ATR contributes to telomere maintenance in human cells

scientific article

ATR contributes to telomere maintenance in human cells is …
instance of (P31):
scholarly articleQ13442814

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P356DOI10.1093/NAR/GKP1248
P932PMC publication ID2874998
P698PubMed publication ID20147462
P5875ResearchGate publication ID41421848

P50authorLaurent R GauthierQ56600293
Christine Granotier-BeckersQ60013524
Denis Serge François BiardQ67543180
Francois BoussinQ67975078
Gaelle PennarunQ73218802
P2093author name stringFrançoise Hoffschir
Patrick Mailliet
Deborah Revaud
P2860cites workMammalian telomeres end in a large duplex loopQ22009893
The Bloom's and Werner's syndrome proteins are DNA structure-specific helicasesQ24291390
Telomere shortening triggers senescence of human cells through a pathway involving ATM, p53, and p21(CIP1), but not p16(INK4a)Q24293520
ERCC1/XPF removes the 3' overhang from uncapped telomeres and represses formation of telomeric DNA-containing double minute chromosomesQ24302611
The human telomere terminal transferase enzyme is a ribonucleoprotein that synthesizes TTAGGG repeatsQ24339608
Chromosomal instability at common fragile sites in Seckel syndromeQ24533727
Preferential binding of a G-quadruplex ligand to human chromosome ends.Q24815673
Homologous recombination generates T-loop-sized deletions at human telomeresQ28116970
Cell cycle-dependent role of MRN at dysfunctional telomeres: ATM signaling-dependent induction of nonhomologous end joining (NHEJ) in G1 and resection-mediated inhibition of NHEJ in G2Q42117260
Werner's syndrome protein is phosphorylated in an ATR/ATM-dependent manner following replication arrest and DNA damage induced during the S phase of the cell cycleQ44357501
Circular chromosome formation in a fission yeast mutant defective in two ATM homologuesQ48016421
Werner syndrome protein, the MRE11 complex and ATR: menage-à-trois in guarding genome stability during DNA replication?Q48026242
Telomerase maintains telomere structure in normal human cells.Q52551445
Double hybridization signals on the chromatid revealed by telomeric probesQ73180846
The Bloom's syndrome helicase unwinds G4 DNAQ77387768
The DNA damage machinery and homologous recombination pathway act consecutively to protect human telomeresQ79365400
Dynamic roles for G4 DNA in the biology of eukaryotic cellsQ79405617
A splicing mutation affecting expression of ataxia-telangiectasia and Rad3-related protein (ATR) results in Seckel syndromeQ28183834
Recruitment of the cell cycle checkpoint kinase ATR to chromatin during S-phaseQ28243999
Resolution of sister telomere association is required for progression through mitosisQ28254648
Shelterin: the protein complex that shapes and safeguards human telomeresQ28272546
Strand-Specific Postreplicative Processing of Mammalian TelomeresQ28315729
DNA ligase IV-dependent NHEJ of deprotected mammalian telomeres in G1 and G2Q28509254
ATR disruption leads to chromosomal fragmentation and early embryonic lethalityQ28591433
p53- and ATM-dependent apoptosis induced by telomeres lacking TRF2Q28609749
ATR: an essential regulator of genome integrityQ29547883
Functional human telomeres are recognized as DNA damage in G2 of the cell cycleQ33227804
Untangling the relationships between DNA repair pathways by silencing more than 20 DNA repair genes in human stable clones.Q33283854
Protection of telomeres through independent control of ATM and ATR by TRF2 and POT1.Q33293671
Dysfunctional telomeres activate an ATM-ATR-dependent DNA damage response to suppress tumorigenesisQ33303185
Ataxia-telangiectasia and Rad3-related and DNA-dependent protein kinase cooperate in G2 checkpoint activation by the DNA strand-breaking nucleoside analogue 2'-C-cyano-2'-deoxy-1-beta-D-arabino-pentofuranosylcytosineQ33315217
ATM and ATR make distinct contributions to chromosome end protection and the maintenance of telomeric DNA in ArabidopsisQ34009139
Drosophila ATM and ATR checkpoint kinases control partially redundant pathways for telomere maintenanceQ34085000
Elevated telomere-telomere recombination in WRN-deficient, telomere dysfunctional cells promotes escape from senescence and engagement of the ALT pathwayQ34116956
Apollo, an Artemis-related nuclease, interacts with TRF2 and protects human telomeres in S phaseQ34531241
Genetic control of telomere integrity in Schizosaccharomyces pombe: rad3(+) and tel1(+) are parts of two regulatory networks independent of the downstream protein kinases chk1(+) and cds1(+).Q34607461
Telomere binding of checkpoint sensor and DNA repair proteins contributes to maintenance of functional fission yeast telomeres.Q34615813
Increased telomere fragility and fusions resulting from TRF1 deficiency lead to degenerative pathologies and increased cancer in miceQ34997279
Phosphorylation of the Bloom's syndrome helicase and its role in recovery from S-phase arrestQ35544616
Functional links between telomeres and proteins of the DNA-damage responseQ35853775
Phosphorylation-dependent interactions of BLM and 53BP1 are required for their anti-recombinogenic roles during homologous recombinationQ36627883
Flap endonuclease 1 contributes to telomere stabilityQ36632697
The ATR pathway: fine-tuning the forkQ36832714
How telomeres are replicatedQ36948200
DNA damage response at functional and dysfunctional telomeresQ37058277
Mammalian telomeres resemble fragile sites and require TRF1 for efficient replicationQ37297007
The mre11 complex and the response to dysfunctional telomeresQ37374755
Interactions of TLC1 (which encodes the RNA subunit of telomerase), TEL1, and MEC1 in regulating telomere length in the yeast Saccharomyces cerevisiaeQ38321503
Heterogeneity in telomere length of human chromosomes.Q39426746
Apoptosis related to telomere instability and cell cycle alterations in human glioma cells treated by new highly selective G-quadruplex ligands.Q40453428
Defective telomere lagging strand synthesis in cells lacking WRN helicase activity.Q40481955
Seckel syndrome exhibits cellular features demonstrating defects in the ATR-signalling pathway.Q40501657
ATR affecting cell radiosensitivity is dependent on homologous recombination repair but independent of nonhomologous end joiningQ40507919
X-ray-induced telomeric instability in Atm-deficient mouse cellsQ40580170
Long G tails at both ends of human chromosomes suggest a C strand degradation mechanism for telomere shorteningQ41121125
Role of ATM in the telomere response to the G-quadruplex ligand 360A.Q41851639
P433issue9
P407language of work or nameEnglishQ1860
P304page(s)2955-2963
P577publication date2010-02-10
P1433published inNucleic Acids ResearchQ135122
P1476titleATR contributes to telomere maintenance in human cells
P478volume38

