Second-generation (atypical) antipsychotics and metabolic effects: a comprehensive literature review

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Second-generation (atypical) antipsychotics and metabolic effects: a comprehensive literature review is …
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P6179Dimensions Publication ID1002073185
P356DOI10.2165/00023210-200519001-00001
P698PubMed publication ID15998156
P5875ResearchGate publication ID7746494

P2093author name stringJohn W Newcomer
John W. Newcomer
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Lactic acidosis and fatal myocardial failure due to clozapine.Q40656400
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Abdominal obesity as important component of insulin-resistance syndromeQ40803600
Medical hazards of obesityQ40841355
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Hypertriglyceridemia, atherogenic dyslipidemia, and the metabolic syndromeQ40864746
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Antipsychotic drugs affect glucose uptake and the expression of glucose transporters in PC12 cellsQ40948198
Polymorphism of the promoter region of the serotonin 5-HT(2C) receptor gene and clozapine-induced weight gainQ44385573
A placebo-controlled trial of risperidone in Tourette syndromeQ44394585
Low-Dose Clozapine and Diabetic KetoacidosisQ44425279
The metabolic syndrome as predictor of type 2 diabetes: the San Antonio heart studyQ44425360
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Type 2 Diabetes Mellitus Induced by an Atypical Antipsychotic MedicationQ44446375
Serum leptin and triglyceride levels in patients on treatment with atypical antipsychotics.Q44446777
Undiagnosed hyperglycemia in clozapine-treated patients with schizophreniaQ44446778
Schizophrenia and diabetes mellitus: not an improbable combinationQ44481505
Relationship between levels of insulin or triglycerides and serum concentrations of the atypical antipsychotics clozapine and olanzapine in patients on treatment with therapeutic dosesQ44507215
Metabolic syndrome with and without C-reactive protein as a predictor of coronary heart disease and diabetes in the West of Scotland Coronary Prevention StudyQ44513183
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Comparative study of the development of diabetes mellitus in patients taking risperidone and olanzapineQ44551305
Eruptive xanthomas associated with olanzapine use.Q44553634
Diabetic ketoacidosis in a patient treated with olanzapine, valproic acid, and venlafaxineQ44562859
A placebo-controlled, double-blind study of the efficacy and safety of aripiprazole in patients with acute bipolar maniaQ44565868
A Pilot Study of Risperidone, Olanzapine, and Haloperidol in Psychotic Youth: A Double-Blind, Randomized, 8-Week TrialQ44635621
Efficacy and safety of aripiprazole vs. haloperidol for long-term maintenance treatment following acute relapse of schizophreniaQ44649979
Aripiprazole for the prevention of relapse in stabilized patients with chronic schizophrenia: a placebo-controlled 26-week study.Q44662788
Deaths from diabetic ketoacidosis after long-term clozapine treatmentQ44669011
Fatal olanzapine-induced ketoacidosisQ44669013
Amisulpride is an "atypical" antipsychotic associated with low weight gainQ44675344
Olanzapine treatment of eight adolescent patients with psychosisQ44723803
Tic reduction with risperidone versus pimozide in a randomized, double-blind, crossover trialQ44730839
Olanzapine induces insulin resistance: results from a prospective studyQ44731801
The effects of atypical antipsychotics on visceral fat distribution in first episode, drug-naive patients with schizophreniaQ44766600
A double-blind, randomized comparative trial of amisulpride versus olanzapine for 6 months in the treatment of schizophreniaQ44838692
Economic costs of diabetes in the US in 2002.Q44892463
Risperidone treatment of children with autistic disorder: effectiveness, tolerability, and pharmacokinetic implicationsQ44895348
A retrospective analysis of the short-term effects of olanzapine and quetiapine on weight and body mass index in children and adolescentsQ45013054
Lack of association between the -759C/T polymorphism of the 5-HT2C receptor gene and clozapine-induced weight gain among German schizophrenic individualsQ45022954
Clozapine-induced weight gain: prevalence and clinical relevanceQ45169845
A comparison of weight change during treatment with olanzapine or aripiprazole: results from a randomized, double-blind studyQ45188329
