Complementary interplay between matrix metalloproteinase-9, vascular endothelial growth factor and osteoclast function drives endochondral bone formation

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Complementary interplay between matrix metalloproteinase-9, vascular endothelial growth factor and osteoclast function drives endochondral bone formation is …
instance of (P31):
scholarly articleQ13442814

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P356DOI10.1242/DMM.004226
P932PMC publication ID2869494
P698PubMed publication ID20142327
P5875ResearchGate publication ID41416664

P50authorNapoleone FerraraQ1769254
Zena WerbQ20642782
P2093author name stringKe Wang
Nathalie Ortega
Zena Werb
Thiennu H Vu
P2860cites workRANK is essential for osteoclast and lymph node developmentQ24598872
MMP-9/gelatinase B is a key regulator of growth plate angiogenesis and apoptosis of hypertrophic chondrocytesQ24628843
Recruitment of stem and progenitor cells from the bone marrow niche requires MMP-9 mediated release of kit-ligandQ24644662
Matrix metalloproteinase-9 triggers the angiogenic switch during carcinogenesisQ28140740
Perlecan is essential for cartilage and cephalic developmentQ28146148
Mutation of the matrix metalloproteinase 2 gene (MMP2) causes a multicentric osteolysis and arthritis syndromeQ28204201
Hypoxia in cartilage: HIF-1alpha is essential for chondrocyte growth arrest and survivalQ28363133
Critical roles for collagenase-3 (Mmp13) in development of growth plate cartilage and in endochondral ossificationQ28505336
Soluble VEGF isoforms are essential for establishing epiphyseal vascularization and regulating chondrocyte development and survivalQ28511090
Type I collagen is a genetic modifier of matrix metalloproteinase 2 in murine skeletal developmentQ28512977
VEGFA is necessary for chondrocyte survival during bone developmentQ28590528
Transgenic mice with targeted inactivation of the Col2 alpha 1 gene for collagen II develop a skeleton with membranous and periosteal bone but no endochondral boneQ28591212
Galectin-3 is a downstream regulator of matrix metalloproteinase-9 function during endochondral bone formationQ28595005
VEGF receptor 1 signaling is essential for osteoclast development and bone marrow formation in colony-stimulating factor 1-deficient miceQ34048015
Bone development.Q34059700
Vascular endothelial growth factor stimulates bone repair by promoting angiogenesis and bone turnoverQ34075040
Merging the old skeletal biology with the new. I. Intramembranous ossification, endochondral ossification, ectopic bone, secondary cartilage, and pathologic considerationsQ34095459
Merging the old skeletal biology with the new. II. Molecular aspects of bone formation and bone growthQ34095465
Reaching a genetic and molecular understanding of skeletal developmentQ34611297
Impaired endochondral ossification and angiogenesis in mice deficient in membrane-type matrix metalloproteinase IQ35669086
Matrix remodeling during endochondral ossificationQ35753177
Targeted disruption of the PU.1 gene results in multiple hematopoietic abnormalitiesQ35911056
Multiple roles of vascular endothelial growth factor (VEGF) in skeletal development, growth, and repairQ36005281
Molecular mechanisms of endochondral bone development.Q36032059
Cellular and molecular interactions regulating skeletogenesis.Q36120043
Matrix metalloproteinase 9 and vascular endothelial growth factor are essential for osteoclast recruitment into developing long bonesQ36316526
MT1-MMP-dependent, apoptotic remodeling of unmineralized cartilage: a critical process in skeletal growthQ36324816
Osteoblastic responses to TGF-beta during bone remodelingQ36891833
RANK is the intrinsic hematopoietic cell surface receptor that controls osteoclastogenesis and regulation of bone mass and calcium metabolismQ37108966
A novel matrix metalloproteinase 2 (MMP2) terminal hemopexin domain mutation in a family with multicentric osteolysis with nodulosis and arthritis with cardiac defectsQ37291740
Enhanced cleavage of type II collagen by collagenases in osteoarthritic articular cartilageQ37365557
Altered endochondral bone development in matrix metalloproteinase 13-deficient miceQ37407318
Vasculotropin/vascular endothelial growth factor induces differentiation in cultured osteoblastsQ38310846
Regulation of trophoblastic gelatinases by proto-oncogenesQ38358048
Skeletal defects in VEGF(120/120) mice reveal multiple roles for VEGF in skeletogenesisQ40648372
Adenovirus‐mediated VEGF‐A gene transfer induces bone formationin vivoQ40656016
Osteopetrosis in mice lacking haematopoietic transcription factor PU.1.Q41121255
VEGF couples hypertrophic cartilage remodeling, ossification and angiogenesis during endochondral bone formationQ41672985
Matrix metalloproteinase-2 regulates vascular patterning and growth affecting tumor cell survival and invasion in GBM.Q41832788
Loss of MMP-2 disrupts skeletal and craniofacial development and results in decreased bone mineralization, joint erosion and defects in osteoblast and osteoclast growthQ43248379
A crucial role for matrix metalloproteinase 2 in osteocytic canalicular formation and bone metabolismQ46281147
Impaired angiogenesis and endochondral bone formation in mice lacking the vascular endothelial growth factor isoforms VEGF164 and VEGF188.Q46288581
Increased bone formation in mice lacking plasminogen activatorsQ47768141
Conditional inactivation of VEGF-A in areas of collagen2a1 expression results in embryonic lethality in the heterozygous state.Q52170390
The urokinase plasminogen activator (u-PA) and its inhibitor (PAI-1) in embryo-fetal bone formation in the human: an immunohistochemical study.Q52205646
Role of collagen type II and perlecan in skeletal development.Q53906565
The new bone biology: pathologic, molecular, and clinical correlatesQ56334024
c-Fos: a key regulator of osteoclast-macrophage lineage determination and bone remodelingQ58326943
The murine mutation osteopetrosis is in the coding region of the macrophage colony stimulating factor geneQ59092154
Osteopetrosis, a New Recessive Skeletal Mutation on Chromosome 12 of the MouseQ67444875
MT1-MMP-deficient mice develop dwarfism, osteopenia, arthritis, and connective tissue disease due to inadequate collagen turnoverQ73082300
Vascular endothelial growth factor receptors in osteoclast differentiation and functionQ81073512
P433issue3-4
P921main subjectendotheliumQ111140
P304page(s)224-235
P577publication date2010-02-08
P1433published inDisease Models & MechanismsQ1524006
P1476titleComplementary interplay between matrix metalloproteinase-9, vascular endothelial growth factor and osteoclast function drives endochondral bone formation
P478volume3

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cites work (P2860)
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