Nimotuzumab Induces NK Cell Activation, Cytotoxicity, Dendritic Cell Maturation and Expansion of EGFR-Specific T Cells in Head and Neck Cancer Patients

scientific article

Nimotuzumab Induces NK Cell Activation, Cytotoxicity, Dendritic Cell Maturation and Expansion of EGFR-Specific T Cells in Head and Neck Cancer Patients is …
instance of (P31):
scholarly articleQ13442814

External links are
P356DOI10.3389/FPHAR.2017.00382
P932PMC publication ID5474456
P698PubMed publication ID28674498

P50authorRobert L FerrisQ38328358
Tatiana M Garcia-BatesQ56494396
P2093author name stringTania Crombet
Fernando Concha-Benavente
Raghvendra M Srivastava
Zaima Mazorra
Iván Cuevas
Amnely González
Anabel Lavastida
Anet Valdés
Braulio F Mestre
Carlos Frómeta
Esperanza Hechavarría
Maria C Barroso
Martha Lugiollo
Zuyen González
P2860cites workNimotuzumab, a promising therapeutic monoclonal for treatment of tumors of epithelial originQ24645217
Interactions between PD-1 and PD-L1 promote tolerance by blocking the TCR-induced stop signal.Q24655516
Nimotuzumab, an antitumor antibody that targets the epidermal growth factor receptor, blocks ligand binding while permitting the active receptor conformationQ27656338
Interaction of Tim-3 and Tim-3 ligand regulates T helper type 1 responses and induction of peripheral toleranceQ28511160
Reversal of NK-cell exhaustion in advanced melanoma by Tim-3 blockadeQ33714165
Targeting CD137 enhances the efficacy of cetuximab.Q33872482
The therapeutic effect of anti-HER2/neu antibody depends on both innate and adaptive immunityQ34073138
4-1BB (CD137), an inducible costimulatory receptor, as a specific target for cancer therapyQ34180031
Tumor antigen-targeted, monoclonal antibody-based immunotherapy: clinical response, cellular immunity, and immunoescapeQ34194706
Humanization of a mouse monoclonal antibody that blocks the epidermal growth factor receptor: recovery of antagonistic activityQ34426559
CD137 stimulation enhances the antilymphoma activity of anti-CD20 antibodiesQ34707604
CTLA-4⁺ Regulatory T Cells Increased in Cetuximab-Treated Head and Neck Cancer Patients Suppress NK Cell Cytotoxicity and Correlate with Poor PrognosisQ35674757
Stimulation of natural killer cells with a CD137-specific antibody enhances trastuzumab efficacy in xenotransplant models of breast cancerQ35780315
In vitro analysis of the proliferative capacity and cytotoxic effects of ex vivo induced natural killer cells, cytokine-induced killer cells, and gamma-delta T cellsQ35803534
Tim-3 is an inducible human natural killer cell receptor that enhances interferon gamma production in response to galectin-9Q35876978
Tim-3 marks human natural killer cell maturation and suppresses cell-mediated cytotoxicityQ35909663
Role of epidermal growth factor receptor pathway-targeted therapy in patients with recurrent and/or metastatic squamous cell carcinoma of the head and neckQ36500969
Fc-dependent expression of CD137 on human NK cells: insights into "agonistic" effects of anti-CD137 monoclonal antibodiesQ36787500
Cetuximab-activated natural killer and dendritic cells collaborate to trigger tumor antigen-specific T-cell immunity in head and neck cancer patientsQ36806268
TIM3(+)FOXP3(+) regulatory T cells are tissue-specific promoters of T-cell dysfunction in cancerQ36845835
Novel immunogenic HLA-A*0201-restricted epidermal growth factor receptor-specific T-cell epitope in head and neck cancer patientsQ36962838
Concurrent trastuzumab and HER2/neu-specific vaccination in patients with metastatic breast cancerQ37369840
Effects of adjuvant chemoradiotherapy on the frequency and function of regulatory T cells in patients with head and neck cancerQ37373689
Tim-3: an activation marker and activation limiter of innate immune cellsQ37379212
PD-1 mediates functional exhaustion of activated NK cells in patients with Kaposi sarcomaQ37687323
Natural killer (NK): dendritic cell (DC) cross talk induced by therapeutic monoclonal antibody triggers tumor antigen-specific T cell immunityQ37895956
Nimotuzumab treatment of malignant gliomasQ38050155
Enhanced natural killer cell binding and activation by low-fucose IgG1 antibody results in potent antibody-dependent cellular cytotoxicity induction at lower antigen densityQ38328896
Immune checkpoint protein inhibition for cancer: preclinical justification for CTLA-4 and PD-1 blockade and new combinationsQ38475048
PD-1 expression on peripheral blood cells increases with stage in renal cell carcinoma patients and is rapidly reduced after surgical tumor resection.Q39143622
