Interferon-α abrogates tolerance induction by human tolerogenic dendritic cells

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Interferon-α abrogates tolerance induction by human tolerogenic dendritic cells is …
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scholarly articleQ13442814

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P819ADS bibcode2011PLoSO...622763B
P356DOI10.1371/JOURNAL.PONE.0022763
P932PMC publication ID3144929
P698PubMed publication ID21818385
P5875ResearchGate publication ID51548944

P50authorHelmut JonuleitQ30511642
P2093author name stringStephan Grabbe
Kerstin Steinbrink
Edith Graulich
Nicole Bacher
P2860cites workDifferentiation of type 1 T regulatory cells (Tr1) by tolerogenic DC-10 requires the IL-10-dependent ILT4/HLA-G pathwayQ24310325
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Differential effects of IFN-alpha on the expression of various TH2 cytokines in human CD4+ T cells.Q54656174
CD4(+) and CD8(+) anergic T cells induced by interleukin-10-treated human dendritic cells display antigen-specific suppressor activityQ56904531
Activation of MAP kinase p38 is critical for the cell-cycle-controlled suppressor function of regulatory T cellsQ58180769
Expression of CCR-7, MIP-3beta , and Th-1 chemokines in type I IFN-induced monocyte-derived dendritic cells: importance for the rapid acquisition of potent migratory and functional activitiesQ60687739
Dendritic cells as mediators of tumor-induced tolerance in metastatic melanomaQ73850975
Induction of tolerance by IL-10-treated dendritic cellsQ73873437
Pro-inflammatory cytokines and prostaglandins induce maturation of potent immunostimulatory dendritic cells under fetal calf serum-free conditionsQ74179201
Interleukin 10 production by human melanomaQ77557398
A dual role of IFN-alpha in the balance between proliferation and death of human CD4+ T lymphocytes during primary responseQ80542447
Dysfunctional CD4+,CD25+ regulatory T cells in untreated active systemic lupus erythematosus secondary to interferon-alpha-producing antigen-presenting cellsQ80800895
APC activation by IFN-alpha decreases regulatory T cell and enhances Th cell functionsQ84126782
Interferon-alpha regulates the dynamic balance between human activated regulatory and effector T cells: implications for antiviral and autoimmune responsesQ84215298
Interferon-α-conditioned human monocytes combine a Th1-orienting attitude with the induction of autologous Th17 responses: role of IL-23 and IL-12.Q33840997
Stat1 and Stat2 but not Stat3 arbitrate contradictory growth signals elicited by alpha/beta interferon in T lymphocytes.Q33862973
Interferon-alpha in tumor immunity and immunotherapyQ34568695
Dendritic cell control of tolerogenic responsesQ34982085
Cytokine therapeutics: lessons from interferon alphaQ35033232
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Interferon-alpha/beta inhibition of interleukin 12 and interferon-gamma production in vitro and endogenously during viral infectionQ35958851
Interferon alpha and Tat involvement in the immunosuppression of uninfected T cells and C-C chemokine decline in AIDS.Q36011366
Type I interferon as a powerful adjuvant for monocyte-derived dendritic cell development and activity in vitro and in Hu-PBL-SCID mice.Q36368488
Quality Assessment in Multiple Sclerosis Therapy (QUASIMS): a comparison of interferon beta therapies for relapsing-remitting multiple sclerosisQ36726382
How tumours escape mass destructionQ37287162
Diagnosis and treatment of melanoma: European consensus-based interdisciplinary guidelineQ37644104
Regulation of antitumor immune responses by the IL-12 family cytokines, IL-12, IL-23, and IL-27.Q37795583
Prognostic significance of autoimmunity during treatment of melanoma with interferonQ37833559
Neuronal nitric oxide synthase modulates maturation of human dendritic cellsQ39710543
Ability of mature dendritic cells to interact with regulatory T cells is imprinted during maturationQ39853571
Melanoma epidemiology and trends.Q40017236
Interferon-alpha2a is sufficient for promoting dendritic cell immunogenicityQ40349921
Gene expression profiling and functional activity of human dendritic cells induced with IFN-alpha-2b: implications for cancer immunotherapyQ40641266
IFN-alpha and IL-10 induce the differentiation of human type 1 T regulatory cells.Q40811244
Increased interleukin-10 serum levels in patients with solid tumours.Q40936263
Interleukin-10-treated human dendritic cells induce a melanoma-antigen-specific anergy in CD8(+) T cells resulting in a failure to lyse tumor cells.Q40971390
Infectious tolerance: human CD25(+) regulatory T cells convey suppressor activity to conventional CD4(+) T helper cellsQ41908906
Prognostic significance of autoimmunity during treatment of melanoma with interferon.Q44019499
MEK and ERK inhibitors enhance the anti-proliferative effect of interferon-alpha2bQ44122072
IFN-alpha 2b reduces IL-2 production and IL-2 receptor function in primary CD4+ T cellsQ44195895
Dendritic cells generated in the presence of interferon-alpha stimulate allogeneic CD4+ T-cell proliferation: modulation by autocrine IL-10, enhanced T-cell apoptosis and T regulatory type 1 cellsQ44927122
Suppressor activity of anergic T cells induced by IL-10-treated human dendritic cells: association with IL-2- and CTLA-4-dependent G1 arrest of the cell cycle regulated by p27Kip1.Q47731326
Addition of interferon-alpha to a standard maturation cocktail induces CD38 up-regulation and increases dendritic cell function.Q47841318
Differential regulation of Th1 responses and CD154 expression in human CD4+ T cells by IFN-alphaQ47969542
P275copyright licenseCreative Commons Attribution 4.0 InternationalQ20007257
P6216copyright statuscopyrightedQ50423863
P433issue7
P407language of work or nameEnglishQ1860
P921main subjectdendritic cellQ506253
P304page(s)e22763
P577publication date2011-07-27
P1433published inPLOS OneQ564954
P1476titleInterferon-α abrogates tolerance induction by human tolerogenic dendritic cells
P478volume6

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cites work (P2860)
Q57947090Functionalized Polystyrene Nanoparticles Trigger Human Dendritic Cell Maturation Resulting in Enhanced CD4+T Cell Activation
Q38646051Interferon-alpha for the therapy of myeloproliferative neoplasms: targeting the malignant clone
Q51050849Primary Human Blood Dendritic Cells for Cancer Immunotherapy-Tailoring the Immune Response by Dendritic Cell Maturation
Q38937281Type I IFN gene delivery suppresses regulatory T cells within tumors
Q37498499Type I interferon response gene expression in established rheumatoid arthritis is not associated with clinical parameters.

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