Subunits of the Drosophila CCR4-NOT complex and their roles in mRNA deadenylation.

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Subunits of the Drosophila CCR4-NOT complex and their roles in mRNA deadenylation. is …
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scholarly articleQ13442814

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P356DOI10.1261/RNA.2145110
P932PMC publication ID2885685
P698PubMed publication ID20504953
P5875ResearchGate publication ID44632669

P50authorElmar WahleQ39897994
Lianbing ZhangQ47412806
P2093author name stringElisabeth Kremmer
Andrea Sinz
Christian Ihling
Claudia Temme
Martine Simonelig
Aymeric Chartier
P2860cites workIdentification of four families of yCCR4- and Mg2+-dependent endonuclease-related proteins in higher eukaryotes, and characterization of orthologs of yCCR4 with a conserved leucine-rich repeat essential for hCAF1/hPOP2 bindingQ21266634
Isolation and characterization of human orthologs of yeast CCR4-NOT complex subunitsQ22011058
Functional organization of the yeast proteome by systematic analysis of protein complexesQ24292209
CCR4, a 3'-5' poly(A) RNA and ssDNA exonuclease, is the catalytic component of the cytoplasmic deadenylaseQ24292432
Interaction between Not1p, a component of the Ccr4-not complex, a global regulator of transcription, and Dhh1p, a putative RNA helicaseQ77130166
Multifunctional deadenylase complexes diversify mRNA controlQ80854891
Conservation of the deadenylase activity of proteins of the Caf1 family in humanQ24298094
Depletion of mammalian CCR4b deadenylase triggers elevation of the p27Kip1 mRNA level and impairs cell growthQ24303821
RAP55, a cytoplasmic mRNP component, represses translation in Xenopus oocytesQ24310395
Mammalian miRNA RISC recruits CAF1 and PABP to affect PABP-dependent deadenylationQ24310618
The BTG2 protein is a general activator of mRNA deadenylationQ24310741
The Ccr4-NOT deadenylase subunits CNOT7 and CNOT8 have overlapping roles and modulate cell proliferationQ24314993
An unconventional human Ccr4-Caf1 deadenylase complex in nuclear cajal bodiesQ24337378
Human Ccr4-Not complexes contain variable deadenylase subunitsQ24339449
mRNA degradation by miRNAs and GW182 requires both CCR4:NOT deadenylase and DCP1:DCP2 decapping complexesQ24554481
Gawky is a component of cytoplasmic mRNA processing bodies required for early Drosophila development.Q24683077
X-ray structure and activity of the yeast Pop2 protein: a nuclease subunit of the mRNA deadenylase complexQ27642540
Similar Modes of Interaction Enable Trailer Hitch and EDC3 To Associate with DCP1 and Me31B in Distinct Protein ComplexesQ27651920
Structural basis for the mutually exclusive anchoring of P body components EDC3 and Tral to the DEAD box protein DDX6/Me31BQ27654110
Structural insights into the human GW182-PABC interaction in microRNA-mediated deadenylationQ27659139
The yeast Ccr4-Not complex controls ubiquitination of the nascent-associated polypeptide (NAC-EGD) complexQ27930672
PUF proteins bind Pop2p to regulate messenger RNAsQ27930941
Purification and characterization of the 1.0 MDa CCR4-NOT complex identifies two novel components of the complexQ27934579
The yeast POP2 gene encodes a nuclease involved in mRNA deadenylationQ27934881
The RNA-binding SAM domain of Smaug defines a new family of post-transcriptional regulatorsQ27934943
The CCR4 and CAF1 proteins of the CCR4-NOT complex are physically and functionally separated from NOT2, NOT4, and NOT5.Q27935175
Ccr4p is the catalytic subunit of a Ccr4p/Pop2p/Notp mRNA deadenylase complex in Saccharomyces cerevisiaeQ27937531
The transcription factor associated Ccr4 and Caf1 proteins are components of the major cytoplasmic mRNA deadenylase in Saccharomyces cerevisiaeQ27937565
