Secondary Prevention of Venous Thromboembolism with the Oral Direct Thrombin Inhibitor Ximelagatran

scientific article published on October 30, 2003

Secondary Prevention of Venous Thromboembolism with the Oral Direct Thrombin Inhibitor Ximelagatran is …
instance of (P31):
scholarly articleQ13442814

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P356DOI10.1056/NEJMOA030104
P953full work available at URLhttp://www.nejm.org/doi/pdf/10.1056/NEJMoa030104
P698PubMed publication ID14585939

P50authorSam SchulmanQ40806287
Henry ErikssonQ76737365
P2093author name stringKarin Wåhlander
Torbjörn Lundström
Solveig Billing Clason
THRIVE III Investigators
P2860cites workThe direct thrombin inhibitor melagatran and its oral prodrug H 376/95: intestinal absorption properties, biochemical and pharmacodynamic effectsQ32067243
A randomized, controlled, dose-guiding study of the oral direct thrombin inhibitor ximelagatran compared with standard therapy for the treatment of acute deep vein thrombosis: THRIVE I.Q33967251
A prospective study of the incidence of deep-vein thrombosis within a defined urban populationQ33977258
Antithrombotic therapy for venous thromboembolic diseaseQ34131105
Long-term, low-intensity warfarin therapy for the prevention of recurrent venous thromboembolismQ34179254
Three months versus one year of oral anticoagulant therapy for idiopathic deep venous thrombosis. Warfarin Optimal Duration Italian Trial InvestigatorsQ43681404
Comparison of the oral direct thrombin inhibitor ximelagatran with enoxaparin as prophylaxis against venous thromboembolism after total knee replacement: a phase 2 dose-finding studyQ43750037
Ximelagatran versus warfarin for the prevention of venous thromboembolism after total knee arthroplasty. A randomized, double-blind trialQ44178713
Ximelagatran and melagatran compared with dalteparin for prevention of venous thromboembolism after total hip or knee replacement: the METHRO II randomised trialQ44217663
Absorption, distribution, metabolism, and excretion of ximelagatran, an oral direct thrombin inhibitor, in rats, dogs, and humansQ44313272
Ximelagatran versus warfarin for stroke prevention in patients with nonvalvular atrial fibrillation. SPORTIF II: a dose-guiding, tolerability, and safety studyQ44437781
Pharmacokinetics and pharmacodynamics of ximelagatran, a novel oral direct thrombin inhibitor, in young healthy male subjectsQ44438922
Comparison of low-intensity warfarin therapy with conventional-intensity warfarin therapy for long-term prevention of recurrent venous thromboembolismQ44548746
A comparison of low-molecular-weight heparin administered primarily at home with unfractionated heparin administered in the hospital for proximal deep-vein thrombosisQ47334930
A comparison of three months of anticoagulation with extended anticoagulation for a first episode of idiopathic venous thromboembolismQ49171054
Evaluation of revised criteria for ventilation-perfusion scintigraphy in patients with suspected pulmonary embolism.Q52882861
The duration of oral anticoagulant therapy after a second episode of venous thromboembolism. The Duration of Anticoagulation Trial Study Group.Q53361537
Comparison of 3 and 6 months of oral anticoagulant therapy after a first episode of proximal deep vein thrombosis or pulmonary embolism and comparison of 6 and 12 weeks of therapy after isolated calf deep vein thrombosisQ73919544
Antithrombotic effects and bleeding time of thrombin inhibitors and warfarin in the ratQ77747914
Cost-effectiveness analysesQ95780120
P433issue18
P407language of work or nameEnglishQ1860
P921main subjectvenous thromboembolismQ9397786
P304page(s)1713-1721
P577publication date2003-10-01
2003-10-30
P1433published inThe New England Journal of MedicineQ582728
P1476titleSecondary Prevention of Venous Thromboembolism with the Oral Direct Thrombin Inhibitor Ximelagatran
P478volume349

