Genomic insights into the overlap between psychiatric disorders: implications for research and clinical practice.

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Genomic insights into the overlap between psychiatric disorders: implications for research and clinical practice. is …
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scholarly articleQ13442814

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P6179Dimensions Publication ID1031790039
P356DOI10.1186/GM546
P2888exact matchhttps://scigraph.springernature.com/pub.10.1186/gm546
P932PMC publication ID4062063
P698PubMed publication ID24944580
P5875ResearchGate publication ID263291569

P50authorJoanne DohertyQ57969839
P2093author name stringMichael J Owen
P2860cites workADHD, major depressive disorder, and simple phobias are prevalent psychiatric conditions in youth with velocardiofacial syndrome.Q51942553
Cognitive performance in schizophrenia patients assessed before and following the first psychotic episode.Q51945465
Clinical findings in 33 subjects with large supernumerary marker(15) chromosomes and 3 subjects with triplication of 15q11-q13.Q53637126
Diagnostic exome sequencing in persons with severe intellectual disabilityQ55670486
Examining the Comorbidity Between Attention Deficit Hyperactivity Disorder and Bipolar I Disorder: A Meta-Analysis of Family Genetic StudiesQ57399796
Increased exonic de novo mutation rate in individuals with schizophreniaQ59667688
A Family Study of Schizoaffective, Bipolar I, Bipolar II, Unipolar, and Normal Control ProbandsQ63869312
Continuity and discontinuity of affective disorders and schizophrenia. Results of a controlled family studyQ72545950
Investigation of NRXN1 deletions: clinical and molecular characterizationQ86393147
Advanced paternal age is associated with impaired neurocognitive outcomes during infancy and childhoodQ21144644
A systematic review of the prevalence of schizophreniaQ21144720
The Kraepelinian dichotomy - going, going... but still not goneQ22241683
The Worldwide Prevalence of ADHD: A Systematic Review and Metaregression AnalysisQ22241865
What causes attention deficit hyperactivity disorder?Q22242209
Rare chromosomal deletions and duplications increase risk of schizophreniaQ22337245
Functional impact of global rare copy number variation in autism spectrum disordersQ24596191
Identification of risk loci with shared effects on five major psychiatric disorders: a genome-wide analysisQ24597718
The bipolar disorder risk allele at CACNA1C also confers risk of recurrent major depression and of schizophreniaQ24619976
Shared heritability of attention-deficit/hyperactivity disorder and autism spectrum disorderQ24627620
Recurrent rearrangements in synaptic and neurodevelopmental genes and shared biologic pathways in schizophrenia, autism, and mental retardationQ24629022
Microduplications of 16p11.2 are associated with schizophreniaQ24634151
Genome-wide association study identifies genetic variation in neurocan as a susceptibility factor for bipolar disorderQ24634497
Disruption of neurexin 1 associated with autism spectrum disorderQ24643899
Disruption of the neurexin 1 gene is associated with schizophreniaQ24647095
Recurrent reciprocal 1q21.1 deletions and duplications associated with microcephaly or macrocephaly and developmental and behavioral abnormalitiesQ24647145
Neurexin 1 (NRXN1) deletions in schizophreniaQ24649863
Large recurrent microdeletions associated with schizophreniaQ24654741
Collaborative genome-wide association analysis supports a role for ANK3 and CACNA1C in bipolar disorderQ24655630
A twin study of genetic relationships between psychotic symptomsQ28211685
Prevalence of autism-spectrum conditions: UK school-based population studyQ28246681
Genome-wide association study identifies five new schizophrenia lociQ28248384
Common polygenic variation contributes to risk of schizophrenia and bipolar disorderQ28250609
Prevalence of disorders of the autism spectrum in a population cohort of children in South Thames: the Special Needs and Autism Project (SNAP)Q28252295
Comparative genome hybridization suggests a role for NRXN1 and APBA2 in schizophreniaQ28256580
Advancing paternal age and autismQ28261936
Association between microdeletion and microduplication at 16p11.2 and autismQ28264205
Patterns and rates of exonic de novo mutations in autism spectrum disordersQ28264242
Rare structural variants disrupt multiple genes in neurodevelopmental pathways in schizophreniaQ28274064
Microdeletion 15q13.3: a locus with incomplete penetrance for autism, mental retardation, and psychiatric disorders.Q37419604
Psychopathology and cognition in children with 22q11.2 deletion syndromeQ37424826
