| P2093 | author name string | Michalides RJ | |
| P2860 | cites work | A matter of life and cell death | Q77164675 |
| | Telomerase activity exclusively in cervical carcinomas and a subset of cervical intraepithelial neoplasia grade III lesions: strong association with elevated messenger RNA levels of its catalytic subunit and high-risk human papillomavirus DNA | Q77220385 |
| | The human p19ARF protein encoded by the beta transcript of the p16INK4a gene is frequently lost in small cell lung cancer | Q77220449 |
| | The INK4a/ARF tumor suppressor: one gene--two products--two pathways | Q77362259 |
| | Cyclin D1 and estrogen receptor messenger RNA levels are positively correlated in primary breast cancer | Q77557054 |
| | Cyclin DI amplification is not associated with reduced overall survival in primary breast cancer but may predict early relapse in patients with features of good prognosis | Q77557279 |
| | Mechanisms restricting DNA replication to once per cell cycle: the role of Cdc6p and ORC | Q80818048 |
| | TGF-beta signal transduction | Q22003891 |
| | Human Cancer Syndromes: Clues to the Origin and Nature of Cancer | Q22242264 |
| | Identification of c-MYC as a target of the APC pathway | Q24310637 |
| | New functional activities for the p21 family of CDK inhibitors | Q24313427 |
| | Mutations of mitotic checkpoint genes in human cancers | Q24320018 |
| | Oncogenic ras provokes premature cell senescence associated with accumulation of p53 and p16INK4a | Q24324559 |
| | Activation of beta-catenin-Tcf signaling in colon cancer by mutations in beta-catenin or APC | Q24336321 |
| | The consensus motif for phosphorylation by cyclin D1-Cdk4 is different from that for phosphorylation by cyclin A/E-Cdk2 | Q24561705 |
| | Activation of cyclin E/CDK2 is coupled to site-specific autophosphorylation and ubiquitin-dependent degradation of cyclin E | Q24562111 |
| | Cyclin D1 stimulation of estrogen receptor transcriptional activity independent of cdk4 | Q24644847 |
| | Transforming growth factor beta stabilizes p15INK4B protein, increases p15INK4B-cdk4 complexes, and inhibits cyclin D1-cdk4 association in human mammary epithelial cells | Q24646540 |
| | Interaction of D-type cyclins with a novel myb-like transcription factor, DMP1 | Q24647887 |
| | E2F-4 switches from p130 to p107 and pRB in response to cell cycle reentry | Q24650515 |
| | Different roles for cyclins D1 and E in regulation of the G1-to-S transition | Q24651978 |
| | Human cyclin E, a nuclear protein essential for the G1-to-S phase transition | Q24652527 |
| | Disruption of epithelial cell-matrix interactions induces apoptosis | Q24673611 |
| | Cdc6 is regulated by E2F and is essential for DNA replication in mammalian cells | Q24682117 |
| | The retinoblastoma protein and cell cycle control | Q27860722 |
| | p53, the cellular gatekeeper for growth and division | Q27860990 |
| | Eliminating all obstacles: regulated proteolysis in the eukaryotic cell cycle | Q27939193 |
| | Mutations in the p16INK4/MTS1/CDKN2, p15INK4B/MTS2, and p18 genes in primary and metastatic lung cancer | Q28235895 |
| | Overexpression of cyclin D1 in human pancreatic carcinoma is associated with poor prognosis | Q28236992 |
| | Inhibition of cyclin D1 phosphorylation on threonine-286 prevents its rapid degradation via the ubiquitin-proteasome pathway | Q28237113 |
| | Identification of CDK4 sequences involved in cyclin D1 and p16 binding | Q28244094 |
| | Genetic alterations of cyclins, cyclin-dependent kinases, and Cdk inhibitors in human cancer | Q28285050 |
| | CDK-independent activation of estrogen receptor by cyclin D1 | Q28304020 |
| | Myc activates telomerase | Q28505489 |
| | Regulation of the retinoblastoma protein-related p107 by G1 cyclin complexes | Q28511710 |
| | Overexpression of cyclin D1 enhances gene amplification | Q28564254 |