Polyubiquitination of the demethylase Jhd2 controls histone methylation and gene expressionQ27937740
Dhh1p, a putative RNA helicase, associates with the general transcription factors Pop2p and Ccr4p from Saccharomyces cerevisiaeQ27937817
S. cerevisiae Vts1p induces deadenylation-dependent transcript degradation and interacts with the Ccr4p-Pop2p-Not deadenylase complexQ27938449
P bodies: at the crossroads of post-transcriptional pathwaysQ28280058
Concerted action of poly(A) nucleases and decapping enzyme in mammalian mRNA turnoverQ28281490
The highways and byways of mRNA decayQ28284717
Messenger RNA turnover in eukaryotes: pathways and enzymesQ28298137
Deadenylation is prerequisite for P-body formation and mRNA decay in mammalian cellsQ28508125
The Drosophila melanogaster Gene cg4930 Encodes a High Affinity Inhibitor for Endonuclease G.Q39897937
Bicaudal-C associates with a Trailer Hitch/Me31B complex and is required for efficient Gurken secretionQ41876566
Nascent peptide-dependent translation arrest leads to Not4p-mediated protein degradation by the proteasomeQ41927521
Cap-dependent translational inhibition establishes two opposing morphogen gradients in Drosophila embryosQ42100834
P-body formation is a consequence, not the cause, of RNA-mediated gene silencingQ42738042
Systematic mutagenesis of the leucine-rich repeat (LRR) domain of CCR4 reveals specific sites for binding to CAF1 and a separate critical role for the LRR in CCR4 deadenylase activityQ44735758
Mouse CAF1 can function as a processive deadenylase/3'-5'-exonuclease in vitro but in yeast the deadenylase function of CAF1 is not required for mRNA poly(A) removalQ44814635
twin, a CCR4 homolog, regulates cyclin poly(A) tail length to permit Drosophila oogenesisQ45259301
Cell-free deadenylation assays with Drosophila embryo extractsQ46181812
Drosophila processing bodies in oogenesisQ46426051
CPEB interacts with an ovary-specific eIF4E and 4E-T in early Xenopus oocytes.Q46945611
bicaudal encodes the Drosophila beta NAC homolog, a component of the ribosomal translational machinery*.Q47070430
Rapid ATP-dependent deadenylation of nanos mRNA in a cell-free system from Drosophila embryosQ47070567
Efficient protein trafficking requires trailer hitch, a component of a ribonucleoprotein complex localized to the ER in DrosophilaQ47070631
An essential cytoplasmic function for the nuclear poly(A) binding protein, PABP2, in poly(A) tail length control and early development in DrosophilaQ47071459
Degradation of hsp70 and other mRNAs in Drosophila via the 5' 3' pathway and its regulation by heat shockQ47071694
Smaug recruits the CCR4/POP2/NOT deadenylase complex to trigger maternal transcript localization in the early Drosophila embryoQ47071930
A deadenylation negative feedback mechanism governs meiotic metaphase arrest.Q48759702
Translational control of maternal Cyclin B mRNA by Nanos in the Drosophila germlineQ48798079
Me31B silences translation of oocyte-localizing RNAs through the formation of cytoplasmic RNP complex during Drosophila oogenesis.Q48879812
Bicaudal-C recruits CCR4-NOT deadenylase to target mRNAs and regulates oogenesis, cytoskeletal organization, and its own expression.Q51973237
The Drosophila PNG kinase complex regulates the translation of cyclin B.Q51997955
PUF protein-mediated deadenylation is catalyzed by Ccr4p.Q53589396
The essential function of Not1 lies within the Ccr4-Not complexQ73053740
Immediate early response of the circadian polyA ribonuclease nocturnin to two extracellular stimuli.Q28586617
P bodies and the control of mRNA translation and degradationQ29547253
General translational repression by activators of mRNA decappingQ29614567
The many pathways of RNA degradationQ29615760
The enzymes and control of eukaryotic mRNA turnoverQ29616563
