Viral infection triggers central nervous system autoimmunity via activation of CD8+ T cells expressing dual TCRs.

scientific article

Viral infection triggers central nervous system autoimmunity via activation of CD8+ T cells expressing dual TCRs. is …
instance of (P31):
scholarly articleQ13442814

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P356DOI10.1038/NI.1888
P932PMC publication ID2900379
P698PubMed publication ID20526343
P5875ResearchGate publication ID44652231

P50authorJoan GovermanQ77702528
P2093author name stringQingyong Ji
Antoine Perchellet
P2860cites workCD8+ T cells maintain tolerance to myelin basic protein by 'epitope theft'.Q47597420
Differential tolerance is induced in T cells recognizing distinct epitopes of myelin basic proteinQ47992214
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Molecular mimicry between a viral peptide and a myelin oligodendrocyte glycoprotein peptide induces autoimmune demyelinating disease in mice.Q52216057
Evaluation of the percentage of peripheral T cells with two different T cell receptor alpha-chains and of their potential role in autoimmunity.Q52543378
Opposing effects of HLA class I molecules in tuning autoreactive CD8+ T cells in multiple sclerosisQ56914273
Expression of two T cell receptor α chains on the surface of normal murine T cellsQ57228132
Multiple Sclerosis After Infectious MononucleosisQ57579862
Expression of two T cell receptor alpha chains: dual receptor T cellsQ61268447
High incidence of spontaneous autoimmune encephalomyelitis in immunodeficient anti-myelin basic protein T cell receptor transgenic miceQ71641038
Incomplete T cell receptor V beta allelic exclusion and dual V beta-expressing cellsQ71746662
Triggers of autoimmune disease in a murine TCR-transgenic model for multiple sclerosisQ73453176
High prevalence of autoreactive, neuroantigen-specific CD8+ T cells in multiple sclerosis revealed by novel flow cytometric assayQ76376758
Regulatory T cells maintain long-term tolerance to myelin basic protein by inducing a novel, dynamic state of T cell toleranceQ79485138
Epstein-Barr virus and multiple sclerosisQ83633324
Epstein-Barr virus and multiple sclerosisQ83636924
A virus-induced molecular mimicry model of multiple sclerosisQ24569603
Epidemiologic evidence for multiple sclerosis as an infectionQ24615844
Epstein-Barr virus infection is not a characteristic feature of multiple sclerosis brainQ24642187
Meta-analysis of genome scans and replication identify CD6, IRF8 and TNFRSF1A as new multiple sclerosis susceptibility lociQ24656799
Alemtuzumab vs. interferon beta-1a in early multiple sclerosisQ33381736
Differential regulation of central nervous system autoimmunity by T(H)1 and T(H)17 cells.Q33619976
Antiviral immune responses: triggers of or triggered by autoimmunity?Q33789445
Viruses and multiple sclerosisQ34052181
Epstein-barr virus infection and multiple sclerosis: a reviewQ34108508
Dual receptor T cells extend the immune repertoire for foreign antigens.Q34111446
Central nervous system pathology caused by autoreactive CD8+ T-cell clones following virus infectionQ34142884
Infectious causes of multiple sclerosisQ34396144
Infectious mononucleosis and risk for multiple sclerosis: a meta-analysisQ34565138
Epitope spreading in immune-mediated diseases: implications for immunotherapyQ34575350
Cutting edge: Highly alloreactive dual TCR T cells play a dominant role in graft-versus-host diseaseQ34981915
Functional differentiation of T cells in the intestine of T cell receptor transgenic miceQ36107410
The role of CD8(+) T cells in multiple sclerosis and its animal modelsQ36107655
Autoreactive CD8+ T cells in multiple sclerosis: a new target for therapy?Q36173589
Dysregulated Epstein-Barr virus infection in the multiple sclerosis brainQ36229219
Peripheral CD8+ T cell tolerance to self-proteins is regulated proximally at the T cell receptor.Q36237834
Expression of two alpha chains on the surface of T cells in T cell receptor transgenic miceQ36362577
Normal T lymphocytes can express two different T cell receptor beta chains: implications for the mechanism of allelic exclusionQ36364722
Dual T cell receptor beta chain expression on human T lymphocytesQ36364748
Dual T cell receptor alpha chain T cells in autoimmunityQ36365722
Regulatory CD4(+) T cells expressing endogenous T cell receptor chains protect myelin basic protein-specific transgenic mice from spontaneous autoimmune encephalomyelitisQ36401257
Treatment of experimental encephalomyelitis with a novel chimeric fusion protein of myelin basic protein and proteolipid proteinQ37360410
The Biology of Persistent Infection: Inflammation and Demyelination following Murine Coronavirus Infection of the Central Nervous SystemQ37436632
Exclusion and inclusion of α and β T cell receptor allelesQ38329183
Multiple sclerosis and viruses: An overviewQ40120762
Dual receptor T-cells. Implications for alloreactivity and autoimmunity.Q40465770
Transgenic mice that express a myelin basic protein-specific T cell receptor develop spontaneous autoimmunityQ43433033
Integrating risk factors: HLA-DRB1*1501 and Epstein-Barr virus in multiple sclerosisQ45397129
Structural requirements for initiation of cross-reactivity and CNS autoimmunity with a PLP139-151 mimic peptide derived from murine hepatitis virusQ45412079
Persistent infection with Theiler's virus leads to CNS autoimmunity via epitope spreadingQ45760081
P433issue7
P407language of work or nameEnglishQ1860
P921main subjectnervous systemQ9404
P304page(s)628-634
P577publication date2010-06-06
P1433published inNature ImmunologyQ1071725
P1476titleViral infection triggers central nervous system autoimmunity via activation of CD8+ T cells expressing dual TCRs
P478volume11

Reverse relations

cites work (P2860)
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