Fusogenic selectivity of the envelope glycoprotein is a major determinant of human immunodeficiency virus type 1 tropism for CD4+ T-cell lines vs. primary macrophages

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Fusogenic selectivity of the envelope glycoprotein is a major determinant of human immunodeficiency virus type 1 tropism for CD4+ T-cell lines vs. primary macrophages is …
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scholarly articleQ13442814

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P819ADS bibcode1995PNAS...92.9004B
P356DOI10.1073/PNAS.92.19.9004
P932PMC publication ID41096
P698PubMed publication ID7568061
P5875ResearchGate publication ID15631179

P2093author name stringBerger EA
Broder CC
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Proteinase-resistant factors in human erythrocyte membranes mediate CD4-dependent fusion with cells expressing human immunodeficiency virus type 1 envelope glycoproteinsQ35832208
Spontaneous substitutions in the vicinity of the V3 analog affect cell tropism and pathogenicity of simian immunodeficiency virusQ36632673
The "V3" domain is a determinant of simian immunodeficiency virus cell tropism.Q36634149
Fusogenic mechanisms of enveloped-virus glycoproteins analyzed by a novel recombinant vaccinia virus-based assay quantitating cell fusion-dependent reporter gene activation.Q36634800
Infection of macrophages with lymphotropic human immunodeficiency virus type 1 can be arrested after viral DNA synthesisQ36654734
Phenotypic heterogeneity in a panel of infectious molecular human immunodeficiency virus type 1 clones derived from a single individualQ36684257
Macrophage-tropic human immunodeficiency virus isolates from different patients exhibit unusual V3 envelope sequence homogeneity in comparison with T-cell-tropic isolates: definition of critical amino acids involved in cell tropismQ36685201
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Regulated expression of foreign genes in vaccinia virus under the control of bacteriophage T7 RNA polymerase and the Escherichia coli lac repressorQ36697418
Viral determinants of human immunodeficiency virus type 1 T-cell or macrophage tropism, cytopathogenicity, and CD4 antigen modulationQ36783052
Human immunodeficiency virus type 1 T-cell tropism is determined by events prior to provirus formationQ36783797
Removal of cryptic poxvirus transcription termination signals from the human immunodeficiency virus type 1 envelope gene enhances expression and immunogenicity of a recombinant vaccinia virus.Q36806386
Identification of human immunodeficiency virus envelope gene sequences influencing viral entry into CD4-positive HeLa cells, T-leukemia cells, and macrophagesQ36820658
Host range, replicative, and cytopathic properties of human immunodeficiency virus type 1 are determined by very few amino acid changes in tat and gp120Q36828914
Identification of a determinant within the human immunodeficiency virus 1 surface envelope glycoprotein critical for productive infection of primary monocytesQ37476959
Identification of the envelope V3 loop as the primary determinant of cell tropism in HIV-1.Q39090316
In vitro differentiation of monocytoid THP-1 cells affects their permissiveness for HIV strains: a model system for studying the cellular basis of HIV differential tropismQ39248709
Restricted replication of simian immunodeficiency virus strain 239 in macrophages is determined by env but is not due to restricted entryQ39268974
HIV-1 tropism for mononuclear phagocytes can be determined by regions of gp120 outside the CD4-binding domainQ39313963
Distinctive pattern of infection and replication of HIV1 strains in blood-derived macrophagesQ39437630
Complementation of murine cells for human immunodeficiency virus envelope/CD4-mediated fusion in human/murine heterokaryonsQ40066675
Changing virus-host interactions in the course of HIV-1 infection.Q40569848
Transmission and pathogenesis of human immunodeficiency virus type 1.Q40693335
Cellular and viral determinants that regulate HIV-1 infection in macrophages.Q40701539
Evaluation of viral membrane fusion assays. Comparison of the octadecylrhodamine dequenching assay with the pyrene excimer assayQ41519776
Early replication steps but not cell type-specific signalling of the viral long terminal repeat determine HIV-1 monocytotropismQ41544138
Role of the fusion peptide sequence in initial stages of influenza hemagglutinin-induced cell fusion.Q41554310
Macrophage and T cell-line tropisms of HIV-1 are determined by specific regions of the envelope gp120 geneQ41699910
Use of a new CD4-positive HeLa cell clone for direct quantitation of infectious human immunodeficiency virus from blood cells of AIDS patientsQ41702349
Human genes other than CD4 facilitate HIV-1 infection of murine cellsQ41702917
Virus-cell membrane fusion does not predict efficient infection of alveolar macrophages by human immunodeficiency virus type 1 (HIV-1)Q44452517
Lipid-anchored influenza hemagglutinin promotes hemifusion, not complete fusionQ44633908
Simian immunodeficiency virus (SIVmac251) membrane lipid mixing with human CD4+ and CD4- cell lines in vitro does not necessarily result in internalization of the viral core proteins and productive infectionQ45772967
Expression of foreign genes in cultured human primary macrophages using recombinant vaccinia virus vectorsQ45778331
Nucleotide sequence and expression of an AIDS-associated retrovirus (ARV-2).Q48381924
The block to HIV-1 envelope glycoprotein-mediated membrane fusion in animal cells expressing human CD4 can be overcome by a human cell component(s)Q70573568
P433issue19
P407language of work or nameEnglishQ1860
P921main subjectmacrophageQ184204
P304page(s)9004-9008
P577publication date1995-09-01
P1433published inProceedings of the National Academy of Sciences of the United States of AmericaQ1146531
P1476titleFusogenic selectivity of the envelope glycoprotein is a major determinant of human immunodeficiency virus type 1 tropism for CD4+ T-cell lines vs. primary macrophages
P478volume92

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