Advancements and challenges in generating accurate animal models of gestational diabetes mellitus.

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Advancements and challenges in generating accurate animal models of gestational diabetes mellitus. is …
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scholarly articleQ13442814

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P356DOI10.1152/AJPENDO.00425.2013
P932PMC publication ID4073988
P698PubMed publication ID24085033

P50authorRaymond C. PasekQ63980566
P2093author name stringMaureen Gannon
P2860cites workPancreatic inflammation, apoptosis, and growth: sequential events after partial pancreatectomy in pigsQ73096659
Demonstration of two different processes of beta-cell regeneration in a new diabetic mouse model induced by selective perfusion of alloxanQ73531719
Maternal and paternal family history of diabetes in women with gestational diabetes or insulin-dependent diabetes mellitus type IQ73765547
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Differential metabolite accumulation may be the cause of strain differences in sensitivity to streptozotocin-induced beta cell death in inbred miceQ74601926
The homeodomain protein IDX-1 increases after an early burst of proliferation during pancreatic regenerationQ74607806
Genetically determined obesity and sterility in the mouseQ78354461
Infrequently studied congenital anomalies as clues to the diagnosis of maternal diabetes mellitusQ79829182
A variant in the transcription factor 7-like 2 (TCF7L2) gene is associated with an increased risk of gestational diabetes mellitusQ79889453
Association of the E23K polymorphism in the KCNJ11 gene with gestational diabetes mellitusQ81557234
Gestational diabetes mellitusQ82638633
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Common variants in MODY genes increase the risk of gestational diabetes mellitusQ83921043
The mechanism of alloxan and streptozotocin action in B cells of the rat pancreasQ28217509
STZ transport and cytotoxicity. Specific enhancement in GLUT2-expressing cellsQ28238596
Mutations in the genes encoding the pancreatic beta-cell KATP channel subunits Kir6.2 (KCNJ11) and SUR1 (ABCC8) in diabetes mellitus and hyperinsulinismQ28292136
Mutations in the hepatocyte nuclear factor-4alpha gene in maturity-onset diabetes of the young (MODY1)Q28298538
Placental thromboxane and prostacyclin production in an ovine diabetic modelQ28330120
Menin regulates pancreatic islet growth by promoting histone methylation and expression of genes encoding p27Kip1 and p18INK4cQ28506197
The MODY1 gene HNF-4alpha regulates selected genes involved in insulin secretionQ28513687
Lactogens promote beta cell survival through JAK2/STAT5 activation and Bcl-XL upregulationQ28571307
Menin controls growth of pancreatic beta-cells in pregnant mice and promotes gestational diabetes mellitusQ28592973
Serotonin 2B receptor is required for heart developmentQ28594131
Adaptive changes in pancreatic beta cell fractional area and beta cell turnover in human pregnancyQ30496377
Gestational diabetes mellitus resulting from impaired beta-cell compensation in the absence of FoxM1, a novel downstream effector of placental lactogenQ33556475
International association of diabetes and pregnancy study groups recommendations on the diagnosis and classification of hyperglycemia in pregnancyQ33683832
Programming of growth, insulin resistance and vascular dysfunction in offspring of late gestation diabetic ratsQ33908574
Serotonin regulates pancreatic beta cell mass during pregnancyQ34065652
Transcription factor 7-like 2 (TCF7L2) is associated with gestational diabetes mellitus and interacts with adiposity to alter insulin secretion in Mexican AmericansQ34078964
Loss of HGF/c-Met signaling in pancreatic β-cells leads to incomplete maternal β-cell adaptation and gestational diabetes mellitus.Q34262132
Placental lactogens induce serotonin biosynthesis in a subset of mouse beta cells during pregnancyQ34284016
Antidepressant medication use, weight gain, and risk of type 2 diabetes: a population-based studyQ34351813
Evidence that the diabetes gene encodes the leptin receptor: identification of a mutation in the leptin receptor gene in db/db miceQ34376178
Diet-induced impaired glucose tolerance and gestational diabetes in the dogQ34598580
Use of antidepressant medication and risk of type 2 diabetes: results from three cohorts of US adultsQ34631395
Mannan-binding lectin: clinical significance and applicationsQ34838091
The role of prolactin and growth hormone in mammary gland developmentQ34997033
Free fatty acids, insulin resistance, and pregnancyQ35179348
Loss of Foxd3 results in decreased β-cell proliferation and glucose intolerance during pregnancyQ35590815
Expansion of adult beta-cell mass in response to increased metabolic demand is dependent on HNF-4alphaQ35720840
Beta cells arise from glucose transporter type 2 (Glut2)-expressing epithelial cells of the developing rat pancreasQ35796459
