Phospholipase Cgamma activation drives increased production of autotaxin in endothelial cells and lysophosphatidic acid-dependent regression.

scientific article

Phospholipase Cgamma activation drives increased production of autotaxin in endothelial cells and lysophosphatidic acid-dependent regression. is …
instance of (P31):
scholarly articleQ13442814

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P356DOI10.1128/MCB.01275-09
P932PMC publication ID2863716
P698PubMed publication ID20231358
P5875ResearchGate publication ID41969010

P50authorTae-Im KimQ59685742
Susan SmythQ116186055
P2093author name stringJorge Aranda
Eun Young Park
Mary L Stracke
Timothy Clair
Andrius Kazlauskas
Eunok Im
Lorenzo Federico
Ruta Motiejunaite
P2860cites workA single autophosphorylation site on KDR/Flk-1 is essential for VEGF-A-dependent activation of PLC-gamma and DNA synthesis in vascular endothelial cellsQ24291278
Nrarp coordinates endothelial Notch and Wnt signaling to control vessel density in angiogenesisQ24318627
Autotaxin has lysophospholipase D activity leading to tumor cell growth and motility by lysophosphatidic acid productionQ24673806
Coregulation of vascular tube stabilization by endothelial cell TIMP-2 and pericyte TIMP-3.Q24682828
Receptor and secreted targets of Wnt-1/beta-catenin signalling in mouse mammary epithelial cellsQ24792463
L-histidine inhibits production of lysophosphatidic acid by the tumor-associated cytokine, autotaxinQ24800365
Autotaxin (NPP-2), a metastasis-enhancing motogen, is an angiogenic factorQ28216396
Identification of human plasma lysophospholipase D, a lysophosphatidic acid-producing enzyme, as autotaxin, a multifunctional phosphodiesteraseQ28217851
Phospholipase C-gamma 1 and phosphatidylinositol 3 kinase are the downstream mediators of the PDGF receptor's mitogenic signalQ28297924
IL-1 beta- and IL-4-induced down-regulation of autotaxin mRNA and PC-1 in fibroblast-like synoviocytes of patients with rheumatoid arthritis (RA)Q28347268
Sphingosylphosphocholine is a naturally occurring lipid mediator in blood plasma: a possible role in regulating cardiac function via sphingolipid receptorsQ28360657
Essential role for sphingosine kinases in neural and vascular developmentQ28505987
Essential role of Flk-1 (VEGF receptor 2) tyrosine residue 1173 in vasculogenesis in miceQ28508807
WNT7b mediates macrophage-induced programmed cell death in patterning of the vasculatureQ28511517
Absence of Erythrogenesis and Vasculogenesis in Plcg1-deficient MiceQ28591776
Angiogenesis in life, disease and medicineQ29614539
Transcriptional regulation by calcium, calcineurin, and NFATQ29620410
Synergistic induction of tumor antigens by Wnt-1 signaling and retinoic acid revealed by gene expression profilingQ34113095
VEGF Receptor Signal TransductionQ34461939
Target genes of the WNT/beta-catenin pathway in Wilms tumorsQ34507325
Roles for lipid phosphate phosphatases in regulation of cellular signalingQ34691433
New pharmacologic approaches to therapy for age-related macular degenerationQ36489172
New insights regarding vessel regressionQ36591997
Tyrosines 1021 and 1009 are phosphorylation sites in the carboxy terminus of the platelet-derived growth factor receptor beta subunit and are required for binding of phospholipase C gamma and a 64-kilodalton protein, respectivelyQ36658598
Positive feedback between vascular endothelial growth factor-A and autotaxin in ovarian cancer cellsQ36742070
Regulation and biological activities of the autotaxin-LPA axis.Q36801833
Autotaxin/lysopholipase D and lysophosphatidic acid regulate murine hemostasis and thrombosisQ37119757
A stable human-derived packaging cell line for production of high titer retrovirus/vesicular stomatitis virus G pseudotypesQ37251604
Integrin alpha6beta4 promotes expression of autotaxin/ENPP2 autocrine motility factor in breast carcinoma cellsQ38326221
Lipid phosphate phosphatase-1 regulates lysophosphatidic acid- and platelet-derived-growth-factor-induced cell migrationQ40339869
Selective ablation of immature blood vessels in established human tumors follows vascular endothelial growth factor withdrawalQ40848490
Autotaxin, a secreted lysophospholipase D, is essential for blood vessel formation during developmentQ41490870
Obligatory participation of macrophages in an angiopoietin 2-mediated cell death switchQ42033503
Cathepsin B regulates the intrinsic angiogenic threshold of endothelial cellsQ42102273
Enhanced leukocyte binding by intestinal microvascular endothelial cells in inflammatory bowel diseaseQ42439317
Regulating angiogenesis at the level of PtdIns-4,5-P2.Q42532910
Macrophages are required for cell death and tissue remodeling in the developing mouse eye.Q42614151
Autotaxin hydrolyzes sphingosylphosphorylcholine to produce the regulator of migration, sphingosine-1-phosphateQ42795815
Pegaptanib for neovascular age-related macular degenerationQ45206481
Intravitreal bevacizumab (Avastin) for neovascular age-related macular degenerationQ46473402
Genetic loci that control the angiogenic response to basic fibroblast growth factorQ47265887
Autotaxin stabilizes blood vessels and is required for embryonic vasculature by producing lysophosphatidic acid.Q52012908
Apoptosis during macrophage-dependent ocular tissue remodellingQ52212753
Src Family Kinases Promote Vessel Stability by Antagonizing the Rho/ROCK PathwayQ57372719
ERK-MAPK signaling opposes Rho-kinase to promote endothelial cell survival and sprouting during angiogenesisQ58001185
The sequence of events in the regression of corneal capillariesQ67300136
A model of angiogenesis in the mouse corneaQ71174063
Culture of retinal capillary cells using selective growth mediaQ71836452
Regression of the hyaloid vessels and pupillary membrane of the mouseQ78166967
P433issue10
P407language of work or nameEnglishQ1860
P921main subjectendotheliumQ111140
P304page(s)2401-2410
P577publication date2010-03-15
P1433published inMolecular and Cellular BiologyQ3319478
P1476titlePhospholipase Cgamma activation drives increased production of autotaxin in endothelial cells and lysophosphatidic acid-dependent regression
P478volume30

