Antitumor effects due to irreversible stoppage of tumor tissue blood flow: evaluation of a novel combretastatin A-4 derivative, AC7700.

scientific article

Antitumor effects due to irreversible stoppage of tumor tissue blood flow: evaluation of a novel combretastatin A-4 derivative, AC7700. is …
instance of (P31):
scholarly articleQ13442814

External links are
P356DOI10.1111/J.1349-7006.1999.TB00851.X
P8608Fatcat IDrelease_rcivwqxpefavxmd3fob7zhy4aq
P932PMC publication ID5926172
P698PubMed publication ID10551334
P5875ResearchGate publication ID227976661

P2093author name stringM Suzuki
Y Sato
S Saito
K Hori
Y Nihei
P2860cites workAntineoplastic agents 389. New syntheses of the combretastatin A-4 prodrug.Q32063233
Relationship between the hydralazine-induced changes in murine tumor blood supply and mouse blood pressureQ33278308
The interaction with tubulin of a series of stilbenes based on combretastatin A-4.Q36080819
Increased growth and incidence of lymph node metastases due to the angiogenesis inhibitor AGM-1470Q36421958
Induction of apoptosis in proliferating human endothelial cells by the tumor-specific antiangiogenesis agent combretastatin A-4.Q36899101
In vitro evaluation of the antineoplastic activity of combretastatin A-4, a natural product from Combretum caffrum (arid shrub).Q41574653
Isolation and structure of the strong cell growth and tubulin inhibitor combretastatin A-4.Q42203168
Effect of sodium nitroprusside-induced hypotension on the blood flow in subcutaneous and intramuscular BT4AN tumors and normal tissues in ratsQ42552804
In vivo targets of recombinant human tumour necrosis factor-alpha: blood flow, oxygen consumption and growth of isotransplanted rat tumoursQ43051041
In vivo analysis of tumor vascularization in the rat.Q45795258
Vinca alkaloids: anti-vascular effects in a murine tumourQ46555781
Novel combretastatin analogues effective against murine solid tumors: design and structure-activity relationshipsQ47762267
Inhibition of nitric oxide synthase induces a selective reduction in tumor blood flow that is reversible with L-arginineQ48794511
Fluctuations in tumor blood flow under normotension and the effect of angiotensin II-induced hypertension.Q51703727
Microvascular mechanisms of change in tumor blood flow due to angiotensin II, epinephrine, and methoxamine: a functional morphometric study.Q54226197
Reduction of tumor blood flow by flavone acetic acid: a possible component of therapy.Q54301098
Blood flow failure as a major determinant in the antitumor action of flavone acetic acid.Q54348915
A novel combretastatin A-4 derivative, AC-7700, shows marked antitumor activity against advanced solid tumors and orthotopically transplanted tumors.Q55241476
Circadian variation of tumor blood flow in rat subcutaneous tumors and its alteration by angiotensin II-induced hypertensionQ67748915
Inhibition of growth of colon 38 adenocarcinoma by vinblastine and colchicine: evidence for a vascular mechanismQ67899407
The effect of hydralazine on the tumor cytotoxicity of the hypoxic cell cytotoxin RSU-1069: evidence for therapeutic gainQ68961901
Vascular collapse after flavone acetic acid: a possible mechanism of its anti-tumour actionQ69393436
Functional characteristics of tumor vessels: selective increase in tumor blood flowQ69475662
Timing of cancer chemotherapy based on circadian variations in tumor tissue blood flowQ70936857
Enzymorphological observation on irradiated tumor, with a particular reference to acid hydrolase activity. I. Light microscopic studyQ71879450
Combretastatin A-4, an agent that displays potent and selective toxicity toward tumor vasculatureQ73352832
Vascular reactions of normal and malignant tissues in Vivo. VI. The role of hypotension in the action of components of podophyllin on transplanted sarcomasQ73726347
Changes of Oxygen Tension in Tumours Induced by Vasoconstrictor and Vasodilator DrugsQ76462387
P433issue9
P1104number of pages13
P304page(s)1026-1038
P577publication date1999-09-01
P1433published inJapanese Journal of Cancer ResearchQ26842384
P1476titleAntitumor effects due to irreversible stoppage of tumor tissue blood flow: evaluation of a novel combretastatin A-4 derivative, AC7700.
P478volume90

