Sex bias in CNS autoimmune disease mediated by androgen control of autoimmune regulator

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Sex bias in CNS autoimmune disease mediated by androgen control of autoimmune regulator is …
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scholarly articleQ13442814

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P819ADS bibcode2016NatCo...711350Z
P6179Dimensions Publication ID1004802467
P356DOI10.1038/NCOMMS11350
P8608Fatcat IDrelease_vk2qormoezg77osxfx6daw6wrm
P932PMC publication ID5512610
P698PubMed publication ID27072778

P50authorJennifer S NelsonQ86882118
Joshua StarmerQ104197052
Maureen A SuQ42722308
P2093author name stringElizabeth M Wilson
Aaron Martin
Bridget Conley
Meghan Free
Meng-Lei Zhu
Pearl Bakhru
P2860cites workSex ratio of multiple sclerosis in Canada: a longitudinal study.Q51779582
The insulin gene is transcribed in the human thymus and transcription levels correlated with allelic variation at the INS VNTR-IDDM2 susceptibility locus for type 1 diabetes.Q52196097
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Androgen depletion increases the efficacy of bone marrow transplantation in ameliorating experimental autoimmune encephalomyelitisQ62078499
Testosterone induces expression of transforming growth factor-beta 1 in the murine thymusQ70731000
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Mechanism of androgen-induced thymolysis in ratsQ71813017
Insulin expression levels in the thymus modulate insulin-specific autoreactive T-cell tolerance: the mechanism by which the IDDM2 locus may predispose to diabetesQ78014697
Ets transcription factors regulate AIRE gene promoterQ80062954
Development of autoimmunity against transcriptionally unrepressed target antigen in the thymus of Aire-deficient miceQ81377810
Experimental autoimmune encephalomyelitis in the mouseQ82837777
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PDEF, a novel prostate epithelium-specific ets transcription factor, interacts with the androgen receptor and activates prostate-specific antigen gene expressionQ22011032
Aire's partners in the molecular control of immunological toleranceQ24296286
Aire and T cell developmentQ24621103
Tumor-specific Th17-polarized cells eradicate large established melanomaQ24648032
Deletional tolerance mediated by extrathymic Aire-expressing cellsQ24652952
edgeR: a Bioconductor package for differential expression analysis of digital gene expression dataQ27860819
Positional cloning of the APECED geneQ28116470
Projection of an immunological self shadow within the thymus by the aire proteinQ28207164
Trimmomatic: a flexible trimmer for Illumina sequence dataQ29547278
HTSeq--a Python framework to work with high-throughput sequencing dataQ29614489
Transplantation of autoimmune regulator-encoding bone marrow cells delays the onset of experimental autoimmune encephalomyelitisQ39627505
Time-dependent rescue of gene expression by androgens in the mouse proximal caput epididymidis-1 cell line after androgen withdrawalQ40223151
Androgen receptor signaling: mechanism of interleukin-6 inhibition.Q40570918
Lymphotoxin pathway directs thymic Aire expressionQ40630236
Global transcriptional profiling reveals distinct functions of thymic stromal subsets and age-related changes during thymic involutionQ42780735
Androgens indirectly accelerate thymocyte apoptosisQ43613360
Androgens are protective in experimental autoimmune encephalomyelitis: implications for multiple sclerosis.Q44708828
Androgen deprivation induces phenotypic and functional changes in the thymus of adult male miceQ45088217
Gonadotropin-Releasing Hormone Antagonists: Novel Members of the Azaline B FamilyQ46745475
Age and sex associations of 40 autoimmune diseasesQ47306926
Antiinflammatory effect of androgen receptor activation in human benign prostatic hyperplasia cellsQ47802044
The human androgen receptor: complementary deoxyribonucleic acid cloning, sequence analysis and gene expression in prostateQ48309646
Longitudinal reproductive hormone profiles in infants: peak of inhibin B levels in infant boys exceeds levels in adult men.Q50907940
Androgens accelerate thymocyte apoptosis.Q50910612
