Dnmt3a-mediated inhibition of Wnt in cardiac progenitor cells improves differentiation and remote remodeling after infarction.

scientific article

Dnmt3a-mediated inhibition of Wnt in cardiac progenitor cells improves differentiation and remote remodeling after infarction. is …
instance of (P31):
scholarly articleQ13442814

External links are
P356DOI10.1172/JCI.INSIGHT.91810
P932PMC publication ID5470891
P698PubMed publication ID28614798

P50authorDenise Hilfiker-KleinerQ38606310
Daniele CatalucciQ53518460
Olivier FeronQ79120745
Vittoria Di MauroQ87971427
Nicolas BarbierQ122866284
P2093author name stringCaroline Bouzin
Jean-Luc Balligand
Bernhard Gerber
Stéphane Moniotte
Axelle Loriot
Charles De Smet
Hrag Esfahani
Aurelia De Pauw
Belaid Sekkali
Emilie Andre
Laetitia Vanhoutte
P2860cites workHeart regenerationQ24562846
MicroRNA-29 family reverts aberrant methylation in lung cancer by targeting DNA methyltransferases 3A and 3BQ24564757
Cell therapy for heart failure: a comprehensive overview of experimental and clinical studies, current challenges, and future directionsQ27001159
Flow-Dependent Epigenetic DNA Methylation in Endothelial Gene Expression and AtherosclerosisQ28261711
Postnatal isl1+ cardioblasts enter fully differentiated cardiomyocyte lineagesQ28306800
Regulation of cardiac expression of the diabetic marker microRNA miR-29Q28541217
Small molecule-mediated disruption of Wnt-dependent signaling in tissue regeneration and cancerQ29616163
Stage-specific optimization of activin/nodal and BMP signaling promotes cardiac differentiation of mouse and human pluripotent stem cell linesQ29616799
Dysregulation of microRNAs after myocardial infarction reveals a role of miR-29 in cardiac fibrosisQ29619873
Cardiac muscle plasticity in adult and embryo by heart-derived progenitor cells.Q33203812
c-kit+ Cardiac stem cells alleviate post-myocardial infarction left ventricular dysfunction despite poor engraftment and negligible retention in the recipient heartQ33578162
Hemodynamic disturbed flow induces differential DNA methylation of endothelial Kruppel-Like Factor 4 promoter in vitro and in vivoQ33787467
Flow-dependent epigenetic DNA methylation regulates endothelial gene expression and atherosclerosisQ33808269
Cardiomyogenic potential of C-kit(+)-expressing cells derived from neonatal and adult mouse heartsQ33887672
Small-molecule inhibitors of the Wnt pathway potently promote cardiomyocytes from human embryonic stem cell-derived mesodermQ33954234
c-kit+ cells minimally contribute cardiomyocytes to the heartQ34021586
Active Wnt signaling in response to cardiac injuryQ34044380
Sca-1+ cardiac stem cells mediate acute cardioprotection via paracrine factor SDF-1 following myocardial ischemia/reperfusionQ34110874
Wnt1/βcatenin injury response activates the epicardium and cardiac fibroblasts to promote cardiac repair.Q34232889
Epigenetic inactivation of Wnt inhibitory factor-1 plays an important role in bladder cancer through aberrant canonical Wnt/beta-catenin signaling pathwayQ34486845
Evidence from a genetic fate-mapping study that stem cells refresh adult mammalian cardiomyocytes after injuryQ34657173
Human cardiomyocyte progenitor cells differentiate into functional mature cardiomyocytes: an in vitro model for studying human cardiac physiology and pathophysiology.Q34938752
Anti-inflammatory peptides from cardiac progenitors ameliorate dysfunction after myocardial infarctionQ35114912
miR-29a maintains mouse hematopoietic stem cell self-renewal by regulating Dnmt3aQ35252628
Developmental stage-specific biphasic roles of Wnt/beta-catenin signaling in cardiomyogenesis and hematopoiesisQ35544524
Distinct association between aberrant methylation of Wnt inhibitors and genetic alterations in acute myeloid leukaemiaQ35653963
