The Toll-like receptor gene family is integrated into human DNA damage and p53 networks.

scientific article

The Toll-like receptor gene family is integrated into human DNA damage and p53 networks. is …
instance of (P31):
scholarly articleQ13442814

External links are
P356DOI10.1371/JOURNAL.PGEN.1001360
P932PMC publication ID3069118
P698PubMed publication ID21483755
P5875ResearchGate publication ID51042519

P50authorStavros GarantziotisQ42388074
Maria ShatzQ53337141
Michael A ResnickQ62124589
Michael B FesslerQ63363549
P2093author name stringDaniel Menendez
Kathleen Azzam
P2860cites workIn vivo activation of the p53 pathway by small-molecule antagonists of MDM2Q27642888
p53, the cellular gatekeeper for growth and divisionQ27860990
Definition of a consensus binding site for p53Q28207794
A large intergenic noncoding RNA induced by p53 mediates global gene repression in the p53 responseQ28592069
p53 Functions through Stress- and Promoter-Specific Recruitment of Transcription Initiation Components before and after DNA DamageQ28609701
Circulating mitochondrial DAMPs cause inflammatory responses to injuryQ29614470
Transcriptional control of human p53-regulated genesQ29617650
Estrogen receptor acting in cis enhances WT and mutant p53 transactivation at canonical and noncanonical p53 target sequencesQ30493233
microRNAs join the p53 network--another piece in the tumour-suppression puzzleQ33344707
Noncanonical DNA motifs as transactivation targets by wild type and mutant p53Q33361623
Triggering of TLR7 and TLR8 expressed by human lung cancer cells induces cell survival and chemoresistanceQ33755300
Functionally distinct polymorphic sequences in the human genome that are targets for p53 transactivation.Q33772124
Genetic variation in radiation-induced expression phenotypesQ33910447
A SNP in the flt-1 promoter integrates the VEGF system into the p53 transcriptional networkQ34334913
Regulation of lung injury and repair by Toll-like receptors and hyaluronanQ34462186
The biological impact of the human master regulator p53 can be altered by mutations that change the spectrum and expression of its target genesQ34519833
Regulation of adaptive immunity by the innate immune systemQ34659642
An agonist of toll-like receptor 5 has radioprotective activity in mouse and primate modelsQ34769152
Functional evolution of the p53 regulatory network through its target response elementsQ36458961
Therapeutic targeting of innate immunity with Toll-like receptor agonists and antagonistsQ36811131
TLR2 is expressed on activated T cells as a costimulatory receptorQ36853515
The effect of toll-like receptors and toll-like receptor genetics in human diseaseQ36936332
ROS and p53: a versatile partnershipQ37085000
Probing the functional impact of sequence variation on p53-DNA interactions using a novel microsphere assay for protein-DNA binding with human cell extractsQ37154221
Intestinal mucosal inflammation leads to systemic genotoxicity in miceQ37259554
Deficiency of the DNA repair enzyme ATM in rheumatoid arthritisQ37273198
A regulatory loop composed of RAP80-HDM2-p53 provides RAP80-enhanced p53 degradation by HDM2 in response to DNA damage.Q37339272
Pattern recognition receptors and control of adaptive immunityQ37361471
Oxidative damage to nucleic acids in severe emphysemaQ37395759
The expanding universe of p53 targetsQ37602507
Pattern recognition by Toll-like receptorsQ37607209
Targeting Toll-like receptors: emerging therapeutics?Q37727910
p53 regulates Toll-like receptor 3 expression and function in human epithelial cell linesQ39941925
p53-induced up-regulation of MnSOD and GPx but not catalase increases oxidative stress and apoptosis.Q40571016
A chemical inhibitor of p53 that protects mice from the side effects of cancer therapyQ40929887
Differential regulation of p53 target genes: it's (core promoter) elementary.Q42044986
Role of toll-like receptor 2 (TLR2) in neutrophil activation: GM-CSF enhances TLR2 expression and TLR2-mediated interleukin 8 responses in neutrophils.Q44102020
Toll-like receptors stimulate human neutrophil functionQ44493366
Differential expression and regulation of toll-like receptors (TLR) in human leukocytes: selective expression of TLR3 in dendritic cellsQ45345615
Differential expression of Toll-like receptor (TLR)-2 and TLR-4 on monocytes in human sepsisQ47759466
Damage effects of dust storm PM2.5 on DNA in alveolar macrophages and lung cells of rats.Q51055950
Control of B-cell responses by Toll-like receptorsQ59066168
Toll-like receptors control activation of adaptive immune responsesQ74486847
Increased expression of toll-like receptor-2 and -4 on leukocytes from patients with sepsisQ80873411
Inhibition of immunological function mediated DNA damage of alveolar macrophages caused by cigarette smoke in miceQ84922234
P275copyright licenseCreative Commons CC0 LicenseQ6938433
P6216copyright statuscopyrighted, dedicated to the public domain by copyright holderQ88088423
P433issue3
P921main subjecttoll-like receptorQ408004
DNA damageQ5205747
P304page(s)e1001360
P577publication date2011-03-31
P1433published inPLOS GeneticsQ1893441
P1476titleThe Toll-like receptor gene family is integrated into human DNA damage and p53 networks
P478volume7