Longitudinal effect of olanzapine on fasting serum lipids: a randomized, prospective, 4-month studyQ45242001
Body mass index and the prevalence of hypertension and dyslipidemiaQ46304972
Role of brain insulin receptor in control of body weight and reproductionQ47229086
Weight stability masks sarcopenia in elderly men and womenQ47233662
Clozapine, diabetes mellitus, weight gain, and lipid abnormalities: A five-year naturalistic studyQ47238068
The long-term effect of quetiapine (Seroquel TM ) monotherapy on weight in patients with schizophreniaQ47250230
Olanzapine increases weight and serum triglyceride levels.Q47252169
Olanzapine: weight gain and therapeutic efficacyQ47264231
Effects of weight loss on regional fat distribution and insulin sensitivity in obesityQ47268456
A prospective study of body mass index, weight change, and risk of stroke in womenQ47308574
Body size and fat distribution as predictors of stroke among US men.Q47319773
Differential effect of clozapine on weight: a controlled studyQ47331289
Weight gain as a risk factor for clinical diabetes mellitus in womenQ47356176
Weight, weight change, and coronary heart disease in women. Risk within the 'normal' weight rangeQ47359474
Weight as a risk factor for clinical diabetes in womenQ47442215
Revealing the cost of Type II diabetes in EuropeQ50110273
P433issueSupplement 1
P921main subjectliterature reviewQ2412849
P304page(s)1-93
P577publication date2005-01-01
P1433published inCNS DrugsQ5013183
P1476titleSecond-Generation (Atypical) Antipsychotics and Metabolic Effects
Second-generation (atypical) antipsychotics and metabolic effects: a comprehensive literature review
P478volume19
19 Suppl 1

Reverse relations

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Q24615556Aripiprazole partial agonism at 5-HT2C: a comparison of weight gain associated with aripiprazole adjunctive to antidepressants with high versus low serotonergic activities
Q37373691Arterial Stiffness in Patients Taking Second-generation Antipsychotics.
Q38070179Asenapine, iloperidone and lurasidone: critical appraisal of the most recently approved pharmacotherapies for schizophrenia in adults
Q49825413Assessing the risk of type 2 diabetes mellitus among children and adolescents with psychiatric disorders treated with atypical antipsychotics: a population-based nested case-control study.
Q92136179Assessment of lipid response to acute olanzapine administration in healthy adults
Q93185385Association between polymorphisms of LEP, LEPR, DRD2, HTR2A and HTR2C genes and risperidone- or clozapine-induced hyperglycemia
Q53234030Association between the GIPR gene and the insulin level after glucose loading in schizophrenia patients treated with olanzapine.
Q43053801Association of HTR2C, but not LEP or INSIG2, genes with antipsychotic-induced weight gain in a German sample.
Q35064650Association of genetic variants of the histamine H1 and muscarinic M3 receptors with BMI and HbA1c values in patients on antipsychotic medication
Q51371509Association of serum retinol-binding protein 4 with insulin resistance and metabolic parameters during olanzapine therapy.
Q47301630Association of the HTR2C gene and antipsychotic induced weight gain: a meta-analysis
Q48124681Atherosclerotic Surrogate Markers in Adults With Down Syndrome: A Case-Control Study.
Q42497888Atypical antipsychotic drugs directly impair insulin action in adipocytes: effects on glucose transport, lipogenesis, and antilipolysis
Q38183274Atypical antipsychotic-induced metabolic disturbances in the elderly
Q34006864Atypical antipsychotic-induced metabolic side effects: insights from receptor-binding profiles
Q38076320Atypical antipsychotics and diabetic ketoacidosis: a review
Q33928935Atypical antipsychotics and metabolic syndrome in patients with schizophrenia: risk factors, monitoring, and healthcare implications
Q34117015Atypical antipsychotics rapidly and inappropriately switch peripheral fuel utilization to lipids, impairing metabolic flexibility in rodents
Q92626334Atypical antipsychotics-induced metabolic syndrome and nonalcoholic fatty liver disease: a critical review
Q37698621Atypical antipsychotics: recent research findings and applications to clinical practice: Proceedings of a symposium presented at the 29th Annual European College of Neuropsychopharmacology Congress, 19 September 2016, Vienna, Austria
Q38826206BAP guidelines on the management of weight gain, metabolic disturbances and cardiovascular risk associated with psychosis and antipsychotic drug treatment.
