Insulin inhibits human erythrocyte cAMP accumulation and ATP release: role of phosphodiesterase 3 and phosphoinositide 3-kinase

scientific article

Insulin inhibits human erythrocyte cAMP accumulation and ATP release: role of phosphodiesterase 3 and phosphoinositide 3-kinase is …
instance of (P31):
scholarly articleQ13442814

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P356DOI10.1258/EBM.2009.009206
P932PMC publication ID2892266
P698PubMed publication ID20404042
P5875ResearchGate publication ID43201412

P2093author name stringAlan H Stephenson
Elizabeth A Bowles
Madelyn S Hanson
Randy S Sprague
P2860cites workReduced exercise arteriovenous O2 difference in Type 2 diabetesQ51687699
Red blood cell regulation of microvascular tone through adenosine triphosphate.Q54056545
Deformation-induced ATP release from red blood cells requires CFTR activity.Q54117015
Phosphorylation of PDE3B by Phosphatidylinositol 3-Kinase Associated with the Insulin ReceptorQ59466721
Characteristics of human erythrocyte insulin receptorsQ67341307
Structure of the human erythrocyte insulin receptorQ68857327
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ATP: the red blood cell link to NO and local control of the pulmonary circulationQ71978359
Essential role of phosphatidylinositol 3-kinase in insulin-induced activation and phosphorylation of the cGMP-inhibited cAMP phosphodiesterase in rat adipocytes. Studies using the selective inhibitor wortmanninQ72150649
Studies on adenosine 3′,5′-monophosphate phosphodiesterase of human erythrocyte membranesQ72864661
Ontogeny of catecholamine and adenosine receptor-mediated cAMP signaling of embryonic red blood cells: role of cGMP-inhibited phosphodiesterase 3 and hemoglobinQ73254143
Insulin stimulates NHE1 activity by sequential activation of phosphatidylinositol 3-kinase and protein kinase C zeta in human erythrocytesQ73442542
Insulin-induced phosphorylation and activation of phosphodiesterase 3B in rat adipocytes: possible role for protein kinase B but not mitogen-activated protein kinase or p70 S6 kinaseQ74013266
Differential modulation of adenylyl cyclases I and II by various G beta subunitsQ74088857
Reduced expression of G(i) in erythrocytes of humans with type 2 diabetes is associated with impairment of both cAMP generation and ATP releaseQ79386804
Japanese IGT subjects with high insulin response are far more frequently associated with the metabolic syndrome than those with low insulin responseQ79755164
Iloprost- and isoproterenol-induced increases in cAMP are regulated by different phosphodiesterases in erythrocytes of both rabbits and humansQ24316393
Phosphodiesterase 3 is present in rabbit and human erythrocytes and its inhibition potentiates iloprost-induced increases in cAMPQ24336559
Erythrocytes: oxygen sensors and modulators of vascular toneQ24653317
Insulin sensitivity and Lp(alpha) concentrations in normoglycemic offspring of type 2 diabetic parentsQ24796609
Cyclic nucleotide phosphodiesterase (PDE) superfamily: A new target for the development of specific therapeutic agentsQ27991377
Insulin-induced phosphorylation and activation of cyclic nucleotide phosphodiesterase 3B by the serine-threonine kinase AktQ28511947
Functional role of phosphodiesterase 3 in cardiomyocyte apoptosis: implication in heart failureQ28579532
The red blood cell as an oxygen sensor: what is the evidence?Q33888508
Insulin inhibits low oxygen-induced ATP release from human erythrocytes: implication for vascular controlQ34003283
Regulation and function of the cyclic nucleotide phosphodiesterase (PDE3) gene familyQ34070572
Defects in microvascular haemodynamics during prediabetes: contributor or epiphenomenon?Q34111033
Cilostazol (pletal): a dual inhibitor of cyclic nucleotide phosphodiesterase type 3 and adenosine uptakeQ34519649
Microvascular vasodilatation in feet of newly diagnosed non-insulin dependent diabetic patientsQ35179319
Red blood cell-derived ATP as a regulator of skeletal muscle perfusionQ35621214
Do we need to target 'prediabetic' hypertensive patients?Q36306242
