Effects of cardiac-restricted overexpression of the A(2A) adenosine receptor on adriamycin-induced cardiotoxicity

scientific article

Effects of cardiac-restricted overexpression of the A(2A) adenosine receptor on adriamycin-induced cardiotoxicity is …
instance of (P31):
scholarly articleQ13442814

External links are
P356DOI10.1152/AJPHEART.00688.2009
P932PMC publication ID2886639
P698PubMed publication ID20363887

P50authorAbdullah HamadQ59832113
Tung O. ChanQ41149903
P2093author name stringXue Li
Jianliang Song
Joseph Y Cheung
Xue-Qian Zhang
Jin Zhang
Arthur M Feldman
Hajime Funakoshi
Jufang Wang
Valerie Myers
Glenn L Radice
David Swope
Jifen Li
John Farber
Ashley Madonick
P2860cites workDoxorubicin directly binds to the cardiac-type ryanodine receptorQ44084096
Early activation of the p42/p44MAPK pathway mediates adenosine-induced nitric oxide production in human endothelial cells: a novel calcium-insensitive mechanismQ44175825
Adriamycin stimulates low-affinity Ca2+ binding and lipid peroxidation but depresses myocardial functionQ44997554
Cardiotoxicity of epirubicin and doxorubicin: assessment by endomyocardial biopsyQ45161679
Mechanical unloading improves intracellular Ca2+ regulation in rats with doxorubicin-induced cardiomyopathyQ45175898
Adenosine A2A receptor facilitates calcium-dependent protein secretion through the activation of protein kinase A and phosphatidylinositol-3 kinase in PC12 cellsQ45234795
Doxorubicin-induced second degree and complete atrioventricular blockQ46476597
Transcriptional analysis of doxorubicin-induced cardiotoxicityQ46769518
Intravascular adenosine at reperfusion reduces infarct size and neutrophil adherenceQ47322889
Cardiac ultrastructural changes induced by daunorubicin therapy.Q53731811
Effects of first-dose doxorubicin on cardiac rhythm as evaluated by continuous 24-hour monitoring.Q53840944
Cardiac-Specific Loss of N-Cadherin Leads to Alteration in Connexins With Conduction Slowing and ArrhythmogenesisQ57396516
Regulated Overexpression of the A 1 -Adenosine Receptor in Mice Results in Adverse but Reversible Changes in Cardiac Morphology and FunctionQ62583213
Heterogeneous Expression of Gap Junction Channels in the Heart Leads to Conduction Defects and Ventricular DysfunctionQ63425482
Adriamycin: the role of lipid peroxidation in cardiac toxicity and tumor responseQ67590955
Electrode positioning for reliable telemetry ECG recordings during social stress in unrestrained ratsQ71840321
Direct effects of adriamycin on the rat heart sarcolemmaQ72574539
Dephosphorylation and intracellular redistribution of ventricular connexin43 during electrical uncoupling induced by ischemiaQ73071883
Upregulation of Na(+)/Ca(2+) exchanger expression and function in an arrhythmogenic rabbit model of heart failureQ73204498
Conditional gene targeting of connexin43: exploring the consequences of gap junction remodeling in the heartQ74299117
Doxorubicin, to treat cancers or to cause cardiac injury, that is the questionQ77194640
Doxorubicin-induced cardiomyopathyQ77323607
Mechanisms underlying conduction slowing and arrhythmogenesis in nonischemic dilated cardiomyopathyQ80522312
The physiological activity of adenine compounds with especial reference to their action upon the mammalian heartQ24540404
The A(2A)-adenosine receptor: a GPCR with unique features?Q24653743
Use of chemotherapy plus a monoclonal antibody against HER2 for metastatic breast cancer that overexpresses HER2.Q27824766
Trastuzumab after adjuvant chemotherapy in HER2-positive breast cancerQ27824847
Remodeling the intercalated disc leads to cardiomyopathy in mice misexpressing cadherins in the heartQ28214586
Cardiac S100A1 protein levels determine contractile performance and propensity toward heart failure after myocardial infarctionQ28261916
Inhibitors of adriamycin-induced histamine release in vitro limit adriamycin cardiotoxicity in vivoQ28337579
