De novo synthesis of sphingolipids is required for cell survival by down-regulating c-Jun N-terminal kinase in Drosophila imaginal discs

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De novo synthesis of sphingolipids is required for cell survival by down-regulating c-Jun N-terminal kinase in Drosophila imaginal discs is …
instance of (P31):
scholarly articleQ13442814

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P356DOI10.1128/MCB.19.10.7276
P932PMC publication ID84720
P698PubMed publication ID10490662
P5875ResearchGate publication ID12808884

P2093author name stringT Gotoh
M Tateno
Y Nishida
H Date
T Onuki
T Adachi-Yamada
I Sugimura
P2860cites workDistortion of proximodistal information causes JNK-dependent apoptosis in Drosophila wingQ59087678
Mutant strains of Saccharomyces cerevisiae lacking sphingolipids synthesize novel inositol glycerophospholipids that mimic sphingolipid structuresQ70527469
puckered, a gene involved in position-specific cell differentiation in the dorsal epidermis of the Drosophila larvaQ72104089
Isolation of Sphingoethanolamine from Pupae of the Green-Bottle Fly, Lucilia caesarQ72182718
cis-4-Methylsphingosine decreases sphingolipid biosynthesis by specifically interfering with serine palmitoyltransferase activity in primary cultured neuronsQ73427505
KSR, a novel protein kinase required for RAS signal transductionQ24310039
Endothelial apoptosis in Braf-deficient miceQ24314857
Basic local alignment search toolQ25938991
Targeted gene expression as a means of altering cell fates and generating dominant phenotypesQ27861039
The LCB2 gene of Saccharomyces and the related LCB1 gene encode subunits of serine palmitoyltransferase, the initial enzyme in sphingolipid synthesisQ27930467
Characterization of enzymatic synthesis of sphingolipid long-chain bases in Saccharomyces cerevisiae: mutant strains exhibiting long-chain-base auxotrophy are deficient in serine palmitoyltransferase activityQ27932869
RNA polymerase II subunit RPB3 is an essential component of the mRNA transcription apparatusQ27936059
Suppressors of the Ca(2+)-sensitive yeast mutant (csg2) identify genes involved in sphingolipid biosynthesis. Cloning and characterization of SCS1, a gene required for serine palmitoyltransferase activity.Q27939364
Human and murine serine-palmitoyl-CoA transferase--cloning, expression and characterization of the key enzyme in sphingolipid synthesisQ28114891
The role of RhoA in tissue polarity and Frizzled signallingQ28238365
Signal transduction by the c-Jun N-terminal kinase (JNK)--from inflammation to developmentQ28268881
Ceramide synthase mediates daunorubicin-induced apoptosis: An alternative mechanism for generating death signalsQ28295232
Serine palmitoyltransferase is the primary target of a sphingosine-like immunosuppressant, ISP-1/myriocinQ28304023
Kinase suppressor of Ras is ceramide-activated protein kinaseQ28307245
Mice with disrupted GM2/GD2 synthase gene lack complex gangliosides but exhibit only subtle defects in their nervous systemQ28587493
A mammalian homolog of the yeast LCB1 encodes a component of serine palmitoyltransferase, the enzyme catalyzing the first step in sphingolipid synthesisQ28587825
KSR modulates signal propagation within the MAPK cascadeQ28609154
MAPKs: new JNK expands the groupQ28611010
Dishevelled activates JNK and discriminates between JNK pathways in planar polarity and wingless signalingQ28616347
Opposing effects of ERK and JNK-p38 MAP kinases on apoptosisQ29547567
An LFA-3 cDNA encodes a phospholipid-linked membrane protein homologous to its receptor CD2Q29614365
Lambda replacement vectors carrying polylinker sequencesQ29616529
JNK, cytoskeletal regulator and stress response kinase? A Drosophila perspectiveQ33536856
Ras promotes cell survival in Drosophila by downregulating hid expressionQ47070193
A protein kinase similar to MAP kinase activator acts downstream of the raf kinase in DrosophilaQ47070200
A JNK signal transduction pathway that mediates morphogenesis and an immune response in DrosophilaQ47070626
A gain-of-function mutation in Drosophila MAP kinase activates multiple receptor tyrosine kinase signaling pathwaysQ47070874
