Cannabinoid receptor-2 (CB2) agonist ameliorates colitis in IL-10(-/-) mice by attenuating the activation of T cells and promoting their apoptosis

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Cannabinoid receptor-2 (CB2) agonist ameliorates colitis in IL-10(-/-) mice by attenuating the activation of T cells and promoting their apoptosis is …
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scholarly articleQ13442814

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P356DOI10.1016/J.TAAP.2011.11.005
P932PMC publication ID4117838
P698PubMed publication ID22119709

P2093author name stringBalwan Singh
Mitzi Nagarkatti
Robert L Price
Narendra P Singh
Prakash S Nagarkatti
Udai P Singh
P2860cites workEnterocolitis and colon cancer in interleukin-10-deficient mice are associated with aberrant cytokine production and CD4(+) TH1-like responsesQ24562026
Ulcerative colitis induces changes on the expression of the endocannabinoid system in the human colonic tissueQ27342536
Molecular characterization of a peripheral receptor for cannabinoidsQ28298338
Aggravation of different types of experimental colitis by depletion or adhesion blockade of neutrophilsQ28571560
Selective depletion of neutrophils by a monoclonal antibody, RP-3, suppresses dextran sulphate sodium-induced colitis in rats.Q64917143
Hapten-induced model of murine inflammatory bowel disease: mucosa immune responses and protection by toleranceQ71396766
Anti-CD11b/CD18 antibodies reduce inflammation in acute colitis in ratsQ71993274
Inhibition of IFN-gamma-inducible protein-10 abrogates colitis in IL-10-/- miceQ73696473
Intercellular adhesion molecule-1 expression in dextran sodium sulfate-induced colitis in ratsQ73936208
Administration of agonistic anti-4-1BB monoclonal antibody leads to the amelioration of experimental autoimmune encephalomyelitisQ77522472
Expression of B7 costimulatory molecules by cells infiltrating the colon in experimental colitis induced by oral dextran sulfate sodium in the mouseQ77792705
Close association between activated platelets and neutrophils in the active phase of ulcerative colitis in humansQ80134910
Critical role for mast cells in the pathogenesis of 2,4-dinitrobenzene-induced murine colonic hypersensitivity reactionQ82878986
Agonists of cannabinoid receptor 1 and 2 inhibit experimental colitis induced by oil of mustard and by dextran sulfate sodiumQ83019190
Inhibition of neutrophil elastase prevents the development of murine dextran sulfate sodium-induced colitisQ83897612
International Union of Pharmacology. XXVII. Classification of cannabinoid receptorsQ29616832
Clinical epidemiology of inflammatory bowel disease: Incidence, prevalence, and environmental influencesQ29617565
Cannabinoid receptor activation induces apoptosis through tumor necrosis factor alpha-mediated ceramide de novo synthesis in colon cancer cellsQ33388613
The cannabinoid 1 receptor (CNR1) 1359 G/A polymorphism modulates susceptibility to ulcerative colitis and the phenotype in Crohn's diseaseQ33535863
Infliximab: a novel chimeric monoclonal antibody for the treatment of Crohn's diseaseQ33707136
Resveratrol (trans-3,5,4'-trihydroxystilbene) induces silent mating type information regulation-1 and down-regulates nuclear transcription factor-kappaB activation to abrogate dextran sulfate sodium-induced colitisQ33714931
Resveratrol suppresses colitis and colon cancer associated with colitisQ33785741
TNBS-colitisQ33867163
Naphthalen-1-yl-(4-pentyloxynaphthalen-1-yl)methanone (SAB378), a peripherally restricted cannabinoid CB1/CB2 receptor agonist, inhibits gastrointestinal motility but has no effect on experimental colitis in miceQ34122251
The neutral cannabinoid CB₁ receptor antagonist AM4113 regulates body weight through changes in energy intake in the rat.Q34504906
Diminished neutrophil function in Crohn's disease and ulcerative colitis identified by decreased oxidative metabolism and low superoxide dismutase contentQ34528907