Q47925621BMI independently relates to glycaemia in patients with severe enduring mental illness (SMI).
Q36970128Balancing efficacy and safety in treatment with antipsychotics.
Q37707188Barriers and facilitators of a healthy lifestyle among persons with serious and persistent mental illness: perspectives of community mental health providers
Q90084710Benserazide, an Inhibitor of Peripheral Kynurenine Metabolism, Attenuates Olanzapine-Induced Weight Gain, Insulin Resistance, and Dyslipidemia in C57Bl/6j Mice
Q36634433Bipolar depression: diagnostic and treatment considerations
Q34613859Blood lactate levels in patients receiving first- or second- generation antipsychotics.
Q54942497Blood-Based Lipidomics Approach to Evaluate Biomarkers Associated With Response to Olanzapine, Risperidone, and Quetiapine Treatment in Schizophrenia Patients.
Q34641561Body weight and metabolic adverse effects of asenapine, iloperidone, lurasidone and paliperidone in the treatment of schizophrenia and bipolar disorder: a systematic review and exploratory meta-analysis
Q36268243COX-2 inhibitors as adjunctive therapy in schizophrenia: rationale for use and evidence to date
Q33155805Cardiac side effects of psychiatric drugs
Q33795131Cardiometabolic Health in Bipolar Disorder
Q37712697Cardiometabolic outcomes in children and adolescents following discontinuation of long-term risperidone treatment
Q35087495Cardiovascular and cerebrovascular risk factors and events associated with second-generation antipsychotic compared to antidepressant use in a non-elderly adult sample: results from a claims-based inception cohort study
Q37788533Cardiovascular aspects of antipsychotics
Q36870063Cardiovascular effects of antipsychotics
Q33440011Care for patients with severe mental illness: the general practitioner's role perspective
Q36468328Challenges associated with controlled psychopharmacological research trials in adolescents with eating disorders.
Q39342764Challenges encountered in the conduct of Optimal Health: A patient-centered comparative effectiveness study of interventions for adults with serious mental illness
Q33632560Change in body mass index before and after Alzheimer's disease onset
Q31145823Change in metabolic syndrome parameters with antipsychotic treatment in the CATIE Schizophrenia Trial: prospective data from phase 1
Q50546113Changes in metabolic parameters in patients with severe mental illness over a 10-year period: A retrospective cohort study.
Q37161980Changes in non-high-density lipoprotein cholesterol levels and triglyceride/high-density lipoprotein cholesterol ratios among patients randomized to aripiprazole versus olanzapine
Q28555023Chronic Olanzapine Treatment Induces Disorders of Plasma Fatty Acid Profile in Balb/c Mice: A Potential Mechanism for Olanzapine-Induced Insulin Resistance
Q51185707Chronic administration of olanzapine induces metabolic and food intake alterations: a mouse model of the atypical antipsychotic-associated adverse effects.
Q38438041Clozapine causes oxidation of proteins involved in energy metabolism: a possible mechanism for antipsychotic-induced metabolic alterations
Q36206591Clozapine modifies the differentiation program of human adipocytes inducing browning
Q47429942Clozapine, Diabetes Mellitus, Cardiovascular Risk and Mortality: Results of a 21-year Naturalistic Study in Patients with Schizophrenia and Schizoaffective Disorder.
Q46098816Clozapine-associated weight loss
Q50773348Comparative effectiveness of switching antipsychotic drug treatment to aripiprazole or ziprasidone for improving metabolic profile and atherogenic dyslipidemia: a 12-month, prospective, open-label study.
Q92621898Comparison of serum levels of asymmetric dimethylarginine between patients who take two types of atypical anti psychotics
Q26773288Concerns about quetiapine
Q38283039Concomitant Use of Topiramate Inducing Neutropenia in a Schizophrenic Male Stabilized on Clozapine
Q49885361Consequences of Undocumented Medication Use.
Q37192896Considerations regarding the genetics of obesity
Q88581527Continuation of Atypical Antipsychotic Medication During Early Pregnancy and the Risk of Gestational Diabetes
Q41656775Cost-Effectiveness of Long-Acting Injectable Paliperidone Palmitate Versus Haloperidol Decanoate in Maintenance Treatment of Schizophrenia
Q35172283Course of health care costs before and after psychiatric inpatient treatment: patient-reported vs. administrative records.
