The role of hepatic fat accumulation in pathogenesis of non-alcoholic fatty liver disease (NAFLD).

scientific article

The role of hepatic fat accumulation in pathogenesis of non-alcoholic fatty liver disease (NAFLD). is …
instance of (P31):
review articleQ7318358
scholarly articleQ13442814

External links are
P6179Dimensions Publication ID1001049337
P356DOI10.1186/1476-511X-9-42
P932PMC publication ID2873482
P698PubMed publication ID20426802

P50authorStig B.S. BengmarkQ54250285
P2093author name stringQing Liu
Shen Qu
P2860cites workHepatocyte apoptosis and fas expression are prominent features of human nonalcoholic steatohepatitisQ73735584
Inflammation and insulin resistanceQ22241893
Insulin degradation: progress and potentialQ28287093
Prevention of fat-induced insulin resistance by salicylateQ28345600
FoxO1 mediates insulin-dependent regulation of hepatic VLDL production in miceQ28507512
Effects of an engineered human anti-TNF-alpha antibody (CDP571) on insulin sensitivity and glycemic control in patients with NIDDM.Q51580928
Hepatic Removal of Insulin in Normal Man: Dose Response to Endogenous Insulin Secretion*Q51646799
Estimation of the secretion rate of insulin from the urinary excretion rate of C-peptide. Study in obese and diabetic subjects.Q51651113
Differences in the hepatic and renal extraction of insulin and glucagon in the dog: evidence for saturability of insulin metabolism.Q51855439
Inhibiting triglyceride synthesis improves hepatic steatosis but exacerbates liver damage and fibrosis in obese mice with nonalcoholic steatohepatitis.Q53555710
Toll-like receptor 9 signaling mediates the anti-inflammatory effects of probiotics in murine experimental colitis.Q54511436
MAP4K4 gene silencing in human skeletal muscle prevents tumor necrosis factor-alpha-induced insulin resistance.Q55042948
Loss-of-function mutation in Toll-like receptor 4 prevents diet-induced obesity and insulin resistanceQ56742768
Insulin production rate following glucose ingestion estimated by splanchnic C-peptide output in normal manQ66960336
Dual-echo, chemical shift gradient-echo magnetic resonance imaging to quantify hepatic steatosis: Implications for living liver donationQ73715097
Cellular mechanism of insulin resistance: potential links with inflammationQ75220930
Relationship among histologic, radiologic, and biochemical assessments of hepatic steatosis: a study of human liver samplesQ79633397
Guidelines for the assessment and management of non-alcoholic fatty liver disease in the Asia-Pacific region: executive summaryQ80470858
Portal fibrosis and hepatic steatosis in morbidly obese subjects: A spectrum of nonalcoholic fatty liver diseaseQ80565685
Levels of serum hyaluronic acid, TNF-alpha and IL-8 in patients with nonalcoholic steatohepatitisQ81301916
Serum cytokine and soluble cytokine receptor levels in patients with non-alcoholic steatohepatitisQ82294435
Free fatty acids induce JNK-dependent hepatocyte lipoapoptosisQ82677113
Predicted coronary risk for adults with coronary heart disease and low HDL-C: an analysis from the US National Health and Nutrition Examination SurveyQ94705856
Inhibition of protein kinase Cepsilon prevents hepatic insulin resistance in nonalcoholic fatty liver diseaseQ28571421
Sterol regulatory element-binding protein-1 as a key transcription factor for nutritional induction of lipogenic enzyme genesQ28646399
TLR4 links innate immunity and fatty acid-induced insulin resistanceQ29617577
Innate immunityQ29618949
Interleukin-1-receptor antagonist in type 2 diabetes mellitusQ29619001
Local and systemic insulin resistance resulting from hepatic activation of IKK-beta and NF-kappaBQ29619314
Sources of fatty acids stored in liver and secreted via lipoproteins in patients with nonalcoholic fatty liver diseaseQ29619334