Reverse relations

cites work (P2860)
Q64107484A Case Demonstrating the Ribaroxaban Therapy for Paradoxical Embolism
Q35852289A new oral anticoagulant: the 50-year challenge
Q36229356A preliminary assessment of the critical differences between novel oral anticoagulants currently in development
Q35747098A review of the clinical uses of ximelagatran in thrombosis syndromes
Q38151264Advantages and limitations of the new anticoagulants
Q37087993Anticoagulant effects of idraparinux after termination of therapy for prevention of recurrent venous thromboembolism: observations from the van Gogh trials
Q24807132Anticoagulation for non-valvular atrial aibrillation - towards a new beginning with ximelagatran
Q57689199Anticoagulation for people with cancer and central venous catheters
Q57689042Anticoagulation for perioperative thromboprophylaxis in people with cancer
Q49834315Anticoagulation for the initial treatment of venous thromboembolism in people with cancer.
Q24243286Anticoagulation for the long term treatment of venous thromboembolism in patients with cancer
Q24194904Anticoagulation for the long-term treatment of venous thromboembolism in patients with cancer
Q24236620Anticoagulation for the long-term treatment of venous thromboembolism in patients with cancer
Q57689134Anticoagulation for the long-term treatment of venous thromboembolism in people with cancer
Q33372751Anticoagulation strategies for treatment of ischemic stroke and antiphospholipid syndrome: case report and review of the literature.
Q24633053Antithrombotic therapy for VTE disease: Antithrombotic Therapy and Prevention of Thrombosis, 9th ed: American College of Chest Physicians Evidence-Based Clinical Practice Guidelines
Q35878355Bleeding profiles of anticoagulants, including the novel oral direct thrombin inhibitor ximelagatran: definitions, incidence and management
Q48560063Can haematological tests predict cardiovascular risk? The 2005 Kettle Lecture
Q38388643Case Fatality Rates of Recurrent Thromboembolism and Bleeding in Patients Receiving Direct Oral Anticoagulants for the Initial and Extended Treatment of Venous Thromboembolism: A Systematic Review.
Q35860195Challenges in the prevention of venous thromboembolism in the elderly
Q36474763Changing paradigms in the management of venous thromboembolism
Q46188988Clinical evidence for rebound hypercoagulability after discontinuing oral anticoagulants for venous thromboembolism
Q35977658Clinical experience with ximelagatran in orthopaedic surgery
Q35977667Clinical potential of oral direct thrombin inhibitors in the prevention and treatment of venous thromboembolism
Q46906665Comparable pharmacokinetics and pharmacodynamics of melagatran in Japanese and caucasian volunteers after oral administration of the direct thrombin inhibitor ximelagatran
Q47328874Comparison of the anticoagulant effect of a direct thrombin inhibitor and a low molecular weight heparin in an acquired antithrombin deficiency in children with acute lymphoblastic leukaemia treated with L-asparaginase: an in vitro study
Q33365707Current issues in anticoagulation
Q37579455Dabigatran etexilate: future directions in anticoagulant treatment.
Q38241091Dabigatran excess: case report and review of the literature
Q81584045Deep vein thrombosis
Q45847579Diagnosis and anticoagulant treatment
Q56003308Direct Thrombin Inhibitors
Q24187415Direct factor Xa inhibitors versus low molecular weight heparins or vitamin K antagonists for prevention of venous thromboembolism in elective primary hip or knee replacement or hip fracture repair
Q24200617Direct thrombin inhibitors and factor Xa inhibitors for atrial fibrillation
Q94337721Direct thrombin inhibitors and factor Xa inhibitors for atrial fibrillation
Q24244149Direct thrombin inhibitors versus vitamin K antagonists or low molecular weight heparin for prevention of venous thromboembolism following total hip or knee replacement or hip repair
Q24235993Direct thrombin inhibitors versus vitamin K antagonists or low molecular weight heparins for prevention of venous thromboembolism following total hip or knee replacement
Q28176666Direct thrombin inhibitors: novel antithrombotics on the horizon in the thromboprophylactic management of atrial fibrillation
Q34284224Duration of anticoagulant therapy for venous thromboembolism: balancing benefits and harms on the long term
Q36550717Effect of patient's sex on risk of recurrent venous thromboembolism: a meta-analysis.
Q27027477Effectiveness and safety of novel oral anticoagulants as compared with vitamin K antagonists in the treatment of acute symptomatic venous thromboembolism: a systematic review and meta-analysis
Q38133389Efficacy and safety outcomes of oral anticoagulants and antiplatelet drugs in the secondary prevention of venous thromboembolism: systematic review and network meta-analysis
