Chitosan and glyceryl monooleate nanostructures containing gemcitabine: potential delivery system for pancreatic cancer treatment

scientific article

Chitosan and glyceryl monooleate nanostructures containing gemcitabine: potential delivery system for pancreatic cancer treatment is …
instance of (P31):
scholarly articleQ13442814

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P6179Dimensions Publication ID1052193116
P356DOI10.1208/S12249-010-9393-0
P932PMC publication ID2850475
P698PubMed publication ID20238190
P5875ResearchGate publication ID42256221

P2093author name stringAlekha K Dash
William J Trickler
Ankita A Nagvekar
Jatin Khurana
P2860cites workUp-regulation of miR-200 and let-7 by natural agents leads to the reversal of epithelial-to-mesenchymal transition in gemcitabine-resistant pancreatic cancer cellsQ24651034
A phase I clinical, plasma, and cellular pharmacology study of gemcitabineQ28334915
Improvements in survival and clinical benefit with gemcitabine as first-line therapy for patients with advanced pancreas cancer: a randomized trialQ29547565
Cancer statistics, 2006Q29615133
Effectiveness of submicron-sized, chitosan-coated liposomes in oral administration of peptide drugsQ33222364
Novel mucoadhesion tests for polymers and polymer-coated particles to design optimal mucoadhesive drug delivery systemsQ33223515
Preparation of poly epsilon-caprolactone nanoparticles containing magnetite for magnetic drug carrier.Q33252054
Mucoadhesive nanoparticulate systems for peptide drug deliveryQ34184353
A novel nanoparticle formulation for sustained paclitaxel deliveryQ34293494
Nucleoside transporters in chronic lymphocytic leukaemiaQ35635321
Pancreatic cancer: diagnosis and management.Q36396324
Nanoparticles for cellular drug delivery: mechanisms and factors influencing deliveryQ36627043
Polymeric nanogels containing the triphosphate form of cytotoxic nucleoside analogues show antitumor activity against breast and colorectal cancer cell linesQ36994110
Novel approaches to deliver gemcitabine to cancersQ37160947
The in vitro sub-cellular localization and in vivo efficacy of novel chitosan/GMO nanostructures containing paclitaxelQ39849321
Targeted delivery of gemcitabine to pancreatic adenocarcinoma using cetuximab as a targeting agentQ40002504
Chitosan-coated PLGA nanoparticles for DNA/RNA delivery: effect of the formulation parameters on complexation and transfection of antisense oligonucleotides.Q40095319
Encapsulation of gemcitabine lipophilic derivatives into polycyanoacrylate nanospheres and nanocapsulesQ40102884
Magnetic poly epsilon-caprolactone nanoparticles containing Fe3O4 and gemcitabine enhance anti-tumor effect in pancreatic cancer xenograft mouse model.Q40110831
Chitosan nanoparticle as gene therapy vector via gastrointestinal mucosa administration: results of an in vitro and in vivo studyQ40214199
A mucoadhesive in situ gel delivery system for paclitaxelQ40263358
Phase I trial and pharmacokinetics of gemcitabine in children with advanced solid tumorsQ40531924
Size-dependent internalization of particles via the pathways of clathrin- and caveolae-mediated endocytosisQ40632272
Rapid endo-lysosomal escape of poly(DL-lactide-co-glycolide) nanoparticles: implications for drug and gene deliveryQ40713744
In vitro cellular accumulation of gadolinium incorporated into chitosan nanoparticles designed for neutron-capture therapy of cancerQ40759040
Mechanisms of uptake and resistance to troxacitabine, a novel deoxycytidine nucleoside analogue, in human leukemic and solid tumor cell lines.Q40776900
[3H]gemcitabine uptake by nucleoside transporters in a human head and neck squamous carcinoma cell lineQ40971672
Preclinical characteristics of gemcitabine.Q41040899
Differential mucin gene expression in human pancreatic and colon cancer cellsQ41679123
Evaluation of the antitumor activity of gemcitabine (2',2'-difluoro-2'-deoxycytidine).Q41728002
Increased sensitivity to gemcitabine of P-glycoprotein and multidrug resistance-associated protein-overexpressing human cancer cell linesQ42142458
RNA interference in vitro and in vivo using a novel chitosan/siRNA nanoparticle system.Q42799200
Polymeric nanoparticulate system augmented the anticancer therapeutic efficacy of gemcitabineQ43289065
Chitosan nanoparticles: a new vehicle for the improvement of the delivery of drugs to the ocular surface. Application to cyclosporin A.Q43687728
Interaction of p53 and DNA-PK in response to nucleoside analogues: potential role as a sensor complex for DNA damageQ43829332
Change in pharmacokinetic and pharmacodynamic behavior of gemcitabine in human tumor xenografts upon entrapment in vesicular phospholipid gelsQ43971548
A comprehensive characterization of pancreatic ductal carcinoma cell lines: towards the establishment of an in vitro research platformQ44401579
A novel in situ gel for sustained drug delivery and targetingQ44869101
Preparation of gemcitabine polybutylcyanoacrylate nanoparticlesQ46892442
The mechanism of resistance to 2', 2'-difluorodeoxycytidine (gemcitabine) in a pancreatic cancer cell lineQ46948429
Magnetic PECA nanoparticles as drug carriers for targeted delivery: synthesis and release characteristics.Q51186635
Functional nucleoside transporters are required for gemcitabine influx and manifestation of toxicity in cancer cell lines.Q54122138
Nanoparticles based on N-trimethylchitosan: Evaluation of absorption properties using in vitro (Caco-2 cells) and ex vivo (excised rat jejunum) modelsQ57360670
Comparison of the cellular pharmacokinetics and toxicity of 2',2'-difluorodeoxycytidine and 1-beta-D-arabinofuranosylcytosineQ68408993
Enteral absorption of insulin in rats from mucoadhesive chitosan-coated liposomesQ71499864
Mucoadhesion of polymer-coated liposomes to rat intestine in vitroQ72791120
Tumor pH: implications for treatment and novel drug designQ74676183
Interaction of 2',2'-difluorodeoxycytidine (gemcitabine) and formycin B with the Na+-dependent and -independent nucleoside transporters of Ehrlich ascites tumor cellsQ77223754
Thiomers: preparation and in vitro evaluation of a mucoadhesive nanoparticulate drug delivery systemQ83087906
P433issue1
P407language of work or nameEnglishQ1860
P921main subjectpancreatic cancerQ212961
nanostructureQ1093894
P304page(s)392-401
P577publication date2010-03-18
P1433published inAAPS PharmSciTechQ15750612
P1476titleChitosan and glyceryl monooleate nanostructures containing gemcitabine: potential delivery system for pancreatic cancer treatment
P478volume11