Pathogenesis of non-alcoholic fatty liver disease.Q33606303
Adipose tissue selective insulin receptor knockout protects against obesity and obesity-related glucose intoleranceQ34137882
Role of stearoyl-coenzyme A desaturase in regulating lipid metabolismQ34361926
Nonalcoholic steatosis and steatohepatitis IV. Nonalcoholic fatty liver disease abnormalities in macrophage function and cytokinesQ34467338
Effect of Intraduodenal Glucose Administration on Hepatic Extraction of Insulin in the Anesthetized DogQ34509786
Lipid metabolism and liver inflammation. II. Fatty liver disease and fatty acid oxidationQ34512108
A placebo-controlled trial of pioglitazone in subjects with nonalcoholic steatohepatitisQ34585893
Biochemical and physiological function of stearoyl-CoA desaturaseQ34898764
A model of insulin resistance and nonalcoholic steatohepatitis in rats: role of peroxisome proliferator-activated receptor-alpha and n-3 polyunsaturated fatty acid treatment on liver injury.Q35222087
Hepatic steatosis: a mediator of the metabolic syndrome. Lessons from animal modelsQ35625539
FoxOs at the crossroads of cellular metabolism, differentiation, and transformationQ35770614
Comparison of the natural history of alcoholic and nonalcoholic fatty liver diseaseQ36034875
Innate immunity in the liverQ36036373
FoxO proteins in insulin action and metabolismQ36110215
Recent concepts in non-alcoholic fatty liver diseaseQ36234172
Role of inflammation in nonalcoholic steatohepatitisQ36284149
Role of endoplasmic reticulum stress and c-Jun NH2-terminal kinase pathways in inflammation and origin of obesity and diabetesQ36321560
Nonalcoholic fatty liver disease: from steatosis to cirrhosisQ36382279
Natural history of nonalcoholic steatohepatitisQ36422700
Contributions of beta-cell dysfunction and insulin resistance to the pathogenesis of impaired glucose tolerance and impaired fasting glucoseQ36462545
The modulation of inflammatory gene expression by lipids: mediation through Toll-like receptors.Q36472264
Non alcoholic fatty liver disease: a clinical approach and reviewQ36475998
Contribution of de novo fatty acid synthesis to hepatic steatosis and insulin resistance: lessons from genetically engineered miceQ36479005
Nonalcoholic steatohepatitis: pathologic features and differential diagnosisQ36580461
Relationship of steatosis grade and zonal location to histological features of steatohepatitis in adult patients with non-alcoholic fatty liver diseaseQ36593429
Central insulin action regulates peripheral glucose and fat metabolism in miceQ36597490
Beyond insulin resistance: Innate immunity in nonalcoholic steatohepatitisQ36669223
1. Fatty liver and non-alcoholic steatohepatitisQ36707085
Fatty liver and insulin resistance: not always linkedQ36742407
siRNA-mediated reduction of inhibitor of nuclear factor-kappaB kinase prevents tumor necrosis factor-alpha-induced insulin resistance in human skeletal muscleQ36807616
Insulin resistance induced by tumor necrosis factor-alpha in myocytes and brown adipocytes.Q36972844
Pathology of nonalcoholic fatty liver diseaseQ36977000
Hepatic stearoyl-CoA desaturase (SCD)-1 activity and diacylglycerol but not ceramide concentrations are increased in the nonalcoholic human fatty liverQ37023053
Cytokines in the pathogenesis of fatty liver and disease progression to steatohepatitis: implications for treatmentQ37051418
Impact of non-alcoholic fatty liver disease on accelerated metabolic complicationsQ37141242
FoxO1 integrates insulin signaling to VLDL productionQ37148966
Aberrant Forkhead box O1 function is associated with impaired hepatic metabolismQ37149810
Hepatic triglyceride synthesis and nonalcoholic fatty liver diseaseQ37156321
Nonalcoholic fatty liver disease: hepatic manifestation of obesity and the metabolic syndromeQ37226355
