The human herpesvirus 6 G protein-coupled receptor homolog U51 positively regulates virus replication and enhances cell-cell fusion in vitro

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The human herpesvirus 6 G protein-coupled receptor homolog U51 positively regulates virus replication and enhances cell-cell fusion in vitro is …
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scholarly articleQ13442814

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P356DOI10.1128/JVI.79.18.11914-11924.2005
P932PMC publication ID1212626
P698PubMed publication ID16140767

P50authorStephen DewhurstQ43125387
P2093author name stringBirgit Bradel-Tretheway
Jean M Bidlack
Zhu Zhen
Sarah Sumagin
P2860cites workHIV-1 Entry Cofactor: Functional cDNA Cloning of a Seven-Transmembrane, G Protein-Coupled ReceptorQ22242268
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Trafficking to the plasma membrane of the seven-transmembrane protein encoded by human herpesvirus 6 U51 gene involves a cell-specific function present in T lymphocytes.Q33639283
The cytomegalovirus-encoded chemokine receptor US28 can enhance cell-cell fusion mediated by different viral proteinsQ33783347
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Human herpesvirus 7 open reading frame U12 encodes a functional beta-chemokine receptorQ35105376
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Deletion of the R78 G protein-coupled receptor gene from rat cytomegalovirus results in an attenuated, syncytium-inducing mutant strain.Q39550824
The R33 G protein-coupled receptor gene of rat cytomegalovirus plays an essential role in the pathogenesis of viral infectionQ39577932
Functional analysis of the human cytomegalovirus US28 gene by insertion mutagenesis with the green fluorescent protein gene.Q39581273
The CC-chemokine RANTES increases the attachment of human immunodeficiency virus type 1 to target cells via glycosaminoglycans and also activates a signal transduction pathway that enhances viral infectivityQ39595163
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Human herpesvirus 6 variant A but not variant B induces fusion from without in a variety of human cells through a human herpesvirus 6 entry receptor, CD46.Q39683944
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Murine cytomegalovirus (CMV) M33 and human CMV US28 receptors exhibit similar constitutive signaling activitiesQ39753137
Short interfering RNA-mediated inhibition of herpes simplex virus type 1 gene expression and function during infection of human keratinocytesQ39992106
Enhanced responsiveness to nuclear factor kappa B contributes to the unique phenotype of simian immunodeficiency virus variant SIVsmmPBj14.Q40042834
Several groups among human herpesvirus 6 strains can be distinguished by Southern blotting and polymerase chain reactionQ40211184
Inhibition of human cytomegalovirus replication by small interfering RNAsQ40600110
Constitutive signaling of the human cytomegalovirus-encoded receptor UL33 differs from that of its rat cytomegalovirus homolog R33 by promiscuous activation of G proteins of the Gq, Gi, and Gs classes.Q40629451
Primary Human Herpesvirus 6 Infection in Young ChildrenQ40733765
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Human herpesvirus KSHV encodes a constitutively active G-protein-coupled receptor linked to cell proliferationQ41133441
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Human cytomegalovirus open reading frame US28 encodes a functional beta chemokine receptorQ41428523
Phenotypic and genetic polymorphisms among human herpesvirus-6 isolates from North American infantsQ41606699
The human cytomegalovirus UL78 gene is highly conserved among clinical isolates, but is dispensable for replication in fibroblasts and a renal artery organ-culture systemQ42645570
Genomic polymorphism, growth properties, and immunologic variations in human herpesvirus-6 isolatesQ42806799
The unique region of the human herpesvirus 6 genome is essentially collinear with the UL segment of human cytomegalovirusQ43546295
Several delta-opioid receptor ligands display no subtype selectivity to the human delta-opioid receptorQ44145452
Transient overexpression of kappa and mu opioid receptors using recombinant adenovirus vectorsQ44345704
Effects of codon-optimization on protein expression by the human herpesvirus 6 and 7 U51 open reading frameQ44551779
The rat cytomegalovirus R78 G protein-coupled receptor gene is required for production of infectious virus in the spleenQ45722223
The human cytomegalovirus chemokine receptor US28 mediates vascular smooth muscle cell migrationQ45863859
Rat cytomegalovirus-accelerated transplant vascular sclerosis is reduced with mutation of the chemokine-receptor R33.Q45881220
Human herpesvirus 6 (HHV6) DNA persistence and reactivation in healthy children.Q54697718
RNAi and double-strand RNAQ64388976
Identification of human herpesvirus-6 as a causal agent for exanthem subitumQ69917877
Human herpesvirus 6 infection inhibits specific lymphocyte proliferation responses and is related to lymphocytopenia after allogeneic stem cell transplantationQ73372638
P433issue18
P407language of work or nameEnglishQ1860
P921main subjectHuman herpesvirus 6Q6974
G protein-coupled receptorQ38173
P304page(s)11914-11924
P577publication date2005-09-01
P1433published inJournal of VirologyQ1251128
P1476titleThe human herpesvirus 6 G protein-coupled receptor homolog U51 positively regulates virus replication and enhances cell-cell fusion in vitro
P478volume79

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