Targeting TRPV1 as an alternative approach to narcotic analgesics to treat chronic pain conditions

scientific article

Targeting TRPV1 as an alternative approach to narcotic analgesics to treat chronic pain conditions is …
instance of (P31):
review articleQ7318358
scholarly articleQ13442814

External links are
P6179Dimensions Publication ID1036223701
P356DOI10.1208/S12248-010-9196-Y
P932PMC publication ID2895451
P698PubMed publication ID20440589
P5875ResearchGate publication ID44571456

P2093author name stringLouis S Premkumar
P2860cites workAn ankyrin-like protein with transmembrane domains is specifically lost after oncogenic transformation of human fibroblastsQ22009055
Cellular basis of itch sensationQ22337064
The capsaicin receptor: a heat-activated ion channel in the pain pathwayQ24322558
Pungent products from garlic activate the sensory ion channel TRPA1Q24529826
Acid-sensing ion channel 3 matches the acid-gated current in cardiac ischemia-sensing neuronsQ24544425
Deletion of vanilloid receptor 1-expressing primary afferent neurons for pain controlQ24568208
Pathological and protective roles of glia in chronic painQ24646738
TRPV1: a target for next generation analgesicsQ24649067
TRP channel activation by reversible covalent modificationQ24677242
Vanilloid receptor-1 is essential for inflammatory thermal hyperalgesiaQ28144926
P2X receptors in sensory neuronesQ28144989
Pain mechanisms: labeled lines versus convergence in central processingQ28185812
painless, a Drosophila Gene Essential for NociceptionQ28198237
Molecular mechanisms of nociceptionQ28216291
Mechanisms of opioid-induced tolerance and hyperalgesiaQ28242425
The TRPV1 receptor and nociceptionQ28281263
Transient receptor potential cation channels in diseaseQ28284143
Opioid-receptor mRNA expression in the rat CNS: anatomical and functional implicationsQ28287619
TRP channels: targets for the relief of painQ28290040
Body-temperature maintenance as the predominant function of the vanilloid receptor TRPV1Q28294635
Opioid-induced hyperalgesia: a qualitative systematic reviewQ28299687
TRPV1 antagonists: the challenges for therapeutic targetingQ28304644
TRPA1 contributes to cold, mechanical, and chemical nociception but is not essential for hair-cell transductionQ28505709
TRPA1 mediates the inflammatory actions of environmental irritants and proalgesic agentsQ28508162
Impaired nociception and pain sensation in mice lacking the capsaicin receptorQ28511370
TRPA1 induced in sensory neurons contributes to cold hyperalgesia after inflammation and nerve injuryQ28769527
Neuronal plasticity: increasing the gain in painQ29615421
Noxious compounds activate TRPA1 ion channels through covalent modification of cysteinesQ29615510
BDNF from microglia causes the shift in neuronal anion gradient underlying neuropathic painQ29616106
Noxious cold ion channel TRPA1 is activated by pungent compounds and bradykininQ29616107
Vanilloid (Capsaicin) receptors and mechanismsQ29617371
Arterial response to shear stress critically depends on endothelial TRPV4 expressionQ30833847
Tonic descending facilitation from the rostral ventromedial medulla mediates opioid-induced abnormal pain and antinociceptive tolerance.Q31813611
Incomplete cross tolerance and multiple mu opioid peptide receptorsQ31887588
Selective targeting of TRPV1 expressing sensory nerve terminals in the spinal cord for long lasting analgesiaQ33503225
Spinal endocannabinoids and CB1 receptors mediate C-fiber-induced heterosynaptic pain sensitization.Q33716248
Mechanisms of painQ33946821
Physiologic and antinociceptive effects of intrathecal resiniferatoxin in a canine bone cancer modelQ33991000
Neurogenic inflammation. A model for studying efferent actions of sensory nervesQ46247803
Level of Toll-like receptor agonist exposure differentially determines chemokine production in humansQ46305481
A-425619 [1-isoquinolin-5-yl-3-(4-trifluoromethyl-benzyl)-urea], a novel and selective transient receptor potential type V1 receptor antagonist, blocks channel activation by vanilloids, heat, and acidQ46443695
Clinical response to morphine in cancer patients and genetic variation in candidate genesQ46653217
Tonic endovanilloid facilitation of glutamate release in brainstem descending antinociceptive pathways.Q46852210
Hearing impairment in TRPV4 knockout miceQ48878721
Revisiting TRPC1 and TRPC6 mechanosensitivity.Q50660189
Release of gamma-aminobutyric acid in the dorsal horn and suppression of tactile allodynia by spinal cord stimulation in mononeuropathic rats.Q51565601
Behavioral and autonomic correlates of the tactile evoked allodynia produced by spinal glycine inhibition: effects of modulatory receptor systems and excitatory amino acid antagonistsQ69349896
