Microvolt T-wave alternans physiological basis, methods of measurement, and clinical utility--consensus guideline by International Society for Holter and Noninvasive Electrocardiology

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Microvolt T-wave alternans physiological basis, methods of measurement, and clinical utility--consensus guideline by International Society for Holter and Noninvasive Electrocardiology is …
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review articleQ7318358
scholarly articleQ13442814

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P356DOI10.1016/J.JACC.2011.06.029
P932PMC publication ID4111570
P698PubMed publication ID21920259
P5875ResearchGate publication ID51645037

P50authorStefan H HohnloserQ110902934
Derek ExnerQ123189909
P2093author name stringTuomo Nieminen
David S Rosenbaum
Sanjiv M Narayan
Marek Malik
Richard L Verrier
Takanori Ikeda
Nabil El-Sherif
Thomas Klingenheben
Juan Pablo Martínez
P2860cites workMicrovolt T-Wave Alternans and the Risk of Death or Sustained Ventricular Arrhythmias in Patients With Left Ventricular DysfunctionQ29039536
Prediction of fatal or near-fatal cardiac arrhythmia events in patients with depressed left ventricular function after an acute myocardial infarctionQ29040770
T-wave alternans predicts mortality in a population undergoing a clinically indicated exercise testQ29041029
Microvolt T-Wave Alternans Distinguishes Between Patients Likely and Patients Not Likely to Benefit From Implanted Cardiac Defibrillator Therapy: A Solution to the Multicenter Automatic Defibrillator Implantation Trial (MADIT) II ConundrumQ29308392
Sudden cardiac death prediction and prevention: report from a National Heart, Lung, and Blood Institute and Heart Rhythm Society WorkshopQ30433543
Criteria for evaluation of novel markers of cardiovascular risk: a scientific statement from the American Heart AssociationQ30434464
Demonstration of the proarrhythmic preconditioning of single premature extrastimuli by use of the magnitude, phase, and distribution of repolarization alternansQ30650497
T wave alternans does not assess arrhythmic risk in patients with Brugada syndrome.Q33151283
Spontaneous T wave alternans in a patient with Brugada syndrome--responses to intravenous administration of class I antiarrhythmic drug, glucose tolerance test, and atrial pacingQ33152355
Are implantable cardioverter defibrillator shocks a surrogate for sudden cardiac death in patients with nonischemic cardiomyopathy?Q33153551
Microvolt t-wave alternans with exercise in pediatrics and congenital heart disease: limitations and predictive valueQ33154119
Predictive value of microvolt T-wave alternans in patients with left ventricular dysfunction.Q33155317
Influence of QRS duration on the prognostic value of T wave alternansQ74730709
Electrophysiological basis of arrhythmogenicity of QT/T alternans in the long-QT syndrome: tridimensional analysis of the kinetics of cardiac repolarizationQ77315003
T-wave alternans as a predictor for sudden cardiac death after myocardial infarctionQ77456447
Onset heart rate of microvolt-level T-wave alternans provides clinical and prognostic value in nonischemic dilated cardiomyopathyQ77480649
Exercise is superior to pacing for T wave alternans measurement in subjects with chronic coronary artery disease and left ventricular dysfunctionQ78375753
Progressive increases in complexity of T-wave oscillations herald ischemia-induced ventricular fibrillationQ78390793
Predictive value of microvolt T-wave alternans for sudden cardiac death in patients with preserved cardiac function after acute myocardial infarction: results of a collaborative cohort studyQ79425794
Endocardial and epicardial repolarization alternans in human cardiomyopathy: evidence for spatiotemporal heterogeneity and correlation with body surface T-wave alternansQ79615285
Noninvasive risk assessment early after a myocardial infarction the REFINE studyQ80167370
Effect of bundle branch block on microvolt T-wave alternans and electrophysiologic testing in patients with ischemic cardiomyopathyQ80544620
Spinal cord stimulation affects T-wave alternans in patients with ischaemic cardiomyopathy: a pilot studyQ80868909
Dichotomizing continuous predictors in multiple regression: a bad ideaQ81336757