The head involution defective gene of Drosophila melanogaster functions in programmed cell deathQ47070937
The Drosophila Jun-N-terminal kinase is required for cell morphogenesis but not for DJun-dependent cell fate specification in the eye.Q47071054
Drosophila Jun relays the Jun amino-terminal kinase signal transduction pathway to the Decapentaplegic signal transduction pathway in regulating epithelial cell sheet movementQ47071191
Drosophila Jun kinase regulates expression of decapentaplegic via the ETS-domain protein Aop and the AP-1 transcription factor DJun during dorsal closureQ47071626
hemipterous encodes a novel Drosophila MAP kinase kinase, required for epithelial cell sheet movement.Q47071857
Fumonisins: fungal toxins that shed light on sphingolipid functionQ47986534
Structures of P transposable elements and their sites of insertion and excision in the Drosophila melanogaster genomeQ48397128
Myelination in the absence of galactocerebroside and sulfatide: normal structure with abnormal function and regional instability.Q48960653
Argos induces programmed cell death in the developing Drosophila eye by inhibition of the Ras pathway.Q52177955
MAP kinase in situ activation atlas during Drosophila embryogenesis.Q52192419
Common and distinct roles of DFos and DJun during Drosophila development.Q52192438
In situ activation pattern of Drosophila EGF receptor pathway during development.Q52192958
Coupling of Jun amino-terminal kinase and Decapentaplegic signaling pathways in Drosophila morphogenesis.Q52193889
decapentaplegic overexpression affects Drosophila wing and leg imaginal disc development and wingless expression.Q52200622
Polar Glycosphingolipids in Insect: Chemical Structures of Glycosphingolipid Series Containing 2′-Aminoethylphosphoryl-(→6)-N-Acetylglucosamine as a Polar Group from Larvae of the Green-Bottle Fly, Lucilia caesar1Q52445875
Cell death in normal and rough eye mutants of DrosophilaQ52446358
Pattern-specific expression of the Drosophila decapentaplegic gene in imaginal disks is regulated by 3' cis-regulatory elements.Q52449820
Decapentaplegic: a gene complex affecting morphogenesis in Drosophila melanogaster.Q52503275
Mutations causing pattern deficiencies and duplications in the imaginal wing disk of Drosophila melanogaster.Q52526646
Cyclin E controls S phase progression and its down-regulation during Drosophila embryogenesis is required for the arrest of cell proliferation.Q52543351
The sevenless signalling cassette mediates Drosophila EGF receptor function during epidermal development.Q52543419
Pattern formation in a secondary field: a hierarchy of regulatory genes subdivides the developing Drosophila wing disc into discrete subregions.Q52544814
Local induction of patterning and programmed cell death in the developing Drosophila retina.Q52563414
Gene disruptions using P transposable elements: an integral component of the Drosophila genome projectQ33737040
A conserved p38 mitogen-activated protein kinase pathway regulates Drosophila immunity gene expressionQ33774350
A stable genomic source of P element transposase in Drosophila melanogaster.Q33953857
The genetics of a small autosomal region of Drosophila melanogaster containing the structural gene for alcohol dehydrogenase. VII. Characterization of the region around the snail and cactus lociQ33957166
p38 mitogen-activated protein kinase can be involved in transforming growth factor beta superfamily signal transduction in Drosophila wing morphogenesisQ33957563
P-lacW insertional mutagenesis on the second chromosome of Drosophila melanogaster: isolation of lethals with different overgrowth phenotypesQ33961577
Dominant mutations of Drosophila MAP kinase kinase and their activities in Drosophila and yeast MAP kinase cascadesQ33969955
cDNA cloning of a germ cell specific lamin B3 from mouse spermatocytes and analysis of its function by ectopic expression in somatic cells.Q34040617
Biosynthesis of phosphoinositol-containing sphingolipids from phosphatidylinositol by a membrane preparation from Saccharomyces cerevisiae.Q34133878
Phospholipid signalingQ34317077