| | Concurrent overexpression of cyclin D1 and cyclin-dependent kinase 4 (Cdk4) in intestinal adenomas from multiple intestinal neoplasia (Min) mice and human familial adenomatous polyposis patients | Q28592867 |
| | Enhanced phosphorylation of p53 by ATM in response to DNA damage | Q28609838 |
| | Effects of p21(Cip1/Waf1) at both the G1/S and the G2/M cell cycle transitions: pRb is a critical determinant in blocking DNA replication and in preventing endoreduplication | Q28611456 |
| | Integrin-mediated signal transduction linked to Ras pathway by GRB2 binding to focal adhesion kinase | Q28646514 |
| | Cancer cell cycles | Q29547756 |
| | Inhibitors of mammalian G1 cyclin-dependent kinases | Q29547907 |
| | Myc signaling via the ARF tumor suppressor regulates p53-dependent apoptosis and immortalization | Q29614701 |
| | Cyclin-dependent kinases: engines, clocks, and microprocessors | Q29614786 |
| | G1 phase progression: cycling on cue | Q29615162 |
| | G1 events and regulation of cell proliferation | Q29618317 |
| | Hypoxia-mediated selection of cells with diminished apoptotic potential in solid tumours | Q29618396 |
| | Cyclins and cancer. II: Cyclin D and CDK inhibitors come of age | Q29618409 |
| | Genetic instability in colorectal cancers | Q29618711 |
| | Effects of an Rb mutation in the mouse | Q29619196 |
| | Tumor suppression at the mouse INK4a locus mediated by the alternative reading frame product p19ARF | Q29619663 |
| | Chromosome 11q13 amplification in head and neck squamous cell carcinoma. Association with poor prognosis | Q30464256 |
| | Disruption of RB/E2F-1 interaction by single point mutations in E2F-1 enhances S-phase entry and apoptosis | Q33571036 |
| | Regulation of the cyclin E gene by transcription factor E2F1 | Q33651067 |
| | Cell cycle regulation of the cyclin A gene promoter is mediated by a variant E2F site | Q33769566 |
| | Inhibition of cyclin D1 kinase activity is associated with E2F-mediated inhibition of cyclin D1 promoter activity through E2F and Sp1. | Q33773323 |
| | Fos family members induce cell cycle entry by activating cyclin D1. | Q33779543 |
| | Cyclin E and c-Myc promote cell proliferation in the presence of p16INK4a and of hypophosphorylated retinoblastoma family proteins. | Q33887377 |
| | Transcriptional repression of the D-type cyclin-dependent kinase inhibitor p16 by the retinoblastoma susceptibility gene product pRb. | Q34325120 |
| | Mutation detection by highly sensitive methods indicates that p53 gene mutations in breast cancer can have important prognostic value | Q37730372 |
| | Microtubule-active drugs taxol, vinblastine, and nocodazole increase the levels of transcriptionally active p53. | Q38288066 |
| | The prognostic significance of p34cdc2 and cyclin D1 protein expression in prostate adenocarcinoma | Q38473917 |
| | Immunohistochemical detection of the cyclin-dependent kinase inhibitor 2/multiple tumor suppressor gene 1 (CDKN2/MTS1) product p16INK4A in archival human solid tumors: correlation with retinoblastoma protein expression | Q38479429 |
| | Reduced expression of retinoblastoma (Rb) gene protein is related to cell proliferation and prognosis in transitional-cell bladder cancer | Q38481899 |
| | Cyclin E associates with components of the pre-mRNA splicing machinery in mammalian cells | Q39575492 |
| | p16INK4A participates in a G1 arrest checkpoint in response to DNA damage | Q39631343 |
| | Nuclear accumulation of p21Cip1 at the onset of mitosis: a role at the G2/M-phase transition | Q39631415 |
| | E2F-1:DP-1 induces p53 and overrides survival factors to trigger apoptosis | Q40017841 |
| | mdm-2 inhibits the G1 arrest and apoptosis functions of the p53 tumor suppressor protein | Q40018842 |
| | Convergence of mitogenic signalling cascades from diverse classes of receptors at the cyclin D-cyclin-dependent kinase-pRb-controlled G1 checkpoint | Q40020499 |
