Up-Regulation of RANK Expression via ERK1/2 by Insulin Contributes to the Enhancement of Osteoclast Differentiation

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Up-Regulation of RANK Expression via ERK1/2 by Insulin Contributes to the Enhancement of Osteoclast Differentiation is …
instance of (P31):
scholarly articleQ13442814

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P356DOI10.14348/MOLCELLS.2017.0025
P932PMC publication ID5463046
P698PubMed publication ID28535663

P2093author name stringJu Hee Oh
Na Kyung Lee
P2860cites workBone metabolism in type 2 diabetes mellitusQ78095348
v-ATPase V0 subunit d2-deficient mice exhibit impaired osteoclast fusion and increased bone formationQ79383955
Birth and Death of Bone Cells: Basic Regulatory Mechanisms and Implications for the Pathogenesis and Treatment of Osteoporosis 1Q22306225
Osteoprotegerin ligand is a cytokine that regulates osteoclast differentiation and activationQ24311588
RANK is essential for osteoclast and lymph node developmentQ24598872
Insulin receptor signaling in osteoblasts regulates postnatal bone acquisition and body compositionQ24629773
Tumor necrosis factor receptor family member RANK mediates osteoclast differentiation and activation induced by osteoprotegerin ligandQ24653311
Osteoclast differentiation factor is a ligand for osteoprotegerin/osteoclastogenesis-inhibitory factor and is identical to TRANCE/RANKLQ24682139
Modulation of osteoclast differentiation and function by the new members of the tumor necrosis factor receptor and ligand familiesQ28137631
Bone resorption by osteoclastsQ28145169
DC-STAMP is essential for cell-cell fusion in osteoclasts and foreign body giant cellsQ28506839
Osteoclast differentiation and activationQ29547556
Induction and activation of the transcription factor NFATc1 (NFAT2) integrate RANKL signaling in terminal differentiation of osteoclastsQ29618116
Insulin enhances RANKL-induced osteoclastogenesis via ERK1/2 activation and induction of NFATc1 and Atp6v0d2.Q33361435
Therapeutic approaches to bone diseasesQ34021178
Insulin signaling in osteoblasts integrates bone remodeling and energy metabolismQ34021680
Gene expression profiling in osteoclast precursors by insulin using microarray analysisQ34628262
Control of osteoblast function and regulation of bone massQ35128237
Obatoclax regulates the proliferation and fusion of osteoclast precursors through the inhibition of ERK activation by RANKLQ35188522
Is insulin an anabolic agent in bone? Dissecting the diabetic bone for cluesQ36281802
Discrepancies in bone mineral density and fracture risk in patients with type 1 and type 2 diabetes--a meta-analysisQ36636165
Early estrogen-induced gene 1, a novel RANK signaling component, is essential for osteoclastogenesisQ36739991
RANK is the intrinsic hematopoietic cell surface receptor that controls osteoclastogenesis and regulation of bone mass and calcium metabolismQ37108966
Insulin receptor substrate-1 in osteoblast is indispensable for maintaining bone turnoverQ37176385
NFATc1 induces osteoclast fusion via up-regulation of Atp6v0d2 and the dendritic cell-specific transmembrane protein (DC-STAMP).Q37302319
Insulin stimulates osteoblast proliferation and differentiation through ERK and PI3K in MG-63 cellsQ39697564
Fra-1 replaces c-Fos-dependent functions in miceQ40445308
Transforming growth factor-beta induces osteoclast formation in the absence of RANKL.Q40594156
Genetic and physical interactions between Microphthalmia transcription factor and PU.1 are necessary for osteoclast gene expression and differentiation.Q42826784
Serum prolidase activity as a marker of osteoporosis in type 2 diabetes mellitusQ44075415
RANKL-independent human osteoclast formation with APRIL, BAFF, NGF, IGF I and IGF II.Q46628325
Disruption of the insulin-like growth factor type 1 receptor in osteoblasts enhances insulin signaling and action.Q50678899
Up-regulation of cyclinD1 and Bcl2A1 by insulin is involved in osteoclast proliferation.Q53031373
Interleukin-6 and interleukin-11 support human osteoclast formation by a RANKL-independent mechanism.Q53941037
Fosl1 is a transcriptional target of c-Fos during osteoclast differentiationQ57675158
Osteopenia in insulin-dependent diabetes mellitus; prevalence and aspects of pathophysiologyQ73958624
P433issue5
P304page(s)371-377
P577publication date2017-05-22
P1433published inMolecules and CellsQ12623193
P1476titleUp-Regulation of RANK Expression via ERK1/2 by Insulin Contributes to the Enhancement of Osteoclast Differentiation
P478volume40

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cites work (P2860)
Q92422244Extracellular Signal-Regulated Kinase: A Regulator of Cell Growth, Inflammation, Chondrocyte and Bone Cell Receptor-Mediated Gene Expression
Q49861077Glucagon-like peptide 2 decreases osteoclasts by stimulating apoptosis dependent on nitric oxide synthase.

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