Neuronal ELAV proteins enhance mRNA stability by a PKCalpha-dependent pathway

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Neuronal ELAV proteins enhance mRNA stability by a PKCalpha-dependent pathway is …
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scholarly articleQ13442814

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P819ADS bibcode2005PNAS..10212065P
P356DOI10.1073/PNAS.0504702102
P932PMC publication ID1189326
P698PubMed publication ID16099831
P5875ResearchGate publication ID7660365

P2093author name stringAlessandro Quattrone
Daniel L Alkon
Giovanni Scapagnini
Stefano Govoni
Alessia Pascale
Marialaura Amadio
Alessandro Provenzani
Cristina Lanni
Marco Racchi
P2860cites workCoordinated movement of RACK1 with activated betaIIPKCQ28144160
Hel-N1/Hel-N2 proteins are bound to poly(A)+ mRNA in granular RNP structures and are implicated in neuronal differentiationQ28295994
The fragile X mental retardation protein binds specifically to its mRNA via a purine quartet motifQ28348391
Decreased sensitivity of tristetraprolin-deficient cells to p38 inhibitors suggests the involvement of tristetraprolin in the p38 signaling pathwayQ28350388
GAP-43 mRNA in growth cones is associated with HuD and ribosomesQ28564747
Dendritic localization of the RNA-binding protein HuD in hippocampal neurons: association with polysomes and upregulation during contextual learningQ28564874
Increase of the RNA-binding protein HuD and posttranscriptional up-regulation of the GAP-43 gene during spatial memoryQ28578336
Expression of mRNA for the elav-like neural-specific RNA binding protein, HuD, during nervous system developmentQ28580069
Increased expression and localization of the RNA-binding protein HuD and GAP-43 mRNA to cytoplasmic granules in DRG neurons during nerve regenerationQ28584245
AU-rich elements: characterization and importance in mRNA degradationQ29547896
HuR and mRNA stabilityQ29615185
RNA stabilization by the AU-rich element binding protein, HuR, an ELAV proteinQ29615186
Overexpression of HuR, a nuclear-cytoplasmic shuttling protein, increases the in vivo stability of ARE-containing mRNAsQ29620269
Spatial memory is related to hippocampal subcellular concentrations of calcium-dependent protein kinase C isoforms in young and aged ratsQ33753600
HuR binding to cytoplasmic mRNA is perturbed by heat shockQ33895914
Posttranscriptional regulation of gene expression in learning by the neuronal ELAV-like mRNA-stabilizing proteins.Q33944818
Amyloid precursor protein mRNA stability is controlled by a 29-base element in the 3'-untranslated regionQ34059660
Messenger RNA degradation: beginning at the end.Q34124819
Ribosomal protein S15 represses its own translation via adaptation of an rRNA-like fold within its mRNA.Q34189055
Therapeutic effects of PKC activators in Alzheimer's disease transgenic miceQ34549472
Evidence for 3' untranslated region-dependent autoregulation of the Drosophila gene encoding the neuronal nuclear RNA-binding protein ELAVQ34605603
The RNA-binding protein HuD is required for GAP-43 mRNA stability, GAP-43 gene expression, and PKC-dependent neurite outgrowth in PC12 cells.Q34760279
Transcriptional and post-transcriptional control of gene expression in inflammationQ35009675
The control of mRNA stability in response to extracellular stimuli.Q35042665
RNA-binding protein HuR enhances p53 translation in response to ultraviolet light irradiationQ35168095
ELAV tumor antigen, Hel-N1, increases translation of neurofilament M mRNA and induces formation of neurites in human teratocarcinoma cellsQ35189616
Protein kinase C: its role in activity-dependent Purkinje cell dendritic development and plasticityQ35543663
Compartmentalized synthesis and degradation of proteins in neurons.Q35558440
Bryostatin-1: a novel PKC inhibitor in clinical developmentQ35634829
Protein kinase C isozymes as potential targets for anticancer therapyQ35699082
Why is Hu where? Shuttling of early-response-gene messenger RNA subsetsQ35965031
Amyloid pathology and protein kinase C (PKC): possible therapeutics effects of PKC activatorsQ36012133
Altered expression of the mRNA stability factor HuR promotes cyclooxygenase-2 expression in colon cancer cellsQ36042811
