Genome-wide analysis of alpharetroviral integration in human hematopoietic stem/progenitor cells.

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Genome-wide analysis of alpharetroviral integration in human hematopoietic stem/progenitor cells. is …
instance of (P31):
scholarly articleQ13442814

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P356DOI10.3390/GENES5020415
P932PMC publication ID4094940
P698PubMed publication ID24840152
P5875ResearchGate publication ID262530800

P50authorGianluca De BellisQ51932877
Ermanno RizziQ56606076
Arianna MoianiQ117281724
Julia Debora SuerthQ117281725
Fulvio MavilioQ41045259
Marco SevergniniQ41108531
P2093author name stringAxel Schambach
Francesco Gandolfi
P2860cites workLEDGF/p75 determines cellular trafficking of diverse lentiviral but not murine oncoretroviral integrase proteins and is a component of functional lentiviral preintegration complexesQ24562936
Retroviral DNA integration: ASLV, HIV, and MLV show distinct target site preferencesQ24798872
Sustained correction of X-linked severe combined immunodeficiency by ex vivo gene therapyQ28215190
Hematopoietic stem cell gene transfer in a tumor-prone mouse model uncovers low genotoxicity of lentiviral vector integrationQ28242708
Hot spots of retroviral integration in human CD34+ hematopoietic cellsQ28302694
Selection of target sites for mobile DNA integration in the human genomeQ28766367
Integration targeting by avian sarcoma-leukosis virus and human immunodeficiency virus in the chicken genomeQ28769415
Transcription start regions in the human genome are favored targets for MLV integrationQ29618456
HIV-1 integration in the human genome favors active genes and local hotspotsQ29618457
Retroviral DNA integration: viral and cellular determinants of target-site selectionQ33247467
Adaptive evolution of conserved noncoding elements in mammalsQ33298406
Stem-cell gene therapy for the Wiskott-Aldrich syndromeQ33392766
Insertional transformation of hematopoietic cells by self-inactivating lentiviral and gammaretroviral vectorsQ33713156
seqMINER: an integrated ChIP-seq data interpretation platformQ33777909
Transposable B2 SINE elements can provide mobile RNA polymerase II promotersQ73813832
High-definition mapping of retroviral integration sites defines the fate of allogeneic T cells after donor lymphocyte infusionQ33784684
The BET family of proteins targets moloney murine leukemia virus integration near transcription start sitesQ34342339
Lentiviral hematopoietic stem cell gene therapy in patients with Wiskott-Aldrich syndrome.Q34356904
Lentiviral hematopoietic stem cell gene therapy benefits metachromatic leukodystrophyQ34356914
Correction of X-linked chronic granulomatous disease by gene therapy, augmented by insertional activation of MDS1-EVI1, PRDM16 or SETBP1.Q34508425
Deletion of the LTR enhancer/promoter has no impact on the integration profile of MLV vectors in human hematopoietic progenitorsQ34576925
Integration profile of retroviral vector in gene therapy treated patients is cell-specific according to gene expression and chromatin conformation of target cellQ34694796
Hematopoietic stem cell gene therapy with a lentiviral vector in X-linked adrenoleukodystrophyQ35011497
Whole transcriptome characterization of aberrant splicing events induced by lentiviral vector integrations.Q35913748
HIV integration site selection: analysis by massively parallel pyrosequencing reveals association with epigenetic modificationsQ35914779
Alpharetroviral self-inactivating vectors: long-term transgene expression in murine hematopoietic cells and low genotoxicity.Q35939492
Lentiviral vector integration in the human genome induces alternative splicing and generates aberrant transcriptsQ35944232
Alpharetroviral vector-mediated gene therapy for X-CGD: functional correction and lack of aberrant splicingQ36659242
Reduced genotoxicity of avian sarcoma leukosis virus vectors in rhesus long-term repopulating cells compared to standard murine retrovirus vectorsQ36923886
BET proteins promote efficient murine leukemia virus integration at transcription start sitesQ37031911
The genotoxic potential of retroviral vectors is strongly modulated by vector design and integration site selection in a mouse model of HSC gene therapyQ37143395
Bromo- and extraterminal domain chromatin regulators serve as cofactors for murine leukemia virus integrationQ37336436
Mechanisms of retroviral integration and mutagenesisQ38075040
Estimated comparative integration hotspots identify different behaviors of retroviral gene transfer vectorsQ38499545
Self-inactivating alpharetroviral vectors with a split-packaging designQ39712155
Genome-scale mapping of DNase I hypersensitivityQ39842882
A role for LEDGF/p75 in targeting HIV DNA integrationQ40346940
Correction of junctional epidermolysis bullosa by transplantation of genetically modified epidermal stem cells.Q42504368
Self-inactivating MLV vectors have a reduced genotoxic profile in human epidermal keratinocytes.Q42820688
High-definition mapping of retroviral integration sites identifies active regulatory elements in human multipotent hematopoietic progenitors.Q43710599
Gene therapy for immunodeficiency due to adenosine deaminase deficiency.Q45882856
Developmentally regulated activation of a SINE B2 repeat as a domain boundary in organogenesisQ46172999
P275copyright licenseCreative Commons Attribution 4.0 InternationalQ20007257
P6216copyright statuscopyrightedQ50423863
P433issue2
P304page(s)415-429
P577publication date2014-05-16
P1433published inGenesQ5532699
P1476titleGenome-wide analysis of alpharetroviral integration in human hematopoietic stem/progenitor cells
P478volume5

Reverse relations

cites work (P2860)
Q38772068Alpharetroviral self-inactivating vectors produced by a superinfection-resistant stable packaging cell line allow genetic modification of primary human T lymphocytes
Q38285765Alpharetroviral vectors: from a cancer-causing agent to a useful tool for human gene therapy
Q92137870Enhancing Lentiviral and Alpharetroviral Transduction of Human Hematopoietic Stem Cells for Clinical Application
Q39214064Evolving Gene Therapy in Primary Immunodeficiency
Q36169656HIV-1 Integrates Widely throughout the Genome of the Human Blood Fluke Schistosoma mansoni.
Q38645986HRAS, EGFR, MET, and RON Genes Are Recurrently Activated by Provirus Insertion in Liver Tumors Induced by the Retrovirus Myeloblastosis-Associated Virus 2.
Q45874795Interactions between Retroviruses and the Host Cell Genome.
Q26795766Multifunctional facets of retrovirus integrase
Q39094431Retroviral Vectors for Cancer Gene Therapy

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