IgG isotype, glycosylation, and EGFR expression determine the induction of antibody-dependent cellular cytotoxicity in vitro by cetuximabQ39617025
Bivalent binding by intermediate affinity of nimotuzumab: a contribution to explain antibody clinical profileQ39621039
Long-lasting antitumor protection by anti-CD20 antibody through cellular immune responseQ39707969
The impact of antigen density and antibody affinity on antibody-dependent cellular cytotoxicity: relevance for immunotherapy of carcinomasQ39708585
T cell immunoglobulin- and mucin-domain-containing molecule-3 (Tim-3) mediates natural killer cell suppression in chronic hepatitis B.Q39743569
Maturation pathways of dendritic cells determine TAP1 and TAP2 levels and cross-presenting functionQ39824406
Role of polymorphic Fc gamma receptor IIIa and EGFR expression level in cetuximab mediated, NK cell dependent in vitro cytotoxicity of head and neck squamous cell carcinoma cellsQ39868562
Immunoglobulin G fragment C receptor polymorphisms and clinical efficacy of trastuzumab-based therapy in patients with HER-2/neu-positive metastatic breast cancer.Q40001571
Antibody-dependent cellular cytotoxicity mediated by cetuximab against lung cancer cell linesQ40164557
Natural killer cells produce T cell-recruiting chemokines in response to antibody-coated tumor cellsQ40333010
CD16 polymorphisms and NK activation induced by monoclonal antibody-coated target cells.Q40383762
Nimotuzumab with chemoradiation confers a survival advantage in treatment-naïve head and neck tumors over expressing EGFR.Q42474675
HER-2/neu-specific monoclonal antibodies collaborate with HER-2/neu-targeted granulocyte macrophage colony-stimulating factor secreting whole cell vaccination to augment CD8+ T cell effector function and tumor-free survival in Her-2/neu-transgenic mQ42798418
Interleukin 2 activation of natural killer cells rapidly induces the expression and phosphorylation of the Leu-23 activation antigenQ42939169
CD137 ligand signaling induces human monocyte to dendritic cell differentiationQ43672129
Functional significance of the activation-associated receptors CD25 and CD69 on human NK-cells and NK-like T-cellsQ44390045
Phase II study of nimotuzumab, a humanized monoclonal anti-epidermal growth factor receptor (EGFR) antibody, in patients with locally advanced or metastatic pancreatic cancerQ44656784
Structural basis for inhibition of the epidermal growth factor receptor by cetuximabQ45345151
Impact of Fc{gamma}RIIa-Fc{gamma}RIIIa polymorphisms and KRAS mutations on the clinical outcome of patients with metastatic colorectal cancer treated with cetuximab plus irinotecan.Q46151045
CD137 Stimulation Enhances Cetuximab-Induced Natural Killer: Dendritic Cell Priming of Antitumor T-Cell Immunity in Patients with Head and Neck CancerQ50043038
A novel approach to induce human DCs from monocytes by triggering 4-1BBL reverse signaling.Q54726334
Antiproliferative, antiangiogenic and proapoptotic activity of h-R3: A humanized anti-EGFR antibodyQ74802802
CD69 is a stimulatory receptor for natural killer cell and its cytotoxic effect is blocked by CD94 inhibitory receptorQ78127360
Cetuximab induce antibody-dependent cellular cytotoxicity against EGFR-expressing esophageal squamous cell carcinomaQ79346005
Nimotuzumab provides survival benefit to patients with inoperable advanced squamous cell carcinoma of the head and neck: a randomized, open-label, phase IIb, 5-year study in Indian patientsQ87419417
Dual Faces of IFNγ in Cancer Progression: A Role of PD-L1 Induction in the Determination of Pro- and Antitumor ImmunityQ89066168
P921main subjectdendritic cellQ506253
head and neck cancerQ1783924
head and neck carcinomaQ18554836
neck cancerQ18966654
P304page(s)382
P577publication date2017-06-19
P1433published inFrontiers in PharmacologyQ2681208
P1476titleNimotuzumab Induces NK Cell Activation, Cytotoxicity, Dendritic Cell Maturation and Expansion of EGFR-Specific T Cells in Head and Neck Cancer Patients
P478volume8

Reverse relations

cites work (P2860)
Q64102265Rationale for Combining Radiotherapy and Immune Checkpoint Inhibition for Patients With Hypoxic Tumors
Q49887925Receptor tyrosine kinases (RTKs) in breast cancer: signaling, therapeutic implications and challenges
Q90290848The Efficacy and Safety of Anti-epidermal Growth Factor Receptor Monoclonal Antibodies in Nasopharyngeal Carcinoma: Literature-based Meta-analyses
Q98466288The Latest Battles Between EGFR Monoclonal Antibodies and Resistant Tumor Cells
Q90176787Unleashing Natural Killer Cells in the Tumor Microenvironment-The Next Generation of Immunotherapy?

Search more.