PIK3CA mutations and copy number gains in human lung cancers

scientific article

PIK3CA mutations and copy number gains in human lung cancers is …
instance of (P31):
scholarly articleQ13442814

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P356DOI10.1158/0008-5472.CAN-07-5084
P932PMC publication ID2874836
P698PubMed publication ID18757405

P50authorIgnacio I WistubaQ74766086
P2093author name stringHiromasa Yamamoto
Kwun M Fong
John D Minna
Adi F Gazdar
Hisayuki Shigematsu
Makoto Suzuki
Shinichi Toyooka
William W Lockwood
Wan L Lam
Hiroshi Date
Huei Lee
Mitsuo Sato
Naoki Okumura
Masaharu Nomura
Junichi Soh
P2860cites workPhosphorylation of the PTEN tail regulates protein stability and functionQ22254305
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Analysis of Relative Gene Expression Data Using Real-Time Quantitative PCR and the 2−ΔΔCT MethodQ25938999
The structure of a human p110alpha/p85alpha complex elucidates the effects of oncogenic PI3Kalpha mutationsQ27649316
EGFR mutations in lung cancer: correlation with clinical response to gefitinib therapyQ27824812
Phosphatidylinositol 3-kinase mutations identified in human cancer are oncogenicQ27824826
High frequency of mutations of the PIK3CA gene in human cancersQ28131776
Gefitinib-sensitizing EGFR mutations in lung cancer activate anti-apoptotic pathwaysQ28274882
Cancer genes and the pathways they controlQ28275089
The evolution of phosphatidylinositol 3-kinases as regulators of growth and metabolismQ29547302
The phosphatidylinositol 3-Kinase AKT pathway in human cancerQ29547860
Lung cancer in never smokers--a different diseaseQ29615414
Clinical and biological features associated with epidermal growth factor receptor gene mutations in lung cancersQ29615475
Mutational analysis of EGFR and related signaling pathway genes in lung adenocarcinomas identifies a novel somatic kinase domain mutation in FGFR4Q33283995
Small interfering RNAs directed against beta-catenin inhibit the in vitro and in vivo growth of colon cancer cellsQ34189399
Immortalization of human bronchial epithelial cells in the absence of viral oncoproteinsQ34377284
Chromosomal imbalances in human lung cancerQ34935902
Somatic alterations in the human cancer genomeQ35948400
Oncogenic PI3K and its role in cancerQ36343294
Mutation of the PIK3CA oncogene in human cancersQ36383360
NCI-Navy Medical Oncology Branch cell line data baseQ36819549
Expression signatures in lung cancer reveal a profile for EGFR-mutant tumours and identify selective PIK3CA overexpression by gene amplificationQ38296583
Whole genome tiling path array CGH analysis of segmental copy number alterations in cervical cancer cell linesQ40209918
PIK3CA mutations in head and neck squamous cell carcinomaQ40305620
High resolution analysis of non-small cell lung cancer cell lines by whole genome tiling path array CGH.Q40368368
Mutant PIK3CA promotes cell growth and invasion of human cancer cellsQ40410776
Somatic mutations of the HER2 kinase domain in lung adenocarcinomas.Q40449400
Microarray analyses reveal strong influence of DNA copy number alterations on the transcriptional patterns in pancreatic cancer: implications for the interpretation of genomic amplificationsQ42801596
Functional analysis of PIK3CA gene mutations in human colorectal cancerQ42814030
Chemically targeting the PI3K familyQ43940837
Missense mutations of the BRAF gene in human lung adenocarcinoma.Q44235698
PTEN and PIK3CA expression is associated with prolonged survival after gefitinib treatment in EGFR-mutated lung cancer patients.Q44846498
Genomic copy number analysis of non-small cell lung cancer using array comparative genomic hybridization: implications of the phosphatidylinositol 3-kinase pathwayQ46613792
Multiple oncogenic changes (K-RAS(V12), p53 knockdown, mutant EGFRs, p16 bypass, telomerase) are not sufficient to confer a full malignant phenotype on human bronchial epithelial cells.Q46952752
PIK3CA gene is frequently mutated in breast carcinomas and hepatocellular carcinomas.Q53629192
Impact of DNA amplification on gene expression patterns in breast cancerQ57274809
Extrapulmonary small cell carcinomaQ73292410
PIK3CA mutation status in Japanese lung cancer patientsQ80163312
P433issue17
P407language of work or nameEnglishQ1860
P304page(s)6913-6921
P577publication date2008-09-01
P1433published inCancer ResearchQ326097
P1476titlePIK3CA mutations and copy number gains in human lung cancers
P478volume68

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