A randomised trial evaluating the effects of the TRPV1 antagonist SB705498 on pruritus induced by histamine, and cowhage challenge in healthy volunteers

scientific article

A randomised trial evaluating the effects of the TRPV1 antagonist SB705498 on pruritus induced by histamine, and cowhage challenge in healthy volunteers is …
instance of (P31):
scholarly articleQ13442814

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P819ADS bibcode2014PLoSO...9j0610G
P356DOI10.1371/JOURNAL.PONE.0100610
P932PMC publication ID4105653
P698PubMed publication ID25047038
P5875ResearchGate publication ID264127281

P50authorStewart McCallumQ57039386
Rachel A GibsonQ57700532
P2093author name stringGil Yosipovitch
Disala Fernando
Jon Robertson
Melody Wyres
Harshna Mistry
P2860cites workTRPV1 antagonist can suppress the atopic dermatitis-like symptoms by accelerating skin barrier recovery.Q52608362
Development of PAC-14028, a novel transient receptor potential vanilloid type 1 (TRPV1) channel antagonist as a new drug for refractory skin diseases.Q53381596
Antipruritic Effects of TRPV1 Antagonist in Murine Atopic Dermatitis and Itching ModelsQ58390465
TRPV1 mediates histamine-induced itching via the activation of phospholipase A2 and 12-lipoxygenaseQ79847967
Scratching the surface: a role of pain-sensing TRPA1 in itchQ83975450
Effect of mucosal TRPV1 inhibition in allergic rhinitisQ84996996
Cowhage-evoked itch is mediated by a novel cysteine protease: a ligand of protease-activated receptorsQ24654106
The effects of the TRPV1 antagonist SB-705498 on TRPV1 receptor-mediated activity and inflammatory hyperalgesia in humansQ28238213
TRPV1-expressing primary afferents generate behavioral responses to pruritogens via multiple mechanismsQ30488724
Activity-dependent silencing reveals functionally distinct itch-generating sensory neuronsQ30540969
Psychophysical and physiological evidence for parallel afferent pathways mediating the sensation of itch.Q33290606
Cowhage-induced itch as an experimental model for pruritus. A comparative study with histamine-induced itchQ33851774
Potentiation of the transient receptor potential vanilloid 1 channel contributes to pruritogenesis in a rat model of liver diseaseQ36742184
Evidence for the role of neurogenic inflammation components in trypsin-elicited scratching behaviour in mice.Q36753567
TRP channels as novel players in the pathogenesis and therapy of itchQ36803162
Histamine 50-skin-prick test: a tool to diagnose histamine intoleranceQ36857443
Effect of the TRPV1 antagonist SB-705498 on the nasal parasympathetic reflex response in the ovalbumin sensitized guinea pig.Q36929439
What causes itch in atopic dermatitis?Q37208966
Therapy of pruritusQ37738911
Urticaria and its subtypes: the role of second-generation antihistaminesQ37966254
Transient receptor potential channels and dermatological disordersQ38083732
Characterization of SB-705498, a potent and selective vanilloid receptor-1 (VR1/TRPV1) antagonist that inhibits the capsaicin-, acid-, and heat-mediated activation of the receptorQ40152909
Protease-activated receptor 2 sensitizes the capsaicin receptor transient receptor potential vanilloid receptor 1 to induce hyperalgesia.Q43677197
Proteinase-activated receptor-2 mediates itch: a novel pathway for pruritus in human skin.Q44516252
Proteinase-activated receptor 2-mediated potentiation of transient receptor potential vanilloid subfamily 1 activity reveals a mechanism for proteinase-induced inflammatory pain.Q44885100
Transient receptor potential vanilloid (TRPV-1) promotes neurogenic inflammation in the pancreas via activation of the neurokinin-1 receptor (NK-1R).Q46396095
The prevalence and clinical characteristics of pruritus among patients with extensive psoriasisQ48710475
P275copyright licenseCreative Commons Attribution 4.0 InternationalQ20007257
P6216copyright statuscopyrightedQ50423863
P433issue7
P407language of work or nameEnglishQ1860
P304page(s)e100610
P577publication date2014-07-21
P1433published inPLOS OneQ564954
P1476titleA randomised trial evaluating the effects of the TRPV1 antagonist SB705498 on pruritus induced by histamine, and cowhage challenge in healthy volunteers
P478volume9

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cites work (P2860)
Q38656850Advances in therapeutic strategies for the treatment of pruritus
Q30655924Distinct functions of opioid-related peptides and gastrin-releasing peptide in regulating itch and pain in the spinal cord of primates.
Q92127855Emerging Perspectives on Pain Management by Modulation of TRP Channels and ANO1
Q60606792Histaminergic and non-histaminergic elicited itch is attenuated in capsaicin-evoked areas of allodynia and hyperalgesia: A healthy volunteer study
Q39429573Inflammatory and Noninflammatory Itch: Implications in Pathophysiology-Directed Treatments
Q38452688Mediators of Chronic Pruritus in Atopic Dermatitis: Getting the Itch Out?
Q39038882Medicinal Chemistry, Pharmacology, and Clinical Implications of TRPV1 Receptor Antagonists
Q50185066Non-opioid analgesic use and concerns for impaired organ protection.
Q48339961Regulation of Pain and Itch by TRP Channels
Q91694412Role of Chemosensory TRP Channels in Lung Cancer
Q47176855Sensing the heat with TRPM3.
Q64956089Sensory nerves mediate spontaneous behaviors in addition to inflammation in a murine model of psoriasis.
Q48193824Sildenafil Treatment Eliminates Pruritogenesis and Thermal Hyperalgesia in Rats with Portacaval Shunts.
Q57297139TRP Channels as Drug Targets to Relieve Itch
Q26739979TRPV1 and TRPM8 in Treatment of Chronic Cough
Q39090248The nervous system of airways and its remodeling in inflammatory lung diseases
Q35560404TriCalm(®) hydrogel is significantly superior to 2% diphenhydramine and 1% hydrocortisone in reducing the peak intensity, duration, and overall magnitude of cowhage-induced itch
Q36703535Trp channels and itch

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