The importin beta binding domain modulates the avidity of importin beta for the nuclear pore complex

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The importin beta binding domain modulates the avidity of importin beta for the nuclear pore complex is …
instance of (P31):
scholarly articleQ13442814

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P356DOI10.1074/JBC.M109.095760
P8608Fatcat IDrelease_bes63zw3zngexkhr2iuj2xh5ym
P932PMC publication ID2859540
P698PubMed publication ID20197273

P50authorAnshul BhardwajQ59950206
Nelly PantéQ92773283
P2093author name stringGino Cingolani
Gregory Mitrousis
Kaylen Lott
P2860cites workStructure of the nuclear transport complex karyopherin-beta2-Ran x GppNHpQ22009923
Mechanisms of Receptor-Mediated Nuclear Import and Nuclear ExportQ22065647
GLFG and FxFG nucleoporins bind to overlapping sites on importin-betaQ24310348
Snurportin1, an m3G-cap-specific nuclear import receptor with a novel domain structureQ24316296
Importin beta, transportin, RanBP5 and RanBP7 mediate nuclear import of ribosomal proteins in mammalian cellsQ24319791
Ran-binding protein 5 (RanBP5) is related to the nuclear transport factor importin-beta but interacts differently with RanBP1Q24336127
Structural basis for m3G-cap-mediated nuclear import of spliceosomal UsnRNPs by snurportin1Q24530167
Dominant-negative mutants of importin-beta block multiple pathways of import and export through the nuclear pore complexQ24532120
Rules for nuclear localization sequence recognition by karyopherin beta 2Q24600321
Structural basis for leucine-rich nuclear export signal recognition by CRM1Q24604395
Gradient of increasing affinity of importin beta for nucleoporins along the pathway of nuclear importQ24652021
Molecular and functional characterization of the p62 complex, an assembly of nuclear pore complex glycoproteinsQ24671748
A role for RanBP1 in the release of CRM1 from the nuclear pore complex in a terminal step of nuclear exportQ24682010
Structure of importin-beta bound to the IBB domain of importin-alphaQ27618407
Structural basis for the interaction between FxFG nucleoporin repeats and importin-beta in nuclear traffickingQ27625995
Molecular basis for the recognition of a nonclassical nuclear localization signal by importin betaQ27640251
The structure of importin-beta bound to SREBP-2: nuclear import of a transcription factorQ27642661
Structural basis for RanGTP independent entry of spliceosomal U snRNPs into the nucleusQ27649114
Molecular basis for the recognition of snurportin 1 by importin betaQ27649519
Crystal structure of the nuclear export receptor CRM1 in complex with Snurportin1 and RanGTPQ27655147
Structures of the tRNA export factor in the nuclear and cytosolic statesQ27657007
Structural basis for the assembly of a nuclear export complex.Q27932010
Natively unfolded nucleoporins gate protein diffusion across the nuclear pore complex.Q27938407
Discovering novel interactions at the nuclear pore complex using bead halo: a rapid method for detecting molecular interactions of high and low affinity at equilibriumQ27940037
Protein import into nuclei: association and dissociation reactions involving transport substrate, transport factors, and nucleoporinsQ28131733
Phospholipid scramblase 1 contains a nonclassical nuclear localization signal with unique binding site in importin alphaQ28299257
Structural basis for nuclear import complex dissociation by RanGTPQ29037436
Structural biology of nucleocytoplasmic transportQ29615350
Molecular mechanism of the nuclear protein import cycleQ29617058
Regulating access to the genome: nucleocytoplasmic transport throughout the cell cycleQ29619289
Nuclear protein import in permeabilized mammalian cells requires soluble cytoplasmic factorsQ29620194
Karyopherins: from nuclear-transport mediators to nuclear-function regulatorsQ30434629
Use of intact Xenopus oocytes in nucleocytoplasmic transport studiesQ33245382
Importin-beta: structural and dynamic determinants of a molecular springQ33345668
The structure of the nuclear export receptor Cse1 in its cytosolic state reveals a closed conformation incompatible with cargo binding.Q34415379
Importin beta-depending nuclear import pathways: role of the adapter proteins in the docking and releasing stepsQ35153638
Importin α: a multipurpose nuclear-transport receptorQ35879618
The FG-repeat asymmetry of the nuclear pore complex is dispensable for bulk nucleocytoplasmic transport in vivoQ36322759
Importin beta contains a COOH-terminal nucleoporin binding region important for nuclear transportQ36322989
Influence of cargo size on Ran and energy requirements for nuclear protein importQ36324496
Nuclear transport is becoming crystal clearQ36372013
The direction of transport through the nuclear pore can be invertedQ36428044
Nuclear import of spliceosomal snRNPsQ36562722
Nup214 is required for CRM1-dependent nuclear protein export in vivoQ38411212
Characterization of Ran-driven cargo transport and the RanGTPase system by kinetic measurements and computer simulationQ39735696
Characterization of the nuclear protein import mechanism using Ran mutants with altered nucleotide binding specificitiesQ41079130
The importin-beta binding domain of snurportin1 is responsible for the Ran- and energy-independent nuclear import of spliceosomal U snRNPs in vitroQ41889373
Atomic resolution structures in nuclear transportQ42426051
Nuclear import of U snRNPs requires importin betaQ42632635
A molecular switch between alternative conformational states in the complex of Ran and importin beta1.Q44479217
Binding dynamics of isolated nucleoporin repeat regions to importin-betaQ46843299
Nuclear protein import in a permeabilized cell assayQ47845959
Crystallization and preliminary X-ray diffraction analysis of nuclear transport factor 2.Q48065822
Conformational Variability of Nucleo-cytoplasmic Transport FactorsQ57091036
Receptor-mediated substrate translocation through the nuclear pore complex without nucleotide triphosphate hydrolysisQ57378150
A Highly Strained Nuclear Conformation of the Exportin Cse1p Revealed by Molecular Dynamics SimulationsQ57834371
Nuclear import factors importin α and importin β undergo mutually induced conformational changes upon associationQ57973315
P433issue18
P407language of work or nameEnglishQ1860
P304page(s)13769-13780
P577publication date2010-03-01
P1433published inJournal of Biological ChemistryQ867727
P1476titleThe importin beta binding domain modulates the avidity of importin beta for the nuclear pore complex
P478volume285