Noninvasive risk stratification of subjects with a Brugada-type electrocardiogram and no history of cardiac arrestQ81414753
Quantitative assessment of microvolt T-wave alternans in patients with congestive heart failureQ81831322
American Heart Association/American College of Cardiology Foundation/Heart Rhythm Society Scientific Statement on Noninvasive Risk Stratification Techniques for Identifying Patients at Risk for Sudden Cardiac Death. A scientific statement from the AQ82010700
Importance of regional specificity of T-wave alternans in assessing risk for cardiovascular mortality and sudden cardiac death during routine exercise testingQ82345413
Antifibrillatory effect of ranolazine during severe coronary stenosis in the intact porcine modelQ82540123
The ABCD (Alternans Before Cardioverter Defibrillator) Trial: strategies using T-wave alternans to improve efficiency of sudden cardiac death preventionQ83300940
Time-domain T-wave alternans measured from Holter electrocardiograms predicts cardiac mortality in patients with left ventricular dysfunction: a prospective studyQ83404815
Do Beta-blockers impact microvolt T-wave alternans testing in patients at risk for ventricular arrhythmias? A meta-analysisQ84043221
Ambulatory ECG-based T-wave alternans and heart rate turbulence predict high risk of arrhythmic events in patients with old myocardial infarctionQ84742429
Clinical significance of macroscopic T-wave alternans after sodium channel blocker administration in patients with Brugada syndromeQ33155579
Intracardiac alternans compared to surface T-wave alternans as a predictor of ventricular arrhythmias in humansQ33156413
The validity of the Finnish Hospital Discharge Register and Causes of Death Register data on coronary heart diseaseQ33213147
Association of Holter-based measures including T-wave alternans with risk of sudden cardiac death in the community-dwelling elderly: the Cardiovascular Health StudyQ33798688
Rate-dependent action potential alternans in human heart failure implicates abnormal intracellular calcium handlingQ34021051
Prevention of torsade de pointes in hospital settings: a scientific statement from the American Heart Association and the American College of Cardiology FoundationQ34100661
Eplerenone, a selective aldosterone blocker, in patients with left ventricular dysfunction after myocardial infarctionQ34187441
Sudden death due to cardiac arrhythmiasQ34496008
Upsurge in T-wave alternans and nonalternating repolarization instability precedes spontaneous initiation of ventricular tachyarrhythmias in humans.Q34539968
Metoprolol-induced reduction in postinfarction mortality: pooled results from five double-blind randomized trialsQ34550514
Usefulness of microvolt T-wave alternans on predicting outcome in patients with ischemic cardiomyopathy with and without defibrillatorsQ34581868
Does microvolt T-wave alternans testing predict ventricular tachyarrhythmias in patients with ischemic cardiomyopathy and prophylactic defibrillators? The MASTER (Microvolt T Wave Alternans Testing for Risk Stratification of Post-Myocardial InfarctiQ34599944
Interpretation and classification of microvolt T wave alternans testsQ34657147
Microvolt T-wave alternans for the risk stratification of ventricular tachyarrhythmic events: a meta-analysisQ36181613
T-wave alternans and the susceptibility to ventricular arrhythmiasQ36368212
Mechanisms of calcium transient and action potential alternans in cardiac cells and tissuesQ36977081
Action potential dynamics explain arrhythmic vulnerability in human heart failure: a clinical and modeling study implicating abnormal calcium handlingQ37037251
Basis for sudden cardiac death prediction by T-wave alternans from an integrative physiology perspectiveQ37167055
Heart rate turbulence: standards of measurement, physiological interpretation, and clinical use: International Society for Holter and Noninvasive Electrophysiology Consensus.Q37304888
Impact of sleep on arrhythmogenesisQ37349197
Explaining the clinical manifestations of T wave alternans in patients at risk for sudden cardiac deathQ37377073
Heart failure enhances susceptibility to arrhythmogenic cardiac alternansQ37393007
