Age-related increase of VGF-expression in T lymphocytes

scientific article

Age-related increase of VGF-expression in T lymphocytes is …
instance of (P31):
scholarly articleQ13442814

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P356DOI10.18632/AGING.100656
P8608Fatcat IDrelease_vs72txzmwnfqppuicuenesa4ri
P932PMC publication ID4100807
P698PubMed publication ID25013207

P2093author name stringBernhard Bogerts
Christian Mawrin
Roland Hartig
Johann Steiner
Henrik Dobrowolny
Mandy Busse
Stefan Busse
Ursula Bommhardt
Michael Adamaszek
Tim J Krause
Justus Micheel
P2860cites workInhibition of mTOR by rapamycin abolishes cognitive deficits and reduces amyloid-beta levels in a mouse model of Alzheimer's diseaseQ21136406
T cell deficiency leads to cognitive dysfunction: implications for therapeutic vaccination for schizophrenia and other psychiatric conditionsQ24562400
Brain-derived neurotrophic factor-induced gene expression reveals novel actions of VGF in hippocampal synaptic plasticityQ24604536
Rapamycin fed late in life extends lifespan in genetically heterogeneous miceQ24647805
TLQP-21, a VGF-derived peptide, increases energy expenditure and prevents the early phase of diet-induced obesityQ24676603
Infiltrating blood-derived macrophages are vital cells playing an anti-inflammatory role in recovery from spinal cord injury in miceQ27307172
Age-related impairment of p56lck and ZAP-70 activities in human T lymphocytes activated through the TcR/CD3 complexQ28199301
Immunosenescence: deficits in adaptive immunity in the elderlyQ28238448
Reflex control of immunityQ28245909
Immune cells contribute to the maintenance of neurogenesis and spatial learning abilities in adulthoodQ28292031
VGF is required for obesity induced by diet, gold thioglucose treatment, and agouti and is differentially regulated in pro-opiomelanocortin- and neuropeptide Y-containing arcuate neurons in response to fastingQ28587343
Macrophages, inflammation, and insulin resistanceQ29614351
Oxidative stress shortens telomeresQ29615533
Ribosomal protein S6 kinase 1 signaling regulates mammalian life spanQ29615975
Adipokines in inflammation and metabolic diseaseQ29620456
Pro-cognitive properties of T cellsQ30412966
Hyper-mitogenic drive coexists with mitotic incompetence in senescent cellsQ30533934
Telomeres and telomerase in Alzheimer's disease: epiphenomena or a new focus for therapeutic strategy?Q33347411
A protein induced by NGF in PC12 cells is stored in secretory vesicles and released through the regulated pathwayQ33572050
CD28(-) T cells: their role in the age-associated decline of immune functionQ33572405
Alternative Perspectives on Aging in Caenorhabditis elegans: Reactive Oxygen Species or Hyperfunction?Q33573959
VGF: a novel role for this neuronal and neuroendocrine polypeptide in the regulation of energy balanceQ33959592
Demography. Broken limits to life expectancyQ34127911
HIV Infection, Inflammation, Immunosenescence, and AgingQ34150710
A novel peptidomics approach to detect markers of Alzheimer's disease in cerebrospinal fluidQ34215634
Acetylcholine-synthesizing T cells relay neural signals in a vagus nerve circuitQ34216728
Thalamus-derived molecules promote survival and dendritic growth of developing cortical neurons.Q34463304
The expression of VGF is reduced in leukocytes of depressed patients and it is restored by effective antidepressant treatmentQ34661044
Immunological memory and late onset autoimmunityQ34667162
Elevated proinflammatory cytokine production by a skewed T cell compartment requires monocytes and promotes inflammation in type 2 diabetes.Q34950622
Origin of late-onset autoimmune diseaseQ35088621
Biology of longevity: role of the innate immune system.Q36445521
Abdominal obesity and metabolic syndromeQ36682671
Age-related changes in immunity: implications for vaccination in the elderlyQ36724216
Answering the ultimate question "what is the proximal cause of aging?"Q36736351
Obesity increases the production of proinflammatory mediators from adipose tissue T cells and compromises TCR repertoire diversity: implications for systemic inflammation and insulin resistanceQ36793320
Rapamycin suppresses brain aging in senescence-accelerated OXYS ratsQ37298898
Immunosenescence and immunogenetics of human longevityQ37338842
Granins as disease-biomarkers: translational potential for psychiatric and neurological disorders.Q37769881