Reverse relations

cites work (P2860)
Q36016499A p53 axis regulates B cell receptor-triggered, innate immune system-driven B cell clonal expansion
Q54858643Antigenotoxic Effect of Trametes spp. Extracts against DNA Damage on Human Peripheral White Blood Cells.
Q35077769Association of TLR2 and TLR4 polymorphisms with risk of cancer: a meta-analysis
Q41432461CHK1 and RAD51 activation after DNA damage is regulated via urokinase receptor/TLR4 signaling
Q40858725CRN13 candidate effectors from plant and animal eukaryotic pathogens are DNA-binding proteins which trigger host DNA damage response.
Q27692076Caught in the cross fire: p53 in inflammation.
Q27692108Cellular stress response and innate immune signaling: integrating pathways in host defense and inflammation.
Q38911126Census and evaluation of p53 target genes.
Q38940069Cooperative interactions between p53 and NFκB enhance cell plasticity.
Q36254960Cytokine response in mouse bone marrow derived macrophages after infection with pathogenic and non-pathogenic Rift Valley fever virus
Q28078628DNA Damage: From Chronic Inflammation to Age-Related Deterioration
Q36068346DNA repair is indispensable for survival after acute inflammation
Q35737507Distinct p53 genomic binding patterns in normal and cancer-derived human cells
Q37122075Diverse stresses dramatically alter genome-wide p53 binding and transactivation landscape in human cancer cells
Q38838059Downregulation of Toll-Like Receptor 9 Expression by Beta Human Papillomavirus 38 and Implications for Cell Cycle Control.
Q33890980Dynamic expression patterns of ATF3 and p53 in the hippocampus of a pentylenetetrazole-induced kindling model
Q58416369ETV7-Mediated DNAJC15 Repression Leads to Doxorubicin Resistance in Breast Cancer Cells
Q36127825Effects of P-MAPA Immunomodulator on Toll-Like Receptors and p53: Potential Therapeutic Strategies for Infectious Diseases and Cancer
Q93378245Encephalitozoon cuniculi and Vittaforma corneae (Phylum Microsporidia) inhibit staurosporine-induced apoptosis in human THP-1 macrophages in vitro
Q34325529Fuzzy tandem repeats containing p53 response elements may define species-specific p53 target genes
Q45089227Gene set enrichment analysis highlights different gene expression profiles in whole blood samples X-irradiated with low and high doses
Q38726846Genetic Variability as a Regulator of TLR4 and NOD Signaling in Response to Bacterial Driven DNA Damage Response (DDR) and Inflammation: Focus on the Gastrointestinal (GI) Tract
Q35668596Genomic regulation of senescence and innate immunity signaling in the retinal pigment epithelium
Q36070462Increased toll-like receptors and p53 levels regulate apoptosis and angiogenesis in non-muscle invasive bladder cancer: mechanism of action of P-MAPA biological response modifier
Q90062620Inflammaging and Oxidative Stress in Human Diseases: From Molecular Mechanisms to Novel Treatments
Q51731314Innate immune system activation in zebrafish and cellular models of Diamond Blackfan Anemia.
Q36906240Interaction between p53 and estradiol pathways in transcriptional responses to chemotherapeutics
Q64943265Key mechanisms involved in ionizing radiation-induced systemic effects. A current review.
Q37641651Ligand dependent restoration of human TLR3 signaling and death in p53 mutant cells.