Androgen receptors in thymic epithelium modulate thymus size and thymocyte developmentQ31957984
Naive tumor-specific CD4(+) T cells differentiated in vivo eradicate established melanoma.Q33730129
Tumor-reactive CD4(+) T cells develop cytotoxic activity and eradicate large established melanoma after transfer into lymphopenic hostsQ33730171
Gender differences in autoimmune diseaseQ34040802
Melanoma antigen-A11 (MAGE-A11) enhances transcriptional activity by linking androgen receptor dimersQ34313140
Aire-dependent production of XCL1 mediates medullary accumulation of thymic dendritic cells and contributes to regulatory T cell developmentQ34577749
An IRF8-binding promoter variant and AIRE control CHRNA1 promiscuous expression in thymusQ34581770
Population and single-cell genomics reveal the Aire dependency, relief from Polycomb silencing, and distribution of self-antigen expression in thymic epitheliaQ34590391
Testosterone treatment in multiple sclerosis: a pilot studyQ34628272
Evidence that androgens modulate human thymic T cell output.Q34796229
Regulatory B cells inhibit EAE initiation in mice while other B cells promote disease progressionQ34831296
Sex hormones have pervasive effects on thymic epithelial cells.Q35926133
Progesterone and autoimmune diseaseQ36202227
Spontaneous autoimmunity prevented by thymic expression of a single self-antigenQ36228141
Proliferative arrest and rapid turnover of thymic epithelial cells expressing AireQ36229072
Identification of a novel cis-regulatory element essential for immune toleranceQ36286062
Gene dosage--limiting role of Aire in thymic expression, clonal deletion, and organ-specific autoimmunity.Q36399327
Mechanisms of an autoimmunity syndrome in mice caused by a dominant mutation in AireQ36540892
Keratinocyte growth factor and androgen blockade work in concert to protect against conditioning regimen-induced thymic epithelial damage and enhance T-cell reconstitution after murine bone marrow transplantationQ36713565
Aire deficiency promotes TRP-1-specific immune rejection of melanomaQ36745323
Aire-dependent thymic development of tumor-associated regulatory T cellsQ36754190
The ETS domain transcription factor ELK1 directs a critical component of growth signaling by the androgen receptor in prostate cancer cellsQ36779605
Immune modulation and increased neurotrophic factor production in multiple sclerosis patients treated with testosteroneQ36841506
The complex role of estrogens in inflammation.Q36886660
Neonatal tolerance revisited: a perinatal window for Aire control of autoimmunityQ37273185
Gender bias in autoimmunity is influenced by microbiota.Q37294725
Systems analysis of sex differences reveals an immunosuppressive role for testosterone in the response to influenza vaccinationQ37495044
An RNAi screen for Aire cofactors reveals a role for Hnrnpl in polymerase release and Aire-activated ectopic transcriptionQ37544045
The nucleotide-binding leucine-rich repeat (NLR) family member NLRX1 mediates protection against experimental autoimmune encephalomyelitis and represses macrophage/microglia-induced inflammationQ37583514
The transcriptional regulator Aire coopts the repressive ATF7ip-MBD1 complex for the induction of immunotolerance.Q38309456
Identification and characterization of androgen response elementsQ38333067
Characterization of regulatory elements and methylation pattern of the autoimmune regulator (AIRE) promoterQ38356484
The human AIRE gene at chromosome 21q22 is a genetic determinant for the predisposition to rheumatoid arthritis in Japanese populationQ39556141
P275copyright licenseCreative Commons Attribution 4.0 InternationalQ20007257
P6216copyright statuscopyrightedQ50423863
P407language of work or nameEnglishQ1860
P921main subjectbiasQ742736
gender biasQ1501326
autoimmune diseaseQ8084905
P304page(s)11350
P577publication date2016-04-13
P1433published inNature CommunicationsQ573880
P1476titleSex bias in CNS autoimmune disease mediated by androgen control of autoimmune regulator
P478volume7

Reverse relations

cites work (P2860)
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Q52712155[Autoimmune disease predisposition: Aire « protects » men].

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