PDGFRα demarcates the cardiogenic clonogenic Sca1+ stem/progenitor cell in adult murine myocardiumQ35775407
Direct comparison of different stem cell types and subpopulations reveals superior paracrine potency and myocardial repair efficacy with cardiosphere-derived cellsQ35799278
miR-29 inhibits bleomycin-induced pulmonary fibrosis in mice.Q36014083
TGF-β1 epigenetically modifies Thy-1 expression in primary lung fibroblastsQ36237065
Cardiac progenitor cells from adult myocardium: Homing, differentiation, and fusion after infarctionQ36349782
Mapping Human Pluripotent-to-Cardiomyocyte Differentiation: Methylomes, Transcriptomes, and Exon DNA Methylation "Memories".Q36645680
Beta-Catenin downregulation attenuates ischemic cardiac remodeling through enhanced resident precursor cell differentiation.Q37018900
Sca1-derived cells are a source of myocardial renewal in the murine adult heart.Q37344589
Stem cell signaling. An integral program for tissue renewal and regeneration: Wnt signaling and stem cell controlQ38256327
The renewal and differentiation of Isl1+ cardiovascular progenitors are controlled by a Wnt/beta-catenin pathwayQ38501598
Stepwise Clearance of Repressive Roadblocks Drives Cardiac Induction in Human ESCs.Q38805334
DNA Methylation in Cancer and AgingQ38852253
Epigenetic Alteration of the Wnt Inhibitory Factor-1 Promoter Is Common and Occurs in Advanced Stage of Tunisian Nasopharyngeal CarcinomaQ39001870
Aza-induced cardiomyocyte differentiation of P19 EC-cells by epigenetic co-regulation and ERK signalingQ39142463
The hypomethylation agent bisdemethoxycurcumin acts on the WIF-1 promoter, inhibits the canonical Wnt pathway and induces apoptosis in human non-small-cell lung cancerQ39471041
Knockdown of DNA methyltransferase 3a alters gene expression and inhibits function of embryonic cardiomyocytesQ39681001
Knockdown of DNMT1 and DNMT3a Promotes the Angiogenesis of Human Mesenchymal Stem Cells Leading to Arterial Specific DifferentiationQ40019301
Transient down-regulation of DNMT1 methyltransferase leads to activation and stable hypomethylation of MAGE-A1 in melanoma cellsQ40312232
DNMT3A silencing RASSF1A promotes cardiac fibrosis through upregulation of ERK1/2.Q42705144
Circulating miR-29a, among other up-regulated microRNAs, is the only biomarker for both hypertrophy and fibrosis in patients with hypertrophic cardiomyopathy.Q44159535
Suppression of Wnt signaling by the miR-29 family is mediated by demethylation of WIF-1 in non-small-cell lung cancerQ47794745
Paracrine nitric oxide induces expression of cardiac sarcomeric proteins in adult progenitor cells through soluble guanylyl cyclase/cyclic-guanosine monophosphate and Wnt/β-catenin inhibitionQ49168754
Isolation and characterization of resident endogenous c-Kit+ cardiac stem cells from the adult mouse and rat heart.Q54343615
Hypoxia-induced epigenetic modifications are associated with cardiac tissue fibrosis and the development of a myofibroblast-like phenotype.Q54495572
Erythropoietin preserves the endothelial differentiation capacity of cardiac progenitor cells and reduces heart failure during anticancer therapies.Q54569784
MicroRNA-29 in Aortic Dilation: Implications for Aneurysm FormationQ58816127
Standardized myocardial segmentation and nomenclature for tomographic imaging of the heart. A statement for healthcare professionals from the Cardiac Imaging Committee of the Council on Clinical Cardiology of the American Heart AssociationQ74503307
P4510describes a project that usesImageJQ1659584
P433issue12
P577publication date2017-06-15
P1433published inJCI insightQ27727187
P1476titleDnmt3a-mediated inhibition of Wnt in cardiac progenitor cells improves differentiation and remote remodeling after infarction
P478volume2