677272

P50authorShih-Jen TsaiQ41185304
P2093author name stringChen-Jee Hong
Chih-Ya Cheng
Irene H Cheng
Ya-Tzu Lin
Yau-Sheng Tsai
Pei-Jane Tsai
Ying-Jay Liou
Chia-Ning Yang
Chuan-Kai Chou
Huei-Fen Jheng
Chih-Wei Hsu
Shiow-Yi Chen
You-Chung Chuang
P2860cites workA peptide leptin antagonist reduces food intake in rodentsQ77900247
Adipokine and insulin profiles distinguish diabetogenic and non-diabetogenic obesities in miceQ80825805
Identification of the hydrophobic strand in the A-B loop of leptin as major binding site III: implications for large-scale preparation of potent recombinant human and ovine leptin antagonists.Q39497807
Mapping of the leptin binding sites and design of a leptin antagonistQ40542294
Functional Analysis of Leptin Receptor Activation Using a Janus Kinase/Signal Transducer and Activator of Transcription Complementation AssayQ40629196
The obese phenotype-inducing N82K mutation in human leptin disrupts receptor-binding and biological activityQ43121827
A human leptin mutant induces weight gain in normal miceQ47311993
A simple method to determine fat cell size and number in four mammalian speciesQ47380162
A novel homozygous missense mutation of the leptin gene (N103K) in an obese Egyptian patient.Q47848461
Partial leptin deficiency and human adiposity.Q55035506
A leptin missense mutation associated with hypogonadism and morbid obesity.Q55067416
No evidence for involvement of the leptin gene in anorexia nervosa, bulimia nervosa, underweight or early onset extreme obesity: identification of two novel mutations in the coding sequence and a novel polymorphism in the leptin gene linked upstreamQ57338240
Identification of two novel missense mutations in the human OB geneQ73294661
Optimal N-ethyl-N-nitrosourea (ENU) doses for inbred mouse strainsQ73627317
The involvement of leptin in humans revealed by mutations in leptin and leptin receptor genesQ77875113
Positional cloning of the mouse obese gene and its human homologueQ22251285
Hexameric structure and assembly of the interleukin-6/IL-6 alpha-receptor/gp130 complexQ24306425
Life with a single isoform of Akt: mice lacking Akt2 and Akt3 are viable but display impaired glucose homeostasis and growth deficienciesQ24672400
A simple method for the isolation and purification of total lipides from animal tissuesQ25939009
Structure of an extracellular gp130 cytokine receptor signaling complexQ27630660
Crystal structure of the obese protein leptin-E100Q27737094
Mapping the protein universeQ27861112
Leptin and the regulation of body weight in mammalsQ29615976
Congenital leptin deficiency is associated with severe early-onset obesity in humansQ29618702
Adipocytes as regulators of energy balance and glucose homeostasisQ29619448
The use of MassARRAY technology for high throughput genotypingQ30847757
Mechanism of attenuation of leptin signaling under chronic ligand stimulationQ33522778
A new mouse model of metabolic syndrome and associated complicationsQ33785757
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The ins and outs of leptin receptor activationQ35163929
Adiponectin and its role in the obesity-induced insulin resistance and related complications.Q35717275
Leptin: structure, function and biologyQ36236088
Decreased PPAR gamma expression compromises perigonadal-specific fat deposition and insulin sensitivityQ37418165
Genetic markers at the leptin (OB) locus are not significantly linked to hypertension in African AmericansQ38336759
Localization of leptin binding domain in the leptin receptor.Q38339486
The molecular basis of the obese mutation in ob2J miceQ38345903
Subcloning, expression, purification, and characterization of recombinant human leptin-binding domainQ38363020
P275copyright licenseCreative Commons Attribution 4.0 InternationalQ20007257
P6216copyright statuscopyrightedQ50423863
P433issue12
P407language of work or nameEnglishQ1860
P921main subjectmorbid obesityQ9051491
P304page(s)e15333
P577publication date2010-12-09
P1433published inPLOS OneQ564954
P1476titleENU mutagenesis identifies mice with morbid obesity and severe hyperinsulinemia caused by a novel mutation in leptin
P478volume5

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cites work (P2860)
Q34343034Adipocyte versus pituitary leptin in the regulation of pituitary hormones: somatotropes develop normally in the absence of circulating leptin.
Q34170436An N-ethyl-N-nitrosourea (ENU)-induced dominant negative mutation in the JAK3 kinase protects against cerebral malaria
Q34205173Approach to assessing determinants of glucose homeostasis in the conscious mouse
Q34576536Autosomal dominant hypercalciuria in a mouse model due to a mutation of the epithelial calcium channel, TRPV5
Q64999131Congenital Leptin Deficiency and Leptin Gene Missense Mutation Found in Two Colombian Sisters with Severe Obesity.
Q34998251Genome-wide mouse mutagenesis reveals CD45-mediated T cell function as critical in protective immunity to HSV-1.
Q37228102Identification of mutations through dominant screening for obesity using C57BL/6 substrains
Q36277860Monogenic forms of childhood obesity due to mutations in the leptin gene
Q34307905Sterols in spermatogenesis and sperm maturation.
Q89295161Uncovering the molecular mechanisms behind disease-associated leptin variants

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