scholarly article | Q13442814 |
P356 | DOI | 10.1016/S0092-8674(00)80761-8 |
P8608 | Fatcat ID | release_4yxpsxwmt5dspfltes5iio5lka |
P698 | PubMed publication ID | 10338215 |
P50 | author | Carol Greider | Q26322 |
P2093 | author name string | Lee KH | |
Chin L | |||
DePinho RA | |||
Singer RH | |||
Greenberg RA | |||
Gottlieb GJ | |||
Femino A | |||
P2860 | cites work | Premature senescence involving p53 and p16 is activated in response to constitutive MEK/MAPK mitogenic signaling | Q22003910 |
ARF promotes MDM2 degradation and stabilizes p53: ARF-INK4a locus deletion impairs both the Rb and p53 tumor suppression pathways | Q24321528 | ||
A new regulatory motif in cell-cycle control causing specific inhibition of cyclin D/CDK4 | Q24322196 | ||
Extension of life-span by introduction of telomerase into normal human cells | Q24336088 | ||
Telomere elongation in immortal human cells without detectable telomerase activity | Q24598626 | ||
Specific Association of Human Telomerase Activity with Immortal Cells and Cancer | Q27860801 | ||
The Ink4a tumor suppressor gene product, p19Arf, interacts with MDM2 and neutralizes MDM2's inhibition of p53 | Q28266637 | ||
Myc activates telomerase | Q28505489 | ||
p53- and ATM-dependent apoptosis induced by telomeres lacking TRF2 | Q28609749 | ||
The serial cultivation of human diploid cell strains | Q29547356 | ||
Telomeres shorten during ageing of human fibroblasts | Q29547357 | ||
Myc signaling via the ARF tumor suppressor regulates p53-dependent apoptosis and immortalization | Q29614701 | ||
Localization of ASH1 mRNA particles in living yeast | Q29614818 | ||
Telomere shortening and tumor formation by mouse cells lacking telomerase RNA | Q29615386 | ||
Telomere shortening associated with chromosome instability is arrested in immortal cells which express telomerase activity | Q29615388 | ||
An alternative pathway for yeast telomere maintenance rescues est1- senescence | Q29616135 | ||
Tumor suppression at the mouse INK4a locus mediated by the alternative reading frame product p19ARF | Q29619663 | ||
Essential role of mouse telomerase in highly proliferative organs | Q29620451 | ||
Two modes of survival of fission yeast without telomerase. | Q30472675 | ||
p53 deficiency rescues the adverse effects of telomere loss and cooperates with telomere dysfunction to accelerate carcinogenesis | Q33862956 | ||
The alternative product from the human CDKN2A locus, p14(ARF), participates in a regulatory feedback loop with p53 and MDM2. | Q33889383 | ||
Developmental and tissue-specific regulation of mouse telomerase and telomere length | Q34265760 | ||
Senescence as a mode of tumor suppression | Q35034137 | ||
E1A signaling to p53 involves the p19(ARF) tumor suppressor | Q35206764 | ||
Senescence of human fibroblasts induced by oncogenic Raf. | Q35210205 | ||
Functional and physical interactions of the ARF tumor suppressor with p53 and Mdm2 | Q36174385 | ||
Telomerase activation in mouse mammary tumors: lack of detectable telomere shortening and evidence for regulation of telomerase RNA with cell proliferation | Q36560900 | ||
p19(Arf) induces p53-dependent apoptosis during abelson virus-mediated pre-B cell transformation | Q36645083 | ||
Telomeres in the mouse have large inter-chromosomal variations in the number of T2AG3 repeats | Q36657077 | ||
Dissociation among in vitro telomerase activity, telomere maintenance, and cellular immortalization | Q36754020 | ||
Expression of mouse telomerase catalytic subunit in embryos and adult tissues. | Q37470406 | ||
Visualization of single RNA transcripts in situ | Q39465222 | ||
Direct activation of TERT transcription by c-MYC. | Q40973563 | ||
The telomere lengthening mechanism in telomerase-negative immortal human cells does not involve the telomerase RNA subunit | Q41108271 | ||
Cooperative effect of antisense-Rb and antisense-p53 oligomers on the extension of life span in human diploid fibroblasts, TIG-1. | Q41668628 | ||
Mouse minor satellite DNA genetically maps to the centromere and is physically linked to the proximal telomere | Q41998916 | ||
Expression of mouse telomerase reverse transcriptase during development, differentiation and proliferation | Q42830375 | ||
Both Rb/p16INK4a inactivation and telomerase activity are required to immortalize human epithelial cells. | Q44816904 | ||
Cap-prevented recombination between terminal telomeric repeat arrays (telomere CPR) maintains telomeres in Kluyveromyces lactis lacking telomerase | Q46140748 | ||
Telomerase reverse transcriptase gene is a direct target of c-Myc but is not functionally equivalent in cellular transformation | Q47987665 | ||
Severe growth defect in mouse cells lacking the telomerase RNA component | Q47991784 | ||
Circular chromosome formation in a fission yeast mutant defective in two ATM homologues | Q48016421 | ||
Tumor surveillance via the ARF-p53 pathway. | Q53430438 | ||
Telomerase and cell proliferation in mouse skin papillomas. | Q53438316 | ||
Cooperating oncogenes converge to regulate cyclin/cdk complexes. | Q53445613 | ||
Role of the INK4a locus in tumor suppression and cell mortality. | Q53455197 | ||
Spontaneous immortalization rate of cultured Chinese hamster cells. | Q53537584 | ||
p14ARF links the tumour suppressors RB and p53. | Q55067966 | ||
Longevity, Stress Response, and Cancer in Aging Telomerase-Deficient Mice | Q56508064 | ||
Differential regulation of telomerase activity and telomerase RNA during multi-stage tumorigenesis | Q56508142 | ||
p19ARF links the tumour suppressor p53 to Ras | Q57562848 | ||
A role for both RB and p53 in the regulation of human cellular senescence | Q64378339 | ||
Evolution of cell senescence, atherosclerosis and benign tumours | Q68817338 | ||
Reconstitution of telomerase activity in normal human cells leads to elongation of telomeres and extended replicative life span | Q74311298 | ||
Time, telomeres and tumours: is cellular senescence more than an anticancer mechanism? | Q75294424 | ||
P433 | issue | 4 | |
P407 | language of work or name | English | Q1860 |
P304 | page(s) | 515-525 | |
P577 | publication date | 1999-05-01 | |
P1433 | published in | Cell | Q655814 |
P1476 | title | Short dysfunctional telomeres impair tumorigenesis in the INK4a(delta2/3) cancer-prone mouse | |
P478 | volume | 97 |