Risk stratification for sudden death in patients with coronary artery diseaseQ37494978
Noninvasive risk stratification after myocardial infarction: rationale, current evidence and the need for definitive trialsQ37517247
Appropriate evaluation and treatment of heart failure patients after implantable cardioverter-defibrillator discharge: time to go beyond the initial shock.Q37635420
Anger-induced T-wave alternans predicts future ventricular arrhythmias in patients with implantable cardioverter-defibrillatorsQ37691447
Microvolt T-wave alternans, peak oxygen consumption, and outcome in patients with severely impaired left ventricular systolic function.Q37727121
T-wave alternans as a therapeutic marker for antiarrhythmic agentsQ37765792
Alternans and arrhythmias: from cell to heartQ37826594
Noninvasive arrhythmia risk stratification in idiopathic dilated cardiomyopathy: results of the Marburg Cardiomyopathy StudyQ40548860
Modified moving average analysis of T-wave alternans to predict ventricular fibrillation with high accuracyQ40665980
Combined assessment of T-wave alternans and late potentials used to predict arrhythmic events after myocardial infarction. A prospective studyQ40774059
Role of microvolt T-wave alternans in assessment of arrhythmia vulnerability among patients with heart failure and systolic dysfunction: primary results from the T-wave alternans sudden cardiac death in heart failure trial substudyQ41773480
Maintenance of intercellular coupling by the antiarrhythmic peptide rotigaptide suppresses arrhythmogenic discordant alternansQ42636318
Assessment of microvolt T-wave alternans in high-risk patients with the congenital long-QT syndrome.Q43694805
Effect of metoprolol and d,l-sotalol on microvolt-level T-wave alternans. Results of a prospective, double-blind, randomized studyQ43818876
Microvolt T-wave alternans as a predictor of ventricular tachyarrhythmias: a prospective study using atrial pacingQ43965330
Long-term benefit of primary prevention with an implantable cardioverter-defibrillator: an extended 8-year follow-up study of the Multicenter Automatic Defibrillator Implantation Trial II.Q44025163
Evidence regarding clinical use of microvolt T-wave alternansQ44150063
Predicting arrhythmia-free survival using spectral and modified-moving average analyses of T-wave alternansQ44388270
High prevalence of cardiac autonomic dysfunction and T-wave alternans in dialysis patientsQ44577936
Relation between Microvolt-Level T-Wave Alternans and cardiac sympathetic nervous system abnormality using iodine-123 metaiodobenzylguanidine imaging in patients with Idiopathic Dilated cardiomyopathyQ44616026
Effects of selective autonomic blockade on T-wave alternans in humansQ45712793
Ambulatory ECG-based T-wave alternans predicts sudden cardiac death in high-risk post-MI patients with left ventricular dysfunction in the EPHESUS studyQ46296932
Usefulness of microvolt T-wave alternans to predict outcomes in patients with ischemic cardiomyopathy beyond one yearQ47444514
Sleep apnoea induces cardiac electrical instability assessed by T-wave alternans in patients with congestive heart failureQ48383713
Quantification of ischaemia induced vulnerability by precordial T wave alternans analysis in dog and humanQ49144098
Ambulatory electrocardiogram-based tracking of T wave alternans in postmyocardial infarction patients to assess risk of cardiac arrest or arrhythmic death.Q50763646
Tracking cardiac electrical instability by computing interlead heterogeneity of T-wave morphology.Q50763868
Dynamic tracking of cardiac vulnerability by complex demodulation of the T wave.Q50796726
Prognostic value of T-wave alternans in patients with heart failure due to nonischemic cardiomyopathy: results of the ALPHA Study.Q50871374
Microvolt T-wave alternans identifies patients with ischemic cardiomyopathy who benefit from implantable cardioverter-defibrillator therapy.Q51088140
ACC/AHA/ESC 2006 guidelines for management of patients with ventricular arrhythmias and the prevention of sudden cardiac death: a report of the American College of Cardiology/American Heart Association Task Force and the European Society of CardioloQ51137889
Prognostic utility of microvolt T-wave alternans in risk stratification of patients with ischemic cardiomyopathy.Q51207701
