Evidence that translation reinitiation abrogates nonsense-mediated mRNA decay in mammalian cells

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Evidence that translation reinitiation abrogates nonsense-mediated mRNA decay in mammalian cells is …
instance of (P31):
scholarly articleQ13442814

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P356DOI10.1093/EMBOJ/16.4.826
P932PMC publication ID1169683
P698PubMed publication ID9049311
P5875ResearchGate publication ID14162726

P2093author name stringL E Maquat
J Zhang
P2860cites workComparison of initiation of protein synthesis in procaryotes, eucaryotes, and organellesQ24654718
A technique for radiolabeling DNA restriction endonuclease fragments to high specific activityQ26778490
Point mutations define a sequence flanking the AUG initiator codon that modulates translation by eukaryotic ribosomesQ27860600
Gene-specific translational control of the yeast GCN4 gene by phosphorylation of eukaryotic initiation factor 2.Q27934963
Primary structure of human triosephosphate isomeraseQ28118965
Structural features in eukaryotic mRNAs that modulate the initiation of translationQ29547921
Translocation of a specific premessenger ribonucleoprotein particle through the nuclear pore studied with electron microscope tomographyQ31168507
Efficiency of reinitiation of translation on human immunodeficiency virus type 1 mRNAs is determined by the length of the upstream open reading frame and by intercistronic distanceQ34058977
Translational termination efficiency in mammals is influenced by the base following the stop codon.Q34222816
Evidence that the decay of nucleus-associated nonsense mRNA for human triosephosphate isomerase involves nonsense codon recognition after splicing.Q34361052
Nonsense mutations inhibit splicing of MVM RNA in cis when they interrupt the reading frame of either exon of the final spliced product.Q34422154
When cells stop making sense: effects of nonsense codons on RNA metabolism in vertebrate cells.Q34693550
Utilizing the GCN4 leader region to investigate the role of the sequence determinants in nonsense-mediated mRNA decay.Q35851318
Dominant beta thalassaemia: molecular basis and pathophysiologyQ36089957
Modulation of tRNA(iMet), eIF-2, and eIF-2B expression shows that GCN4 translation is inversely coupled to the level of eIF-2.GTP.Met-tRNA(iMet) ternary complexesQ36555932
Characterization of cis-acting sequences and decay intermediates involved in nonsense-mediated mRNA turnoverQ36566764
Effect of sequence context at stop codons on efficiency of reinitiation in GCN4 translational controlQ36644113
Requirements for intercistronic distance and level of eukaryotic initiation factor 2 activity in reinitiation on GCN4 mRNA vary with the downstream cistronQ36650671
Introns are cis effectors of the nonsense-codon-mediated reduction in nuclear mRNA abundanceQ36666048
T cell receptor-beta mRNA splicing: regulation of unusual splicing intermediatesQ36676308
Nonsense mutations in the dihydrofolate reductase gene affect RNA processingQ36769262
Termination-reinitiation occurs in the translation of mammalian cell mRNAsQ36917860
Effect of upstream reading frames on translation efficiency in simian virus 40 recombinantsQ36917883
Distribution of reversing factor in reticulocyte lysates during active protein synthesis and on inhibition by heme deprivation or double-stranded RNA.Q37576852
Low cytoplasmic mRNA levels of immunoglobulin kappa light chain genes containing nonsense codons correlate with inefficient splicing.Q37636788
Nonsense-mediated mRNA decay in yeastQ40663894
The second to last amino acid in the nascent peptide as a codon context determinant.Q40790501
The immediate downstream codon strongly influences the efficiency of utilization of eukaryotic translation initiation codons.Q40792763
The identity of the base following the stop codon determines the efficiency of in vivo translational termination in Escherichia coliQ40805404
Evidence for degradation of mRNA encoding alpha-L-iduronidase in Hurler fibroblasts with premature termination alleles.Q41433267
Mechanism of translation of the bicistronic mRNA encoding human papillomavirus type 16 E6-E7 genesQ41438087
Defects in RNA splicing and the consequence of shortened translational reading framesQ42590534
GCD10, a translational repressor of GCN4, is the RNA-binding subunit of eukaryotic translation initiation factor-3.Q42675542
Maintenance of an open reading frame as an additional level of scrutiny during splice site selectionQ42689167
Dominant thalassemia-like phenotypes associated with mutations in exon 3 of the beta-globin geneQ44734112
The skipping of constitutive exons in vivo induced by nonsense mutationsQ70554031
Nonsense mutations inhibit RNA splicing in a cell-free system: recognition of mutant codon is independent of protein synthesisQ71046937
mRNA surveillance by the Caenorhabditis elegans smg genesQ72234045
Nonsense codon mutations in the terminal exon of the beta-globin gene are not associated with a reduction in beta-mRNA accumulation: a mechanism for the phenotype of dominant beta-thalassemiaQ72372067
mRNA destabilization triggered by premature translational termination depends on at least three cis-acting sequence elements and one trans-acting factorQ72921331
P433issue4
P407language of work or nameEnglishQ1860
P304page(s)826-833
P577publication date1997-02-01
P1433published inThe EMBO JournalQ1278554
P1476titleEvidence that translation reinitiation abrogates nonsense-mediated mRNA decay in mammalian cells
P478volume16

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