Racial/ethnic differences in the percentage of gestational diabetes mellitus cases attributable to overweight and obesity, Florida, 2004-2007.Q36122347
Expansion of beta-cell mass in response to pregnancyQ36768314
Different diabetogenic response to moderate doses of streptozotocin in pregnant rats, and its long-term consequences in the offspringQ36782258
Prolactin receptor gene polymorphisms are associated with gestational diabetesQ36979414
The genetics of gestational diabetes mellitus: evidence for relationship with type 2 diabetes mellitusQ37139067
Maternal obesity accelerates fetal pancreatic beta-cell but not alpha-cell development in sheep: prenatal consequencesQ37337548
Establishing consensus in the diagnosis of gestational diabetes following HAPO: where do we stand?Q38051220
Lessons learned regarding symptoms of tryptophan deficiency and excess from animal requirement studiesQ38053140
Expression and shifting subcellular localization of the transcription factor, Foxd3, in embryonic and adult pancreasQ38312635
Alloxan: history and mechanism of actionQ39521666
Sex differences in the multiple-dose streptozotocin model of diabetesQ39877050
Regulation of glucokinase in pancreatic islets by prolactin: a mechanism for increasing glucose-stimulated insulin secretion during pregnancyQ40126524
Distinctive roles for prolactin and growth hormone in the activation of signal transducer and activator of transcription 5 in pancreatic islets of langerhansQ40556043
A morphological study of the endocrine pancreas in human pregnancyQ40964083
Site-specific DNA methylation and apoptosis: induction by diabetogenic streptozotocinQ40965945
Selective uptake of alloxan by pancreatic B-cellsQ41864437
Expression of epidermal growth factor receptor after partial pancreatectomy in adult rats: an immunohistochemical studyQ42457612
Ultrastructural evaluation of B-cell recruitment in virgin and pregnant offspring of diabetic mothersQ42462294
High-saturated-fat diet induces gestational diabetes and placental vasculopathy in C57BL/6 miceQ43215049
Adaptation of islets of Langerhans to pregnancy: increased islet cell proliferation and insulin secretion correlates with the onset of placental lactogen secretionQ43485718
Leptin administration prevents spontaneous gestational diabetes in heterozygous Lepr(db/+) mice: effects on placental leptin and fetal growthQ43646649
Streptozocin-induced diabetes mellitus in the pregnant eweQ43791061
Inheritance of diabetes mellitus as consequence of gestational hyperglycemia in ratsQ43811449
Effect of spontaneous gestational diabetes on fetal and postnatal hepatic insulin resistance in Lepr(db/+) miceQ44321524
Population health significance of gestational diabetesQ44495224
Mannose-binding lectin gene polymorphisms are associated with gestational diabetes mellitusQ44743457
Diet-induced obesity in the rat: a model for gestational diabetes mellitusQ44812999
Development of a porcine model of type 1 diabetes by total pancreatectomy and establishment of a glucose tolerance evaluation methodQ45123525
Ethnicity and gestational diabetes in New York City, 1995-2003.Q45338208
Prolactin receptor is required for normal glucose homeostasis and modulation of beta-cell mass during pregnancyQ46226373
Gestational diabetes mellitus - an analysis of risk factors.Q46268296
Maternal blood glucose levels determine the severity of diabetic embryopathy in mice with different expression of copper-zinc superoxide dismutase (CuZnSOD).Q46575915
Maternal diabetes affects specific extracellular matrix components during placentation.Q46859838
Hepatocyte nuclear factor-4alpha is essential for glucose-stimulated insulin secretion by pancreatic beta-cellsQ46868194
Number and size of islets of Langerhans in pregnant, human growth hormone-expressing transgenic, and pituitary dwarf mice: effect of lactogenic hormonesQ47354503
Effect of dietary cholesterol and alloxan-diabetes on tissue cholesterol and apolipoprotein E mRNA levels in the rabbitQ48771486
The mechanism of the hypoglycemic action of alloxan.Q49177968
Endocrine control of blood sugar, lipaemia, and ketonaemia in diabetic baboonsQ50170964
Beta-cell growth in adolescent and adult rats treated with streptozotocin during the neonatal period.Q51018586
Islet endothelial cells and pancreatic beta-cell proliferation: studies in vitro and during pregnancy in adult rats.Q51281395
Species difference in drug metabolism by liver microsomes in alloxan diabetic or fasted animals. II. The substrate interaction with cytochrome P-450 in drug oxidationQ51683446
Effects of streptozotocin- and alloxan-induced diabetes mellitus on mouse follicular and early embryo development.Q52246629
Delay in pulmonary glycogen degradation in fetuses of streptozotocin diabetic rats.Q52286237
Abnormal glucose tolerance and insulin secretion in pancreas-specific Tcf7l2-null mice.Q53161614
The FoxM1 transcription factor is required to maintain pancreatic beta-cell mass.Q53630908