Inhibition of stearoyl-coenzyme A desaturase 1 dissociates insulin resistance and obesity from atherosclerosisQ37276342
Hepatic, cardiovascular, and endocrine outcomes of the histological subphenotypes of nonalcoholic fatty liver disease.Q37310292
The role of the lipogenic pathway in the development of hepatic steatosis.Q37386081
New insights into the pathophysiology of nonalcoholic fatty liver disease.Q37452721
Combined therapy of dietary fish oil and stearoyl-CoA desaturase 1 inhibition prevents the metabolic syndrome and atherosclerosisQ37485124
Nonalcoholic fatty liver disease/nonalcoholic steatohepatitis: histological diagnostic criteria and scoring systemsQ37499907
Probiotics and antibodies to TNF inhibit inflammatory activity and improve nonalcoholic fatty liver diseaseQ38358419
Extraction of Insulin by LiverQ39927378
C-Peptide as a Measure of the Secretion and Hepatic Extraction of Insulin: Pitfalls and LimitationsQ40177948
Escherichia coli strain Nissle 1917 ameliorates experimental colitis via toll-like receptor 2- and toll-like receptor 4-dependent pathwaysQ40264330
Activation of Toll-like receptor 4 is associated with insulin resistance in adipocytesQ40266335
Foxo1 mediates insulin action on apoC-III and triglyceride metabolism.Q40301333
A pilot trial of pentoxifylline in nonalcoholic steatohepatitis.Q40464366
Inhibition of insulin sensitivity by free fatty acids requires activation of multiple serine kinases in 3T3-L1 adipocytesQ40555990
Saturated fatty acid activates but polyunsaturated fatty acid inhibits Toll-like receptor 2 dimerized with Toll-like receptor 6 or 1.Q40589626
Mechanism of hepatic insulin resistance in non-alcoholic fatty liver disease.Q42462295
Hepatic lipid partitioning and liver damage in nonalcoholic fatty liver disease: role of stearoyl-CoA desaturaseQ42563412
Insulin secretion and insulin sensitivity pattern is different in isolated impaired glucose tolerance and impaired fasting glucose: the risk factor in Impaired Glucose Tolerance for Atherosclerosis and Diabetes studyQ43654161
Clinical features and outcomes of cirrhosis due to non-alcoholic steatohepatitis compared with cirrhosis caused by chronic hepatitis C.Q44190785
Neutralization of tumor necrosis factor-alpha reverses insulin resistance in skeletal muscle but not adipose tissueQ44948837
Beneficial effects of tumor necrosis factor-alpha inhibition by pentoxifylline on clinical, biochemical, and metabolic parameters of patients with nonalcoholic steatohepatitisQ45077756
NAFLD as a risk factor for the development of diabetes and the metabolic syndrome: an eleven-year follow-up studyQ46084938
Are non-invasive tests accurate enough to predict hepatic fibrosis in non-alcoholic fatty liver disease (NAFLD)?Q46368206
Pulsatile insulin secretion dictates systemic insulin delivery by regulating hepatic insulin extraction in humansQ46513257
Beneficial effects of a probiotic VSL#3 on parameters of liver dysfunction in chronic liver diseases.Q46533800
Increased liver fat, impaired insulin clearance, and hepatic and adipose tissue insulin resistance in type 2 diabetesQ46599718
JNK1 but not JNK2 promotes the development of steatohepatitis in miceQ46865809
Effect of liver fat on insulin clearanceQ46982115
P275copyright licenseCreative Commons Attribution 2.0 GenericQ19125117
P6216copyright statuscopyrightedQ50423863
P407language of work or nameEnglishQ1860
P921main subjectliver diseaseQ929737
metabolic dysfunction–associated steatotic liver diseaseQ1546498
fatty liver diseaseQ6058862
non-alcoholic fatty liverQ66299798
P5008on focus list of Wikimedia projectScienceSourceQ55439927
P304page(s)42
P577publication date2010-04-28
P1433published inLipids in Health and DiseaseQ15756695
P1476titleThe role of hepatic fat accumulation in pathogenesis of non-alcoholic fatty liver disease (NAFLD).
P478volume9

