A role for human brain pericytes in neuroinflammation.

scientific article

A role for human brain pericytes in neuroinflammation. is …
instance of (P31):
scholarly articleQ13442814

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P6179Dimensions Publication ID1014661472
P356DOI10.1186/1742-2094-11-104
P932PMC publication ID4105169
P698PubMed publication ID24920309
P5875ResearchGate publication ID263054630

P50authorRichard FaullQ28101943
Daniel HurleyQ58366401
Justin RustenhovenQ61095795
Deidre JanssonQ61096488
P2093author name stringEdward W Mee
Mike Dragunow
Peter S Bergin
Robyn L Oldfield
Sheryl Feng
P2860cites workMechanism of action and in vivo role of platelet-derived growth factorQ22010594
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An alternatively spliced variant of CXCR3 mediates the inhibition of endothelial cell growth induced by IP-10, Mig, and I-TAC, and acts as functional receptor for platelet factor 4Q24303828
The role of interleukin-15 in inflammation and immune responses to infection: implications for its therapeutic useQ24599103
Pericytes Control Key Neurovascular Functions and Neuronal Phenotype in the Adult Brain and during Brain AgingQ24600644
Chemokines regulate hippocampal neuronal signaling and gp120 neurotoxicityQ24650569
Apolipoprotein L1, a novel Bcl-2 homology domain 3-only lipid-binding protein, induces autophagic cell deathQ24652950
Analysis of Relative Gene Expression Data Using Real-Time Quantitative PCR and the 2−ΔΔCT MethodQ25938999
Pericytes regulate vascular basement membrane remodeling and govern neutrophil extravasation during inflammationQ27318097
Diversified expression of NG2/CSPG4 isoforms in glioblastoma and human foetal brain identifies pericyte subsetsQ27334435
Independent and Cooperative Antiviral Actions of Beta Interferon and Gamma Interferon against Herpes Simplex Virus Replication in Primary Human FibroblastsQ27485444
Inflammatory process in Alzheimer's DiseaseQ27500412
The pathological and physiological roles of IL-6 amplifier activationQ27690908
Inflammation and metabolic disordersQ27860923
Astrocyte-endothelial interactions at the blood-brain barrierQ28131675
NF-kappaB regulation in the immune systemQ28205043
Essential involvement of interleukin-8 (IL-8) in acute inflammationQ28241161
Brain endothelial hemostasis regulation by pericytesQ28261487
Phosphorylation of NG2 proteoglycan by protein kinase C-alpha regulates polarized membrane distribution and cell motilityQ28289670
Role of the chemokine SDF-1 as the meningeal attractant for embryonic cerebellar neuronsQ28571274
Inhibition of IkappaB kinase-beta protects dopamine neurons against lipopolysaccharide-induced neurotoxicityQ28577454
Adult human brain neural progenitor cells (NPCs) and fibroblast-like cells have similar properties in vitro but only NPCs differentiate into neuronsQ28728890
Gene transfer of stromal cell-derived factor-1alpha enhances ischemic vasculogenesis and angiogenesis via vascular endothelial growth factor/endothelial nitric oxide synthase-related pathway: next-generation chemokine therapy for therapeutic neovascQ47590872
Expression and glycanation of the NG2 proteoglycan in developing, adult, and damaged peripheral nerve.Q48121211
The transcription factor PU.1 is critical for viability and function of human brain microgliaQ48129649
Production of the cytokines interleukin 1 and 6 by murine brain microvessel endothelium and smooth muscle pericytesQ48237221
Role of central nervous system microvascular pericytes in activation of antigen-primed splenic T-lymphocytesQ48260181
Reprogramming of pericyte-derived cells of the adult human brain into induced neuronal cells.Q48348076
A novel immune-to-CNS communication pathway: cells of the meninges surrounding the spinal cord CSF space produce proinflammatory cytokines in response to an inflammatory stimulusQ48416184
Establishment of human adult astrocyte cultures derived from postmortem multiple sclerosis and control brain and spinal cord regions: immunophenotypical and functional characterizationQ48650304
Modelling the neurovascular unit and the blood-brain barrier with the unique function of pericytes.Q48823131
Leptomeningeal cells activate microglia and astrocytes to induce IL-10 production by releasing pro-inflammatory cytokines during systemic inflammation.Q51372902
Valproic acid induces microglial dysfunction, not apoptosis, in human glial cultures.Q53302459
Pericytes from Brain Microvessels Strengthen the Barrier Integrity in Primary Cultures of Rat Brain Endothelial CellsQ57283471
Cellular composition of human glial cultures from adult biopsy brain tissueQ60513577
Characterization of platelet-derived growth factor beta-receptor expressing cells in the vasculature of human rheumatoid synoviumQ67914082
Immunocytochemical characterization of primary glial cell cultures from normal adult human brainQ68032561
Expression of the chemokine receptor CXCR3 on neurons and the elevated expression of its ligand IP-10 in reactive astrocytes: in vitro ERK1/2 activation and role in Alzheimer's diseaseQ74016859
