Targeted gene sequencing identifies variants in the protein C and endothelial protein C receptor genes in patients with unprovoked venous thromboembolism

scientific article

Targeted gene sequencing identifies variants in the protein C and endothelial protein C receptor genes in patients with unprovoked venous thromboembolism is …
instance of (P31):
scholarly articleQ13442814

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P356DOI10.1161/ATVBAHA.113.302137
P932PMC publication ID4115806
P698PubMed publication ID24051141
P5875ResearchGate publication ID256836798

P50authorJeffrey I. WeitzQ29561411
P2093author name stringCynthia Wu
Clive Kearon
David Ginsburg
Dhruva J Dwivedi
Laura Pepler
Patricia C Liaw
Jim Julian
Zakhar Lysov
Karl Desch
John Waye
P2860cites workIdentification, cloning, and regulation of a novel endothelial cell protein C/activated protein C receptorQ24323189
The crystal structure of the endothelial protein C receptor and a bound phospholipidQ27639046
Identification of the protein C/activated protein C binding sites on the endothelial cell protein C receptor. Implications for a novel mode of ligand recognition by a major histocompatibility complex class 1-type receptorQ28139028
A 23bp insertion in the endothelial protein C receptor (EPCR) gene impairs EPCR functionQ28202832
Prevalence of a 23bp insertion in exon 3 of the endothelial cell protein C receptor gene in venous thrombophiliaQ28214512
Endothelial cell protein C receptor plays an important role in protein C activation in vivoQ28628837
Mutation nomenclature extensions and suggestions to describe complex mutations: a discussionQ29616531
Common vs. rare allele hypotheses for complex diseasesQ34038820
Disruption of the endothelial cell protein C receptor gene in mice causes placental thrombosis and early embryonic lethality.Q34148383
Protein C activators from snake venoms and their diagnostic use.Q34574878
A genome-wide association study of venous thromboembolism identifies risk variants in chromosomes 1q24.2 and 9q.Q36166323
Shifting paradigm of association studies: value of rare single-nucleotide polymorphismsQ36477625
Prophylaxis and treatment of venous thromboembolism in individuals with inherited thrombophilia.Q36685162
The endothelial cell protein C receptor augments protein C activation by the thrombin-thrombomodulin complex.Q37331775
A genome-wide association study for venous thromboembolism: the extended cohorts for heart and aging research in genomic epidemiology (CHARGE) consortiumQ37708719
Beta protein C is not glycosylated at asparagine 329. The rate of translation may influence the frequency of usage at asparagine-X-cysteine sitesQ38340035
Protein-C: biochemistry, physiology, and clinical implicationsQ40138549
Regulated endothelial protein C receptor shedding is mediated by tumor necrosis factor-alpha converting enzyme/ADAM17.Q40199261
The Ser219-->Gly dimorphism of the endothelial protein C receptor contributes to the higher soluble protein levels observed in individuals with the A3 haplotypeQ40330593
Selective modulation of protein C affinity for EPCR and phospholipids by Gla domain mutation.Q40474485
Activation mechanism of anticoagulant protein C in large blood vessels involving the endothelial cell protein C receptorQ41043951
Glycosylation of human protein C affects its secretion, processing, functional activities, and activation by thrombinQ41683621
Plasma levels of endothelial protein C receptor respond to anticoagulant treatment.Q43847726
Comparison of low-intensity warfarin therapy with conventional-intensity warfarin therapy for long-term prevention of recurrent venous thromboembolismQ44548746
Influence of thrombophilia on risk of recurrent venous thromboembolism while on warfarin: results from a randomized trialQ46368145
Common susceptibility alleles are unlikely to contribute as strongly as the FV and ABO loci to VTE risk: results from a GWAS approach.Q51773327
Mutations which introduce free cysteine residues in the Gla-domain of vitamin K dependent proteins result in the formation of complexes with alpha 1-microglobulin.Q52520223
Fast functional protein C assay using Protac, a novel protein C activator.Q54017734
The Protein C PathwayQ56502503
A simple, automated functional assay for protein CQ69672746
Compound heterozygous protein C deficiency resulting in the presence of only the beta-form of protein C in plasmaQ71571067
Bimodal distribution of soluble endothelial protein C receptor levels in healthy populationsQ73690764
The endothelial cell protein C receptorQ73818060
Prevalence of the 23bp endothelial protein C receptor (EPCR) gene insertion in the Irish populationQ74091017
The endothelial protein C receptor (EPCR) 23 bp insert mutation and the risk of venous thrombosisQ74553517
Endothelial cell protein C receptor (EPCR) gene exon III, 23 bp insertion mutation in the Turkish pediatric thrombotic patientsQ78800642
Inherited thrombophilia and venous thromboembolismQ79197431
A haplotype of the EPCR gene is associated with increased plasma levels of sEPCR and is a candidate risk factor for thrombosisQ79202743
P433issue11
P407language of work or nameEnglishQ1860
P921main subjectendotheliumQ111140
venous thromboembolismQ9397786
P304page(s)2674-2681
P577publication date2013-09-19
P1433published inArteriosclerosis, Thrombosis, and Vascular BiologyQ4797542
P1476titleTargeted gene sequencing identifies variants in the protein C and endothelial protein C receptor genes in patients with unprovoked venous thromboembolism
P478volume33

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cites work (P2860)
Q88933117Coagulation factor V gene 1691G>A polymorphism as an indicator for risk and prognosis of lower extremity deep venous thrombosis in Chinese Han population
Q40239904Endothelial protein C receptor polymorphisms and risk of sepsis in a Chinese population
Q40383043Identification of Genetic Variants Linking Protein C and Lipoprotein Metabolism: The ARIC Study (Atherosclerosis Risk in Communities).
Q35070627Multilocus genetic risk scores for venous thromboembolism risk assessment
Q47983961Thrombophilic Gene Mutations in Relation to Different Manifestations of Venous Thromboembolism: A Single Tertiary Center Study.

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