Mammalian ELAV-like neuronal RNA-binding proteins HuB and HuC promote neuronal development in both the central and the peripheral nervous systemsQ36438588
Ectopic expression of Hel-N1, an RNA-binding protein, increases glucose transporter (GLUT1) expression in 3T3-L1 adipocytesQ36565455
Testing the in vivo role of protein kinase C and c-fos in neurite outgrowth by microinjection of antibodies into PC12 cellsQ37370860
Protein kinase C redistribution within CA3 stratum oriens during acquisition of nictitating membrane conditioning in the rabbitQ37558349
Regulation of interleukin 3 mRNA expression in mast cells occurs at the posttranscriptional level and is mediated by calcium ionsQ37678593
Role of the RNA-binding protein HuR in colon carcinogenesisQ38349167
ARED 2.0: an update of AU-rich element mRNA database.Q38430539
A spatial-temporal model of cell activationQ39184223
Somatic mRNA turnover mutants implicate tristetraprolin in the interleukin-3 mRNA degradation pathway.Q39453060
Regulation of cyclooxygenase 2 mRNA stability by the mitogen-activated protein kinase p38 signaling cascadeQ39453587
Target specificity of neuronal RNA-binding protein, Mel-N1: direct binding to the 3' untranslated region of its own mRNA.Q39716528
The RNP domain: a sequence-specific RNA-binding domain involved in processing and transport of RNA.Q40403034
The anti-Hu syndrome: a model paraneoplastic disorder.Q40681602
The protein kinase C family for neuronal signalingQ40766065
Cytoplasmic localization is required for the mammalian ELAV-like protein HuD to induce neuronal differentiationQ40908578
Plasminogen activator inhibitor type 2 gene induction by tumor necrosis factor and phorbol ester involves transcriptional and post-transcriptional events. Identification of a functional nonameric AU-rich motif in the 3'-untranslated regionQ41157827
Protein kinase C isoenzymes: regulation and function.Q41203838
Memory formation in the chick depends on membrane-bound protein kinase C.Q41221799
Retinoic acid stimulates the protein kinase C pathway before activation of its beta-nuclear receptor during human teratocarcinoma differentiationQ41514613
Increased PKA and PKC activities accompany neuronal differentiation of NT2/D1 cellsQ41700903
Role of the cAMP-dependent protein kinase and protein kinase C in regulating the morphological differentiation of PC12 cellsQ41738773
The p38 MAP kinase pathway signals for cytokine-induced mRNA stabilization via MAP kinase-activated protein kinase 2 and an AU-rich region-targeted mechanism.Q41850515
Immunocytochemical distribution of Ca(2+)-independent protein kinase C subtypes (delta, epsilon, and zeta) in regenerating axonal growth cones of rat peripheral nerveQ42444409
Distribution of protein kinase C (α, β, γ subtypes) in normal nerve fibers and in regenerating growth cones of the rat peripheral nervous systemQ42481730
Selective inhibition of protein kinase C isozymes by the indolocarbazole Gö 6976.Q42558480
A conserved AU-rich element in the 3' untranslated region of bcl-2 mRNA is endowed with a destabilizing function that is involved in bcl-2 down-regulation during apoptosis.Q42806811
Overexpression of poly(A)-binding protein down-regulates the translation or the abundance of its own mRNA.Q42811304
ELAV protein HuA (HuR) can redistribute between nucleus and cytoplasm and is upregulated during serum stimulation and T cell activation.Q42825905
Identification of sequences within the murine granulocyte-macrophage colony-stimulating factor mRNA 3'-untranslated region that mediate mRNA stabilization induced by mitogen treatment of EL-4 thymoma cellsQ42826667
Identification of an AUUUA-specific messenger RNA binding proteinQ43512990
Effects of sphingosine, staurosporine, and phorbol ester on neurites of rat sympathetic neurons growing in compartmented cultures.Q43654286
Imaging of memory-specific changes in the distribution of protein kinase C in the hippocampusQ44579821
5,6-Dichloro-1-beta-D-ribofuranosylbenzimidazole inhibits transcription elongation by RNA polymerase II in vitro.Q44748430
Cytosolic hippocampal PKC and aging: correlation with discrimination performanceQ48484145
Functional impairment in protein kinase C by RACK1 (receptor for activated C kinase 1) deficiency in aged rat brain cortex.Q48856700