Ex vivo priming of endothelial progenitor cells with SDF-1 before transplantation could increase their proangiogenic potentialQ80604936
Astrocyte TLR4 activation induces a proinflammatory environment through the interplay between MyD88-dependent NFκB signaling, MAPK, and Jak1/Stat1 pathwaysQ82705613
Chemokine expression by astrocytes plays a role in microglia/macrophage activation and subsequent neurodegeneration in secondary progressive multiple sclerosisQ83870435
Capillary and arteriolar pericytes attract innate leukocytes exiting through venules and 'instruct' them with pattern-recognition and motility programsQ85522762
The adult human brain harbors multipotent perivascular mesenchymal stem cellsQ28730559
Genomic responses in mouse models poorly mimic human inflammatory diseasesQ29547718
Pericytes regulate the blood-brain barrierQ29615840
Functional interactions between the gut microbiota and host metabolismQ29616815
Mechanisms underlying inflammation in neurodegenerationQ29617977
Insulin-induced endothelial cell cortical actin filament remodeling: a requirement for trans-endothelial insulin transportQ30417980
Pericytes support neutrophil subendothelial cell crawling and breaching of venular walls in vivo.Q30515728
CCL2 disrupts the adherens junction: implications for neuroinflammationQ30523821
Dendritic cell CNS recruitment correlates with disease severity in EAE via CCL2 chemotaxis at the blood-brain barrier through paracellular transmigration and ERK activationQ30530989
Interferon gamma (IFNgamma ) and tumor necrosis factor alpha synergism in ME-180 cervical cancer cell apoptosis and necrosis. IFNgamma inhibits cytoprotective NF-kappa B through STAT1/IRF-1 pathwaysQ33181838
Blood-brain barrier dysfunction and epilepsy: pathophysiologic role and therapeutic approachesQ33354141
Central nervous system pericytes in health and diseaseQ33609398
Activation and regulation of NFkappaB during acute inflammationQ33649815
Reperfusion and neurovascular dysfunction in stroke: from basic mechanisms to potential strategies for neuroprotectionQ33879330
Tissue localization of beta receptors for platelet-derived growth factor and platelet-derived growth factor B chain during wound repair in humansQ33899101
TRAIL-R4 promotes tumor growth and resistance to apoptosis in cervical carcinoma HeLa cells through AKTQ33916314
CCL2-expressing astrocytes mediate the extravasation of T lymphocytes in the brain. Evidence from patients with glioma and experimental models in vivoQ34154663
Indoleamine 2,3-dioxygenase and 3-hydroxykynurenine modifications are found in the neuropathology of Alzheimer's diseaseQ34207080
Predominant interferon-γ-mediated expression of CXCL9, CXCL10, and CCL5 proteins in the brain during chronic infection with Toxoplasma gondii in BALB/c mice resistant to development of toxoplasmic encephalitis.Q34238253
Inhibitor of kappaB kinase is required to activate a subset of interferon gamma-stimulated genes.Q34330967
An IP-10 (CXCL10)-derived peptide inhibits angiogenesisQ34345236
Establishment of primary cultures of human brain microvascular endothelial cells to provide an in vitro cellular model of the blood-brain barrierQ35029148
Adult human glia, pericytes and meningeal fibroblasts respond similarly to IFNy but not to TGFβ1 or M-CSF.Q35067317
Neuronal apoptosis is mediated by CXCL10 overexpression in simian human immunodeficiency virus encephalitisQ35098067
Microglia: scapegoat, saboteur, or something else?Q35606301
Immortalized CNS pericytes are quiescent smooth muscle actin-negative and pluripotentQ35647234
Inhibitory effect of 4-O-methylhonokiol on lipopolysaccharide-induced neuroinflammation, amyloidogenesis and memory impairment via inhibition of nuclear factor-kappaB in vitro and in vivo modelsQ35881235
Microarray analysis of gene expression in West Nile virus-infected human retinal pigment epitheliumQ35883310
Pericyte regulation of vascular remodeling through the CXC receptor 3Q36112820
Infection and upregulation of proinflammatory cytokines in human brain vascular pericytes by human cytomegalovirusQ36146446
NG2-expressing cells in the nervous system: role of the proteoglycan in migration and glial-neuron interactionQ36347835
Fibrinogen-induced perivascular microglial clustering is required for the development of axonal damage in neuroinflammation.Q36445604
Programming of neurotoxic cofactor CXCL-10 in HIV-1-associated dementia: abrogation of CXCL-10-induced neuro-glial toxicity in vitro by PKC activatorQ36498596
Blood-spinal cord barrier breakdown and pericyte reductions in amyotrophic lateral sclerosisQ36503292
Induction of inhibitory factor kappaBalpha mRNA in the central nervous system after peripheral lipopolysaccharide administration: an in situ hybridization histochemistry study in the ratQ36603949
L-glutamate released from activated microglia downregulates astrocytic L-glutamate transporter expression in neuroinflammation: the 'collusion' hypothesis for increased extracellular L-glutamate concentration in neuroinflammationQ36618166
