Tumor-suppressive functions of 15-Lipoxygenase-2 and RB1CC1 in prostate cancer

scientific article

Tumor-suppressive functions of 15-Lipoxygenase-2 and RB1CC1 in prostate cancer is …
instance of (P31):
scholarly articleQ13442814

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P356DOI10.4161/CC.28757
P932PMC publication ID4111726
P698PubMed publication ID24732589
P5875ResearchGate publication ID261735170

P50authorDingxiao ZhangQ42247868
P2093author name stringDean G Tang
John DiGiovanni
Mark Badeaux
John R Moore
Mahipal V Suraneni
Donna Kusewitt
Marc D Macaluso
P2860cites workDifferential characteristics of human 15-lipoxygenase isozymes and a novel splice variant of 15S-lipoxygenaseQ22010728
Identification of amino acid determinants of the positional specificity of mouse 8S-lipoxygenase and human 15S-lipoxygenase-2Q22011034
Evidence that arachidonate 15-lipoxygenase 2 is a negative cell cycle regulator in normal prostate epithelial cellsQ24292284
Subcellular Localization and Tumor-suppressive Functions of 15-Lipoxygenase 2 (15-LOX2) and Its Splice VariantsQ24300188
Discovery of a second 15S-lipoxygenase in humansQ24336768
The microRNA miR-34a inhibits prostate cancer stem cells and metastasis by directly repressing CD44Q24617130
Crucial role of p53-dependent cellular senescence in suppression of Pten-deficient tumorigenesisQ24681977
Identification of RB1CC1, a novel human gene that can induce RB1 in various human cellsQ28202104
Truncating mutations of RB1CC1 in human breast cancerQ28204953
c-MYC: more than just a matter of life and deathQ28205057
RB1CC1 suppresses cell cycle progression through RB1 expression in human neoplastic cellsQ28208056
Neuromuscular abundance of RB1CC1 contributes to the non-proliferating enlarged cell phenotype through both RB1 maintenance and TSC1 degradationQ28253890
Molecular cloning and functional expression of a phorbol ester-inducible 8S-lipoxygenase from mouse skinQ28510563
Integrative genomic profiling of human prostate cancerQ29619905
Integrative molecular concept modeling of prostate cancer progression.Q33266777
RB1CC1 activates RB1 pathway and inhibits proliferation and cologenic survival in human cancerQ33627736
15-lipoxygenase-2 (15-LOX-2) is expressed in benign prostatic epithelium and reduced in prostate adenocarcinomaQ33867006
Cooperativity of Nkx3.1 and Pten loss of function in a mouse model of prostate carcinogenesis.Q34014956
Downregulation of vascular endothelial growth factor and induction of tumor dormancy by 15-lipoxygenase-2 in prostate cancerQ34033679
Evidence that Sp1 positively and Sp3 negatively regulate and androgen does not directly regulate functional tumor suppressor 15-lipoxygenase 2 (15-LOX2) gene expression in normal human prostate epithelial cellsQ34332767
Lipoxygenase modulation to reverse carcinogenesis.Q34346656
15-lipoxygenase 2 (15-LOX2) is a functional tumor suppressor that regulates human prostate epithelial cell differentiation, senescence, and growth (size).Q34590246
Effect of 15-lipoxygenase metabolites, 15-(S)-HPETE and 15-(S)-HETE on chronic myelogenous leukemia cell line K-562: reactive oxygen species (ROS) mediate caspase-dependent apoptosisQ34630569
Nuclear MYC protein overexpression is an early alteration in human prostate carcinogenesisQ35207795
Prostate pathology of genetically engineered mice: definitions and classification. The consensus report from the Bar Harbor meeting of the Mouse Models of Human Cancer Consortium Prostate Pathology Committee.Q35693712
FIP200, a key signaling node to coordinately regulate various cellular processesQ36515638
Prostate cancer stem/progenitor cells: identification, characterization, and implications.Q36572143
In vivo functional studies of tumor-specific retrogene NanogP8 in transgenic animalsQ37344789
The new stereological tools: disector, fractionator, nucleator and point sampled intercepts and their use in pathological research and diagnosis.Q39540612
RB1CC1 activates the p16 promoter through the interaction with hSNF5.Q39743172
Critical and distinct roles of p16 and telomerase in regulating the proliferative life span of normal human prostate epithelial progenitor cells.Q39956460
RB1CC1 activates the promoter and expression of RB1 in human cancer.Q39980189
Sex-determining region Y box 4 is a transforming oncogene in human prostate cancer cellsQ40291759
Suppression of Myc-induced apoptosis in beta cells exposes multiple oncogenic properties of Myc and triggers carcinogenic progression.Q40731052
Elevated expression of 12/15-lipoxygenase and cyclooxygenase-2 in a transgenic mouse model of prostate carcinomaQ42440649
Transgenic expression of 15-lipoxygenase 2 (15-LOX2) in mouse prostate leads to hyperplasia and cell senescenceQ42472293
Cell-autonomous induction of functional tumor suppressor 15-lipoxygenase 2 (15-LOX2) contributes to replicative senescence of human prostate progenitor cellsQ42475181
A small composite probasin promoter confers high levels of prostate-specific gene expression through regulation by androgens and glucocorticoids in vitro and in vivoQ42496913
Nkx3.1; Pten mutant mice develop invasive prostate adenocarcinoma and lymph node metastasesQ44521056
Myc-driven murine prostate cancer shares molecular features with human prostate tumorsQ45049671
Evidence that senescent human prostate epithelial cells enhance tumorigenicity: cell fusion as a potential mechanism and inhibition by p16INK4a and hTERT.Q53326362
Immortalization of primary human prostate epithelial cells by c-Myc.Q53359625
LRIG1 and the liar paradox in prostate cancer: A study of the expression and clinical significance of LRIG1 in prostate cancerQ60651155
Role of hydroperoxyeicosatetraenoic acids in oxidative stress-induced activating protein 1 (AP-1) activityQ71763053
Reduced 15-lipoxygenase-2 immunostaining in prostate adenocarcinoma: correlation with grade and expression in high-grade prostatic intraepithelial neoplasiaQ73028655
Nuclear volume estimates in prostatic atypical adenomatous hyperplasiaQ73369390
Reversible activation of c-Myc in skin: induction of a complex neoplastic phenotype by a single oncogenic lesionQ77847672
P433issue11
P921main subjectprostate cancerQ181257
P1104number of pages13
P304page(s)1798-1810
P577publication date2014-04-14
P1433published inCell CycleQ1254166
P1476titleTumor-suppressive functions of 15-Lipoxygenase-2 and RB1CC1 in prostate cancer
P478volume13