The generation of hydrogen peroxide, superoxide radical, and hydroxyl radical by 6-hydroxydopamine, dialuric acid, and related cytotoxic agents.Q54578393
Summary and recommendations of the Fourth International Workshop-Conference on Gestational Diabetes Mellitus. The Organizing Committee.Q55067756
Gestational Diabetes MellitusQ56428291
NECROSIS OF ISLETS OF LANGERHANS PRODUCED EXPERIMENTALLYQ56670505
Disturbance of pulmonary prostaglandin metabolism in fetuses of alloxan-diabetic rabbitsQ61769191
Gestational Diabetes Mellitus: Influence of Race on Disease Prevalence and Perinatal Outcome in a U.S. PopulationQ67773997
Comparison of streptozotocin and alloxan-induced diabetes in the rat, including volumetric quantitation of the pancreatic isletsQ68511356
Placental transfer of streptozotocin in the rhesus monkeyQ68535318
Streptozotocin: depression of mouse liver pyridine nucleotidesQ68582371
Clinical antitumor activity and toxicity of streptozotocin (NSC-85998)Q68699417
Experimental diabetes impairs rat embryo development during the preimplantation periodQ68802252
Alloxan-induced diabetes mellitus in the pregnant ewe: metabolic and cardiovascular effects on the mother and her fetusQ69505632
Screening criteria for high-risk gestational diabetic patientsQ69550823
Carbohydrate metabolism in pregnancy. XVII. Diurnal profiles of plasma glucose, insulin, free fatty acids, triglycerides, cholesterol, and individual amino acids in late normal pregnancyQ70164809
A new model for the study of mild diabetes during pregnancy. Syngeneic islet-transplanted STZ-induced diabetic ratsQ70542262
An animal model of gestational diabetesQ70964259
Changes in food intake during menstrual cycles and pregnancy of normal and diabetic rhesus monkeysQ71297636
Effect of streptozotocin diabetes on polysomal aggregation and protein synthesis rate in the liver of pregnant rats and their offspringQ71706562
Light and electron microscopy of lesions in rats rendered diabetic with streptozotocinQ72197412
Diabetes, a New Mutation in the MouseQ72798788
Eicosanoid production by uterine strips and by embryos obtained from diabetic pregnant ratsQ72807543
Effects of Maternal Streptozonocin-Diabetes on Fetal Growth, Energy Reserves and Body Composition of Newborn Pigs2Q72833043
Alteration in IGF-I mRNA content of fetal swine tissues in response to maternal diabetesQ72850749
P433issue11
P921main subjectgestational diabetesQ126691
P304page(s)E1327-38
P577publication date2013-10-01
P1433published inAmerican Journal of Physiology - Endocrinology and MetabolismQ15765671
P1476titleAdvancements and challenges in generating accurate animal models of gestational diabetes mellitus
P478volume305

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cites work (P2860)
Q103805051Brief high fat high sugar diet results in altered energy and fat metabolism during pregnancy in mice
Q42357005Connective tissue growth factor is critical for proper β-cell function and pregnancy-induced β-cell hyperplasia in adult mice
Q48152519Consequences of gestational diabetes to the brain and behavior of the offspring
Q93047774Diabetes in Pregnancy and MicroRNAs: Promises and Limitations in Their Clinical Application
Q47858300Effects of acute exposure to a high-fat, high-sucrose diet on gestational glucose tolerance and subsequent maternal health in mice
Q92604460Efficacy of continuous intravenous pumping of insulin for patients with diabetes complicated with perianal abscess and the effect on inflammatory cytokines
Q41781358Gestational Diabetes Mellitus From Inactivation of Prolactin Receptor and MafB in Islet β-Cells
Q55332813Gestational diabetes influences the expression of hypertrophic genes in left ventricle of rat's offspring.
Q37683748Gestational diabetes leads to down-regulation of CDK4-pRB-E2F1 pathway genes in pancreatic islets of rat offspring
Q37347656Impulsive alcohol-related risk-behavior and emotional dysregulation among individuals with a serotonin 2B receptor stop codon
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Q90574842Naringenin improves insulin sensitivity in gestational diabetes mellitus mice through AMPK
Q36926481New insights into gestational glucose metabolism: lessons learned from 21st century approaches
Q91471318The effects of myo-inositol and probiotic supplementation in a high-fat-fed preclinical model of glucose intolerance in pregnancy
Q35783844The short-chain fatty acid receptor, FFA2, contributes to gestational glucose homeostasis
Q35983720Transcription Factor 7-Like 2 (TCF7L2) rs7903146 Polymorphism as a Risk Factor for Gestational Diabetes Mellitus: A Meta-Analysis
Q89918519UCN2: a new candidate influencing pancreatic β-cell adaptations in pregnancy
Q37286795Unexpected effects of the MIP-CreER transgene and tamoxifen on β-cell growth in C57Bl6/J male mice
Q47431367Vascular-derived connective tissue growth factor (Ctgf) is critical for pregnancy-induced β cell hyperplasia in adult mice.