| | Ectopic expression of cyclin D1 but not cyclin E induces anchorage-independent cell cycle progression | Q40023454 |
| | D-type cyclins | Q40443885 |
| | Cyclin D1/bcl-1 cooperates with myc genes in the generation of B-cell lymphoma in transgenic mice. | Q40792693 |
| | Cyclin D1 and human neoplasia | Q40794379 |
| | Lack of cyclin D-Cdk complexes in Rb-negative cells correlates with high levels of p16INK4/MTS1 tumour suppressor gene product | Q40805644 |
| | Mammalian G1 and G2 phase checkpoints | Q40911094 |
| | Cell regulation. Innocent bystanders or chosen collaborators? | Q40953639 |
| | DNA-dependent protein kinase acts upstream of p53 in response to DNA damage | Q41013003 |
| | G1 cyclin-dependent kinases are sufficient to initiate DNA synthesis in quiescent human fibroblasts | Q41056387 |
| | Differential interaction of the cyclin-dependent kinase (Cdk) inhibitor p27Kip1 with cyclin A-Cdk2 and cyclin D2-Cdk4. | Q41084699 |
| | Induction of DNA synthesis and apoptosis are separable functions of E2F-1. | Q41099375 |
| | Increased expression of the P27KIP1 protein in human esophageal cancer cell lines that over-express cyclin D1. | Q41107163 |
| | Estrogen-induced activation of Cdk4 and Cdk2 during G1-S phase progression is accompanied by increased cyclin D1 expression and decreased cyclin-dependent kinase inhibitor association with cyclin E-Cdk2. | Q41115396 |
| | Antisense to cyclin D1 inhibits the growth and tumorigenicity of human colon cancer cells | Q41115794 |
| | Functional roles of E2F in cell cycle regulation | Q41121018 |
| | Aberrant expression of cyclin D2 is an early event in human male germ cell tumorigenesis. | Q41125327 |
| | Increased expression of cyclin D1 in a murine mammary epithelial cell line induces p27kip1, inhibits growth, and enhances apoptosis. | Q41194531 |
| | Inactivation of p53 enhances sensitivity to multiple chemotherapeutic agents | Q41228017 |
| | Dependence of cyclin E-CDK2 kinase activity on cell anchorage. | Q41237386 |
| | The retinoblastoma protein pathway and the restriction point | Q41239146 |
| | Oncoprotein networks | Q41352439 |
| | Ectopic expression of cyclin D1 prevents activation of gene transcription by myogenic basic helix-loop-helix regulators | Q41450893 |
| | Bcl-1/cyclin D1 in malignant lymphoma | Q41519370 |
| | Cyclins and the G2/M transition. | Q41617180 |
| | Cyclin dependent kinase inhibitors | Q41617198 |
| | E2F: a nodal point in cell cycle regulation | Q41679355 |
| | Key effectors of signal transduction and G1 progression | Q41750240 |
| | Overexpression of cyclin D1 correlates with early recurrence in superficial bladder cancers | Q41855173 |
| | Association of p27Kip1 levels with recurrence and survival in patients with stage C prostate carcinoma | Q42457106 |
| | Regulated ectopic expression of cyclin D1 induces transcriptional activation of the cdk inhibitor p21 gene without altering cell cycle progression | Q42800502 |
| | Overexpression of mouse D-type cyclins accelerates G1 phase in rodent fibroblasts | Q42807624 |
| | Cyclin A-kinase regulation of E2F-1 DNA binding function underlies suppression of an S phase checkpoint | Q42818873 |
| | Rapamycin inhibition of the G1 to S transition is mediated by effects on cyclin D1 mRNA and protein stability | Q42829486 |
| | A transgenic mouse model with cyclin D1 overexpression results in cell cycle, epidermal growth factor receptor, and p53 abnormalities. | Q43652924 |
| | Determination of the prognostic value of cyclin D1 overexpression in breast cancer | Q43814067 |
| | Expression of class I major histocompatibility antigens switched off by highly oncogenic adenovirus 12 in transformed rat cells | Q44899739 |
| | The regulation of anoikis: MEKK-1 activation requires cleavage by caspases | Q46102806 |
| | Cdk2 kinase is required for entry into mitosis as a positive regulator of Cdc2-cyclin B kinase activity | Q46220244 |
