Early stage transplantation of bone marrow cells markedly ameliorates copper metabolism and restores liver function in a mouse model of Wilson disease

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Early stage transplantation of bone marrow cells markedly ameliorates copper metabolism and restores liver function in a mouse model of Wilson disease is …
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scholarly articleQ13442814

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P6179Dimensions Publication ID1018558721
P356DOI10.1186/1471-230X-11-75
P932PMC publication ID3141753
P698PubMed publication ID21676234

P2093author name stringXi Chen
Songlin Chen
Zhong Pei
Shihui Xing
Yanqing Feng
Xiuling Liang
Chuhuai Wang
P2860cites workClinical presentation, diagnosis and long-term outcome of Wilson's disease: a cohort studyQ24679692
Anterograde tracing method using DiI to label vagal innervation of the embryonic and early postnatal mouse gastrointestinal tractQ24684676
Morphologic and chemical studies on a murine mutation (toxic milk mice) resulting in hepatic copper toxicosisQ28513165
Defective localization of the Wilson disease protein (ATP7B) in the mammary gland of the toxic milk mouse and the effects of copper supplementationQ28592976
Diminution of toxic copper accumulation in toxic milk mice modeling Wilson disease by embryonic hepatocyte intrasplenic transplantationQ33217543
Study of copper metabolism and liver damage in TX Mice-an animal model for liver diseaseQ33507192
Cell transplantation after oxidative hepatic preconditioning with radiation and ischemia-reperfusion leads to extensive liver repopulationQ34191819
The Wilson disease gene is a putative copper transporting P-type ATPase similar to the Menkes geneQ34348941
Stem and progenitor cells: origins, phenotypes, lineage commitments, and transdifferentiationsQ34425181
Human cord blood stem cells generate human cytokeratin 18-negative hepatocyte-like cells in injured mouse liverQ35085099
Kinetics of liver repopulation after bone marrow transplantation.Q35747636
Innervation of the gastrointestinal tract: patterns of agingQ36099657
Liver transplantation for metabolic liver diseases in adults: indications and outcomeQ36949474
Correction of copper metabolism is not sustained long term in Wilson's disease mice post bone marrow transplantation.Q37278160
Bone marrow as a potential source of hepatic oval cellsQ38501137
Liver transplantation for Wilson's disease: indications and outcomeQ40720647
Liver transplantation for Wilson's disease: The burden of neurological and psychiatric disordersQ43687446
Normal hepatocytes correct serum bilirubin after repopulation of Gunn rat liver subjected to irradiation/partial resectionQ44080040
Cell fusion is the principal source of bone-marrow-derived hepatocytesQ44383220
Transplanted bone marrow regenerates liver by cell fusionQ44383224
Metal-catalyzed oxidation of extracellular matrix components perturbs hepatocyte survival with activation of intracellular signaling pathwaysQ44673150
Development of cell therapy strategies to overcome copper toxicity in the LEC rat model of Wilson diseaseQ45875560
The potential of bone marrow stem cells to correct liver dysfunction in a mouse model of Wilson's diseaseQ45881061
Human mesenchymal stem cells xenografted directly to rat liver are differentiated into human hepatocytes without fusion.Q46427722
Fluorescent double-labeling with carbocyanine neuronal tracing and immunohistochemistry using a cholesterol-specific detergent digitoninQ46449929
Hematopoietic stem cells convert into liver cells within days without fusionQ47631908
Chronological changes in tissue copper, zinc and iron in the toxic milk mouse and effects of copper loadingQ48435325
Reversal of severe neurological manifestations of Wilson's disease following orthotopic liver transplantationQ68232154
Measurement of ceruloplasmin from its oxidase activity in serum by use of o-dianisidine dihydrochlorideQ68352170
The toxic milk mutation, tx, which results in a condition resembling Wilson disease in humans, is linked to mouse chromosome 8Q71150725
Altered gene expression in the liver of gamma-glutamyl transpeptidase-deficient miceQ74228259
Early cell transplantation in LEC rats modeling Wilson's disease eliminates hepatic copper with reversal of liver diseaseQ77607518
The canals of hering might represent a target of methotrexate hepatic toxicityQ79780244
P921main subjectWilson diseaseQ117121
P304page(s)75
P577publication date2011-06-15
P1433published inBMC GastroenterologyQ15759922
P1476titleEarly stage transplantation of bone marrow cells markedly ameliorates copper metabolism and restores liver function in a mouse model of Wilson disease
P478volume11

Reverse relations

Q35399294Transplantation of ATP7B-transduced bone marrow mesenchymal stem cells decreases copper overload in ratscites workP2860