Retinoid X receptor-alpha-dependent transactivation by a naturally occurring structural variant of human constitutive androstane receptor (NR1I3).

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Retinoid X receptor-alpha-dependent transactivation by a naturally occurring structural variant of human constitutive androstane receptor (NR1I3). is …
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scholarly articleQ13442814

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P356DOI10.1124/MOL.105.013417
P932PMC publication ID4064472
P698PubMed publication ID16099843
P5875ResearchGate publication ID7660377

P50authorShengzhong SuQ57052564
P2093author name stringScott S Auerbach
Curtis J Omiecinski
Matthew A Stoner
P2860cites workAndrostane metabolites bind to and deactivate the nuclear receptor CAR-betaQ22003994
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The xenobiotic compound 1,4-bis[2-(3,5-dichloropyridyloxy)]benzene is an agonist ligand for the nuclear receptor CARQ24554260
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Alternatively spliced isoforms of the human constitutive androstane receptorQ24679627
Induction of bilirubin clearance by the constitutive androstane receptor (CAR)Q24683238
Control of steroid, heme, and carcinogen metabolism by nuclear pregnane X receptor and constitutive androstane receptorQ24683260
Alternative splicing affects the function and tissue-specific expression of the human constitutive androstane receptorQ24797407
The repressed nuclear receptor CAR responds to phenobarbital in activating the human CYP2B6 geneQ28137778
A unified nomenclature system for the nuclear receptor superfamilyQ28142509
Modulation of acetaminophen-induced hepatotoxicity by the xenobiotic receptor CARQ28207193
Nuclear receptor response elements mediate induction of intestinal MDR1 by rifampinQ28211706
Diverse roles of the nuclear orphan receptor CAR in regulating hepatic genes in response to phenobarbitalQ28212942
Identification of a novel human constitutive androstane receptor (CAR) agonist and its use in the identification of CAR target genesQ28213013
Transcriptional regulation of the human CYP3A4 gene by the constitutive androstane receptorQ28215455
Regulation of human CYP2C9 by the constitutive androstane receptor: discovery of a new distal binding siteQ28218180
A regulatory role for RIP140 in nuclear receptor activationQ28273693
Orphan nuclear receptors constitutive androstane receptor and pregnane X receptor share xenobiotic and steroid ligandsQ28375193
Using advanced intercross lines for high-resolution mapping of HDL cholesterol quantitative trait lociQ33680644
The nuclear orphan receptor CAR-retinoid X receptor heterodimer activates the phenobarbital-responsive enhancer module of the CYP2B geneQ33779787
Phenobarbital-elicited activation of nuclear receptor CAR in induction of cytochrome P450 genesQ34057827
A necessary good: nuclear hormone receptors and their chromatin templatesQ34122957
Binding of ligands and activation of transcription by nuclear receptors.Q34243256
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Separation of retinoid X receptor homo- and heterodimerization functionsQ36139646
Interactions between hepatic Mrp4 and Sult2a as revealed by the constitutive androstane receptor and Mrp4 knockout miceQ38343998
Regulation of CYP2B6 in primary human hepatocytes by prototypical inducersQ40587140
The nuclear receptor CAR mediates specific xenobiotic induction of drug metabolismQ40845372
The orphan human pregnane X receptor mediates the transcriptional activation of CYP3A4 by rifampicin through a distal enhancer moduleQ40916686
Hypoxia induces proteasome-dependent degradation of estrogen receptor alpha in ZR-75 breast cancer cellsQ42526349
Effects of ligand binding on the association properties and conformation in solution of retinoic acid receptors RXR and RAR.Q43545167
The phenobarbital response enhancer module in the human bilirubin UDP-glucuronosyltransferase UGT1A1 gene and regulation by the nuclear receptor CAR.Q43601213
Transcriptional regulation of CYP2C9 gene. Role of glucocorticoid receptor and constitutive androstane receptorQ43779017
Glucocorticoid receptor-interacting protein 1 mediates ligand-independent nuclear translocation and activation of constitutive androstane receptor in vivoQ43986663
Nuclear pregnane x receptor and constitutive androstane receptor regulate overlapping but distinct sets of genes involved in xenobiotic detoxificationQ44104285
Squalestatin 1-inducible expression of rat CYP2B: evidence that an endogenous isoprenoid is an activator of the constitutive androstane receptorQ44187758
A novel distal enhancer module regulated by pregnane X receptor/constitutive androstane receptor is essential for the maximal induction of CYP2B6 gene expressionQ44305000
Identification of constitutive androstane receptor and glucocorticoid receptor binding sites in the CYP2C19 promoterQ44517600
Characterization of DNA complexes formed by the nuclear receptor constitutive androstane receptorQ44535717
Complementary roles of farnesoid X receptor, pregnane X receptor, and constitutive androstane receptor in protection against bile acid toxicityQ44552108
Alternative splicing within the ligand binding domain of the human constitutive androstane receptor.Q44624379
A novel constitutive androstane receptor-mediated and CYP3A-independent pathway of bile acid detoxificationQ44741483
Identification of novel alternative splice variants of human constitutive androstane receptor and characterization of their expression in the liverQ44772875
The nuclear receptor CAR is a regulator of thyroid hormone metabolism during caloric restrictionQ44788639
Expression of constitutive androstane receptor splice variants in human tissues and their functional consequencesQ44934633
Trans-species gene transfer for analysis of glucocorticoid-inducible transcriptional activation of transiently expressed human CYP3A4 and rabbit CYP3A6 in primary cultures of adult rat and rabbit hepatocytesQ48062732
P433issue5
P304page(s)1239-1253
P577publication date2005-08-11
P1433published inMolecular PharmacologyQ1943386
P1476titleRetinoid X receptor-alpha-dependent transactivation by a naturally occurring structural variant of human constitutive androstane receptor (NR1I3)
P478volume68