| | Amplification of oncogenes in human cancer cells | Q47705957 |
| | Frequent overexpression of the cyclin D1 oncogene in invasive lobular carcinoma of the breast | Q47854842 |
| | A small deletion in the 3'-untranslated region of the cyclin D1/PRAD1/bcl-1 oncogene in a patient with chronic lymphocytic leukemia. | Q47975845 |
| | p21WAF1/Cip1 is associated with cyclin D1CCND1 expression and tubular differentiation but is independent of p53 overexpression in human breast carcinoma | Q48008933 |
| | Alternate splicing produces a novel cyclin D1 transcript | Q48070740 |
| | Prognostic value of the immunohistochemical detection of p16INK4 expression in nonsmall cell lung carcinoma. | Q50944026 |
| | Cyclin D1 provides a link between development and oncogenesis in the retina and breast | Q52206604 |
| | Apoptosis induced by ectopic expression of cyclin D1 but not cyclin E. | Q52522957 |
| | Close correlation between telomerase expression and adenomatous polyp progression in multistep colorectal carcinogenesis. | Q53430744 |
| | Mice lacking cyclin D1 are small and show defects in eye and mammary gland development. | Q53461014 |
| | The extracellular matrix and mitogenic growth factors control G1 phase cyclins and cyclin-dependent kinase inhibitors. | Q53533279 |
| | pRB and p107/p130 are required for the regulated expression of different sets of E2F responsive genes. | Q54048106 |
| | Aberrant p53 expression predicts clinical resistance to cisplatin-based chemotherapy in locally advanced non-small cell lung cancer | Q54159355 |
| | p14ARF links the tumour suppressors RB and p53. | Q55067966 |
| | Alternatively spliced forms of cyclin D1 modulate entry into the cell cycle in an inverse manner. | Q55477811 |
| | Regulation of the cdk inhibitor p21 gene during cell cycle progression is under the control of the transcription factor E2F. | Q55477832 |
| | CDKN2 (p16/MTS1) gene deletion or CDK4 amplification occurs in the majority of glioblastomas. | Q55481499 |
| | Cyclin gene amplification and overexpression in breast and ovarian cancers: Evidence for the selection ofcyclin D1 in breast andcyclin E in ovarian tumors | Q57287626 |
| | p19ARF links the tumour suppressor p53 to Ras | Q57562848 |
| | Analysis of mismatch repair genes in hereditary non–polyposis colorectal cancer patients | Q57570041 |
| | Amplification of genes within the chromosome 11q13 region is indicative of poor prognosis in patients with operable breast cancer | Q57891142 |
| | A death in the life of p53 | Q59062854 |
| | p53, guardian of Rb | Q59068113 |
| | Retinoblastoma-protein-dependent cell-cycle inhibition by the tumour suppressor p16 | Q59082348 |
| | Mammary hyperplasia and carcinoma in MMTV-cyclin D1 transgenic mice | Q34342812 |
| | Expression of transcription factor E2F1 induces quiescent cells to enter S phase | Q34354875 |
| | Genetic progression model for head and neck cancer: implications for field cancerization | Q34382909 |
| | E-cadherin is inactivated in a majority of invasive human lobular breast cancers by truncation mutations throughout its extracellular domain. | Q34408492 |
| | Cyclin D2 is an FSH-responsive gene involved in gonadal cell proliferation and oncogenesis | Q34409582 |
| | Prognostic role of the cyclin-dependent kinase inhibitor p27 in non-small cell lung cancer | Q34436736 |
| | Inhibition of cyclin-dependent kinases by p21 | Q34447738 |
| | Loss of cyclin-dependent kinase inhibitor p27Kip1 is a novel prognostic factor in localized human prostate adenocarcinoma | Q34455472 |
| | Function of a human cyclin gene as an oncogene | Q34994859 |
| | Cyclin D1 expression is regulated by the retinoblastoma protein | Q35145847 |
| | E1A signaling to p53 involves the p19(ARF) tumor suppressor | Q35206764 |
