Esophageal adenocarcinoma: treatment modalities in the era of targeted therapy

scientific article

Esophageal adenocarcinoma: treatment modalities in the era of targeted therapy is …
instance of (P31):
scholarly articleQ13442814
review articleQ7318358

External links are
P6179Dimensions Publication ID1000320841
P356DOI10.1007/S10620-010-1187-4
P932PMC publication ID2890301
P698PubMed publication ID20300841
P5875ResearchGate publication ID42346389

P2093author name stringWael El-Rifai
Laura W Goff
A Bapsi Chakravarthy
Kaushik Mukherjee
P2860cites workPreoperative chemotherapy for resectable thoracic esophageal cancerQ24245213
Gastric cancers overexpress DARPP-32 and a novel isoform, t-DARPPQ28215053
Gains and Amplifications of c-myc, EGFR, and 20.q13 Loci in the No Dysplasia-Dysplasia-Adenocarcinoma Sequence of Barrett's EsophagusQ61814005
Combined chemotherapy and radiotherapy compared with radiotherapy alone in patients with cancer of the esophagusQ68122887
The value of preoperative radiotherapy in esophageal cancer: results of a study of the E.O.R.T.C.Q69254547
Randomized clinical trial on the combination of preoperative irradiation and surgery in the treatment of esophageal carcinoma: report on 206 patientsQ69487537
A comparison of multimodal therapy and surgery for esophageal adenocarcinomaQ71164736
Preoperative radiotherapy for carcinoma of the esophagusQ71572381
Concomitant analysis of the epidermal growth factor receptor family in esophageal cancer: overexpression of epidermal growth factor receptor mRNA but not of c-erbB-2 and c-erbB-3Q73062638
Colonic interposition after esophagectomy for cancerQ73066648
Eliminating the cervical esophagogastric anastomotic leak with a side-to-side stapled anastomosisQ73388258
Proposal for improved staging criteria for carcinoma of the esophagus and cardiaQ73794187
Chemoradiotherapy of locally advanced esophageal cancer: long-term follow-up of a prospective randomized trial (RTOG 85-01). Radiation Therapy Oncology GroupQ77424043
Chemotherapy followed by surgery compared with surgery alone for localized esophageal cancerQ77738544
Extended transthoracic resection compared with limited transhiatal resection for adenocarcinoma of the esophagusQ78551320
Frequent homogeneous HER-2 amplification in primary and metastatic adenocarcinoma of the esophagusQ79401515
Expression of epidermal growth factor receptor in esophageal and esophagogastric junction adenocarcinomas: association with poor outcomeQ79522451
Comparing outcomes after transthoracic and transhiatal esophagectomy: a 5-year prospective cohort of 17,395 patientsQ79950185
Her-2/neu in barrett esophagus: a comparative study between histology, immunohistochemistry, and fluorescence in situ hybridizationQ80165950
The role of overdiagnosis and reclassification in the marked increase of esophageal adenocarcinoma incidenceQ81290009
Cetuximab with concurrent chemoradiation for esophagogastric cancer: assessment of toxicityQ81547151
Preoperative therapy for esophageal cancerQ83572036
Aurora kinase inhibitors in preclinical and clinical testingQ83589206
Survival in lymph node negative adenocarcinoma of the esophagus after R0 resection with and without neoadjuvant therapy: evidence for downstaging of N statusQ83936521
Increased CDX2 and decreased PITX1 homeobox gene expression in Barrett's esophagus and Barrett's-associated adenocarcinomaQ28282119
Tumour amplified kinase STK15/BTAK induces centrosome amplification, aneuploidy and transformationQ28285317
Perioperative chemotherapy versus surgery alone for resectable gastroesophageal cancerQ29619394
Genetic differences between adenocarcinomas arising in Barrett's esophagus and gastric mucosaQ30307786
Silencing of MGMT expression by promoter hypermethylation in the metaplasia-dysplasia-carcinoma sequence of Barrett's esophagusQ30412980
DNA hypermethylation regulates the expression of members of the Mu-class glutathione S-transferases and glutathione peroxidases in Barrett's adenocarcinomaQ30436675