Q31156407Microbial pathogens trigger host DNA double-strand breaks whose abundance is reduced by plant defense responses
Q37584840Mouse embryonic stem cells undergo charontosis, a novel programmed cell death pathway dependent upon cathepsins, p53, and EndoG, in response to etoposide treatment
Q37110140Network analysis reveals centrally connected genes and pathways involved in CD8+ T cell exhaustion versus memory.
Q93105342Overcoming adaptive therapy resistance in AML by targeting immune response pathways
Q36887608PDL1 Regulation by p53 via miR-34
Q37018148Pathways analysis of differential gene expression induced by engrafting doses of total body irradiation for allogeneic bone marrow transplantation in mice
Q38690773Pattern recognition receptors: immune targets to enhance cancer immunotherapy
Q38739590Predicting RTS,S Vaccine-Mediated Protection from Transcriptomes in a Malaria-Challenge Clinical Trial
Q35717532Primed for cancer: Li Fraumeni Syndrome and the pre-cancerous niche
Q59136284RRAD, IL4I1, CDKN1A, and SERPINE1 genes are potentially co-regulated by NF-κB and p53 transcription factors in cells exposed to high doses of ionizing radiation
Q38284081Radiation and inflammation
Q36083353Radiation takes its Toll
Q50221002Relationship between radioadaptive response and individual radiosensitivity to low doses of gamma radiation: an extended study of chromosome damage in blood lymphocytes of three donors
Q58788860Revealing a human p53 universe
Q30009394STAT1-induced ASPP2 transcription identifies a link between neuroinflammation, cell polarity, and tumor suppression
Q42043686Salicylic acid activates DNA damage responses to potentiate plant immunity
Q38038940TLR signaling and DNA repair: are they associated?
Q40131966TLR1-10, NF-κB and p53 expression is increased in oral lichenoid disease
Q40721174TLR2∆22 (-196-174) significantly increases the risk of breast cancer in females carrying proline allele at codon 72 of TP53 gene: a case-control study from four ethnic groups of North Eastern region of India.
Q92989385TLR5 participates in the TLR4 receptor complex and promotes MyD88-dependent signaling in environmental lung injury
Q37991536Targeting pattern recognition receptors in cancer immunotherapy.
Q40319984The Cytidine Deaminase APOBEC3 Family Is Subject to Transcriptional Regulation by p53.
Q90598608The Inhibitory Mechanisms of Tumor PD-L1 Expression by Natural Bioactive Gallic Acid in Non-Small-Cell Lung Cancer (NSCLC) Cells
Q35958116The effects of storage temperature on PBMC gene expression
Q36237533The human TLR innate immune gene family is differentially influenced by DNA stress and p53 status in cancer cells
Q50356776The novel p53 target TNFAIP8 variant 2 is increased in cancer and offsets p53-dependent tumor suppression.
Q24273295The transcription factor p53: not a repressor, solely an activator
Q27026790Transcriptional Activation of Inflammatory Genes: Mechanistic Insight into Selectivity and Diversity
Q36231932p53 amplifies Toll-like receptor 5 response in human primary and cancer cells through interaction with multiple signal transduction pathways
Q37714779p53 and NF-κB coregulate proinflammatory gene responses in human macrophages
Q92726625p53-responsive TLR8 SNP enhances human innate immune response to respiratory syncytial virus

Search more.