Amiodarone: ionic and cellular mechanisms of action of the most promising class III agent

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Amiodarone: ionic and cellular mechanisms of action of the most promising class III agent is …
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scholarly articleQ13442814
review articleQ7318358

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P356DOI10.1016/S0002-9149(99)00698-0
P698PubMed publication ID10568656

P2093author name stringKodama I
Kamiya K
Toyama J
P2860cites workThe effect of amiodarone, a new anti-anginal drug, on cardiac muscleQ24669966
Amiodarone: biochemical evidence for binding to a receptor for class I drugs associated with the rat cardiac sodium channelQ28342765
Effect of the antiarrhythmic agent moricizine on survival after myocardial infarctionQ33970406
Differential and tissue-specific regulation of the multiple rat c-erbA messenger RNA species by thyroid hormoneQ34239775
Preliminary report: effect of encainide and flecainide on mortality in a randomized trial of arrhythmia suppression after myocardial infarctionQ34415281
Effects of Amiodarone and Bepridil on Ventricular Depolarization and RepolarizationaQ35227028
Resting, and rate-dependent depression of Vmax of guinea-pig ventricular action potentials by amiodarone and desethylamiodaroneQ35754950
Effects of long-term oral administration of amiodarone on the electromechanical performance of rabbit ventricular muscleQ35871237
Comparison of the chronic and acute effects of amiodarone on the calcium and potassium currents in rabbit isolated cardiac myocytesQ35873960
Does amiodarone affect heart rate by inhibiting the intracellular generation of triiodothyronine from thyroxine?Q36004441
Two components of cardiac delayed rectifier K+ current. Differential sensitivity to block by class III antiarrhythmic agentsQ36434545
The historical development, cellular electrophysiology and pharmacology of amiodaroneQ38596609
Effect of oral triiodothyronine during amiodarone treatment for ventricular premature complexesQ39541478
Amiodarone: Historical development and pharmacologic profileQ40156963
Amiodarone: electrophysiologic actions, pharmacokinetics and clinical effectsQ40172905
Amiodarone and post-MI patientsQ40488579
Controlling cardiac arrhythmias by lengthening repolarization: historical overviewQ40779074
Cellular electropharmacology of amiodaroneQ40888033
Expanding indications for the use of Class III agents in patients at high risk for sudden deathQ40938926
Antiarrhythmic drug therapy for ventricular arrhythmias: current perspectivesQ41112408
Voltage- and use-dependent modulation of calcium channel current in guinea pig ventricular cells by amiodarone and des-oxo-amiodaroneQ41139598
Acute and chronic effects of amiodarone on mammalian ventricular cellsQ41279579
Effects of class III antiarrhythmic drugs on the Na(+)-activated K+ channels in guinea-pig ventricular cellsQ42232591
Desethylamiodarone is a competitive inhibitor of the binding of thyroid hormone to the thyroid hormone α1-receptor proteinQ42276695
Desethylamiodarone is a noncompetitive inhibitor of the binding of thyroid hormone to the thyroid hormone beta 1-receptor proteinQ42285062
Block of cardiac sodium channels by amiodarone studied by using Vmax of action potential in single ventricular myocytesQ42561319
The effects of amiodarone on the electrocardiogram of the guinea-pig are not explained by interaction with thyroid hormone metabolism aloneQ42573076
Block of single cardiac Na+ channels by antiarrhythmic drugs: the effect of amiodarone, propafenone and diprafenoneQ43683887
Differential Effects of Amiodarone and Desethylamiodarone on Calcium Antagonist ReceptorsQ44436917
Suppression of time-dependent outward current in guinea pig ventricular myocytes. Actions of quinidine and amiodaroneQ46159179
Amiodarone alters thyroxine transfer and distribution in humansQ46201174
Use-dependent effects of amiodarone on Vmax in cardiac Purkinje and ventricular muscle fibersQ46294164
Block of inactivated sodium channels and of depolarization-induced automaticity in guinea pig papillary muscle by amiodaroneQ46989385
Amiodarone and thyroid hormone actionQ48512947