Myelinated afferent fibres responding specifically to noxious stimulation of the skinQ72291143
Pronounced changes in the activity of nociceptive modulatory neurons in the rostral ventromedial medulla in response to prolonged thermal noxious stimuliQ72374035
Ectopic sensory discharges and paresthesiae in patients with disorders of peripheral nerves, dorsal roots and dorsal columnsQ72407089
Hyperexcitability at sites of nerve injury depends on voltage-sensitive Na+ channelsQ72816452
Rapid sprouting of sympathetic axons in dorsal root ganglia of rats with a chronic constriction injuryQ73337716
Involvement of increased excitatory amino acids and intracellular Ca2+ concentration in the spinal dorsal horn in an animal model of neuropathic painQ73574695
Bradykinin activates a cross-signaling pathway between sensory and adrenergic nerve endings in the heart: a novel mechanism of ischemic norepinephrine release?Q78016259
Antisense knock down of TRPA1, but not TRPM8, alleviates cold hyperalgesia after spinal nerve ligation in ratsQ82873313
TRP channels and painQ83830678
TRPV1+ sensory neurons control beta cell stress and islet inflammation in autoimmune diabetesQ34001477
Neuronal plasticity and signal transduction in nociceptive neurons: implications for the initiation and maintenance of pathological painQ34132344
The kallikrein-kinin system: current and future pharmacological targets.Q34452928
The neurobiology of opioid dependence: implications for treatmentQ34787830
Transient receptor potential channels: targeting pain at the sourceQ34912798
Dissociation of the opioid receptor mechanisms that control mechanical and heat painQ34986633
CB2 cannabinoid receptor agonists: pain relief without psychoactive effects?Q35054351
Mechanosensation and painQ35884821
Preventing the development of complex regional pain syndrome after surgeryQ35927947
The mechanosensitive nature of TRPV channelsQ36134906
Molecular mechanisms of neuropathic pain-phenotypic switch and initiation mechanismsQ36197310
Interleukin-1 and neuronal injuryQ36202191
Synaptic modulation in pain pathways.Q36214190
Spinal and supraspinal contributions to central sensitization in peripheral neuropathyQ36281892
Mu opioid receptor regulation and opiate responsivenessQ36341679
Influence of TRPV1 on diabetes-induced alterations in thermal pain sensitivityQ36509492
The emerging role of TRP channels in mechanisms of temperature and pain sensationQ36726641
The vanilloid receptor TRPV1: 10 years from channel cloning to antagonist proof-of-conceptQ36803753
TRP channel and cardiovascular diseaseQ37174911
Pharmacological blockade of TRPA1 inhibits mechanical firing in nociceptorsQ37190540
Transient receptor potential A1 is a sensory receptor for multiple products of oxidative stressQ37258131
Molecular mechanisms of TRPV4-mediated neural signalingQ37348481
Roles of transient receptor potential channels in painQ37388690
Hot flash: TRPV channels in the brain.Q37414701
Synaptic plasticity in the spinal dorsal hornQ37476040
TRP channel antagonists for pain--opportunities beyond TRPV1.Q37541918
The sensory-efferent function of capsaicin-sensitive sensory neuronsQ39631475
Importance of the non-selective cation channel TRPV1 for microglial reactive oxygen species generation.Q39812135
Pain, nociception and spinal opioid receptorsQ40096837
Insights into opioid action in the intestinal tractQ41293298
Hypotonic shocks activate rat TRPV4 in yeast in the absence of polyunsaturated fatty acids.Q41872715
Capsaicin receptor TRPV1 in urothelium of neurogenic human bladders and effect of intravesical resiniferatoxin.Q42474245
Evidence for a functional role of endothelial transient receptor potential V4 in shear stress-induced vasodilatationQ42494772
TRPA1 modulates mechanotransduction in cutaneous sensory neurons.Q42555945
Opioid action on respiratory neuron activity of the isolated respiratory network in newborn ratsQ43749680
PGE(2) selectively blocks inhibitory glycinergic neurotransmission onto rat superficial dorsal horn neuronsQ43820595
Cardiac vanilloid receptor 1-expressing afferent nerves and their role in the cardiogenic sympathetic reflex in ratsQ44493505
Putative role of epithelial sodium channels (ENaC) in the afferent limb of cardio renal reflexes in ratsQ44615499
Sensory nerve desensitization by resiniferatoxin improves glucose tolerance and increases insulin secretion in Zucker Diabetic Fatty rats and is associated with reduced plasma activity of dipeptidyl peptidase IV.Q45284220
P433issue3
P407language of work or nameEnglishQ1860
P921main subjectchronic painQ1088113
P304page(s)361-370
P577publication date2010-05-04
P1433published inThe AAPS JournalQ10695361
P1476titleTargeting TRPV1 as an alternative approach to narcotic analgesics to treat chronic pain conditions
P478volume12

