Friedreich's ataxia (GAA)n•(TTC)n repeats strongly stimulate mitotic crossovers in Saccharomyces cerevisae.

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Friedreich's ataxia (GAA)n•(TTC)n repeats strongly stimulate mitotic crossovers in Saccharomyces cerevisae. is …
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scholarly articleQ13442814

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P356DOI10.1371/JOURNAL.PGEN.1001270
P932PMC publication ID3020933
P698PubMed publication ID21249181
P5875ResearchGate publication ID49768946

P50authorSergei MirkinQ11256582
Vidhya NarayananQ125342706
Margaret DominskaQ125342739
Zachary M HarvanekQ59705226
P2093author name stringPatricia W Greenwell
Thomas D Petes
Wei Tang
Hyun-Min Kim
Kirill S Lobachev
P2860cites workStructure-dependent recombination hot spot activity of GAA.TTC sequences from intron 1 of the Friedreich's ataxia geneQ79304939
Somatic instability of the expanded GAA triplet-repeat sequence in Friedreich ataxia progresses throughout lifeQ80325491
Expansion of GAA trinucleotide repeats in mammalsQ81550110
Features of trinucleotide repeat instability in vivoQ37048169
Models for chromosomal replication-independent non-B DNA structure-induced genetic instabilityQ37362336
Both CAG repeats and inverted DNA repeats stimulate spontaneous unequal sister-chromatid exchange in Saccharomyces cerevisiaeQ40250302
Molecular structures of crossover and noncrossover intermediates during gap repair in yeast: implications for recombinationQ40384769
The CDK regulates repair of double-strand breaks by homologous recombination during the cell cycleQ40619582
Replication stalling at Friedreich's ataxia (GAA)n repeats in vivo.Q40633778
Chromosome fragility at GAA tracts in yeast depends on repeat orientation and requires mismatch repairQ42556770
Large-scale expansions of Friedreich's ataxia GAA repeats in yeastQ43077169
Replication dynamics of the yeast genome.Q52053905
Contractions and expansions of CAG/CTG trinucleotide repeats occur during ectopic gene conversion in yeast, by a MUS81-independent mechanismQ64387600
Tetrad analysis shows that gene conversion is the major mechanism involved in mutation at the human minisatellite MS1 integrated in Saccharomyces cerevisiaeQ64388624
Meiotic instability of human minisatellite CEB1 in yeast requires DNA double-strand breaksQ64388755
Expansion and length-dependent fragility of CTG repeats in yeastQ74128701
A fine-structure map of spontaneous mitotic crossovers in the yeast Saccharomyces cerevisiaeQ21563348
Multiple pathways of recombination induced by double-strand breaks in Saccharomyces cerevisiaeQ24548535
DNA end resection, homologous recombination and DNA damage checkpoint activation require CDK1Q27938100
High-resolution mapping of meiotic crossovers and non-crossovers in yeastQ27938210
Elevated recombination rates in transcriptionally active DNAQ28131616
Yeast recombination: the association between double-strand gap repair and crossing-overQ28265497
Friedreich's ataxia: autosomal recessive disease caused by an intronic GAA triplet repeat expansionQ28275699
Regulation of Saccharomyces Rad53 checkpoint kinase during adaptation from DNA damage-induced G2/M arrest.Q30657462
Progressive GAA.TTC repeat expansion in human cell linesQ33513958
R loops stimulate genetic instability of CTG.CAG repeatsQ33639972
Human minisatellites, repeat DNA instability and meiotic recombinationQ33704277
From the Cover: mitotic gene conversion events induced in G1-synchronized yeast cells by gamma rays are similar to spontaneous conversion eventsQ33841932
Segregation of recombinant chromatids following mitotic crossing over in yeastQ33958496
Analysis of a gene conversion gradient at the HIS4 locus in Saccharomyces cerevisiaeQ33959781
Meiotic recombination hot spots and cold spotsQ34238005
The connection between transcription and genomic instabilityQ34514282
Infrequent co-conversion of markers flanking a meiotic recombination initiation site in Saccharomyces cerevisiae.Q34572477
Factors affecting inverted repeat stimulation of recombination and deletion in Saccharomyces cerevisiaeQ34604021
Efficient incorporation of large (>2 kb) heterologies into heteroduplex DNA: Pms1/Msh2-dependent and -independent large loop mismatch repair in Saccharomyces cerevisiaeQ34612288
Patterns of Heteroduplex Formation Associated With the Initiation of Meiotic Recombination in the Yeast Saccharomyces cerevisiaeQ34618616
Triplet repeats form secondary structures that escape DNA repair in yeastQ34995821
Selection and analysis of spontaneous reciprocal mitotic cross-overs in Saccharomyces cerevisiaeQ34999035
Meiotic instability of CAG repeat tracts occurs by double-strand break repair in yeastQ35049665
Trinucleotide repeat instability: a hairpin curve at the crossroads of replication, recombination, and repairQ35550042
Orientation-dependent and sequence-specific expansions of CTG/CAG trinucleotide repeats in Saccharomyces cerevisiaeQ36524919
Meiosis-specific double-strand DNA breaks at the HIS4 recombination hot spot in the yeast Saccharomyces cerevisiae: control in cis and transQ36550076
Double-strand breaks associated with repetitive DNA can reshape the genomeQ36836268
Expandable DNA repeats and human disease.Q36854284
P275copyright licenseCreative Commons Attribution 4.0 InternationalQ20007257
P6216copyright statuscopyrightedQ50423863
P433issue1
P921main subjectFriedreich ataxiaQ913856
P304page(s)e1001270
P577publication date2011-01-13
P1433published inPLOS GeneticsQ1893441
P1476titleFriedreich's ataxia (GAA)n•(TTC)n repeats strongly stimulate mitotic crossovers in Saccharomyces cerevisae
P478volume7