| | Amplification of CCND1 and expression of its protein product, cyclin D1, in ductal carcinoma in situ of the breast | Q35763656 |
| | Cyclin D1 expression in invasive breast cancer. Correlations and prognostic value. | Q35764646 |
| | A question of balance: the role of cyclin-kinase inhibitors in development and tumorigenesis | Q35780692 |
| | High frequency of aberrant p16(INK4A) expression in human breast cancer | Q35782316 |
| | Deregulated transcription factor E2F-1 expression leads to S-phase entry and p53-mediated apoptosis | Q35885582 |
| | Growth arrest by the cyclin-dependent kinase inhibitor p27Kip1 is abrogated by c-Myc | Q35915994 |
| | A clinicopathological study on overexpression of cyclin D1 and of p53 in a series of 248 patients with operable breast cancer | Q36134760 |
| | High level expression of p27(kip1) and cyclin D1 in some human breast cancer cells: inverse correlation between the expression of p27(kip1) and degree of malignancy in human breast and colorectal cancers | Q36184676 |
| | Adhesion-dependent cell cycle progression linked to the expression of cyclin D1, activation of cyclin E-cdk2, and phosphorylation of the retinoblastoma protein | Q36236717 |
| | Anchorage-dependent cell cycle progression | Q36254508 |
| | E-Cadherin-dependent growth suppression is mediated by the cyclin-dependent kinase inhibitor p27(KIP1) | Q36256290 |
| | Integrin-mediated signals regulated by members of the rho family of GTPases | Q36256316 |
| | Cyclin D1 overexpression related to retinoblastoma protein expression as a prognostic marker in human oesophageal squamous cell carcinoma | Q36294947 |
| | Lack of cyclin E immunoreactivity in non-malignant breast and association with proliferation in breast cancer | Q36431462 |
| | Expression of cyclin D1 correlates with malignancy in human ovarian tumours | Q36431722 |
| | Cyclin D1 is dispensable for G1 control in retinoblastoma gene-deficient cells independently of cdk4 activity. | Q36550924 |
| | Altered cell cycle kinetics, gene expression, and G1 restriction point regulation in Rb-deficient fibroblasts | Q36559514 |
| | Cyclin D1 triggers autonomous growth of breast cancer cells by governing cell cycle exit | Q36559825 |
| | Induction of mammary gland hyperplasia and carcinomas in transgenic mice expressing human cyclin E | Q36564958 |
| | Estrogen-dependent cyclin E-cdk2 activation through p21 redistribution | Q36569390 |
| | A dominant-negative cyclin D1 mutant prevents nuclear import of cyclin-dependent kinase 4 (CDK4) and its phosphorylation by CDK-activating kinase | Q36574144 |
| | Regulation of estrogen receptor transcriptional enhancement by the cyclin A/Cdk2 complex | Q36583051 |
| | Expression of cyclin D1 in epithelial tissues of transgenic mice results in epidermal hyperproliferation and severe thymic hyperplasia | Q37429299 |
| | Cyclin D1 overexpression in primary hypopharyngeal carcinomas | Q59420223 |
| | Awakening angels | Q60098849 |
| | The PRAD-1/cyclin D1 oncogene product accumulates aberrantly in a subset of colorectal carcinomas | Q60200200 |
| | Cdk2-dependent phosphorylation of p27 facilitates its Myc-induced release from cyclin E/cdk2 complexes | Q63407040 |
| | Acute overexpression of wt p53 facilitates anticancer drug-induced death of cancer and normal cells | Q64382166 |
| | Correlation between long-term survival in breast cancer patients and amplification of two putative oncogene-coamplification units: hst-1/int-2 and c-erbB-2/ear-1 | Q69369907 |
| | Regulation of p21WAF1/CIP1 expression through mitogen-activated protein kinase signaling pathway | Q70866412 |
| | p53 and chemosensitivity | Q71031884 |
| | A comparative study of p53 gene mutations, protein accumulation, and response to cisplatin-based chemotherapy in advanced ovarian carcinoma | Q71079779 |
| | The p53 gene in breast cancer: prognostic value of complementary DNA sequencing versus immunohistochemistry | Q71082995 |