Relationship of insulin resistance to microvascular dysfunction in subjects with fasting hyperglycaemiaQ36848310
Red not dead: signaling in and from erythrocytesQ36981005
Loss of epinephrine stimulated synthesis of cyclic adenosine 3':5' monophosphate during maturation of rabbit and human reticulocytesQ39948922
Apparent multiple forms of cyclic AMP phosphodiesterase from rat erythrocytesQ40007877
Microvascular function in human diabetes. A physiological perspectiveQ40550044
Hormonal stimulation of adenylyl cyclase through Gi-protein beta gamma subunitsQ41635276
Regulation of skeletal muscle perfusion during exerciseQ41760246
Phosphoinositide 3-kinase: the key switch mechanism in insulin signallingQ42991205
Role of erythrocyte in regulating local O2 delivery mediated by hemoglobin oxygenationQ43610552
Receptor-mediated activation of the heterotrimeric G-protein Gs results in ATP release from erythrocytesQ43658728
Participation of cAMP in a signal-transduction pathway relating erythrocyte deformation to ATP releaseQ43730250
Dynamics of microvascular oxygen pressure during rest-contraction transition in skeletal muscle of diabetic ratsQ44103904
Estimated number of adults with prediabetes in the US in 2000: opportunities for preventionQ44333422
Heterotrimeric G protein Giis involved in a signal transduction pathway for ATP release from erythrocytesQ44654252
Cyclic nucleotide phosphodiesterase activity in the plasma and erythrocytes of normal and diabetic ratsQ44664290
NO inhibits signal transduction pathway for ATP release from erythrocytes via its action on heterotrimeric G protein Gi.Q44836445
Impaired endothelium-dependent and independent vasodilation in patients with type 2 (non-insulin-dependent) diabetes mellitusQ44895987
Predictors of and longitudinal changes in insulin sensitivity and secretion preceding onset of type 2 diabetesQ45199153
Isolated impaired fasting glucose and peripheral insulin sensitivity: not a simple relationshipQ46686470
Rabbit erythrocytes possess adenylyl cyclase type II that is activated by the heterotrimeric G proteins Gs and Gi.Q46895879
Human erythrocytes contain Ca2+, calmodulin-dependent cyclic nucleotide phosphodiesterase which is involved in the hydrolysis of cGMP.Q47694797
Regulation of Gi and Go by mastoparan, related amphiphilic peptides, and hydrophobic amines. Mechanism and structural determinants of activityQ48916036
Reduced microvascular hyperaemia in subjects at risk of developing type 2 (non-insulin-dependent) diabetes mellitus.Q51596790
P433issue2
P921main subjectpreproinsulinQ7240673
human erythrocyteQ111535219
P304page(s)256-262
P577publication date2010-02-01
P1433published inExperimental Biology and MedicineQ15716535
P1476titleInsulin inhibits human erythrocyte cAMP accumulation and ATP release: role of phosphodiesterase 3 and phosphoinositide 3-kinase
P478volume235

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cites work (P2860)
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Q35055216Cyclic phosphatidic acid stimulates cAMP production and inhibits growth in human colon cancer cells
Q33917040Defects in oxygen supply to skeletal muscle of prediabetic ZDF rats
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Q37781833Erythrocytes as controllers of perfusion distribution in the microvasculature of skeletal muscle
Q37723601Kinetics of extracellular ATP in mastoparan 7-activated human erythrocytes
Q58728940Leptin Stimulates Cellular Glycolysis Through a STAT3 Dependent Mechanism in Tilapia
Q43499334Liposomal delivery of a phosphodiesterase 3 inhibitor rescues low oxygen-induced ATP release from erythrocytes of humans with type 2 diabetes
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Q48238409Mechanisms of C-peptide-mediated rescue of low O2-induced ATP release from erythrocytes of humans with type 2 diabetes.
Q39295378Purinergic control of red blood cell metabolism: novel strategies to improve red cell storage quality
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Q36005577Vascular disease in pre-diabetes: new insights derived from systems biology

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