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cites work (P2860)
Q38091630Advances in chitosan-based drug delivery vehicles
Q46968656Antitumor efficacy, tumor distribution and blood pharmacokinetics of chitosan/glyceryl-monooleate nanostructures containing paclitaxel
Q39346357Chitosan-Pluronic nanoparticles as oral delivery of anticancer gemcitabine: preparation and in vitro study
Q46007249Effect of high-pressure homogenization and stabilizers on the physicochemical properties of curcumin-loaded glycerol monooleate/chitosan nanostructures.
Q50044141Fabrication of novel GMO/Eudragit E100 nanostructures for enhancing oral bioavailability of carvedilol
Q47199315Gemcitabine hydrochloride-loaded liposomes and nanoparticles: comparison of encapsulation efficiency, drug release, particle size, and cytotoxicity
Q31098128Mechanistic studies of Gemcitabine-loaded nanoplatforms in resistant pancreatic cancer cells
Q35024399Multifunctional nanoparticles for prostate cancer therapy
Q60959037Silver Nanoparticles Potentiates Cytotoxicity and Apoptotic Potential of Camptothecin in Human Cervical Cancer Cells
Q33659863Silver nanoparticle induced blood-brain barrier inflammation and increased permeability in primary rat brain microvessel endothelial cells
Q39588127Surface-modified gemcitabine with mucoadhesive polymer for oral delivery.
Q46218236Surface-modified solid lipid nanoparticulate formulation for ifosfamide: development and characterization

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