Discrimination learning alters the distribution of protein kinase C in the hippocampus of ratsQ48867332
Pharmacological demonstration of the differential involvement of protein kinase C isoforms in short- and long-term memory formation and retrieval of one-trial avoidance in rats.Q52026276
Protein kinase C activation and anti-amnesic effect of acetyl-L-carnitine: in vitro and in vivo studies.Q52055939
A hierarchy of Hu RNA binding proteins in developing and adult neurons.Q52195067
Calcium-mediated reduction of ionic currents: a biophysical memory trace.Q52209286
Developmental and physiological analysis of a conditional mutation affecting photoreceptor and optic lobe development in Drosophila melanogaster.Q52264935
Phosphorylation events mediated by protein kinase C alpha and epsilon participate in regulation of tau steady-state levels and generation of certain "Alzheimer-like" phospho-epitopes.Q53218700
Structural determinants for post-transcriptional stabilization of lactate dehydrogenase A mRNA by the protein kinase C signal pathway.Q55475778
A redox switch and phosphorylation are involved in the post-translational up-regulation of the adenosine-uridine binding factor by phorbol ester and ionophoreQ68194321
Protein kinase C-alpha and -epsilon are enriched in growth cones of differentiating SH-SY5Y human neuroblastoma cellsQ71588162
Modulation of granulocyte-macrophage colony-stimulating factor mRNA stability in vitro by the adenosine-uridine binding factorQ72723852
Post-transcriptional regulation of the GAP-43 gene by specific sequences in the 3' untranslated region of the mRNAQ73101272
Protein kinase C inhibition has only a transient growth arresting effect on in vitro regenerating mouse sensory neuronsQ73225295
An insight into the post-transcriptional control of gene expression in cell functionQ73681851
p38 Mitogen-activated protein kinase stabilizes mRNAs that contain cyclooxygenase-2 and tumor necrosis factor AU-rich elements by inhibiting deadenylationQ73712359
Messenger ribonucleoprotein complexes containing human ELAV proteins: interactions with cytoskeleton and translational apparatusQ73955735
Overexpression of HuD, but not of its truncated form HuD I+II, promotes GAP-43 gene expression and neurite outgrowth in PC12 cells in the absence of nerve growth factorQ74146354
P433issue34
P407language of work or nameEnglishQ1860
P304page(s)12065-12070
P577publication date2005-08-11
P1433published inProceedings of the National Academy of Sciences of the United States of AmericaQ1146531
P1476titleNeuronal ELAV proteins enhance mRNA stability by a PKCalpha-dependent pathway
P478volume102

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cites work (P2860)
Q28584273A structural basis for enhancement of long-term associative memory in single dendritic spines regulated by PKC
Q58134353Alpha1-adrenergic receptor antagonist tamsulosin ameliorates aging-induced memory impairment by enhancing neurogenesis and suppressing apoptosis in the hippocampus of old-aged rats
Q35775944Arginine methylation of RNA-binding proteins regulates cell function and differentiation
Q52632553Autophagy Stimulus Promotes Early HuR Protein Activation and p62/SQSTM1 Protein Synthesis in ARPE-19 Cells by Triggering Erk1/2, p38MAPK, and JNK Kinase Pathways.
Q36533472Bryostatin-1: pharmacology and therapeutic potential as a CNS drug.
Q36980917Closing the phenotypic gap between transformed neuronal cell lines in culture and untransformed neurons
Q35009090Critical period of memory enhancement during taste avoidance conditioning in Lymnaea stagnalis
Q50579725Cytoplasmic poly(A)-binding protein 1 (PABPC1) interacts with the RNA-binding protein hnRNPLL and thereby regulates immunoglobulin secretion in plasma cells.
Q48297985ELAV-GAP43 pathway activation following combined exposure to cocaine and stress
Q38122142Emerging complexity of the HuD/ELAVl4 gene; implications for neuronal development, function, and dysfunction
Q89697243Evaluation of Toxic Amyloid 42 Oligomers in Rat Primary Cerebral Cortex Cells and Human iPS-derived Neurons Treated with 10-Me-Aplog-1, a New PKC Activator
Q48493230GAP43 overexpression and enhanced neurite outgrowth in mucopolysaccharidosis type IIIB cortical neuron cultures.
