Limited redundancy in genes regulated by Cyclin T2 and Cyclin T1.

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Limited redundancy in genes regulated by Cyclin T2 and Cyclin T1. is …
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scholarly articleQ13442814

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P6179Dimensions Publication ID1000186296
P356DOI10.1186/1756-0500-4-260
P932PMC publication ID3160394
P698PubMed publication ID21791050
P5875ResearchGate publication ID51522865

P50authorAndrew P RiceQ55277928
P2093author name stringRajesh Ramakrishnan
Wendong Yu
P2860cites worksiRNA depletion of 7SK snRNA induces apoptosis but does not affect expression of the HIV-1 LTR or P-TEFb-dependent cellular genesQ81190993
Cyclin T1 but not cyclin T2a is induced by a post-transcriptional mechanism in PAMP-activated monocyte-derived macrophagesQ81579403
55K isoform of CDK9 associates with Ku70 and is involved in DNA repairQ24314522
Identification of multiple cyclin subunits of human P-TEFbQ24317025
The human immunodeficiency virus Tat proteins specifically associate with TAK in vivo and require the carboxyl-terminal domain of RNA polymerase II for functionQ24682531
Accuracy of cDNA microarray methods to detect small gene expression changes induced by neuregulin on breast epithelial cellsQ24797824
MAPPFinder: using Gene Ontology and GenMAPP to create a global gene-expression profile from microarray dataQ24804397
Evaluation of methods for oligonucleotide array data via quantitative real-time PCRQ25257085
DAVID: Database for Annotation, Visualization, and Integrated DiscoveryQ27499374
Systematic and integrative analysis of large gene lists using DAVID bioinformatics resourcesQ27860739
P-TEFb containing cyclin K and Cdk9 can activate transcription via RNAQ28205857
Cell cycle kinases as therapeutic targets for cancerQ28250447
Regulation of TAK/P-TEFb in CD4+ T lymphocytes and macrophagesQ28253165
Controlling the elongation phase of transcription with P-TEFbQ28255518
Multi-modal proteomic analysis of retinal protein expression alterations in a rat model of diabetic retinopathyQ28476732
MyoD recruits the cdk9/cyclin T2 complex on myogenic-genes regulatory regionsQ28589051
A chromatin landmark and transcription initiation at most promoters in human cellsQ29547180
Rational siRNA design for RNA interferenceQ29614450
Cyclin T1-dependent genes in activated CD4 T and macrophage cell lines appear enriched in HIV-1 co-factorsQ33367106
miR-198 inhibits HIV-1 gene expression and replication in monocytes and its mechanism of action appears to involve repression of cyclin T1Q33400321
Tat-associated kinase, TAK, activity is regulated by distinct mechanisms in peripheral blood lymphocytes and promonocytic cell linesQ33786066
Antiapoptotic function of Cdk9 (TAK/P-TEFb) in U937 promonocytic cellsQ33836069
Chronic insulin treatment of diabetes does not fully normalize alterations in the retinal transcriptomeQ33901377
Flavopiridol inhibits P-TEFb and blocks HIV-1 replicationQ33910799
T-loop phosphorylated Cdk9 localizes to nuclear speckle domains which may serve as sites of active P-TEFb function and exchange between the Brd4 and 7SK/HEXIM1 regulatory complexes.Q33922921
Flavopiridol inactivates P-TEFb and blocks most RNA polymerase II transcription in vivoQ34082542
Inhibiting HIV-1 infection in human T cells by lentiviral-mediated delivery of small interfering RNA against CCR5.Q34169244
A role for CDK9-cyclin K in maintaining genome integrityQ34621011
Cyclin T: three forms for different roles in physiological and pathological functionsQ35031398
The Yin and Yang of P-TEFb regulation: implications for human immunodeficiency virus gene expression and global control of cell growth and differentiationQ35072999