Q58780376Critical Review of the Use of Second-Generation Antipsychotics in Obsessive-Compulsive and Related Disorders
Q28079821Current Data on and Clinical Insights into the Treatment of First Episode Nonaffective Psychosis: A Comprehensive Review
Q79858778Decreased serum activity of semicarbazide-sensitive amine oxidase (SSAO) in patients treated with second generation antipsychotics: a link to impaired glucose metabolism?
Q49120111Development of a health screening clinic
Q37613388Development of diabetes mellitus associated with quetiapine: A case series.
Q36777672Diabetes Screening Among Underserved Adults With Severe Mental Illness Who Take Antipsychotic Medications
Q46642105Diabetes Screening among Antipsychotic-Treated Adults with Severe Mental Illness in an Integrated Delivery System: A Retrospective Cohort Study
Q38826676Diabetes and Cardiovascular Care Among People with Severe Mental Illness: A Literature Review
Q36143815Diabetes and glucose disturbances in patients with psychosis in Sweden
Q34069228Diabetes mellitus and suicide
Q37163569Diabetic control and atypical antipsychotics: a case report
Q34459114Diagnosis and treatment of bipolar disorders in adults: a review of the evidence on pharmacologic treatments
Q92637067Differences in the Effectiveness of Long-Acting Injection and Orally Administered Antipsychotics in Reducing Rehospitalization among Patients with Schizophrenia Receiving Home Care Services
Q39436079Differential effects of various typical and atypical antipsychotics on plasma glucose and insulin levels in the mouse: evidence for the involvement of sympathetic regulation
Q33707663Does adherence to medications for type 2 diabetes differ between individuals with vs without schizophrenia?
Q37281587Does antipsychotic polypharmacy increase the risk for metabolic syndrome?
Q36826582Dopamine 2 Receptor Genes Are Associated with Raised Blood Glucose in Schizophrenia
Q40218754Double jeopardy for the mentally ill: higher cardiovascular risk and reduced frequency of certain interventional procedures
Q33946973Drug metabolism and pharmacokinetics, the blood-brain barrier, and central nervous system drug discovery
Q37681620Dyslipidaemia and Medical Outcome (Health Related Quality of Life) in Patients with Schizophrenia Taking Antipsychotics in Enugu, Nigeria.
Q43120982Early intervention in psychosis: keeping the body in mind
Q21284525Eating disorders in schizophrenia: implications for research and management
Q36194233Effect of Psychotropic Drugs on Development of Diabetes Mellitus in Patients With Alzheimer's Disease
Q46150855Effect of lactational exposure of olanzapine on body weight of mice: a comparative study on neonates of both the sexes during post-natal development
Q50987064Effect of long-term olanzapine treatment on meal-induced insulin sensitization and on gastrointestinal peptides in female Sprague-Dawley rats.
Q36075717Effectiveness of a cognitive behavioral weight management intervention in obese patients with psychotic disorders compared to patients with nonpsychotic disorders or no psychiatric disorders: results from a 12-month, real-world study
Q34661011Effectiveness of medications used to attenuate antipsychotic-related weight gain and metabolic abnormalities: a systematic review and meta-analysis
Q33914295Effectiveness of paliperidone palmitate vs haloperidol decanoate for maintenance treatment of schizophrenia: a randomized clinical trial
Q64915990Effects of Cariprazine, Aripiprazole, and Olanzapine on Mouse Fibroblast Culture: Changes in Adiponectin Contents in Supernatants, Triglyceride Accumulation, and Peroxisome Proliferator-Activated Receptor-γ Expression.