Reverse relations

cites work (P2860)
Q46756203A stable RNA G-quadruplex within the 5'-UTR of Arabidopsis thaliana ATR mRNA inhibits translation.
Q61811967ALT cancer cells are specifically sensitive to lysine acetyl transferase inhibition
Q28117859ATM and ATR Signaling Regulate the Recruitment of Human Telomerase to Telomeres
Q89520185ATM, ATR and DNA-PKcs kinases-the lessons from the mouse models: inhibition ≠ deletion
Q90346173Alternative lengthening of telomeres: from molecular mechanisms to therapeutic outlooks
Q39204805DNA Replication Origins and Fork Progression at Mammalian Telomeres
Q36740850DNA damage signaling induced by the G-quadruplex ligand 12459 is modulated by PPM1D/WIP1 phosphatase
Q84282108Dyskeratosis congenita
Q38084623Fluorescent probes for G-quadruplex structures.
Q26740026Hallmarks of progeroid syndromes: lessons from mice and reprogrammed cells
Q38774203Mismatch repair enhances convergent transcription-induced cell death at trinucleotide repeats by activating ATR.
Q35092634Molecular characterization of apoptosis induced by CARF silencing in human cancer cells
Q42265703Opposite effects of GCN5 and PCAF knockdowns on the alternative mechanism of telomere maintenance.
Q24619372Partial complementation of a DNA ligase I deficiency by DNA ligase III and its impact on cell survival and telomere stability in mammalian cells
Q38943974Polymerase η suppresses telomere defects induced by DNA damaging agents
Q39251262Primary microcephaly, impaired DNA replication, and genomic instability caused by compound heterozygous ATR mutations
Q34672718Primordial dwarfism: overview of clinical and genetic aspects.
Q39503969Rad51 and DNA-PKcs are involved in the generation of specific telomere aberrations induced by the quadruplex ligand 360A that impair mitotic cell progression and lead to cell death.
Q35093084The replicometer is broken: telomeres activate cellular senescence in response to genotoxic stresses

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