Reverse relations

cites work (P2860)
Q40979775A Combined Water Extract of Frankincense and Myrrh Alleviates Neuropathic Pain in Mice via Modulation of TRPV1.
Q24620790A genome-wide Drosophila screen for heat nociception identifies α2δ3 as an evolutionarily conserved pain gene
Q35216840Activation characteristics of transient receptor potential ankyrin 1 and its role in nociception
Q39588200Assessment of Free Drug Concentration in Cyclodextrin Formulations Is Essential to Determine Drug Potency in Functional In Vitro Assays.
Q33967275Capsaicin induces "brite" phenotype in differentiating 3T3-L1 preadipocytes
Q37937444Current and emerging "at-site" pain medications: a review
Q97882666Efficacy of intermittent epidural dexamethasone bolus for zoster-associated pain beyond the acute phase
Q41566415Expression-dependent pharmacology of transient receptor potential vanilloid subtype 1 channels in Xenopus laevis oocytes
Q26801569Herpes Zoster and Postherpetic Neuralgia: Practical Consideration for Prevention and Treatment
Q28681983How Far Could We Go with Open Data - A Case Study for TRPV1 Antagonists
Q35894592Hunting for origins of migraine pain: cluster analysis of spontaneous and capsaicin-induced firing in meningeal trigeminal nerve fibers.
Q58770772Identification of key genes and pathways involved in response to pain in goat and sheep by transcriptome sequencing
Q39265748Is electrical brain activity a reliable biomarker for opioid analgesia in the gut?
Q35690123Modulation of spinal cord synaptic activity by tumor necrosis factor α in a model of peripheral neuropathy
Q39023266Novel scaffolds for modulation of TRPV1 identified with pharmacophore modeling and virtual screening.
Q37937421Perineural invasion and associated pain in pancreatic cancer
Q50111328Potential Uses of Isolated Toxin Peptides in Neuropathic Pain Relief: A Literature Review
Q49609102Preclinical characterization of three transient receptor potential vanilloid receptor 1 antagonists for early use in human intradermal microdose analgesic studies.
Q36819550Preservation of acute pain and efferent functions following intrathecal resiniferatoxin-induced analgesia in rats
Q35168721Streptozotocin-induced early thermal hyperalgesia is independent of glycemic state of rats: role of transient receptor potential vanilloid 1(TRPV1) and inflammatory mediators
Q38984941TRP channels: potential drug target for neuropathic pain
Q48701369TRPV1 channels regulate cortical excitability in humans
Q28741571Transient receptor potential channel polymorphisms are associated with the somatosensory function in neuropathic pain patients

Search more.