Risk of mental illness in offspring of parents with schizophrenia, bipolar disorder, and major depressive disorder: a meta-analysis of family high-risk studiesQ37451503
Analysis of copy number variations at 15 schizophrenia-associated loci.Q37541157
Fine mapping of ZNF804A and genome-wide significant evidence for its involvement in schizophrenia and bipolar disorderQ37571848
High frequencies of de novo CNVs in bipolar disorder and schizophreniaQ37578876
The role of DNA copy number variation in schizophrenia.Q37595947
Genome-wide association analysis of copy number variation in recurrent depressive disorder.Q37611740
Molecular genetic evidence for overlap between general cognitive ability and risk for schizophrenia: a report from the Cognitive Genomics consorTium (COGENT).Q37670805
Genetic relationships between schizophrenia, bipolar disorder, and schizoaffective disorderQ37699386
Molecular and clinical characterization of 25 individuals with exonic deletions of NRXN1 and comprehensive review of the literatureQ38093545
Neurodevelopmental disorders and genetic testing: current approaches and future advances.Q38115271
New ethical issues for genetic counseling in common mental disordersQ38125112
Global burden of disease attributable to mental and substance use disorders: findings from the Global Burden of Disease Study 2010.Q38133045
Learning disabilities and executive dysfunction in boys with attention-deficit/hyperactivity disorderQ38437146
Genomics and the classification of mental illness: focus on broader categoriesQ39325276
A controlled family study of chronic psychoses. Schizophrenia and schizoaffective disorderQ39709714
Toward new approaches to psychotic disorders: the NIMH Research Domain Criteria projectQ42399695
The internet is parents' main source of information about psychiatric manifestations of 22q11.2 deletion syndrome (22q11.2DS).Q42556773
Autism symptoms in Attention-Deficit/Hyperactivity Disorder: a familial trait which correlates with conduct, oppositional defiant, language and motor disordersQ42662785
Impaired intellect and memory: a missing link between genetic risk and schizophrenia?Q42674378
Psychiatry, the pharmaceutical industry, and the road to better therapeuticsQ43233120
Polygenic risk for schizophrenia is associated with cognitive change between childhood and old age.Q44592961
Association between schizophrenia and common variation in neurocan (NCAN), a genetic risk factor for bipolar disorderQ45075170
The Roscommon Family Study. IV. Affective illness, anxiety disorders, and alcoholism in relativesQ45090793
Genetics of autism: overview and new directionsQ45107766
Maternal and paternal age and risk of autism spectrum disorders.Q45936043
The symptoms of autism spectrum disorders in adolescence and adulthoodQ47274092
Autistic spectrum disorders in velo-cardio facial syndrome (22q11.2 deletion).Q48332601
Specificity of psychosis, mania and major depression in a contemporary family study.Q48413890
IQ and risk for schizophrenia: a population-based cohort study.Q48582691
Sustained attention deficit in bipolar disorder.Q48643730
Intellectual disability and major psychiatric disorders: a continuum of neurodevelopmental causality.Q48704419
Relationship between clinical and neuropsychological characteristics in child and adolescent first degree relatives of subjects with schizophrenia.Q49018246
No evidence that common genetic risk variation is shared between schizophrenia and autism.Q50303685
Reduced burden of very large and rare CNVs in bipolar affective disorder.Q50309743
Microdeletion/microduplication of proximal 15q11.2 between BP1 and BP2: a susceptibility region for neurological dysfunction including developmental and language delay.Q50312488
Nine patients with a microdeletion 15q11.2 between breakpoints 1 and 2 of the Prader-Willi critical region, possibly associated with behavioural disturbances.Q50341061
The Research Domain Criteria: moving the goalposts to change the game.Q50656914
15q11.2 microdeletion - seven new patients with delayed development and/or behavioural problems.Q51822786
Neurocognitive endophenotypes in a multiplex multigenerational family study of schizophrenia.Q51904034
Childhood antecedent disorders to bipolar disorder in adults: a controlled study.Q51930938
Range of genetic mutations associated with severe non-syndromic sporadic intellectual disability: an exome sequencing studyQ28275978
Strong association of de novo copy number mutations with sporadic schizophreniaQ28282047
Psychiatric disorders in children with autism spectrum disorders: prevalence, comorbidity, and associated factors in a population-derived sampleQ28288117
Array-based technology and recommendations for utilization in medical genetics practice for detection of chromosomal abnormalitiesQ28296227
Genetic relationship between five psychiatric disorders estimated from genome-wide SNPsQ28296286