Q98735760HuD Binds to and Regulates Circular RNAs Derived From Neuronal Development- and Synaptic Plasticity-Associated Genes
Q35096285HuD interacts with Bdnf mRNA and is essential for activity-induced BDNF synthesis in dendrites
Q34045640HuR uses AUF1 as a cofactor to promote p16INK4 mRNA decay
Q39196694Identification of peptides with ELAV-like mRNA-stabilizing effect: an integrated in vitro/in silico approach
Q34101299Il-19 reduces VSMC activation by regulation of mRNA regulatory factor HuR and reduction of mRNA stability
Q36154872Increased steady-state levels of CUGBP1 in myotonic dystrophy 1 are due to PKC-mediated hyperphosphorylation
Q45054089Inhibition of coactivator-associated arginine methyltransferase 1 modulates dendritic arborization and spine maturation of cultured hippocampal neurons
Q37093591Interleukin-19 decreases leukocyte-endothelial cell interactions by reduction in endothelial cell adhesion molecule mRNA stability
Q36661312Modulation of neoplastic gene regulatory pathways by the RNA-binding factor AUF1
Q36457156Modulation of utrophin A mRNA stability in fast versus slow muscles via an AU-rich element and calcineurin signaling.
Q37226514Molecular mechanisms, biological actions, and neuropharmacology of the growth-associated protein GAP-43.
Q36913106Musashi1: a stem cell marker no longer in search of a function
Q37107632Mutant copper-zinc superoxide dismutase associated with amyotrophic lateral sclerosis binds to adenine/uridine-rich stability elements in the vascular endothelial growth factor 3'-untranslated region
Q35059020Opposite effects of acute ethanol exposure on GAP-43 and BDNF expression in the hippocampus versus the cerebellum of juvenile rats
Q42496987PKC Activation Counteracts ADAM10 Deficit in HuD-Silenced Neuroblastoma Cells
Q36376317PKC in Regenerative Therapy: New Insights for Old Targets
Q44962410PKC ε activation prevents synaptic loss, Aβ elevation, and cognitive deficits in Alzheimer's disease transgenic mice
Q34271052PKCα binds G3BP2 and regulates stress granule formation following cellular stress
Q35172084PKCε promotes HuD-mediated neprilysin mRNA stability and enhances neprilysin-induced Aβ degradation in brain neurons
Q37225291Posttranscriptional regulation of insulin family ligands and receptors
Q28114829Posttranslational modification of the AU-rich element binding protein HuR by protein kinase Cdelta elicits angiotensin II-induced stabilization and nuclear export of cyclooxygenase 2 mRNA
Q38906742Pre-exposure of neuroblastoma cell line to pulsed electromagnetic field prevents H2 O2 -induced ROS production by increasing MnSOD activity.
Q38784086Protein Kinase C Activation as a Potential Therapeutic Strategy in Alzheimer's Disease: Is there a Role for Embryonic Lethal Abnormal Vision-like Proteins?
Q28118240Protein kinase C alpha-dependent phosphorylation of the mRNA-stabilizing factor HuR: implications for posttranscriptional regulation of cyclooxygenase-2
Q28575286Protein kinase C stimulates HuD-mediated mRNA stability and protein expression of neurotrophic factors and enhances dendritic maturation of hippocampal neurons in culture
Q35516501Protein kinase C-dependent growth-associated protein 43 phosphorylation regulates gephyrin aggregation at developing GABAergic synapses
Q90975580RNA binding protein HuD contributes to β-cell dysfunction by impairing mitochondria dynamics
Q35869792RNA-binding protein HuD controls insulin translation
Q27023916Regulation of AU-Rich Element RNA Binding Proteins by Phosphorylation and the Prolyl Isomerase Pin1
Q42737769Ribonucleoprotein therapy in Alzheimer's disease?
Q98164546Sovateltide (IRL-1620) activates neuronal differentiation and prevents mitochondrial dysfunction in adult mammalian brains following stroke
Q93178767The ELAV family of RNA-binding proteins in synaptic plasticity and long-term memory
Q43450344The RNA-binding protein HuD binds acetylcholinesterase mRNA in neurons and regulates its expression after axotomy
Q37930474The complex world of post-transcriptional mechanisms: is their deregulation a common link for diseases? Focus on ELAV-like RNA-binding proteins
Q26798135The molecular mechanism of translational control via the communication between the microRNA pathway and RNA-binding proteins
Q28570605The survival of motor neuron (SMN) protein interacts with the mRNA-binding protein HuD and regulates localization of poly(A) mRNA in primary motor neuron axons.
Q64088874Treadmill Exercise Alleviates Circadian Rhythm Disruption-Induced Memory Deficits by Activation of Glucocorticoid Receptor and Brain-Derived Neurotrophic Factor-Dependent Pathway
Q36773503mRNA stability control: a clandestine force in normal and malignant hematopoiesis
Q34119806miR-375 inhibits differentiation of neurites by lowering HuD levels
Q39883245nELAV proteins alteration in Alzheimer's disease brain: a novel putative target for amyloid-beta reverberating on AbetaPP processing

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