Q36223890Effects of Low Dose Metformin on Metabolic Traits in Clozapine-Treated Schizophrenia Patients: An Exploratory Twelve-Week Randomized, Double-Blind, Placebo-Controlled Study
Q42162953Effects of adjunctive treatment with aripiprazole on body weight and clinical efficacy in schizophrenia patients treated with clozapine: a randomized, double-blind, placebo-controlled trial
Q36241602Effects of auricular acupressure on body weight parameters in patients with chronic schizophrenia
Q36573210Effects of dopamine D2/D3 receptor ligands on food-cocaine choice in socially housed male cynomolgus monkeys
Q40295381Effects of lisdexamfetamine in a rat model of binge-eating
Q47302385Effects of naltrexone on food intake and body weight gain in olanzapine-treated rats
Q35191252Effects of switching from olanzapine to aripiprazole on the metabolic profiles of patients with schizophrenia and metabolic syndrome: a double-blind, randomized, open-label study
Q36756154Effects of switching from olanzapine, quetiapine, and risperidone to aripiprazole on 10-year coronary heart disease risk and metabolic syndrome status: results from a randomized controlled trial
Q33503890Effects of typical and atypical antipsychotic drugs on gene expression profiles in the liver of schizophrenia subjects
Q41733975Effects of weight loss diet therapy on anthropometric measurements and biochemical variables in schizophrenic patients.
Q34791688Efficacy and safety of bifeprunox in patients with an acute exacerbation of schizophrenia: results from a randomized, double-blind, placebo-controlled, multicenter, dose-finding study
Q35143365Efficacy and safety of pharmacotherapy in cancer-related psychiatric disorders across the trajectory of cancer care: a review
Q37737291Efficacy, safety and tolerability of Symbyax for acute-phase management of treatment-resistant depression
Q34124590Engaging families in research to determine health literacy needs related to the use of second-generation antipsychotics in children and adolescents
Q35844191Enhanced peripheral toll-like receptor responses in psychosis: further evidence of a pro-inflammatory phenotype.
Q27021810Epigenetic mechanisms in mood disorders: targeting neuroplasticity
Q90731688Evaluating the cost and clinical effectiveness of long-acting, injectable aripiprazole and paliperidone palmitate once a month in a real-world setting
Q37625064Evaluation of reproductive function in women treated for bipolar disorder compared to healthy controls
Q48933903Evidence-based pharmacotherapy of schizophrenia
Q33663582Excess heart-disease-related mortality in a national study of patients with mental disorders: identifying modifiable risk factors
Q50606762Excess mortality from mental, neurological and substance use disorders in the Global Burden of Disease Study 2010.
Q38246512Excess mortality in bipolar disorders
Q33256430Excessive weight gain after remission of depression in a schizophrenic patient treated with risperidone: case report
Q49456987Exercise Protects Against Olanzapine-Induced Hyperglycemia in Male C57BL/6J Mice
Q33845881First do no harm: promoting an evidence-based approach to atypical antipsychotic use in children and adolescents
Q40165139First-episode psychosis: a window of opportunity for best practices
Q33488312Fluoxetine and olanzapine combination therapy in treatment-resistant major depression: review of efficacy and safety data
Q64039164From Clinical Research to Clinical Practice: A 4-Year Review of Ziprasidone
Q24685521From the Cover: Antipsychotic drug-induced weight gain mediated by histamine H1 receptor-linked activation of hypothalamic AMP-kinase
Q92713065Galphimia glauca and Natural Galphimines Block Schizophrenia-Like Symptoms Induced with Apomorphine and MK-801 in Mice
Q47332928Gender-dependent consequences of chronic olanzapine in the rat: effects on body weight, inflammatory, metabolic and microbiota parameters
Q37661867Gene-specific DNA methylation may mediate atypical antipsychotic-induced insulin resistance.
Q40562486Genetic Determinants of Clozapine-Induced Metabolic Side Effects
Q37365437Genetic risk factors for type 2 diabetes with pharmacologic intervention in African-American patients with schizophrenia or schizoaffective disorder
Q36698123Genetic underpinnings of left superior temporal gyrus thickness in patients with schizophrenia
Q33257886Genetics of antipsychotic treatment emergent weight gain in schizophrenia
Q36817242Genome-Wide Association Study Suggested the PTPRD Polymorphisms Were Associated With Weight Gain Effects of Atypical Antipsychotic Medications.
Q40590073Genome-wide association study on antipsychotic-induced weight gain in the CATIE sample
Q38708352Glucagon-like peptide-1 agonists combating clozapine-associated obesity and diabetes
Q34631699Guideline concordant monitoring of metabolic risk in people treated with antipsychotic medication: systematic review and meta-analysis of screening practices.