Genome-wide association analysis identifies 13 new risk loci for schizophreniaQ28297287
Copy number variants in schizophrenia: confirmation of five previous findings and new evidence for 3q29 microdeletions and VIPR2 duplicationsQ28304430
The worldwide prevalence of ADHD: a systematic review and metaregression analysisQ28304626
Multiple Recurrent De Novo CNVs, Including Duplications of the 7q11.23 Williams Syndrome Region, Are Strongly Associated with AutismQ29013643
CNVs conferring risk of autism or schizophrenia affect cognition in controlsQ29308426
Rare De Novo and Transmitted Copy-Number Variation in Autistic Spectrum DisordersQ29394511
De Novo Gene Disruptions in Children on the Autistic SpectrumQ29394534
Identification of loci associated with schizophrenia by genome-wide association and follow-upQ29417130
Large-scale genome-wide association analysis of bipolar disorder identifies a new susceptibility locus near ODZ4Q29417143
Recurrent reciprocal 16p11.2 rearrangements associated with global developmental delay, behavioural problems, dysmorphism, epilepsy, and abnormal head sizeQ29544005
GCTA: a tool for genome-wide complex trait analysisQ29547216
De novo mutations revealed by whole-exome sequencing are strongly associated with autismQ29547269
Exome sequencing in sporadic autism spectrum disorders identifies severe de novo mutationsQ29614573
A copy number variation morbidity map of developmental delayQ29616033
Exome sequencing supports a de novo mutational paradigm for schizophrenia.Q30405748
Using large clinical data sets to infer pathogenicity for rare copy number variants in autism cohortsQ30572502
De novo CNV analysis implicates specific abnormalities of postsynaptic signalling complexes in the pathogenesis of schizophrenia.Q33398247
Polygenic dissection of diagnosis and clinical dimensions of bipolar disorder and schizophreniaQ33662873
Deletion 17q12 is a recurrent copy number variant that confers high risk of autism and schizophreniaQ33740241
Microdeletion/duplication at 15q13.2q13.3 among individuals with features of autism and other neuropsychiatric disordersQ33874840
Schizophrenia susceptibility associated with interstitial deletions of chromosome 22q11.Q33992163
Schizophrenia: an integrated sociodevelopmental-cognitive modelQ34023115
Prevalence and correlates of bipolar spectrum disorder in the world mental health survey initiativeQ34026000
Microdeletions of 3q29 confer high risk for schizophreniaQ34050937
A polygenic burden of rare disruptive mutations in schizophreniaQ34060200
Identifying loci for the overlap between attention-deficit/hyperactivity disorder and autism spectrum disorder using a genome-wide QTL linkage approachQ34089144
Rare chromosomal deletions and duplications in attention-deficit hyperactivity disorder: a genome-wide analysisQ34247422
Estimating the proportion of variation in susceptibility to schizophrenia captured by common SNPs.Q34255285
Family history of schizophrenia and bipolar disorder as risk factors for autismQ34295552
A 15q13.3 microdeletion segregating with autismQ34326191
Using summary data from the danish national registers to estimate heritabilities for schizophrenia, bipolar disorder, and major depressive disorderQ34333039
Changes in prevalence of parent-reported autism spectrum disorder in school-aged U.S. children: 2007 to 2011-2012.Q34427570
The penetrance of copy number variations for schizophrenia and developmental delay.Q34497136
De novo mutations in schizophrenia implicate synaptic networksQ34540372
A review of the evidence from family, twin and adoption studies for a genetic contribution to adult psychiatric disordersQ34561361
Family, twin, and adoption studies of bipolar diseaseQ34577196
Advanced parental age and the risk of autism spectrum disorderQ34599167
Lifetime prevalence and age-of-onset distributions of mental disorders in the World Health Organization's World Mental Health Survey InitiativeQ34734906
Analysis of genetic deletions and duplications in the University College London bipolar disorder case control sampleQ34873753
Strong genetic evidence for a selective influence of GABAA receptors on a component of the bipolar disorder phenotypeQ34902898
Common genetic determinants of schizophrenia and bipolar disorder in Swedish families: a population-based studyQ34923924
Meta-analytic evidence for familial coaggregation of schizophrenia and bipolar disorder.Q34990933
Copy number variation in schizophrenia in the Japanese populationQ35010699
Childhood developmental abnormalities in schizophrenia: evidence from high-risk studiesQ35068141
Cognitive decline in schizophrenia from childhood to midlife: a 33-year longitudinal birth cohort studyQ35252525