Sphingolipid synthesis: identification and characterization of mammalian cDNAs encoding the Lcb2 subunit of serine palmitoyltransferaseQ34407688
Searching for pattern and mutation in the Drosophila genome with a P-lacZ vectorQ34457701
Insertional mutagenesis of the Drosophila genome with single P elementsQ36312073
Functional cDNA libraries from Drosophila embryosQ36438705
Phenotypic and molecular characterization of SerD, a dominant allele of the Drosophila gene Serrate.Q36698907
MKK7 is a stress-activated mitogen-activated protein kinase kinase functionally related to hemipterous.Q36884483
The Drosophila rolled locus encodes a MAP kinase required in the sevenless signal transduction pathway.Q37630688
Genetic and molecular analyses of mutations involved in Drosophila raf signal transductionQ37633011
An update of the enzymology and regulation of sphingomyelin metabolismQ37923512
Genetic control of programmed cell death in DrosophilaQ38468332
Sphingolipid long-chain-base auxotrophs of Saccharomyces cerevisiae: genetics, physiology, and a method for their selectionQ39933726
The phosphoinositol sphingolipids of Saccharomyces cerevisiae are highly localized in the plasma membraneQ39941568
Cloning and characterization of LCB1, a Saccharomyces gene required for biosynthesis of the long-chain base component of sphingolipidsQ39942299
puckered encodes a phosphatase that mediates a feedback loop regulating JNK activity during dorsal closure in DrosophilaQ40442820
Diversity in function and regulation of MAP kinase pathwaysQ40695933
The sphingomyelin cycle and the second messenger function of ceramide.Q40713913
The sphingomyelin pathway in tumor necrosis factor and interleukin-1 signalingQ40751632
Lipid second messengersQ40751641
The MAP kinase cascade is essential for diverse signal transduction pathwaysQ40853991
The Drosophila gene hid is a direct molecular target of Ras-dependent survival signalingQ40995001
Molecular cloning and characterization of a Drosophila p38 mitogen-activated protein kinaseQ41067708
Protein kinase cascades activated by stress and inflammatory cytokinesQ41075765
Complete removal of sphingolipids from the plasma membrane disrupts cell to substratum adhesion of mouse melanoma cellsQ41191999
Requirement for ceramide-initiated SAPK/JNK signalling in stress-induced apoptosis.Q41218044
Requirement of an ICE-like protease for induction of apoptosis and ceramide generation by REAPER.Q41228922
Dual roles of sphingolipids in signaling of the escape from and onset of apoptosis in a mouse cytotoxic T-cell line, CTLL-2.Q41238109
Functions of ceramide in coordinating cellular responses to stressQ41243489
JNK signaling and morphogenesis in Drosophila.Q41692516
Sphingolipids are essential for the growth of Chinese hamster ovary cells. Restoration of the growth of a mutant defective in sphingoid base biosynthesis by exogenous sphingolipidsQ42805556
Sphingolipid biosynthesis in cultured neurons. Down-regulation of serine palmitoyltransferase by sphingoid basesQ44266466
Glycosphingolipids in insects. The amphoteric moiety, N-acetylglucosamine-linked phosphoethanolamine, distinguishes a group of ceramide oligosaccharides from the pupae of Calliphora vicina (Insecta: Diptera).Q44646556
Subcellular localization and membrane topology of serine palmitoyltransferase, 3-dehydrosphinganine reductase, and sphinganine N-acyltransferase in mouse liverQ45365052
Localized cell death caused by mutations in a Drosophila gene coding for a transforming growth factor-beta homologQ46665353
Drosophila homologs of baculovirus inhibitor of apoptosis proteins function to block cell deathQ46725238
Expression of baculovirus P35 prevents cell death in DrosophilaQ46962065
P433issue10
P407language of work or nameEnglishQ1860
P921main subjectDrosophilaQ312154
sphingolipidsQ410395
Lace Dmel_CG4162Q29813911
P304page(s)7276-7286
P577publication date1999-10-01
P1433published inMolecular and Cellular BiologyQ3319478
P1476titleDe novo synthesis of sphingolipids is required for cell survival by down-regulating c-Jun N-terminal kinase in Drosophila imaginal discs
P478volume19

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cites work (P2860)
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