Multiple actions of the chemokine stromal cell-derived factor-1alpha on neuronal activityQ36752538
Differential expression of interferon-γ and chemokine genes distinguishes Rasmussen encephalitis from cortical dysplasia and provides evidence for an early Th1 immune responseQ36854093
Expression of CD74 is increased in neurofibrillary tangles in Alzheimer's diseaseQ36932516
Nutraceutical agents with anti-inflammatory properties prevent dietary saturated-fat induced disturbances in blood-brain barrier function in wild-type miceQ36958137
Brain pericytes increase the lipopolysaccharide-enhanced transcytosis of HIV-1 free virus across the in vitro blood-brain barrier: evidence for cytokine-mediated pericyte-endothelial cell crosstalkQ37008640
M-CSF increases proliferation and phagocytosis while modulating receptor and transcription factor expression in adult human microgliaQ37060394
A novel and simple method for culturing pericytes from mouse brainQ37106956
Blood-brain barrier dysfunction as a cause and consequence of Alzheimer's disease.Q37216153
SOD2 in mitochondrial dysfunction and neurodegenerationQ37262897
Elevated CNS inflammation in patients with preclinical Alzheimer's disease.Q37459897
Cardiac workup of ischemic stroke: can we improve our diagnostic yield?Q37499711
Changing face of microgliaQ37807203
Pleiotropic actions of insulin resistance and inflammation in metabolic homeostasisQ38073225
Meningeal and choroid plexus cells--novel drug targets for CNS disordersQ38074759
Cellular kinetics of perivascular MSC precursors.Q38136188
The human side of microgliaQ38175607
Identification of genes selectively regulated by IFNs in endothelial cellsQ38306049
Systems biology approaches identify ATF3 as a negative regulator of Toll-like receptor 4.Q38313431
Brain microvascular pericytes are immunoactive in culture: cytokine, chemokine, nitric oxide, and LRP-1 expression in response to lipopolysaccharideQ38937481
Synergistic expression of the CXCL10 gene in response to IL-1β and IFN-γ involves NF-κB, phosphorylation of STAT1 at Tyr701, and acetylation of histones H3 and H4.Q39143407
OASL1 inhibits translation of the type I interferon-regulating transcription factor IRF7.Q39193091
Peripheral nerve pericytes modify the blood-nerve barrier function and tight junctional molecules through the secretion of various soluble factorsQ39674615
Establishment of a new conditionally immortalized human brain microvascular endothelial cell line retaining an in vivo blood-brain barrier functionQ39705355
Altered expression of basement membrane-related molecules in rat brain pericyte, endothelial, and astrocyte cell lines after transforming growth factor-beta1 treatmentQ40082979
Dimethylfumarate inhibits microglial and astrocytic inflammation by suppressing the synthesis of nitric oxide, IL-1beta, TNF-alpha and IL-6 in an in-vitro model of brain inflammationQ40891679
Activating transcription factor 3 and the nervous systemQ41098388
Lipopolysaccharide activates Toll-like receptor 4 (TLR4)-mediated NF-κB signaling pathway and proinflammatory response in human pericytesQ41889316
Roles of IKK-beta, IRF1, and p65 in the activation of chemokine genes by interferon-gammaQ42021111
Central origin of IL-1beta produced during peripheral inflammation: role of meninges.Q42484014
Induction of alpha-smooth muscle actin expression in cultured human brain pericytes by transforming growth factor-beta 1.Q42754593
Heterogeneity of microvascular pericytes for smooth muscle type alpha-actinQ43107823
Lipopolysaccharide up-regulates IL-6R alpha expression in cultured leptomeningeal cells via activation of ERK1/2 pathwayQ44314716
A broad upregulation of cerebral chemokine genes by peripherally-generated inflammatory mediatorsQ44962669
Monocyte chemoattractant protein-1 regulation of blood-brain barrier permeabilityQ45250155
Reduction in mitochondrial superoxide dismutase modulates Alzheimer's disease-like pathology and accelerates the onset of behavioral changes in human amyloid precursor protein transgenic mice.Q46706796
Brain capillary pericytes contribute to the immune defense in response to cytokines or LPS in vitroQ46946884
P2507corrigendum / erratumErratum to: A role for human brain pericytes in neuroinflammation.Q43162874
P4510describes a project that useslimmaQ112236343
affyQ113334509
P921main subjectpericyteQ500446
neuronitisQ17157137
P304page(s)104
P577publication date2014-06-11
P1433published inJournal of NeuroinflammationQ15716679
P1476titleA role for human brain pericytes in neuroinflammation
P478volume11

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Q43162874Erratum to: A role for human brain pericytes in neuroinflammation.
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Q43162874Erratum to: A role for human brain pericytes in neuroinflammation.main subjectP921

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