Rare copy number variants: a point of rarity in genetic risk for bipolar disorder and schizophreniaQ35764622
Copy number variations of chromosome 16p13.1 region associated with schizophreniaQ35900760
Evidence for a fragile X mental retardation protein-mediated translational switch in metabotropic glutamate receptor-triggered Arc translation and long-term depression.Q35949697
Children with 7q11.23 Duplication Syndrome: Speech, Language, Cognitive, and Behavioral Characteristics and their Implications for InterventionQ36059777
Further delineation of the 15q13 microdeletion and duplication syndromes: a clinical spectrum varying from non-pathogenic to a severe outcomeQ36091184
Maternally derived microduplications at 15q11-q13: implication of imprinted genes in psychotic illnessQ36193455
Synapse proteomics of multiprotein complexes: en route from genes to nervous system diseases.Q36252737
A 600 kb deletion syndrome at 16p11.2 leads to energy imbalance and neuropsychiatric disordersQ36386207
22q11.2 deletion syndrome: attitudes towards disclosing the risk of psychiatric illnessQ36431058
Schizophrenia genetic variants are not associated with intelligenceQ36551460
Genome-wide analysis of copy number variants in attention deficit hyperactivity disorder: the role of rare variants and duplications at 15q13.3.Q36695755
Attention-deficit hyperactivity disorder symptoms in a clinic sample of children and adolescents with pervasive developmental disordersQ36698562
Risk of bipolar disorder and schizophrenia in relatives of people with attention-deficit hyperactivity disorderQ37061214
Shared polygenic contribution between childhood attention-deficit hyperactivity disorder and adult schizophreniaQ37061218
Support for the involvement of large copy number variants in the pathogenesis of schizophreniaQ37147142
Mortality, ADHD, and psychosocial adversity in adults with childhood ADHD: a prospective studyQ37290084
Singleton deletions throughout the genome increase risk of bipolar disorderQ37326513
Reciprocal duplication of the Williams-Beuren syndrome deletion on chromosome 7q11.23 is associated with schizophreniaQ37337299
Evidence that duplications of 22q11.2 protect against schizophreniaQ37414526
P433issue4
P304page(s)29
P577publication date2014-04-28
P1433published inGenome MedicineQ15816848
P1476titleGenomic insights into the overlap between psychiatric disorders: implications for research and clinical practice
P478volume6

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cites work (P2860)
Q47276840A Genome-Wide Association Study and Complex Network Identify Four Core Hub Genes in Bipolar Disorder
Q35802831A cross-species genetic analysis identifies candidate genes for mouse anxiety and human bipolar disorder
Q61849574A genome-wide association study of shared risk across psychiatric disorders implicates gene regulation during fetal neurodevelopment
Q38757268A genome-wide quantitative trait locus (QTL) linkage scan of NEO personality factors in Latino families segregating bipolar disorder
Q37739910ASD and schizophrenia show distinct developmental profiles in common genetic overlap with population-based social communication difficulties
Q37696565Addressing reverse inference in psychiatric neuroimaging: Meta-analyses of task-related brain activation in common mental disorders
Q50345507Adult autism spectrum as a transnosographic dimension.
Q38759421Altering the course of schizophrenia: progress and perspectives
Q37310541Animal Models of Maternal Immune Activation in Depression Research
Q37005185Association of Genetic Risk for Schizophrenia With Nonparticipation Over Time in a Population-Based Cohort Study
Q90781341Attention-deficit hyperactivity disorder shares copy number variant risk with schizophrenia and autism spectrum disorder
Q35620380Autism beyond diagnostic categories: characterization of autistic phenotypes in schizophrenia
Q91831376Autistic Traits and Illness Trajectories
Q91774669Brain gray matter network organization in psychotic disorders
Q47552092Comorbid autism spectrum disorder and anxiety disorders: a brief review
Q35988422Comparison of visual perceptual organization in schizophrenia and body dysmorphic disorder
Q40128202Converging evidence for an impact of a functional NOS gene variation on anxiety-related processes.
Q35246537Copy number variants encompassing Mendelian disease genes in a large multigenerational family segregating bipolar disorder
Q64228579Cytochrome P450 2C19 Poor Metabolizer Phenotype in Treatment Resistant Depression: Treatment and Diagnostic Implications
Q61801094Dynamic expression of genes associated with schizophrenia and bipolar disorder across development
Q47913477Effects of common GRM5 genetic variants on cognition, hippocampal volume and mGluR5 protein levels in schizophrenia.
