Clarifying the role of Stat5 in lymphoid development and Abelson-induced transformation

scientific article

Clarifying the role of Stat5 in lymphoid development and Abelson-induced transformation is …
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scholarly articleQ13442814

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P356DOI10.1182/BLOOD-2005-09-3596
P932PMC publication ID2875852
P698PubMed publication ID16493008
P5875ResearchGate publication ID7284276

P50authorRichard MorigglQ38327183
Boris KovacicQ42847409
Lothar HennighausenQ51971727
P2093author name stringHartmut Beug
Veronika Sexl
Marc A Kerenyi
Wolfgang Warsch
Yongzhi Cui
Olivia Simma
Andrea Hoelbl
P2860cites workA role for Stat5 in CD8+ T cell homeostasis.Q52008748
Stat5 is essential for the myelo- and lymphoproliferative disease induced by TEL/JAK2Q57054898
Jak1 deficiency leads to enhanced Abelson-induced B-cell tumor formationQ58029707
Stat5 tetramer formation is associated with leukemogenesisQ58326863
The IL-7 receptor controls the accessibility of the TCRgamma locus by Stat5 and histone acetylationQ77307375
STAT5 activation by BCR-Abl contributes to transformation of K562 leukemia cellsQ78039810
Cell intrinsic defects in cytokine responsiveness of STAT5-deficient hematopoietic stem cellsQ78409855
Osteopontin is upregulated by BCR-ABLQ81917793
Stat5 is required for IL-2-induced cell cycle progression of peripheral T cellsQ22009002
TYK2 is a key regulator of the surveillance of B lymphoid tumorsQ24559982
A unique clonal JAK2 mutation leading to constitutive signalling causes polycythaemia veraQ28241887
Constitutive activation of STAT5 by the BCR-ABL oncogene in chronic myelogenous leukemiaQ28285018
Stat5a/b contribute to interleukin 7-induced B-cell precursor expansion, but abl- and bcr/abl-induced transformation are independent of stat5Q28508796
Stat5 activation is uniquely associated with cytokine signaling in peripheral T cellsQ28511057
Stat5a and Stat5b proteins have essential and nonessential, or redundant, roles in cytokine responsesQ28592023
STAT5 is required for thymopoiesis in a development stage-specific mannerQ28592686
RAG-2-deficient mice lack mature lymphocytes owing to inability to initiate V(D)J rearrangementQ28594711
Stats: transcriptional control and biological impactQ29547776
Activating mutation in the tyrosine kinase JAK2 in polycythemia vera, essential thrombocythemia, and myeloid metaplasia with myelofibrosisQ29614337
Signal transducer and activator of transcription (STAT)5 activation by BCR/ABL is dependent on intact Src homology (SH)3 and SH2 domains of BCR/ABL and is required for leukemogenesisQ30175784
Reduced lymphomyeloid repopulating activity from adult bone marrow and fetal liver of mice lacking expression of STAT5.Q33183255
Proliferation of adult T cell leukemia/lymphoma cells is associated with the constitutive activation of JAK/STAT proteinsQ33734222
Physiological significance of STAT proteins: investigations through gene disruption in vivoQ33754086
The role of Stat5a and Stat5b in signaling by IL-2 family cytokinesQ33941389
B-cell commitment, development and selectionQ33996192
Stat proteins and oncogenesisQ34627064
B-cell commitment: deciding on the playersQ35084264
STAT proteins: From normal control of cellular events to tumorigenesisQ35540165
A new modality for immunosuppression: targeting the JAK/STAT pathwayQ35825869
STAT proteins as novel targets for cancer drug discoveryQ35911116
Signal transducer and activator of transcription (STAT) signalling and T-cell lymphomas.Q36048656
Hematopoietic stem cells and their niche.Q36175339
The JAK2V617F tyrosine kinase mutation in myeloproliferative disorders: status report and immediate implications for disease classification and diagnosisQ36189058
A role for niches in hematopoietic cell developmentQ36194591
Developmental regulation of lck gene expression in T lymphocytesQ36229919
Early lymphocyte expansion is severely impaired in interleukin 7 receptor-deficient miceQ36364066
Tyrosyl phosphorylation and DNA binding activity of signal transducers and activators of transcription (STAT) proteins in hematopoietic cell lines transformed by Bcr/AblQ36365946
A novel element upstream of the Vgamma2 gene in the murine T cell receptor gamma locus cooperates with the 3' enhancer to act as a locus control regionQ36375288
Stat5 synergizes with T cell receptor/antigen stimulation in the development of lymphoblastic lymphomaQ36376661
IL-7 receptor signaling is necessary for stage transition in adult B cell development through up-regulation of EBF.Q36403451
Inactivation of Stat5 in mouse mammary epithelium during pregnancy reveals distinct functions in cell proliferation, survival, and differentiationQ37493064
Inhibition of Bcr-Abl kinase activity by PD180970 blocks constitutive activation of Stat5 and growth of CML cellsQ38359739
STAT5 promotes multilineage hematolymphoid development in vivo through effects on early hematopoietic progenitor cellsQ39122429
Loss of Tolerance and Autoimmunity Affecting Multiple Organs inSTAT5A/5B-Deficient MiceQ39127345
Activated STAT5 proteins induce activation of the PI 3-kinase/Akt and Ras/MAPK pathways via the Gab2 scaffolding adapterQ40434680
Constitutively active STAT5 variants induce growth and survival of hematopoietic cells through a PI 3-kinase/Akt dependent pathway.Q40804665
Bcr/Abl activates transcription of the Bcl-X gene through STAT5.Q40856047
STAT5-Dependent CyclinD1 and Bcl-xL expression in Bcr-Abl-transformed cellsQ40858154
STAT5 activation contributes to growth and viability in Bcr/Abl-transformed cells.Q40895248
Physiologic roles of interleukin-2, interleukin-4, and interleukin-7.Q41645019
Activated Stat related transcription factors in acute leukemiaQ41719633
Functional cooperation among Ras, STAT5, and phosphatidylinositol 3-kinase is required for full oncogenic activities of BCR/ABL in K562 cellsQ43847051
JAK2 in myeloproliferative disorders is not just another kinase.Q46560527
STAT5 activation underlies IL7 receptor-dependent B cell developmentQ47810418
Functional dissection of the murine lck distal promoterQ48071793
Restricted STAT5 activation dictates appropriate thymic B versus T cell lineage commitment.Q50966213
Distinct effects of STAT5 activation on CD4+ and CD8+ T cell homeostasis: development of CD4+CD25+ regulatory T cells versus CD8+ memory T cells.Q52004102
P433issue12
P407language of work or nameEnglishQ1860
P304page(s)4898-4906
P577publication date2006-02-21
P1433published inBloodQ885070
P1476titleClarifying the role of Stat5 in lymphoid development and Abelson-induced transformation
P478volume107