Darpp-32: a novel antiapoptotic gene in upper gastrointestinal carcinomasQ30437615
Hypermethylation and loss of expression of glutathione peroxidase-3 in Barrett's tumorigenesisQ30438403
Malignant progression in Barrett's esophagus: pathology and molecular biologyQ30842376
Coamplification and coexpression of GRB7 and ERBB2 is found in high grade intraepithelial neoplasia and in invasive Barrett's carcinomaQ31114947
Downregulation of TS, DPD, ERCC1, GST-Pi, EGFR, and HER2 gene expression after neoadjuvant three-modality treatment in patients with esophageal cancerQ31150414
Preoperative radiotherapy in esophageal carcinoma: a meta-analysis using individual patient data (Oesophageal Cancer Collaborative Group).Q32060428
Molecular determinants in targeted therapy for esophageal adenocarcinomaQ33243542
Three-tiered risk stratification model to predict progression in Barrett's esophagus using epigenetic and clinical featuresQ33326627
Frequent overexpression of Aurora Kinase A in upper gastrointestinal adenocarcinomas correlates with potent antiapoptotic functionsQ33647697
Persistent association of nailfold capillaroscopy changes and skin involvement over thirty-six months with duration of untreated disease in patients with juvenile dermatomyositis.Q33694649
Expression of t-DARPP mediates trastuzumab resistance in breast cancer cellsQ33743601
Molecular biology of esophageal cancer.Q34020458
Esophageal carcinoma: depth of tumor invasion is predictive of regional lymph node statusQ34462598
Aurora kinases: new targets for cancer therapyQ34587271
A meta-analysis of randomized controlled trials that compared neoadjuvant chemoradiation and surgery to surgery alone for resectable esophageal cancerQ35143202
Biomarkers of esophageal adenocarcinoma and Barrett's esophagusQ35680678
Oncogenic K-Ras signals through epidermal growth factor receptor and wild-type H-Ras to promote radiation survival in pancreatic and colorectal carcinoma cells.Q35756960
Epidermal growth factor receptor expression correlates with histologic grade in resected esophageal adenocarcinomaQ35761590
Preoperative chemoradiotherapy for oesophageal cancer: a systematic review and meta-analysisQ35803550
Vascular endothelial growth factor in esophageal cancerQ35849980
Cell and molecular biology of the small intestine: new insights into differentiation, growth and repair.Q36036420
Aurora kinases: shining lights on the therapeutic horizon?Q36210257
Drosophila Aurora A kinase is required to localize D-TACC to centrosomes and to regulate astral microtubules.Q36324220
Systematic overview of preoperative (neoadjuvant) chemoradiotherapy trials in oesophageal cancer: evidence of a radiation and chemotherapy dose responseQ36424588
Mechanisms of disease: Oncogene addiction--a rationale for molecular targeting in cancer therapyQ36559283
Aurora-A and p16 polymorphisms contribute to an earlier age at diagnosis of pancreatic cancer in CaucasiansQ36627355
Modeling oncogene addiction using RNA interference.Q36840172
Incidence of adenocarcinoma of the esophagus among white Americans by sex, stage, and age.Q36841557
Epidermal growth factor receptor tyrosine kinase inhibitor, erlotinib, and concurrent 5-fluorouracil, cisplatin and radiotherapy for patients with esophageal cancer: a phase I studyQ46827347
Induction cisplatin and paclitaxel followed by combination chemoradiotherapy with 5-fluorouracil, cisplatin, and paclitaxel before resection in localized esophageal cancer: a phase II reportQ46898344
Expression of carbonic anhydrase IX (CA IX), a hypoxia-related protein, rather than vascular-endothelial growth factor (VEGF), a pro-angiogenic factor, correlates with an extremely poor prognosis in esophageal and gastric adenocarcinomasQ46958508
A phase II study of gefitinib monotherapy in advanced esophageal adenocarcinoma: evidence of gene expression, cellular, and clinical responseQ46972228
