Rep-mediated nicking of the adeno-associated virus origin requires two biochemical activities, DNA helicase activity and transesterification.

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Rep-mediated nicking of the adeno-associated virus origin requires two biochemical activities, DNA helicase activity and transesterification. is …
instance of (P31):
scholarly articleQ13442814

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P356DOI10.1128/JVI.73.11.9325-9336.1999
P932PMC publication ID112967
P698PubMed publication ID10516041

P2093author name stringN Muzyczka
J R Brister
P2860cites workAdeno-associated virus (AAV) Rep proteins mediate complex formation between AAV DNA and its integration site in human DNAQ24562760
Adeno-associated virus Rep proteins target DNA sequences to a unique locus in the human genomeQ24671566
Biochemical activities of minute virus of mice nonstructural protein NS1 are modulated In vitro by the phosphorylation state of the polypeptideQ28368835
Cellular proteins required for adeno-associated virus DNA replication in the absence of adenovirus coinfectionQ32077025
Biochemical characterization of adeno-associated virus rep68 DNA helicase and ATPase activitiesQ33642052
Adeno-associated virus (AAV) type 5 Rep protein cleaves a unique terminal resolution site compared with other AAV serotypes.Q33648013
High-mobility group 1/2 proteins are essential for initiating rolling-circle-type DNA replication at a parvovirus hairpin origin.Q33785156
Replicative functions of minute virus of mice NS1 protein are regulated in vitro by phosphorylation through protein kinase C.Q33786100
Initiation of rolling-circle replication in pT181 plasmid: initiator protein enhances cruciform extrusion at the originQ33878225
Origin recognition specificity in pT181 plasmids is determined by a functionally asymmetric palindromic DNA element.Q34040351
The AAV origin binding protein Rep68 is an ATP-dependent site-specific endonuclease with DNA helicase activityQ34186060
Rep protein of tomato yellow leaf curl geminivirus has an ATPase activity required for viral DNA replication.Q34244273
In vitro cleavage and joining at the viral origin of replication by the replication initiator protein of tomato yellow leaf curl virusQ34388668
The NS1 polypeptide of the murine parvovirus minute virus of mice binds to DNA sequences containing the motif [ACCA]2-3Q35834553
Asymmetric replication in vitro from a human sequence element is dependent on adeno-associated virus Rep proteinQ35837075
A DNA structure is required for geminivirus replication origin function.Q35853350
Sequence requirements for binding of Rep68 to the adeno-associated virus terminal repeatsQ35856414
The adeno-associated virus (AAV) Rep protein acts as both a repressor and an activator to regulate AAV transcription during a productive infectionQ35876419
Adeno-associated virus type 2 DNA replication in vivo: mutation analyses of the D sequence in viral inverted terminal repeats.Q35881175
Parvovirus initiation factor PIF: a novel human DNA-binding factor which coordinately recognizes two ACGT motifsQ35889334
Mutational analysis of the adeno-associated virus type 2 Rep68 protein helicase motifs.Q35892700
Role of tyrosine phosphorylation of a cellular protein in adeno-associated virus 2-mediated transgene expressionQ36599393
Identification of linear DNA sequences that specifically bind the adeno-associated virus Rep protein.Q36624752
Interaction of the adeno-associated virus Rep protein with a sequence within the A palindrome of the viral terminal repeat.Q36624790
Biologically active Rep proteins of adeno-associated virus type 2 produced as fusion proteins in Escherichia coliQ36626646
Features of the adeno-associated virus origin involved in substrate recognition by the viral Rep proteinQ36653678
Analysis of mutations in adeno-associated virus Rep protein in vivo and in vitroQ36698702
Evidence for covalent attachment of the adeno-associated virus (AAV) rep protein to the ends of the AAV genomeQ36796289
Adeno-associated virus general transduction vectors: analysis of proviral structuresQ36868692
The inactive pT181 initiator heterodimer, RepC/C, binds but fails to induce melting of the plasmid replication originQ38350662
Charged-to-alanine scanning mutagenesis of the N-terminal half of adeno-associated virus type 2 Rep78 proteinQ39549723
Control of adeno-associated virus type 2 cap gene expression: relative influence of helper virus, terminal repeats, and Rep proteins.Q39882175
Expression of minute virus of mice major nonstructural protein in insect cells: Purification and identification of ATPase and helicase activitiesQ41657884
In vitro resolution of covalently joined AAV chromosome endsQ42631247
Involvement of protein-DNA interaction in adeno-associated virus Rep78-mediated inhibition of HIV-1.Q44793938
Down-regulation of the human c-fos and c-myc proto-oncogene promoters by adeno-associated virus Rep78.Q45781514
Analysis of African cassava mosaic virus recombinants suggests strand nicking occurs within the conserved nonanucleotide motif during the initiation of rolling circle DNA replicationQ45784417
P433issue11
P407language of work or nameEnglishQ1860
P304page(s)9325-9336
P577publication date1999-11-01
P1433published inJournal of VirologyQ1251128
P1476titleRep-mediated nicking of the adeno-associated virus origin requires two biochemical activities, DNA helicase activity and transesterification
P478volume73

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cites work (P2860)
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