Q37428883Emergence of new oral antithrombotics: a critical appraisal of their clinical potential.
Q36066023Emerging strategies for treatment of venous thromboembolism
Q28069617Evidence-based selection of training compounds for use in the mechanism-based integrated prediction of drug-induced liver injury in man
Q28081717Extended Anticoagulant and Aspirin Treatment for the Secondary Prevention of Thromboembolic Disease: A Systematic Review and Meta-Analysis
Q64096953Extended anticoagulation for the secondary prevention of venous thromboembolic events: An updated network meta-analysis
Q37844472Extended anticoagulation for unprovoked venous thromboembolism: a majority of patients should be treated
Q36019805Extended anticoagulation therapy for the primary and secondary prevention of venous thromboembolism
Q83067930Factor Xa and thrombin as targets for new oral anticoagulants
Q33590496Five-year follow-up of pulmonary embolism under anticoaugulation: The PISA-PEET (Pulmonary Embolism Extension Therapy) study
Q40519867Guidelines for the diagnosis, treatment, and follow-up of pulmonary embolism
Q36077273Hepatic findings in long-term clinical trials of ximelagatran
Q46896359Incidence of recurrent venous thromboembolism of patients after termination of treatment with ximelagatran
Q39889806Insights from the dabigatran versus warfarin trial in patients with venous thromboembolism (the RE-COVER trial).
Q36764001Investigational treatments of venous thromboembolism
Q85246815Isolated Calf Vein Thrombosis Should Be Treated With Anticoagulation
Q93646291JournalScan
Q33375535Latest medical treatment strategies for venous thromboembolism
Q92152596Long term risk of symptomatic recurrent venous thromboembolism after discontinuation of anticoagulant treatment for first unprovoked venous thromboembolism event: systematic review and meta-analysis
Q37806826Long-term Anticoagulation for Venous Thromboembolism: Duration of Treatment and Management of Warfarin Therapy
Q33380411Low-molecular-weight heparins are superior to vitamin K antagonists for the long term treatment of venous thromboembolism in patients with cancer: a cochrane systematic review
Q26828750Major bleeding during secondary prevention of venous thromboembolism in patients who have completed anticoagulation: a systematic review and meta-analysis
Q36718482Management of patients with unprovoked venous thromboembolism: an evidence-based and practical approach
Q36590609Management of venous thromboembolism in the elderly
Q57254147Managing medical complications in patients with brain tumors
Q79680819Menorrhagia and minor bleeding symptoms in women on oral anticoagulation
Q89628720Milestone 9: Ximelagatran sets the stage for NOACs
Q98181527Mortality risk associated with venous thromboembolism: a systematic review and Bayesian meta-analysis
Q28081366New Insights into the Pros and Cons of the Clinical Use of Vitamin K Antagonists (VKAs) Versus Direct Oral Anticoagulants (DOACs)
Q37806825New Synthetic Antithrombotic Agents for Venous Thromboembolism: Pentasaccharides, Direct Thrombin Inhibitors, Direct Xa Inhibitors
Q37899258New anticoagulants - promising and failed developments.
Q24681351New anticoagulants for the prevention and treatment of venous thromboembolism
Q33370261New anticoagulants: anti IIa vs anti Xa--is one better?
Q36042279New anticoagulants: beyond heparin, low-molecular-weight heparin and warfarin
Q35860943New approaches to anticoagulation in atrial fibrillation
Q46832922New strategies in the secondary prevention of relapsing venous thromboembolism
Q45306740No effect of encapsulation on the pharmacokinetics of warfarin
Q51751921No influence of food on the pharmacokinetics, pharmacodynamics or tolerability of the 24mg and 36mg oral tablet formulations of ximelagatran.
Q45001577No pharmacokinetic or pharmacodynamic interaction between atorvastatin and the oral direct thrombin inhibitor ximelagatran
Q45001580No pharmacokinetic or pharmacodynamic interaction between digoxin and the oral direct thrombin inhibitor ximelagatran in healthy volunteers.
Q37697501Novel oral anticoagulants to prevent stroke in atrial fibrillation
Q35779232Novel uses for current and future direct thrombin inhibitors: focus on ximelagatran and bivalirudin
Q34781477Optimal duration of anticoagulation after venous thromboembolism
Q47235947Oral anticoagulation in people with cancer who have no therapeutic or prophylactic indication for anticoagulation.
Q24186935Oral direct thrombin inhibitors or oral factor Xa inhibitors for the treatment of deep vein thrombosis
Q24187205Oral direct thrombin inhibitors or oral factor Xa inhibitors for the treatment of pulmonary embolism