Expression of the intestinal marker Cdx2 in the columnar-lined esophagus with and without intestinal (Barrett's) metaplasiaQ47418093
A prospective randomized comparison of transhiatal and transthoracic resection for lower-third esophageal carcinoma.Q50931006
Multicenter phase II study of irinotecan, cisplatin, and bevacizumab in patients with metastatic gastric or gastroesophageal junction adenocarcinoma.Q51776237
Phase II trial of erlotinib in gastroesophageal junction and gastric adenocarcinomas: SWOG 0127.Q51779657
Molecular dissection of 17q12 amplicon in upper gastrointestinal adenocarcinomas.Q54591709
K-ras codon 12 mutations in Barrett's oesophagus and adenocarcinomas of the oesophagus and oesophagogastric junctionQ56591148
Amplification and over-expression of theEGFR anderbB-2 genes in human esophageal adenocarcinomasQ57421139
Adenocarcinoma of the gastroesophageal junction: influence of esophageal resection margin and operative approach on outcomeQ57846070
Symptomatic Gastroesophageal Reflux as a Risk Factor for Esophageal AdenocarcinomaQ58204833
Early esophageal cancer: pattern of lymphatic spread and prognostic factors for long-term survival after surgical resectionQ58484694
Aurora kinase A inhibition leads to p73-dependent apoptosis in p53-deficient cancer cellsQ36984707
Genetic polymorphisms of VEGF, interactions with cigarette smoking exposure and esophageal adenocarcinoma riskQ37090696
The aurora kinase A regulates GSK-3beta in gastric cancer cellsQ37096754
Oncogene addictionQ37152445
Oncogene addiction versus oncogene amnesia: perhaps more than just a bad habit?Q37152449
Perioperative anesthetic management for esophagectomyQ37154390
Epidermal growth factor receptor-directed therapy in esophageal cancerQ37162929
Esophageal adenocarcinoma arising in Barrett esophagusQ37169303
Acid, bile, and CDX: the ABCs of making Barrett's metaplasiaQ37192028
Treatment results of adenocarcinoma of the gastroesophageal junctionQ37211127
The Aurora kinase family in cell division and cancer.Q37228956
Epidermal growth factor receptor kinase domain mutations in esophageal and pancreatic adenocarcinomasQ37252270
Tumor dormancy and oncogene addictionQ37286246
Targeting aurora kinase with MK-0457 inhibits ovarian cancer growth.Q37398815
Aurora kinase inhibitorsQ37445283
Current Opinion on Optimal Treatment Choices in First-line Therapy for Advanced or Metastatic Colorectal Cancer: Report From the Adelaide Colorectal Tumour Group Meeting; Stockholm, Sweden; September 2008.Q37681185
Surgical therapy of oesophageal carcinomaQ37950431
Simultaneous blockade of the epidermal growth factor receptor/mammalian target of rapamycin pathway by epidermal growth factor receptor inhibitors and rapamycin results in reduced cell growth and survival in biliary tract cancer cellsQ39840571
Both t-Darpp and DARPP-32 can cause resistance to trastuzumab in breast cancer cells and are frequently expressed in primary breast cancers.Q39870542
The Aurora kinase inhibitor VE-465 has anticancer effects in pre-clinical studies of human hepatocellular carcinomaQ39893220
Bile acids induce overexpression of homeobox gene CDX-2 and vascular endothelial growth factor (VEGF) in human Barrett's esophageal mucosa and adenocarcinoma cell line.Q40081597
Activation of downstream epidermal growth factor receptor (EGFR) signaling provides gefitinib-resistance in cells carrying EGFR mutationQ40176065
Heparin-binding EGF-like growth factor is an early response gene to chemotherapy and contributes to chemotherapy resistanceQ40227623
Phase I/II study of trastuzumab, paclitaxel, cisplatin and radiation for locally advanced, HER2 overexpressing, esophageal adenocarcinomaQ40271053
Targeting the epidermal growth factor receptor by erlotinib (Tarceva) for the treatment of esophageal cancerQ40363293
Trastuzumab, paclitaxel, cisplatin, and radiation for adenocarcinoma of the esophagus: a phase I study.Q40463186
Monoclonal antibody to HER-2/neu receptor enhances radiosensitivity of esophageal cancer cell lines expressing HER-2/neu oncoprotein.Q40475456