| | 17beta-Estradiol induces cyclin D1 gene transcription, p36D1-p34cdk4 complex activation and p105Rb phosphorylation during mitogenic stimulation of G(1)-arrested human breast cancer cells | Q71124075 |
| | High frequency of p16 (CDKN2/MTS-1/INK4A) inactivation in head and neck squamous cell carcinoma | Q71254205 |
| | Cyclin D1 induced apoptosis maintains the integrity of the G1/S checkpoint following ionizing radiation irradiation | Q71472156 |
| | Overexpression of cyclin D mRNA distinguishes invasive and in situ breast carcinomas from non-malignant lesions | Q71563730 |
| | Expression of cyclin D1 protein in centrocytic/mantle cell lymphomas with and without rearrangement of the BCL1/cyclin D1 gene | Q71710119 |
| | Infrequent inactivation of the retinoblastoma gene despite frequent loss of chromosome 13q in head and neck squamous cell carcinoma | Q72132750 |
| | p53-dependent and independent expression of p21 during cell growth, differentiation, and DNA damage | Q72297293 |
| | Absence of cyclin D/cdk complexes in cells lacking functional retinoblastoma protein | Q72420823 |
| | Inducible regulatory elements in the human cyclin D1 promoter | Q72530064 |
| | Overexpression of cyclin D1 correlates with recurrence in a group of forty-seven operable squamous cell carcinomas of the head and neck | Q72571234 |
| | Cyclin E, a potential prognostic marker for breast cancer | Q72662855 |
| | Mutational analysis of CDKN2 (MTS1/p16ink4) in human breast carcinomas | Q72710368 |
| | CDK4 amplification is an alternative mechanism to p16 gene homozygous deletion in glioma cell lines | Q72789779 |
| | Deregulation of cyclin E and D1 in breast cancer is associated with inactivation of the retinoblastoma protein | Q73034011 |
| | Expression of cell-cycle regulators p27Kip1 and cyclin E, alone and in combination, correlate with survival in young breast cancer patients | Q73034313 |
| | Alterations of the p16 gene in head and neck cancer: frequency and association with p53, PRAD-1 and HPV | Q73104142 |
| | The cell cycle inhibitor p27 is an independent prognostic marker in small (T1a,b) invasive breast carcinomas | Q73221172 |
| | Markers for assessment of nodal metastasis in laryngeal carcinoma | Q73245302 |
| | Overexpression of cyclin D1 indicates a poor prognosis in squamous cell carcinoma of the head and neck | Q73353859 |
| | Cyclin D1 and retinoblastoma gene expression in human breast carcinoma: correlation with tumour proliferation and oestrogen receptor status | Q73634270 |
| | Reduced expression of retinoblastoma gene product (pRB) and high expression of p53 are associated with poor prognosis in ovarian cancer | Q73684220 |
| | p21WAF1/Cip1 expression is associated with cell differentiation but not with p53 mutations in squamous cell carcinomas of the larynx | Q73923942 |
| | Novel mutations in the p16/CDKN2A binding region of the cyclin-dependent kinase-4 gene | Q74027669 |
| | Cyclin D1 overexpression and prognosis in colorectal adenocarcinoma | Q74305457 |
| | p27KIP1 in human lung cancers: differential changes in small cell and non-small cell carcinomas | Q74309784 |
| | Inactivation of p53 and amplification of cyclin D1 correlate with clinical outcome in head and neck cancer | Q74318728 |
| | Prognostic value of P53 gene mutations in a large series of node-negative breast cancer patients | Q74427938 |
| | Aberrant p16INK4 expression related to clinical stage and prognosis in patients with pancreatic cancer | Q74430143 |
| P433 | issue | 8 | |
| P407 | language of work or name | English | Q1860 |
| P304 | page(s) | 555-568 | |
| P577 | publication date | 1999-08-01 | |
| P1433 | published in | Journal of Clinical Pathology | Q6294965 |
| P1476 | title | Cell cycle regulators: mechanisms and their role in aetiology, prognosis, and treatment of cancer | |
| P478 | volume | 52 | |