Reverse relations

cites work (P2860)
Q42443326Analysing calcium dependent and independent regulation of eNOS in endothelium triggered by extracellular signalling events
Q37620329Arguing the case for the autotaxin-lysophosphatidic acid-lipid phosphate phosphatase 3-signaling nexus in the development and complications of atherosclerosis
Q34660049Autotaxin is induced by TSA through HDAC3 and HDAC7 inhibition and antagonizes the TSA-induced cell apoptosis
Q35625325Autotaxin overexpression causes embryonic lethality and vascular defects
Q36399256Autotaxin, a lysophospholipase D with pleomorphic effects in oncogenesis and cancer progression
Q28116976Axl is essential for VEGF-A-dependent activation of PI3K/Akt
Q36664243Controlling cancer through the autotaxin-lysophosphatidic acid receptor axis
Q35902906Diabetes Disrupts the Response of Retinal Endothelial Cells to the Angiomodulator Lysophosphatidic Acid
Q54548435Expression of autotaxin and acylglycerol kinase in proliferative vitreoretinal epiretinal membranes
Q34292377Expression of lysophosphatidic acid, autotaxin and acylglycerol kinase as biomarkers in diabetic retinopathy.
Q42209269Human periprostatic adipose tissue promotes prostate cancer aggressiveness in vitro.
Q35172962Insulin-like growth factor 1 (IGF-1) stabilizes nascent blood vessels
Q37175153Lactate Engages Receptor Tyrosine Kinases Axl, Tie2, and Vascular Endothelial Growth Factor Receptor 2 to Activate Phosphoinositide 3-Kinase/Akt and Promote Angiogenesis
Q35907288Lysophosphatidic acid causes endothelial dysfunction in porcine coronary arteries and human coronary artery endothelial cells
Q38272614Lysophosphatidic acid contributes to angiogenic homeostasis
Q36044670MEF2C ablation in endothelial cells reduces retinal vessel loss and suppresses pathologic retinal neovascularization in oxygen-induced retinopathy
Q35025845MT-MMPS as Regulators of Vessel Stability Associated with Angiogenesis
Q36083085Primary human endothelial cells secrete agents that reduce responsiveness to lysophosphatidic acid (LPA)
Q37098594Regression activity that is naturally present in vitreous becomes ineffective as patients develop proliferative diabetic retinopathy

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