CDK-9/cyclin T (P-TEFb) is required in two postinitiation pathways for transcription in the C. elegans embryoQ35780509
Transcription inhibition by flavopiridol: mechanism of chronic lymphocytic leukemia cell deathQ35848241
Inhibition of HIV-1 replication by P-TEFb inhibitors DRB, seliciclib and flavopiridol correlates with release of free P-TEFb from the large, inactive form of the complexQ35940053
Host-cell positive transcription elongation factor b kinase activity is essential and limiting for HIV type 1 replicationQ36390969
Direct inhibition of CDK9 blocks HIV-1 replication without preventing T-cell activation in primary human peripheral blood lymphocytesQ36419687
Inhibition of human immunodeficiency virus type 1 replication by RNA interference directed against human transcription elongation factor P-TEFb (CDK9/CyclinT1).Q36954414
Mechanism of action of SNS-032, a novel cyclin-dependent kinase inhibitor, in chronic lymphocytic leukemiaQ37187536
RNA-driven cyclin-dependent kinase regulation: when CDK9/cyclin T subunits of P-TEFb meet their ribonucleoprotein partners.Q37226677
Cyclin T2 is essential for mouse embryogenesis.Q37233387
Selective control of gene expression by CDK9 in human cellsQ37437860
Induction of the HIV-1 Tat co-factor cyclin T1 during monocyte differentiation is required for the regulated expression of a large portion of cellular mRNAs.Q38518336
Effects of prostratin on Cyclin T1/P-TEFb function and the gene expression profile in primary resting CD4+ T cellsQ38557763
Control of inducible gene expression by signal-dependent transcriptional elongationQ39285490
Accuracy and calibration of commercial oligonucleotide and custom cDNA microarraysQ39607930
Transient induction of cyclin T1 during human macrophage differentiation regulates human immunodeficiency virus type 1 Tat transactivation function.Q39685314
Xylocydine, a novel Cdk inhibitor, is an effective inducer of apoptosis in hepatocellular carcinoma cells in vitro and in vivo.Q45925933
Phosphorylated positive transcription elongation factor b (P-TEFb) is tagged for inhibition through association with 7SK snRNA.Q46675052
Cyclin T1 expression is regulated by multiple signaling pathways and mechanisms during activation of human peripheral blood lymphocytesQ46792411
Indirubin-3'-monoxime, a derivative of a Chinese antileukemia medicine, inhibits P-TEFb function and HIV-1 replicationQ46801294
P275copyright licenseCreative Commons Attribution 2.0 GenericQ19125117
P6216copyright statuscopyrightedQ50423863
P4510describes a project that usesImageJQ1659584
P304page(s)260
P577publication date2011-07-26
P1433published inBMC Research NotesQ15762797
P1476titleLimited redundancy in genes regulated by Cyclin T2 and Cyclin T1
P478volume4

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cites work (P2860)
Q28511857Activation and function of murine Cyclin T2A and Cyclin T2B during skeletal muscle differentiation
Q39385318Flavopiridol induces phosphorylation of AKT in a human glioblastoma cell line, in contrast to siRNA-mediated silencing of Cdk9: Implications for drug design and development.
Q41274276Identification of novel CDK9 and Cyclin T1-associated protein complexes (CCAPs) whose siRNA depletion enhances HIV-1 Tat function
Q36850296Inhibition of HIV-1 transcription and replication by a newly identified cyclin T1 splice variant.
Q38091888Lost in transcription: molecular mechanisms that control HIV latency
Q36274198MD simulation of the Tat/Cyclin T1/CDK9 complex revealing the hidden catalytic cavity within the CDK9 molecule upon Tat binding
Q38212042Making a Short Story Long: Regulation of P-TEFb and HIV-1 Transcriptional Elongation in CD4+ T Lymphocytes and Macrophages.
Q35826285Regulation of cyclin T1 and HIV-1 Replication by microRNAs in resting CD4+ T lymphocytes.

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