Nocturnin, a deadenylase in Xenopus laevis retina: a mechanism for posttranscriptional control of circadian-related mRNA.Q30310487
mRNA silencing in human erythroid cell maturation: heterogeneous nuclear ribonucleoprotein K controls the expression of its regulator c-SrcQ30319602
A conserved role of a DEAD box helicase in mRNA maskingQ30447068
Mapping the topology and determination of a low-resolution three-dimensional structure of the calmodulin-melittin complex by chemical cross-linking and high-resolution FTICRMS: direct demonstration of multiple binding modesQ33201952
PAP- and GLD-2-type poly(A) polymerases are required sequentially in cytoplasmic polyadenylation and oogenesis in DrosophilaQ34011295
Drosophila Cup is an eIF4E-binding protein that functions in Smaug-mediated translational repressionQ34107349
Identification of a ubiquitin-protein ligase subunit within the CCR4-NOT transcription repressor complexQ34112326
Staufen- and FMRP-containing neuronal RNPs are structurally and functionally related to somatic P bodiesQ34592681
Xp54 and related (DDX6-like) RNA helicases: roles in messenger RNP assembly, translation regulation and RNA degradationQ34674713
Drosophila Brain Tumor is a translational repressorQ35077727
The CCR4-NOT complex plays diverse roles in mRNA metabolismQ35185687
Global control of gene expression in yeast by the Ccr4-Not complexQ35212570
CCR4/NOT complex associates with the proteasome and regulates histone methylationQ35749532
The eukaryotic Ccr4-not complex: a regulatory platform integrating mRNA metabolism with cellular signaling pathways?Q35805081
Preferential deadenylation of Hsp70 mRNA plays a key role in regulating Hsp70 expression in Drosophila melanogasterQ36654109
A role for Caf1 in mRNA deadenylation and decay in trypanosomes and human cellsQ36715587
Isolation of new polar granule components in Drosophila reveals P body and ER associated proteinsQ36944982
Role of p54 RNA helicase activity and its C-terminal domain in translational repression, P-body localization and assemblyQ37175404
The Ccr4-Pop2-NOT mRNA deadenylase contributes to septin organization in Saccharomyces cerevisiaeQ37310383
Curled encodes the Drosophila homolog of the vertebrate circadian deadenylase NocturninQ37351796
BTG/TOB factors impact deadenylasesQ37455743
A complex containing the CCR4 and CAF1 proteins is involved in mRNA deadenylation in DrosophilaQ37491669
The GW182 protein family in animal cells: new insights into domains required for miRNA-mediated gene silencingQ37522850
Oskar allows nanos mRNA translation in Drosophila embryos by preventing its deadenylation by Smaug/CCR4.Q38308404
Identification of multiple RNA features that influence CCR4 deadenylation activityQ38357623
SMAUG is a major regulator of maternal mRNA destabilization in Drosophila and its translation is activated by the PAN GU kinase.Q38517095
The Drosophila poly(A)-binding protein II is ubiquitous throughout Drosophila development and has the same function in mRNA polyadenylation as its bovine homolog in vitroQ39729116
Stimulation of poly(A) polymerase through a direct interaction with the nuclear poly(A) binding protein allosterically regulated by RNA.Q39790864
The silencing domain of GW182 interacts with PABPC1 to promote translational repression and degradation of microRNA targets and is required for target releaseQ39792632
P433issue7
P407language of work or nameEnglishQ1860
P921main subjectDrosophilaQ312154
Curled Dmel_CG31299Q86406979
CCR4-NOT transcription complex subunit 3 Dmel_CG8426Q29813224
CCR4-NOT transcription complex subunit 10 Dmel_CG18616Q29816752
Regena Dmel_CG2161Q29817771
P304page(s)1356-1370
P577publication date2010-05-26
P1433published inRNAQ7277164
P1476titleSubunits of the Drosophila CCR4-NOT complex and their roles in mRNA deadenylation
P478volume16