Reverse relations

cites work (P2860)
Q55530834A comprehensive bioinformatics analysis on multiple Gene Expression Omnibus datasets of nonalcoholic fatty liver disease and nonalcoholic steatohepatitis.
Q34779049Adipokines and proinflammatory cytokines, the key mediators in the pathogenesis of nonalcoholic fatty liver disease.
Q36941874Apigenin Ameliorates Dyslipidemia, Hepatic Steatosis and Insulin Resistance by Modulating Metabolic and Transcriptional Profiles in the Liver of High-Fat Diet-Induced Obese Mice
Q42756198Association between Nicotinamide Phosphoribosyltransferase and de novo Lipogenesis in Nonalcoholic Fatty Liver Disease.
Q35782502Association between serum alanine aminotransferase level and obesity indices in Korean adolescents
Q97524395Beneficial effects of Chinese herbs in the treatment of fatty liver diseases
Q37443840Bibliometric analysis of top 100 cited articles in nonalcoholic fatty liver disease research.
Q33591710Body composition variables as predictors of NAFLD by ultrasound in obese children and adolescents
Q92204214CHP1 Regulates Compartmentalized Glycerolipid Synthesis by Activating GPAT4
Q38327569Carnosic acid (CA) prevents lipid accumulation in hepatocytes through the EGFR/MAPK pathway
Q45392774Characterisation of betatrophin concentrations in childhood and adolescent obesity and insulin resistance
Q44222140Cohort study of non-alcoholic fatty liver disease, NAFLD fibrosis score, and the risk of incident diabetes in a Korean population
Q47145626Curcumin enhances liver SIRT3 expression in the rat model of cirrhosis.
Q51082561Deficiency of CKIP-1 aggravates high-fat diet-induced fatty liver in mice.
Q40987059Dietary restriction, caloric value and the accumulation of hepatic fat.
Q89529434Effects of 1,25-dihydroxyvitamin D3 on the Inflammatory Responses of Stromal Vascular Cells and Adipocytes from Lean and Obese Mice
Q91727269Effects of Propolis Extract and Propolis-Derived Compounds on Obesity and Diabetes: Knowledge from Cellular and Animal Models
Q90157746Effects of high-intensity interval and moderate-intensity continuous aerobic exercise on diabetic obese patients with nonalcoholic fatty liver disease: A comparative randomized controlled trial
Q58740690Evaluation of two-point Dixon water-fat separation for liver specific contrast-enhanced assessment of liver maximum capacity
Q44583057Expression of genes for microRNA-processing enzymes is altered in advanced non-alcoholic fatty liver disease.
Q41944168GLP-1 Receptor Agonist and Non-Alcoholic Fatty Liver Disease
Q38234416GLP-1 receptor agonists: effects on the progression of non-alcoholic fatty liver disease
Q36369189Global publication trends and research hotspots of nonalcoholic fatty liver disease: a bibliometric analysis and systematic review
Q92059925Health Benefits of Carotenoids: A Role of Carotenoids in the Prevention of Non-Alcoholic Fatty Liver Disease
Q35905331Hyperinsulinemia Enhances Hepatic Expression of the Fatty Acid Transporter Cd36 and Provokes Hepatosteatosis and Hepatic Insulin Resistance
Q87610149Identification and validation co-differentially expressed genes with NAFLD and insulin resistance
Q86048539Impaired PI3 K Akt expression in liver and skeletal muscle of ovariectomized rats
Q93004201Improvement of Nonalcoholic Fatty Liver Disease Reduces the Risk of Type 2 Diabetes Mellitus
Q93355678Is non-alcoholic fatty liver disease a reflection of what we eat or simply how much we eat?
Q91792524MTP genetic variants associated with non-alcoholic fatty liver in metabolic syndrome patients
Q50115683Metabolic profiling of ob/ob mouse fatty liver using HR-MAS 1H-NMR combined with gene expression analysis reveals alterations in betaine metabolism and the transsulfuration pathway
Q34992352Metabolic syndrome and gastro-esophageal reflux: A link towards a growing interest in developed countries
Q26738646Micronutrient Antioxidants and Nonalcoholic Fatty Liver Disease
Q92714639N,N'-diacetylcystine ameliorates inflammation in experimental non-alcoholic steatohepatitis by regulating nuclear transcription factor kappa B activation
Q93379612Non-alcoholic fatty liver disease: a pandemic disease with multisystem burden
Q90750222Potential Therapeutic Application of Estrogen in Gender Disparity of Nonalcoholic Fatty Liver Disease/Nonalcoholic Steatohepatitis
Q35380845Potential epigenetic mechanism in non-alcoholic Fatty liver disease
Q90284167Relationship between Muscle Mass/Strength and Hepatic Fat Content in Post-Menopausal Women
Q33690123Repeated sense of hunger leads to the development of visceral obesity and metabolic syndrome in a mouse model
Q24610857Role of nuclear receptor corepressor RIP140 in metabolic syndrome
Q38820176Steatosis induced CCL5 contributes to early-stage liver fibrosis in nonalcoholic fatty liver disease progress
Q39973908Structure and age-dependent development of the turkey liver: a comparative study of a highly selected meat-type and a wild-type turkey line.
Q27497351Systematic review on the treatment of pentoxifylline in patients with non-alcoholic fatty liver disease
Q33653828The Possible Role of Helicobacter pylori Infection in Non-alcoholic Fatty Liver Disease
Q92151798The Role of the Gut Microbiota in Lipid and Lipoprotein Metabolism
Q50673306The TIR/BB-loop mimetic AS-1 prevents non-alcoholic steatohepatitis and hepatic insulin resistance by inhibiting NLRP3-ASC inflammasome activation.
Q37867697The mechanistic basis for the induction of hepatic steatosis by xenobiotics
Q43094757The role of small heterodimer partner in nonalcoholic fatty liver disease improvement after sleeve gastrectomy in mice.
Q38819558Turmeric Supplementation Improves Serum Glucose Indices and Leptin Levels in Patients with Nonalcoholic Fatty Liver Diseases.
Q36616784What is the role of adiponectin in obesity related non-alcoholic fatty liver disease?

Search more.