Sustained CD28 expression delays multiple features of replicative senescence in human CD8 T lymphocytesQ37780978
VGF: an inducible gene product, precursor of a diverse array of neuro-endocrine peptides and tissue-specific disease biomarkersQ37881441
Protective autoimmunity: interferon-gamma enables microglia to remove glutamate without evoking inflammatory mediators.Q38330556
Rapamycin decelerates cellular senescenceQ39846812
Divergent telomerase and CD28 expression patterns in human CD4 and CD8 T cells following repeated encounters with the same antigenic stimulusQ40683550
Challenges for vaccination in the elderly.Q41957098
Functional disruption of the CD28 gene transcriptional initiator in senescent T cellsQ42495629
The neuropeptide VGF is reduced in human bipolar postmortem brain and contributes to some of the behavioral and molecular effects of lithiumQ42970228
Modulation of human lymphocyte proliferative response with agingQ43842965
Dopamine, through the extracellular signal-regulated kinase pathway, downregulates CD4+CD25+ regulatory T-cell activity: implications for neurodegeneration.Q44969003
Virus-induced CD8+ T cell clonal expansion is associated with telomerase up-regulation and telomere length preservation: a mechanism for rescue from replicative senescenceQ45750058
Distribution of VGF peptides in the human cortex and their selective changes in Parkinson's and Alzheimer's diseases.Q46628274
Neuroprotective immunity: T cell-derived glutamate endows astrocytes with a neuroprotective phenotypeQ46717069
Adaptive immunity affects learning behavior in miceQ48361938
Reduced density of hypothalamic VGF-immunoreactive neurons in schizophrenia: a potential link to impaired growth factor signaling and energy homeostasisQ48783271
Brain-derived neurotrophic factor supports facial motoneuron survival after facial nerve transection in immunodeficient mice.Q49123376
Accelerated telomere shortening in leukocyte subpopulations of patients with coronary heart disease: role of cytomegalovirus seropositivity.Q51890245
Telomere shortening in T cells correlates with Alzheimer's disease status.Q51951567
Will telomere erosion lead to a loss of T-cell memory?Q51998145
NK phenotypic markers and IL2 response in NK cells from elderly people.Q53861904
Expansion of CD4+CD28null T-lymphocytes in diabetic patients: exploring new pathogenetic mechanisms of increased cardiovascular risk in diabetes mellitusQ58230169
Circulating levels of TNF-alpha and IL-6-relation to truncal fat mass and muscle mass in healthy elderly individuals and in patients with type-2 diabetesQ59326276
The impairment of natural killer function in the healthy aged is due to a postbinding deficient mechanismQ67573777
In vivo loss of telomeric repeats with age in humansQ68048615
Increased number of circulating Leu 11+ (CD 16) large granular lymphocytes and decreased NK activity during human ageingQ68828979
Changes in the expression of HLA-class II antigens on peripheral blood monocytes from aged humansQ68888998
Production of neurotrophins by activated T cells: implications for neuroprotective autoimmunityQ73098016
White cell telomere length and risk of premature myocardial infarctionQ73154540
Decline in CD28+ T cells in centenarians and in long-term T cell cultures: a possible cause for both in vivo and in vitro immunosenescenceQ74066784
Telomere shortening in atherosclerosisQ74402888
P433issue6
P304page(s)440-453
P577publication date2014-06-01
P1433published inAgingQ2845875
P1476titleAge-related increase of VGF-expression in T lymphocytes
P478volume6

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cites work (P2860)
Q35944207A Systematic Investigation into Aging Related Genes in Brain and Their Relationship with Alzheimer's Disease
Q47670316Adaptive Immunity and Metabolic Health: Harmony Becomes Dissonant in Obesity and Aging
Q90643182AgeGuess, a Methylomic Prediction Model for Human Ages
Q40059032Diabetes Prevalence and its Impact on Health-Related Quality of Life in Tuberculosis Patients
Q35149607Tumor promoter-induced cellular senescence: cell cycle arrest followed by geroconversion
Q36020851VGF expression by T lymphocytes in patients with Alzheimer's disease
Q92240381VGF: a biomarker and potential target for the treatment of neuropathic pain?

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