Q47551857Parenteral anticoagulation in ambulatory patients with cancer.
Q80044845Pharmacokinetics and pharmacodynamics of the oral direct thrombin inhibitor ximelagatran co-administered with different classes of antibiotics in healthy volunteers
Q55043926Pharmacokinetics, preliminary efficacy and safety of subcutaneous melagatran and oral ximelagatran : a multicentre study of thromboprophylaxis in elective abdominal surgery.
Q53150344Pharmacologic strategies for the prevention of stroke in patients with atrial fibrillation.
Q33419567Pharmacotherapy with oral Xa inhibitors for venous thromboembolism
Q37076516Predicting the future: it's not a SNP.
Q45241751Prevention of embolism among patients with atrial fibrillation
Q33359976Prevention of venous thromboembolism following orthopaedic surgery: clinical potential of direct thrombin inhibitors
Q79954098Pulmonary embolism
Q37903926Recent progress in anticoagulant therapy: oral direct inhibitors of thrombin and factor Xa.
Q34153343Risk assessment for recurrent venous thrombosis
Q46972220Risk of recurrent venous thromboembolism or bleeding in relation to thrombophilic risk factors in patients receiving ximelagatran or placebo for long-term secondary prevention of venous thromboembolism
Q37578092Rivaroxaban in orthopedic surgery--a change of paradigm?
Q38827190Sex-based disparities in venous thromboembolism outcomes: A National Inpatient Sample (NIS)-based analysis
Q36933765Should anticoagulation be resumed after intracerebral hemorrhage?
Q46921671Stroke prevention using the oral direct thrombin inhibitor ximelagatran in patients with non-valvular atrial fibrillation. Pooled analysis from the SPORTIF III and V studies
Q35904418Switching from enoxaparin to dabigatran etexilate: pharmacokinetics, pharmacodynamics, and safety profile
Q36925998Targeted inhibition of coagulation: oral agents show promise in phase III trials
Q44132363Ten-year experience with acenocoumarol treatment in an ambulatory cohort of Spanish patients
Q36905848The direct thrombin inhibitor ximelagatran/melagatran: a systematic review on clinical applications and an evidence based assessment of risk benefit profile.
Q38015427The emergence of factor Xa inhibitors for the treatment of cardiovascular diseases: a patent review
Q80098649The genetics of vitamin K antagonists
Q45006391The new anticoagulants are here!
Q44820370The pharmacokinetics and pharmacodynamics of ximelagatran, an oral direct thrombin inhibitor, are unaffected by a single dose of alcohol
Q35996023The role of oral direct thrombin inhibitors in the treatment of venous thromboembolism
Q33369274The role of ximelagatran in the treatment of venous thromboembolism
Q36520745The status of new anticoagulants
Q38086147Top practice-changing articles over the last two years
Q40458080Transitioning from traditional to novel anticoagulants: the impact of oral direct thrombin inhibitors on anticoagulation management.
Q44636983Treating Thrombosis in the 21st Century
Q48846277Treatment of Medical Complications in Patients with Brain Tumors
Q35977663Treatment of venous thromboembolism and long-term prevention of recurrence: present treatment options and ximelagatran
Q36286443Update on the diagnosis and management of pulmonary embolism.
Q33945088Ximelagatran (Exanta): alternative to warfarin?
Q36216784Ximelagatran for stroke prevention in atrial fibrillation
Q36884659Ximelagatran for treatment and prophylaxis of recurrent events in deep vein thrombosis.
Q36745430Ximelagatran versus warfarin for prophylaxis of venous thromboembolism in major orthopedic surgery: systematic review of randomized controlled trials.
Q35843864Ximelagatran, a new oral direct thrombin inhibitor, for the prevention of venous thromboembolic events in major elective orthopaedic surgery. Efficacy, safety and anaesthetic considerations
Q46688989Ximelagatran--recent comparisons with warfarin
Q44960484Ximelagatran/Melagatran. Perspectives for new oral antithrombin drugs
Q33226419Ximelagatran: a new type of oral anticoagulant
Q35895188Ximelagatran: an oral direct thrombin inhibitor
Q24681333Ximelagatran: direct thrombin inhibitor
Q46686851Ximelagatran: hopes and controversies
Q35843153Ximelagatran: light at the end of the tunnel or the next tunnel?
Q35996015Ximelagatran: pharmacology, pharmacokinetics, and pharmacodynamics
Q85334982[Dabigatran: transforming the management of oral anticoagulation]
Q80088631[New antitoagulants]
Q80984232[Therapeutical perspectives in systemic lupus erythematosus]
Q80938075[Treatment of deep vein thrombosis. When to use which substance?]
Q84564050[Treatment of postoperative thrombosis]
Q81512866[Treatment of venous thromboembolic disease]
Q81873866[Venous thromboembolism]

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