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cites work (P2860)
Q38838622Antineoplastic effects of 15(S)-hydroxyeicosatetraenoic acid and 13-S-hydroxyoctadecadienoic acid in non-small cell lung cancer.
Q49334906Comparison of the expression of TGF-β1, E-cadherin, N-cadherin, TP53, RB1CC1 and HIF-1α in oral squamous cell carcinoma and lymph node metastases of humans and mice
Q39104480Cross-Talk between Cancer Cells and the Tumour Microenvironment: The Role of the 5-Lipoxygenase Pathway.
Q48226915Different Lipid Regulation in Ovarian Cancer: Inhibition of the Immune System.
Q40134213Genome-wide association study of clinical parameters in immunoglobulin light chain amyloidosis in three patient cohorts.
Q40757101Involvement of 15-lipoxygenase-1 in the regulation of breast cancer cell death induced by sodium butyrate
Q92105279Regulation and Functions of 15-Lipoxygenases in Human Macrophages
Q42626453Strict Regiospecificity of Human Epithelial 15-Lipoxygenase-2 Delineates Its Transcellular Synthesis Potential
Q49231491Transcriptomic features of primary prostate cancer and their prognostic relevance to castration-resistant prostate cancer
Q42750079Tumor-suppressing 15-lipoxygenase-2: time for prime time?
Q91750471Up-regulation of 15-lipoxygenase enzymes and products in functional and non-functional pituitary adenomas

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