Overexpression of metallothionein in the heart of transgenic mice suppresses doxorubicin cardiotoxicityQ28379102
Conduction slowing and sudden arrhythmic death in mice with cardiac-restricted inactivation of connexin43Q28506915
Molecular mechanisms of doxorubicin-induced cardiomyopathy. Selective suppression of Reiske iron-sulfur protein, ADP/ATP translocase, and phosphofructokinase genes is associated with ATP depletion in rat cardiomyocytesQ28565992
Altered contractility and [Ca2+]i homeostasis in phospholemman-deficient murine myocytes: role of Na+/Ca2+ exchangeQ30444270
The A2B adenosine receptor protects against inflammation and excessive vascular adhesionQ30477474
Optimal rotational interval for 3-dimensional echocardiography data acquisition for rapid and accurate measurement of left ventricular functionQ30607015
Doxorubicin selectively inhibits muscle gene expression in cardiac muscle cells in vivo and in vitroQ33614685
Broad-spectrum cardioprotection with adenosineQ33786692
Adenosine and cardioprotection during ischaemia and reperfusion--an overviewQ34058386
Daunomycin, an antitumor antibiotic, in the treatment of neoplastic disease. Clinical evaluation with special reference to childhood leukemiaQ34205638
Acute adenosinergic cardioprotection in ischemic-reperfused heartsQ35560907
Connexin phosphorylation as a regulatory event linked to gap junction channel assemblyQ36162583
SERCA2a in heart failure: role and therapeutic prospectsQ36476041
N-cadherin haploinsufficiency affects cardiac gap junctions and arrhythmic susceptibility.Q36561910
Remodelling of cardiac repolarization: how homeostatic responses can lead to arrhythmogenesis.Q37282970
Subcellular effects of adriamycin in the heart: a concise reviewQ39686848
Cardiac-restricted overexpression of the A(2A)-adenosine receptor in FVB mice transiently increases contractile performance and rescues the heart failure phenotype in mice overexpressing the A(1)-adenosine receptorQ39828113
Inhibition of sodium-potassium-activated adenosine 5'-triphosphatase and ion transport by adriamycinQ40203178
Anthracycline-associated cardiac and renal damage in rabbits. Evidence for mediation by vasoactive substancesQ41540340
Changes in lysosomal morphology and enzyme activities during the development of adriamycin-induced cardiomyopathyQ42226173
HIF-1 is expressed in normoxic tissue and displays an organ-specific regulation under systemic hypoxiaQ42512319
Molecular biology of doxorubicin-induced cardiomyopathyQ42583605
Overexpression of Na+/Ca2+ exchanger alters contractility and SR Ca2+ content in adult rat myocytesQ43773147
P433issue6
P921main subjectoverexpressionQ61643320
P304page(s)H1738-47
P577publication date2010-04-02
P1433published inAmerican Journal of Physiology Heart and Circulatory PhysiologyQ3193662
P1476titleEffects of cardiac-restricted overexpression of the A(2A) adenosine receptor on adriamycin-induced cardiotoxicity
P478volume298

Reverse relations

cites work (P2860)
Q37891696Adenosine receptor subtypes and the heart failure phenotype: translating lessons from mice to man.
Q30537619Alterations in cardiac DNA methylation in human dilated cardiomyopathy
Q34335762Cardioprotection of controlled and cardiac-specific over-expression of A(2A)-adenosine receptor in the pressure overload
Q35178670Ca²⁺ entry via Trpm2 is essential for cardiac myocyte bioenergetics maintenance
Q37700637Identification of candidate long noncoding RNAs associated with left ventricular hypertrophy
Q35543463Myocardial injury after ischemia-reperfusion in mice deficient in Akt2 is associated with increased cardiac macrophage density
Q49631774Phenotyping of Mice with Heart Specific Overexpression of A2A-Adenosine Receptors: Evidence for Cardioprotective Effects of A2A-Adenosine Receptors

Search more.