ERBB2 amplifications in esophageal adenocarcinomaQ40498835
HER-2/neu gene amplification by FISH predicts poor survival in Barrett's esophagus-associated adenocarcinomaQ40779159
Is radiation therapy needed in the treatment of gastroesophageal junction adenocarcinoma?Q42022302
Neoadjuvant chemoradiotherapy for resectable esophageal carcinoma: a meta-analysisQ42951422
Phase II study of cetuximab in combination with FOLFIRI in patients with untreated advanced gastric or gastroesophageal junction adenocarcinoma (FOLCETUX study).Q43604675
Changing patterns in the incidence of esophageal and gastric carcinoma in the United StatesQ43873434
Pre-operative radiotherapy prolongs survival in operable esophageal carcinoma: a randomized, multicenter study of pre-operative radiotherapy and chemotherapy. The second Scandinavian trial in esophageal cancerQ43956924
Surgical resection with or without preoperative chemotherapy in oesophageal cancer: a randomised controlled trialQ44017893
Survival benefits from neoadjuvant chemoradiotherapy or chemotherapy in oesophageal carcinoma: a meta-analysis.Q44022873
Predictors of major morbidity and mortality after esophagectomy for esophageal cancer: a Society of Thoracic Surgeons General Thoracic Surgery Database risk adjustment modelQ44247929
Outcomes after transhiatal and transthoracic esophagectomy for cancerQ44448365
Epidermal growth factor receptor, p53 mutation, and pathological response predict survival in patients with locally advanced esophageal cancer treated with preoperative chemoradiotherapy.Q44705891
Polymorphisms of the AURKA (STK15/Aurora Kinase) Gene and Breast Cancer Risk (United States).Q45299793
Multicenter phase II trial of preoperative induction chemotherapy followed by chemoradiation with docetaxel and cisplatin for locally advanced esophageal carcinoma (SAKK 75/02).Q45998771
En bloc esophagectomy reduces local recurrence and improves survival compared with transhiatal resection after neoadjuvant therapy for esophageal adenocarcinomaQ46165349
Bile acid alone, or in combination with acid, induces CDX2 expression through activation of the epidermal growth factor receptor (EGFR).Q46316834
Pilot study of gefitinib, oxaliplatin, and radiotherapy for esophageal adenocarcinoma: tissue effect predicts clinical responseQ46322646
Prevalence and location of nodal metastases in distal esophageal adenocarcinoma confined to the wall: implications for therapyQ46605436
Surgery alone versus chemoradiotherapy followed by surgery for resectable cancer of the oesophagus: a randomised controlled phase III trial.Q46675470
P433issue12
P407language of work or nameEnglishQ1860
P921main subjectadenocarcinomaQ356033
P304page(s)3304-3314
P577publication date2010-03-19
P1433published inDigestive Diseases and SciencesQ15716711
P1476titleEsophageal adenocarcinoma: treatment modalities in the era of targeted therapy
P478volume55

Reverse relations

cites work (P2860)
Q53394190Association of HOTAIR expression with PI3K/Akt pathway activation in adenocarcinoma of esophagogastric junction.
Q54342465Clinicopathological and prognostic significance of epidermal growth factor receptor overexpression in patients with esophageal adenocarcinoma: a meta-analysis.
Q37593285Integrated molecular analysis reveals complex interactions between genomic and epigenomic alterations in esophageal adenocarcinomas
Q35043996Prognostic importance and therapeutic implications of PAK1, a drugable protein kinase, in gastroesophageal junction adenocarcinoma
Q35159395Screening and selection of peptides specific for esophageal cancer cells from a phage display peptide library
Q27026253Signaling pathways in the molecular pathogenesis of adenocarcinomas of the esophagus and gastroesophageal junction
Q36763844Three-gene immunohistochemical panel adds to clinical staging algorithms to predict prognosis for patients with esophageal adenocarcinoma

Search more.