Reverse relations

cites work (P2860)
Q24651931A novel combretastatin A-4 derivative, AC7700, strongly stanches tumour blood flow and inhibits growth of tumours developing in various tissues and organs
Q37598267AVE8062: a new combretastatin derivative vascular disrupting agent.
Q37597936An open-label, dose-escalation, safety, and pharmacokinetics phase I study of ombrabulin, a vascular disrupting agent, administered as a 30-min intravenous infusion every 3 weeks in Japanese patients with advanced solid tumors
Q36287729Antineoplastic strategy: irreversible tumor blood flow stasis induced by the combretastatin A-4 derivative AVE8062 (AC7700).
Q44580396Antitumor activity of TZT-1027 (Soblidotin) against vascular endothelial growth factor-secreting human lung cancer in vivo
Q78594497Antitumor efficacy of conventional anticancer drugs is enhanced by the vascular targeting agent ZD6126
Q44412196Combination effect of AC-7700, a novel combretastatin A-4 derivative, and cisplatin against murine and human tumors in vivo
Q44558813Differential relationship between changes in tumour size and microcirculatory functions induced by therapy with an antivascular drug and with cytotoxic drugs. implications for the evaluation of therapeutic efficacy of AC7700 (AVE8062).
Q36146900Disrupting tumour blood vessels
Q36900208Enhanced permeability and retention of macromolecular drugs in solid tumors: a royal gate for targeted anticancer nanomedicines.
Q33183693Enhancement of radiation therapy by the novel vascular targeting agent ZD6126.
Q55031551Evaluation of antivascular and antimitotic effects of tubulin binding agents in solid tumor therapy.
Q38796352Induction of tumour blood flow stasis and necrosis: a new function for epinephrine similar to that of combretastatin A-4 derivative AVE8062 (AC7700)
Q48300160Maintaining unperturbed cerebral blood flow is key in the study of brain metastasis and its interactions with stress and inflammatory responses.
Q38602109Microvascular mechanisms by which the combretastatin A-4 derivative AC7700 (AVE8062) induces tumour blood flow stasis
Q44507596Modulation of tumor-selective vascular blood flow and extravasation by the stable prostaglandin 12 analogue beraprost sodium
Q89587161Necrosis in the Tumor Microenvironment and Its Role in Cancer Recurrence
Q34293629New agents in cancer clinical trials
Q38979348Prevention of cancer recurrence in tumor margins by stopping microcirculation in the tumor and tumor-host interface
Q34829230Role of the cytoskeleton in formation and maintenance of angiogenic sprouts
Q37958731Starvation tactics for solid tumors: tumor blood flow interruption via a combretastatin derivative (Cderiv), and its microcirculation mechanism
Q44501064Synthesis and Biological Evaluation of Benzocyclooctene-based and Indene-based Anticancer Agents that Function as Inhibitors of Tubulin Polymerization.
Q40654786Synthesis, in vitro, and in vivo evaluation of phosphate ester derivatives of combretastatin A-4.
Q55040537TZT-1027, an antimicrotubule agent, attacks tumor vasculature and induces tumor cell death.
Q34572069Targeting tumour vasculature: the development of combretastatin A4.
Q56450717The Vascular-Disrupting Agent Combretastatin Impairs Splitting and Sprouting Forms of Physiological Angiogenesis
Q34680614The biology of the combretastatins as tumour vascular targeting agents
Q52627703The vascular disrupting agent ombrabulin (AVE8062) enhances the efficacy of standard therapies in head and neck squamous cell carcinoma xenograft models.
Q38118663Tubulin-interactive stilbene derivatives as anticancer agents.
Q46614854Tumor blood flow interruption after radiotherapy strongly inhibits tumor regrowth
Q52614294Tumor environment changed by combretastatin derivative (Cderiv) pretreatment that leads to effective tumor targeting, MRI studies, and antitumor activity of polymeric micelle carrier systems.
Q54975278Tumor-selective blood flow decrease induced by an angiotensin converting enzyme inhibitor, temocapril hydrochloride.
Q37280244Tumour vascular disrupting agents: combating treatment resistance
Q79202325Vascular targeting effects of ZD6126 in a C3H mouse mammary carcinoma and the enhancement of radiation response
Q35805639Vascular-targeting therapies for treatment of malignant disease.