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cites work (P2860)
Q27670487A Minimal Nuclear Localization Signal (NLS) in Human Phospholipid Scramblase 4 That Binds Only the Minor NLS-binding Site of Importin α1
Q39194782An Arabidopsis homolog of importin β1 is required for ABA response and drought tolerance
Q36103946Architecture of the Complex Formed by Large and Small Terminase Subunits from Bacteriophage P22.
Q27661684Conformational selection in the recognition of the snurportin importin beta binding domain by importin beta
Q36058458Conservation of inner nuclear membrane targeting sequences in mammalian Pom121 and yeast Heh2 membrane proteins
Q28652765Disordered proteinaceous machines
Q36622387Distinctive Properties of the Nuclear Localization Signals of Inner Nuclear Membrane Proteins Heh1 and Heh2.
Q36987737Divergent Evolution of Nuclear Localization Signal Sequences in Herpesvirus Terminase Subunits
Q36455386Forces, fluctuations, and self-organization in the nucleus
Q37025439How to operate a nuclear pore complex by Kap-centric control
Q33561466Karyopherin-centric control of nuclear pores based on molecular occupancy and kinetic analysis of multivalent binding with FG nucleoporins
Q38342357Molecular basis for the recognition of phosphorylated STAT1 by importin alpha5.
Q35136748Molecular determinants for nuclear import of influenza A PB2 by importin α isoforms 3 and 7.
Q36342658Nuclear transport receptor binding avidity triggers a self-healing collapse transition in FG-nucleoporin molecular brushes.
Q36163461Nucleocytoplasmic transport: a role for nonspecific competition in karyopherin-nucleoporin interactions
Q37823682Phosphorylation meets nuclear import: a review
Q48297118Prolines in the α-helix confer the structural flexibility and functional integrity of importin-β.
Q40044584Synergy of two low-affinity NLSs determines the high avidity of influenza A virus nucleoprotein NP for human importin α isoforms
Q64065862Terminase Large Subunit Provides a New Drug Target for Herpesvirus Treatment
Q42048428The Structural Biology of Hepatitis B Virus: Form and Function
Q35943783The bovine immunodeficiency virus Rev protein: identification of a novel nuclear import pathway and nuclear export signal among retroviral Rev/Rev-like proteins
Q34024480The importin β binding domain as a master regulator of nucleocytoplasmic transport

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