Characterization of repolarization alternans during ischemia: time-course and spatial analysis.Q51230595
Methodological principles of T wave alternans analysis: a unified framework.Q51504307
Prediction of sudden cardiac death in patients after acute myocardial infarction using T-wave alternans: a prospective study.Q51531920
Enhanced detection of arrhythmia vulnerability using T wave alternans, left ventricular ejection fraction, and programmed ventricular stimulation: a prospective study in subjects with chronic ischemic heart disease.Q51700685
Enhanced predictive power of quantitative TWA during routine exercise testing in the Finnish Cardiovascular Study.Q51853647
"Indeterminate" microvolt T-wave alternans tests predict high risk of death or sustained ventricular arrhythmias in patients with left ventricular dysfunction.Q51932482
Mechanism of discordant T wave alternans in the in vivo heart.Q52012232
Combined assessment of heart rate recovery and T-wave alternans during routine exercise testing improves prediction of total and cardiovascular mortality: the Finnish Cardiovascular Study.Q53793465
Sudden Death in Patients with Myocardial Infarction and Left Ventricular Dysfunction, Heart Failure, or BothQ57396339
Post-Exercise Assessment of Cardiac Repolarization Alternans in Patients With Coronary Artery Disease Using the Modified Moving Average MethodQ57417461
A Multilead Scheme Based on Periodic Component Analysis for T-Wave Alternans Analysis in the ECGQ57559995
Prognostic Significance of Risk Stratifiers of Mortality, Including T Wave Alternans, After Acute Myocardial Infarction: Results of a Prospective Follow-Up StudyQ57914811
Guidelines for the interpretation of the neonatal electrocardiogramQ58010911
Electrocardiographic Prediction of Abnormal Genotype in Congenital Long QT Syndrome: Experience in 101 Related Family MembersQ58010947
Baroreflex sensitivity and heart-rate variability in prediction of total cardiac mortality after myocardial infarctionQ58011025
Electrical alternation of the T-wave: Clinical and experimental evidence of its relationship with the sympathetic nervous system and with the long Q-T syndromeQ58011829
Temporal Variations in Microvolt T-Wave Alternans Testing after Acute Myocardial InfarctionQ63508791
Electrical alternans and cardiac electrical instabilityQ68248564
Significance of discordant ST alternans in ventricular fibrillationQ68606416
Potent antifibrillatory effect of combined blockade of calcium channels and 5-HT2 receptors with nexopamil during myocardial ischemia and reperfusion in dogs: comparison to diltiazemQ71410386
Electrical alternans and vulnerability to ventricular arrhythmiasQ72684261
A comparison of T-wave alternans, signal averaged electrocardiography and programmed ventricular stimulation for arrhythmia risk stratificationQ73321670
Usefulness of microvolt T-wave alternans for prediction of ventricular tachyarrhythmic events in patients with dilated cardiomyopathy: results from a prospective observational studyQ73562122
T-wave alternans negative coronary patients with low ejection and benefit from defibrillator implantationQ73681965
Optimal target heart rate for exercise-induced T-wave alternansQ73828571
Incidence of T wave alternation after acute myocardial infarction and correlation with other prognostic parameters: results of a prospective studyQ74188131
Predictive value of T-wave alternans for arrhythmic events in patients with congestive heart failureQ74252421
Microvolt T wave alternans in human cardiac hypertrophy: electrical instability and abnormal myocardial arrangementQ74254384
Influence of heart rate and sympathetic stimulation on arrhythmogenic T wave alternansQ74332496
Short-term reproducibility of T wave alternans measurementQ74516288
P433issue13
P407language of work or nameEnglishQ1860
P921main subjectmicrovoltQ1916026
P304page(s)1309-1324
P577publication date2011-09-01
P1433published inJournal of the American College of CardiologyQ2984355
P1476titleMicrovolt T-wave alternans physiological basis, methods of measurement, and clinical utility--consensus guideline by International Society for Holter and Noninvasive Electrocardiology
P478volume58

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