Human TCR-alpha beta+ CD4- CD8- T cells can derive from CD8+ T cells and display an inflammatory effector phenotype

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Human TCR-alpha beta+ CD4- CD8- T cells can derive from CD8+ T cells and display an inflammatory effector phenotype is …
instance of (P31):
scholarly articleQ13442814

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P356DOI10.4049/JIMMUNOL.0901533
P8608Fatcat IDrelease_homyvpliirbb7m5aae5fkqwoqm
P932PMC publication ID2878279
P698PubMed publication ID19734235
P5875ResearchGate publication ID26793286

P2093author name stringGeorge C Tsokos
José C Crispín
P2860cites workGene Expression Omnibus: NCBI gene expression and hybridization array data repositoryQ27860523
Systemic lupus erythematosus serum IgG increases CREM binding to the IL-2 promoter and suppresses IL-2 production through CaMKIVQ28972565
Analysis of T cell antigen receptor (TCR) expression by human peripheral blood CD4-8- alpha/beta T cells demonstrates preferential use of several V beta genes and an invariant TCR alpha chainQ34356372
Isolation and characterization of human antigen-specific TCR alpha beta+ CD4(-)CD8- double-negative regulatory T cellsQ34552979
Expanded double negative T cells in patients with systemic lupus erythematosus produce IL-17 and infiltrate the kidneysQ34892862
A novel lymphoproliferative/autoimmune syndrome resembling murine lpr/gld diseaseQ35604700
A new mutation, gld, that produces lymphoproliferation and autoimmunity in C3H/HeJ miceQ36348408
Induction of a cationic shift in IgG anti-DNA autoantibodies. Role of T helper cells with classical and novel phenotypes in three murine models of lupus nephritisQ36352584
Role of interleukin 10 in the B lymphocyte hyperactivity and autoantibody production of human systemic lupus erythematosusQ36364479
CD1d- and MR1-restricted invariant T cells: of mice and men.Q36548001
Human T-cell receptor (TCR) alpha/beta + CD4-CD8- T cells express oligoclonal TCRs, share junctional motifs across TCR V beta-gene families, and phenotypically resemble memory T cellsQ36726518
Double-negative T cells from MRL-lpr/lpr mice mediate cytolytic activity when triggered through adhesion molecules and constitutively express perforin gene.Q38313878
Thymic selection threshold defined by compartmentalization of Ras/MAPK signallingQ39773899
Human double-negative T cells in systemic lupus erythematosus provide help for IgG and are restricted by CD1cQ40846574
Fas ligand expression and function in systemic lupus erythematosusQ41085091
Human TCR alpha/beta+ CD4-CD8- double-negative T cells in patients with autoimmune lymphoproliferative syndrome express restricted Vbeta TCR diversity and are clonally related to CD8+ T cellsQ42659751
The effect of thymectomy on lupus-prone miceQ43872426
T cell receptor alpha/beta expressing double-negative (CD4-/CD8-) and CD4+ T helper cells in humans augment the production of pathogenic anti-DNA autoantibodies associated with lupus nephritisQ44381577
Characterization of CD3+ CD4- CD8- (double negative) T cells in patients with systemic lupus erythematosus: production of IL-4.Q44400621
CD2-CD4-CD8- lymph node T lymphocytes in MRL lpr/lpr mice are derived from a CD2+CD4+CD8+ thymic precursorQ51141123
Unique phenotype and distinct TCR V beta repertoire in human peripheral blood alpha beta TCR+, CD4-, and CD8- double negative T cells.Q52058907
CD4-CD8- thymocytes that express the T cell receptor may have previously expressed CD8.Q52865220
Characterization of CD3+ CD4- CD8- (double negative) T cells in patients with systemic lupus erythematosus: activation markersQ56904721
Expansion of the population of double negative CD4-8- T alpha beta-cells in the liver is a common feature of autoimmune miceQ67903296
CD4-CD8- human T cells: phenotypic heterogeneity and activation requirements of freshly isolated "double-negative" T cellsQ68420303
CD4+ T cell lines with selective patterns of autoreactivity as well as CD4- CD8- T helper cell lines augment the production of idiotypes shared by pathogenic anti-DNA autoantibodies in the NZB x SWR model of lupus nephritisQ70049950
In vivo CD4+ lymph node T cells from lpr mice generate CD4-CD8-B220+TCR-beta low cellsQ71651086
Targeted mutation in the Fas gene causes hyperplasia in peripheral lymphoid organs and liverQ71794021
B220+ double-negative T cells suppress polyclonal T cell activation by a Fas-independent mechanism that involves inhibition of IL-2 productionQ73827831
Identification of a previously unknown antigen-specific regulatory T cell and its mechanism of suppressionQ73977252
TCR ligation on CD8+ T cells creates double-negative cells in vivoQ77123351
Participation of the CD69 antigen in the T-cell activation process of patients with systemic lupus erythematosusQ77143628
Inactivation of misselected CD8 T cells by CD8 gene methylation and cell deathQ77744353
Invariant or highly conserved TCR alpha are expressed on double-negative (CD3+CD4-CD8-) and CD8+ T cellsQ77929230
P433issue7
P407language of work or nameEnglishQ1860
P921main subjectphenotypeQ104053
P304page(s)4675-4681
P577publication date2009-09-04
P1433published inJournal of ImmunologyQ3521441
P1476titleHuman TCR-alpha beta+ CD4- CD8- T cells can derive from CD8+ T cells and display an inflammatory effector phenotype
P478volume183

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