Q38681930Epigenetics of Autism Spectrum Disorder
Q91892352Exome sequencing identifies de novo splicing variant in XRCC6 in sporadic case of autism
Q35990042FXR1P is a GSK3β substrate regulating mood and emotion processing
Q99353130Familial coaggregation of major psychiatric disorders in first-degree relatives of individuals with autism spectrum disorder: a nationwide population-based study
Q40418374Fine-mapping of antipsychotic response genome-wide association studies reveals novel regulatory mechanisms
Q28071570From Asperger's Autistischen Psychopathen to DSM-5 Autism Spectrum Disorder and Beyond: A Subthreshold Autism Spectrum Model
Q47552479Gene regulatory mechanisms underlying sex differences in brain development and psychiatric disease.
Q100737121Genetic association of FMRP targets with psychiatric disorders
Q39424410Genetics of Schizophrenia: Overview of Methods, Findings and Limitations
Q91770400Genotype-phenotype associations in children with copy number variants associated with high neuropsychiatric risk in the UK (IMAGINE-ID): a case-control cohort study
Q37223293Immune signatures and disorder-specific patterns in a cross-disorder gene expression analysis
Q39130188Modeling neurodevelopmental and psychiatric diseases with human iPSCs
Q38679839Modeling psychiatric disorders with patient-derived iPSCs
Q100736965Mutations associated with neuropsychiatric conditions delineate functional brain connectivity dimensions contributing to autism and schizophrenia
Q31114703Negative affect predicts social functioning across schizophrenia and bipolar disorder: Findings from an integrated data analysis
Q38917986Neurodevelopmental Perspectives on Wnt Signaling in Psychiatry
Q30844089New statistical approaches exploit the polygenic architecture of schizophrenia--implications for the underlying neurobiology
Q35737901Novel genetic advances in schizophrenia: an interview with Michael O'Donovan
Q52884385Overlapping 16p13.11 deletion and gain of copies variations associated with childhood onset psychosis include genes with mechanistic implications for autism associated pathways: Two case reports.
Q42286241Patient-derived hiPSC neurons with heterozygous CNTNAP2 deletions display altered neuronal gene expression and network activity
Q42361493Pharmacogenomics in the treatment of mood disorders: Strategies and Opportunities for personalized psychiatry
Q36972791Prefrontal neuronal integrity predicts symptoms and cognition in schizophrenia and is sensitive to genetic heterogeneity
Q48342101Prenatal testing for neuropsychiatric disorders.
Q39145749Proteomic analysis of the postsynaptic density implicates synaptic function and energy pathways in bipolar disorder
Q60915706Protocol for a transdiagnostic study of children with problems of attention, learning and memory (CALM)
Q26744368Recent Advances in Autism Spectrum Disorders: Applications of Whole Exome Sequencing Technology
Q48901423Review: changing (shared) heritability of ASD and ADHD across the lifespan.
Q30377846Risk Factors Associated With Language in Autism Spectrum Disorder: Clues to Underlying Mechanisms.
Q41658777Schizophrenia and the neurodevelopmental continuum:evidence from genomics
Q34447169Schizophrenia genetics: emerging themes for a complex disorder.
Q92432772Shared vulnerability for connectome alterations across psychiatric and neurological brain disorders
Q31150357Structural brain imaging correlates of ASD and ADHD across the lifespan: a hypothesis-generating review on developmental ASD-ADHD subtypes
Q36424672Systems biology and gene networks in neurodevelopmental and neurodegenerative disorders
Q40183800Systems genetics identifies a convergent gene network for cognition and neurodevelopmental disease
Q59052397The Concept of Schizophrenia: From Unity to Diversity
Q48164870The association of proopiomelanocortin polymorphisms with the risk of major depressive disorder and the response to antidepressants via interactions with stressful life events
Q58657746The ethics of patenting autism genes
Q38802467The promises and challenges of human brain organoids as models of neuropsychiatric disease
Q24288977Top 10 Replicated Findings From Behavioral Genetics
Q91199127Transcriptomic networks implicate neuronal energetic abnormalities in three mouse models harboring autism and schizophrenia-associated mutations
Q89984725Ubiquitous neurocognitive dysfunction in familial adenomatous polyposis: proof-of-concept of the role of APC protein in neurocognitive function
Q57403235Use of schizophrenia and bipolar disorder polygenic risk scores to identify psychotic disorders
Q42544634What can we learn from the high rates of schizophrenia in people with 22q11.2 deletion syndrome?

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