Thrombin and collagen induce a feedback inhibitory signaling pathway in platelets involving dissociation of the catalytic subunit of protein kinase A from an NFkappaB-IkappaB complex

scientific article

Thrombin and collagen induce a feedback inhibitory signaling pathway in platelets involving dissociation of the catalytic subunit of protein kinase A from an NFkappaB-IkappaB complex is …
instance of (P31):
scholarly articleQ13442814

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P356DOI10.1074/JBC.M109.077602
P932PMC publication ID2881761
P698PubMed publication ID20356841

P50authorStepan GambaryanQ40206073
P2093author name stringUlrich Walter
Natalia Rukoyatkina
Albert Smolenski
Anna Kobsar
Joerg Geiger
Sabine Herterich
Suzanne M Lohmann
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Potent inhibition of human platelets by cGMP analogs independent of cGMP-dependent protein kinase.Q44673838
Vasodilator-stimulated phosphoprotein is a substrate for protein kinase C.Q44714826
Disabled-2 is a novel IIb-integrin-binding protein that negatively regulates platelet-fibrinogen interactions and platelet aggregationQ57375290
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Stromal-derived factor 1 and thrombopoietin regulate distinct aspects of human megakaryopoiesisQ73281156
Demonstration of an activation regulated NF-kappaB/I-kappaBalpha complex in human plateletsQ77147370
c-Src interacts with and phosphorylates RelA/p65 to promote thrombin-induced ICAM-1 expression in endothelial cellsQ79166171
Canonical Wnt signaling negatively regulates platelet functionQ28510525
Phosphorylation of NF-kappa B p65 by PKA stimulates transcriptional activity by promoting a novel bivalent interaction with the coactivator CBP/p300Q28619230
G6b-B inhibits constitutive and agonist-induced signaling by glycoprotein VI and CLEC-2Q29347516
Shared principles in NF-kappaB signalingQ29547234
Analysis of SAGE data in human platelets: features of the transcriptome in an anucleate cellQ31036312
The transcriptional activity of NF-kappaB is regulated by the IkappaB-associated PKAc subunit through a cyclic AMP-independent mechanismQ33292331
Cyclic nucleotide-dependent protein kinases: intracellular receptors for cAMP and cGMP actionQ33732652
Platelets and megakaryocytes contain functional nuclear factor-kappaB.Q33782701
Cyclic nucleotides and phosphodiesterases in plateletsQ33800099
Rap1GAP2 is a new GTPase-activating protein of Rap1 expressed in human platelets.Q34381692
Taming platelets with cyclic nucleotidesQ34436565
Cyclic nucleotide-dependent protein kinases inhibit binding of 14-3-3 to the GTPase-activating protein Rap1GAP2 in platelets.Q34718342
mTOR-dependent synthesis of Bcl-3 controls the retraction of fibrin clots by activated human platelets.Q35642870
Thrombin regulates intracellular cyclic AMP concentration in human platelets through phosphorylation/activation of phosphodiesterase 3A.Q35989423
Tracking functions of cGMP-dependent protein kinases (cGK).Q36071677
Adhesion mechanisms in platelet functionQ36856340
Mechanics of proplatelet elaborationQ36884299
Cyclic AMP signaling and gene regulationQ36898041
Unresolved roles of platelet nitric oxide synthaseQ36974994
Platelet activation and atherothrombosisQ37031278
Cell adhesion mechanisms in plateletsQ37049884
Acute activation of NHE3 by dexamethasone correlates with activation of SGK1 and requires a functional glucocorticoid receptorQ37225408
cGMP and cGMP-dependent protein kinase in platelets and blood cells.Q37352810
cAMP-dependent protein kinase: framework for a diverse family of regulatory enzymesQ37886477
NF-kappaB inhibitors impair platelet activation responsesQ38352662
Efficient nuclear export of p65-IkappaBalpha complexes requires 14-3-3 proteins.Q40239759
Role of nuclear receptor signaling in platelets: antithrombotic effects of PPARbetaQ40337760
A novel mechanism of G protein-dependent phosphorylation of vasodilator-stimulated phosphoproteinQ40392883
Stimulation of c-Rel transcriptional activity by PKA catalytic subunit betaQ40545229
Human bone marrow megakaryocytes and platelets express PPARgamma, and PPARgamma agonists blunt platelet release of CD40 ligand and thromboxanesQ40558422
Structure and function of cyclic nucleotide-dependent protein kinasesQ40660658
Role of cyclic nucleotide-dependent protein kinases and their common substrate VASP in the regulation of human plateletsQ40765799
Concentration and regulation of cyclic nucleotides, cyclic-nucleotide-dependent protein kinases and one of their major substrates in human platelets. Estimating the rate of cAMP-regulated and cGMP-regulated protein phosphorylation in intact cellsQ41083638
NFkappaB regulation of platelet function: no nucleus, no genes, no problem?Q41769481
Protein kinase C-mediated phosphorylation and activation of PDE3A regulate cAMP levels in human platelets.Q41808295
Vasodilator-stimulated phosphoprotein (VASP) is phosphorylated on Ser157 by protein kinase C-dependent and -independent mechanisms in thrombin-stimulated human platelets.Q41831428
Non-genomic effects of PPARgamma ligands: inhibition of GPVI-stimulated platelet activationQ41928597
Role of Akt2 in contraction-stimulated cell signaling and glucose uptake in skeletal muscleQ42497456
Agonist and antagonist effects of diadenosine tetraphosphate, a platelet dense granule constituent, on platelet P2Y1, P2Y12 and P2X1 receptors.Q42909234
A noble function of BAY 11-7082: Inhibition of platelet aggregation mediated by an elevated cAMP-induced VASP, and decreased ERK2/JNK1 phosphorylationsQ43242551
P433issue24
P407language of work or nameEnglishQ1860
P304page(s)18352-18363
P577publication date2010-03-31
P1433published inJournal of Biological ChemistryQ867727
P1476titleThrombin and collagen induce a feedback inhibitory signaling pathway in platelets involving dissociation of the catalytic subunit of protein kinase A from an NFkappaB-IkappaB complex
P478volume285

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