Short dysfunctional telomeres impair tumorigenesis in the INK4a(delta2/3) cancer-prone mouse

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Short dysfunctional telomeres impair tumorigenesis in the INK4a(delta2/3) cancer-prone mouse is …
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scholarly articleQ13442814

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P356DOI10.1016/S0092-8674(00)80761-8
P8608Fatcat IDrelease_4yxpsxwmt5dspfltes5iio5lka
P698PubMed publication ID10338215

P50authorCarol GreiderQ26322
P2093author name stringLee KH
Chin L
DePinho RA
Singer RH
Greenberg RA
Gottlieb GJ
Femino A
P2860cites workPremature senescence involving p53 and p16 is activated in response to constitutive MEK/MAPK mitogenic signalingQ22003910
ARF promotes MDM2 degradation and stabilizes p53: ARF-INK4a locus deletion impairs both the Rb and p53 tumor suppression pathwaysQ24321528
A new regulatory motif in cell-cycle control causing specific inhibition of cyclin D/CDK4Q24322196
Extension of life-span by introduction of telomerase into normal human cellsQ24336088
Telomere elongation in immortal human cells without detectable telomerase activityQ24598626
Specific Association of Human Telomerase Activity with Immortal Cells and CancerQ27860801
The Ink4a tumor suppressor gene product, p19Arf, interacts with MDM2 and neutralizes MDM2's inhibition of p53Q28266637
Myc activates telomeraseQ28505489
p53- and ATM-dependent apoptosis induced by telomeres lacking TRF2Q28609749
The serial cultivation of human diploid cell strainsQ29547356
Telomeres shorten during ageing of human fibroblastsQ29547357
Myc signaling via the ARF tumor suppressor regulates p53-dependent apoptosis and immortalizationQ29614701
Localization of ASH1 mRNA particles in living yeastQ29614818
Telomere shortening and tumor formation by mouse cells lacking telomerase RNAQ29615386
Telomere shortening associated with chromosome instability is arrested in immortal cells which express telomerase activityQ29615388
An alternative pathway for yeast telomere maintenance rescues est1- senescenceQ29616135
Tumor suppression at the mouse INK4a locus mediated by the alternative reading frame product p19ARFQ29619663
Essential role of mouse telomerase in highly proliferative organsQ29620451
Two modes of survival of fission yeast without telomerase.Q30472675
p53 deficiency rescues the adverse effects of telomere loss and cooperates with telomere dysfunction to accelerate carcinogenesisQ33862956
The alternative product from the human CDKN2A locus, p14(ARF), participates in a regulatory feedback loop with p53 and MDM2.Q33889383
Developmental and tissue-specific regulation of mouse telomerase and telomere lengthQ34265760
Senescence as a mode of tumor suppressionQ35034137
E1A signaling to p53 involves the p19(ARF) tumor suppressorQ35206764
Senescence of human fibroblasts induced by oncogenic Raf.Q35210205
Functional and physical interactions of the ARF tumor suppressor with p53 and Mdm2Q36174385
Telomerase activation in mouse mammary tumors: lack of detectable telomere shortening and evidence for regulation of telomerase RNA with cell proliferationQ36560900
p19(Arf) induces p53-dependent apoptosis during abelson virus-mediated pre-B cell transformationQ36645083
Telomeres in the mouse have large inter-chromosomal variations in the number of T2AG3 repeatsQ36657077
Dissociation among in vitro telomerase activity, telomere maintenance, and cellular immortalizationQ36754020
Expression of mouse telomerase catalytic subunit in embryos and adult tissues.Q37470406
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Direct activation of TERT transcription by c-MYC.Q40973563
The telomere lengthening mechanism in telomerase-negative immortal human cells does not involve the telomerase RNA subunitQ41108271
Cooperative effect of antisense-Rb and antisense-p53 oligomers on the extension of life span in human diploid fibroblasts, TIG-1.Q41668628
Mouse minor satellite DNA genetically maps to the centromere and is physically linked to the proximal telomereQ41998916
Expression of mouse telomerase reverse transcriptase during development, differentiation and proliferationQ42830375
Both Rb/p16INK4a inactivation and telomerase activity are required to immortalize human epithelial cells.Q44816904
Cap-prevented recombination between terminal telomeric repeat arrays (telomere CPR) maintains telomeres in Kluyveromyces lactis lacking telomeraseQ46140748
Telomerase reverse transcriptase gene is a direct target of c-Myc but is not functionally equivalent in cellular transformationQ47987665
Severe growth defect in mouse cells lacking the telomerase RNA componentQ47991784
Circular chromosome formation in a fission yeast mutant defective in two ATM homologuesQ48016421
Tumor surveillance via the ARF-p53 pathway.Q53430438
Telomerase and cell proliferation in mouse skin papillomas.Q53438316
Cooperating oncogenes converge to regulate cyclin/cdk complexes.Q53445613
Role of the INK4a locus in tumor suppression and cell mortality.Q53455197
Spontaneous immortalization rate of cultured Chinese hamster cells.Q53537584
p14ARF links the tumour suppressors RB and p53.Q55067966
Longevity, Stress Response, and Cancer in Aging Telomerase-Deficient MiceQ56508064
Differential regulation of telomerase activity and telomerase RNA during multi-stage tumorigenesisQ56508142
p19ARF links the tumour suppressor p53 to RasQ57562848
A role for both RB and p53 in the regulation of human cellular senescenceQ64378339
Evolution of cell senescence, atherosclerosis and benign tumoursQ68817338
Reconstitution of telomerase activity in normal human cells leads to elongation of telomeres and extended replicative life spanQ74311298
Time, telomeres and tumours: is cellular senescence more than an anticancer mechanism?Q75294424
P433issue4
P407language of work or nameEnglishQ1860
P304page(s)515-525
P577publication date1999-05-01
P1433published inCellQ655814
P1476titleShort dysfunctional telomeres impair tumorigenesis in the INK4a(delta2/3) cancer-prone mouse
P478volume97