Neuronal localization of cannabinoid receptors in the basal ganglia of the rat.Q34602111
Evolving pathophysiologic models of functional gastrointestinal disordersQ34676855
Marihuana as medicine. A plea for reconsiderationQ34722488
The current future understanding of inflammatory bowel diseaseQ35021166
Prospects for cannabinoids as anti-inflammatory agentsQ35047572
Induction of TH1 and TH2 responses: a key role for the 'natural' immune response?Q35451574
Key role of mast cells and their major secretory products in inflammatory bowel diseaseQ35648042
CB2 cannabinoid receptor agonist, JWH-015, triggers apoptosis in immune cells: potential role for CB2-selective ligands as immunosuppressive agents.Q35781582
Antibodies to interleukin 12 abrogate established experimental colitis in miceQ36365464
CXCL10-producing mucosal CD4+ T cells, NK cells, and NKT cells are associated with chronic colitis in IL-10(-/-) mice, which can be abrogated by anti-CXCL10 antibody inhibitionQ36732325
T cell transfer model of chronic colitis: concepts, considerations, and tricks of the tradeQ37100252
The endogenous cannabinoid system protects against colonic inflammationQ37370275
The effects of Delta-tetrahydrocannabinol and cannabidiol alone and in combination on damage, inflammation and in vitro motility disturbances in rat colitisQ39283731
The immunologic basis of inflammatory bowel diseaseQ39460849
Activation of cannabinoid 2 receptors protects against cerebral ischemia by inhibiting neutrophil recruitmentQ39780145
Differential roles of CB1 and CB2 cannabinoid receptors in mast cellsQ40649554
Activation of the cannabinoid 2 receptor (CB2) protects against experimental colitisQ41155333
Neuro-immune pathobiology of infectious enteric disease.Q41506204
Modulation of neutrophil motility by curcumin: implications for inflammatory bowel diseaseQ41858578
The jejunal secretion of histamine is increased in active Crohn's diseaseQ41933777
A discrete subpopulation of dendritic cells transports apoptotic intestinal epithelial cells to T cell areas of mesenteric lymph nodesQ42039464
Release of mast cell tryptase from human colorectal mucosa in inflammatory bowel diseaseQ42501267
Mice lacking cannabinoid CB1-, CB2-receptors or both receptors show increased susceptibility to trinitrobenzene sulfonic acid (TNBS)-induced colitisQ43130152
Down-regulation by cannabinoids of the immunological activation of human basophils and guinea pig mast cellsQ43995349
Activation through cannabinoid receptors 1 and 2 on dendritic cells triggers NF-kappaB-dependent apoptosis: novel role for endogenous and exogenous cannabinoids in immunoregulationQ44904050
Delta9-tetrahydrocannabinol-induced apoptosis in Jurkat leukemia T cells is regulated by translocation of Bad to mitochondria.Q44922532
The endocannabinoid 2-arachidonylglycerol decreases the immunological activation of Guinea pig mast cells: involvement of nitric oxide and eicosanoids.Q44929021
Targeting endocannabinoid degradation protects against experimental colitis in mice: involvement of CB1 and CB2 receptorsQ46584481
Up-regulation of anandamide levels as an endogenous mechanism and a pharmacological strategy to limit colon inflammationQ46887706
Cannabidiol decreases body weight gain in rats: involvement of CB2 receptorsQ47400210
Neutralization of interleukin-17 aggravates dextran sulfate sodium-induced colitis in mice.Q51037509
P433issue2
P407language of work or nameEnglishQ1860
P921main subjectcannabinoid receptorQ421237
cannabinoidsQ422936
colitisQ2453464
apoptotic processQ14599311
CNR2Q17907844
P304page(s)256-267
P577publication date2011-11-18
P1433published inToxicology and Applied PharmacologyQ2446974
P1476titleCannabinoid receptor-2 (CB2) agonist ameliorates colitis in IL-10(-/-) mice by attenuating the activation of T cells and promoting their apoptosis
P478volume258