Amiodarone inhibits production of tumor necrosis factor-alpha by human mononuclear cells: a possible mechanism for its effect in heart failure.Q51536095
Effects of a new amiodarone-like agent, SR 33589, in comparison to amiodarone, D,L-sotalol, and lignocaine, on ischemia-induced ventricular arrhythmias in anesthetized pigs.Q51592904
Amiodarone is a dose-dependent noncompetitive and competitive inhibitor of T3 binding to thyroid hormone receptor subtype beta 1, whereas disopyramide, lignocaine, propafenone, metoprolol, dl-sotalol, and verapamil have no inhibitory effect.Q51598836
Amiodarone blocks inactivated cardiac sodium channelsQ53929101
Evidences of antagonism between amiodarone and triiodothyronine on the K+ channel activities of cultured rat cardiomyocytes.Q54205483
Efficacy and safety of quinidine therapy for maintenance of sinus rhythm after cardioversion. A meta-analysis of randomized control trials.Q55054117
In vivo effects of amiodarone on cardiac beta-adrenoceptor density and heart rate require thyroid hormonesQ67541590
Quinidine-related mortality in the short-to-medium-term treatment of ventricular arrhythmias. A meta-analysisQ67903871
An antiarrhythmic drug experience in 941 patients resuscitated from an initial cardiac arrest between 1970 and 1985Q68024944
Electrophysiologic effects of desethylamiodarone, an active metabolite of amiodarone: comparison with amiodarone during chronic administration in rabbitsQ68263566
Two types of sodium channel block by class-I antiarrhythmic drugs studied by using Vmax of action potential in single ventricular myocytesQ68455521
AmiodaroneQ68930408
Effects of amiodarone and its metabolite, desethylamiodarone, on the electrophysiologic properties of isolated cardiac muscleQ68955965
Interaction of amiodarone and desethylamiodarone with solubilized nuclear thyroid hormone receptorsQ68964233
The antiarrhythmic efficacy of amiodarone and desethylamiodarone, alone and in combination, in dogs with acute myocardial infarctionQ69012466
Frequency-dependent effects of amiodarone on atrioventricular nodal function and slow-channel action potentials: evidence for calcium channel-blocking activityQ69122924
Electropharmacology of amiodarone: absence of relationship to serum, myocardial, and cardiac sarcolemmal membrane drug concentrationsQ69653883
Comparative electrophysiologic effects of intravenous amiodarone and desethylamiodarone in dogs: evidence for clinically relevant activity of the metaboliteQ69688204
Rate-related electrophysiologic effects of long-term administration of amiodarone on canine ventricular myocardium in vivoQ69962160
Pharmacokinetic significance of serum reverse T3 levels during amiodarone treatment: a potential method for monitoring chronic drug therapyQ70367697
Decreased transport of thyroxine (T4), 3,3',5-triiodothyronine (T3) and 3,3',5'-triiodothyronine (rT3) into rat hepatocytes in primary culture due to a decrease of cellular ATP content and various drugsQ70370199
Amiodarone and thyroid function: clinical implications during antiarrhythmic therapyQ70446958
Amiodarone inhibits the conversion of thyroxine to triiodothyronine in isolated rat hepatocytesQ70616975
Electrophysiologic effects of amiodarone: experimental and clinical observation relative to serum and tissue drug concentrationsQ70635769
Contemporary clinical trials in ventricular tachycardia and fibrillation: implications of ESVEM, CASCADE, and CASH for clinical managementQ70864697
Antagonism between T3 and amiodarone on the contractility and the density of beta-adrenoceptors of chicken cardiac myocytesQ71989452
SR 33589, a new amiodarone-like antiarrhythmic agent: electrophysiological effects in anesthetized dogsQ72242665
Quantitative overview of randomized trials of amiodarone to prevent sudden cardiac deathQ73914750
Vesnarinone prolongs action potential duration without reverse frequency dependence in rabbit ventricular muscle by blocking the delayed rectifier K+ currentQ73937003
P433issue9A
P407language of work or nameEnglishQ1860
P921main subjectamiodaroneQ410061
P304page(s)20R-28R
P577publication date1999-11-01
P1433published inAmerican Journal of CardiologyQ2208417
P1476titleAmiodarone: ionic and cellular mechanisms of action of the most promising class III agent
P478volume84

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