Q37131022Guideline-concordant antipsychotic use and mortality in schizophrenia
Q47274265HTR2C haplotypes and antipsychotics-induced weight gain: X-linked multimarker analysis
Q36593819Haloperidol and olanzapine mediate metabolic abnormalities through different molecular pathways.
Q36375877Health Information Preference among Youth and Caregivers related to Second-Generation Antipsychotic Treatment.
Q55479566High-density lipoprotein-cholesterol and antipsychotic medication in overweight inpatients with schizophrenia: post-hoc analysis of a Japanese nationwide survey.
Q38430215Homeless women with schizophrenia reported lower adherence to their medication than men: results from the French Housing First experience
Q37187021Homocysteine levels in patients with schizophrenia on clozapine monotherapy
Q88938477Hospital-Based Quality Measures for Pediatric Mental Health Care
Q37535043How quickly do physicians adopt new drugs? The case of second-generation antipsychotics
Q94561344Immunoendocrine Peripheral Effects Induced by Atypical Antipsychotics
Q37060706Impact of atypical antipsychotic therapy on leptin, ghrelin, and adiponectin
Q33737076Impact of race on efficacy and safety during treatment with olanzapine in schizophrenia, schizophreniform or schizoaffective disorder
Q39167145Implementation of a Reverse Colocation Model: Lessons from Two Community Behavioral Health Agencies in Rural Pennsylvania
Q43510246Implementation of a weight loss program for Latino outpatients with severe mental illness
Q53834183Improvements in body composition, anthropometric measurements and lipid profile following discontinuation of clozapine.
Q36510504Improving lifestyle interventions for people with serious mental illnesses: Qualitative results from the STRIDE study
Q35019136Improving physical health and reducing substance use in psychosis--randomised control trial (IMPACT RCT): study protocol for a cluster randomised controlled trial
Q45893502In Search of Stakeholder Collaboration to Stem the Cardiometabolic Epidemic
Q48292762In vivo actions of aripiprazole on serotonergic and dopaminergic systems in rodent brain
Q37464232Increasing use of atypical antipsychotics and anticonvulsants during pregnancy
Q36374128Inequalities in physical comorbidity: a longitudinal comparative cohort study of people with severe mental illness in the UK.
Q37095956Inflammatory markers in schizophrenia: comparing antipsychotic effects in phase 1 of the clinical antipsychotic trials of intervention effectiveness study.
Q36301864Inhibition of mouse brown adipocyte differentiation by second-generation antipsychotics
Q28608153Integrating multiple data sources (MUDS) for meta-analysis to improve patient-centered outcomes research: a protocol for a systematic review
Q36111806Interferon-alpha effects on diurnal hypothalamic-pituitary-adrenal axis activity: relationship with proinflammatory cytokines and behavior
Q53006399Interpreting the efficacy findings in the CATIE study: what clinicians should know.
Q36377890Interventions to Address Medical Conditions and Health-Risk Behaviors Among Persons With Serious Mental Illness: A Comprehensive Review
Q51912991Intramuscular aripiprazole for the treatment of acute agitation in patients with schizophrenia or schizoaffective disorder: a double-blind, placebo-controlled comparison with intramuscular haloperidol.
Q34785866Investigating the safety and efficacy of naltrexone for anti-psychotic induced weight gain in severe mental illness: study protocol of a double-blind, randomized, placebo-controlled trial
Q36921831Is Metabolic Syndrome On the Radar? Improving Real-Time Detection of Metabolic Syndrome and Physician Response by Computerized Scan of the Electronic Medical Record
Q26752771Is There Room for Second-Generation Antipsychotics in the Pharmacotherapy of Panic Disorder? A Systematic Review Based on PRISMA Guidelines
Q39158338Is abnormal non-high-density lipoprotein cholesterol a gender-specific predictor for metabolic syndrome in patients with schizophrenia taking second-generation antipsychotics?
Q27027832Is the prevalence of metabolic syndrome and metabolic abnormalities increased in early schizophrenia? A comparative meta-analysis of first episode, untreated and treated patients
Q36729616Lack of insight in schizophrenia: impact on treatment adherence
Q36113742Lipid profiles in schizophrenia associated with clinical traits: a five year follow-up study
Q37674020Lithium or Valproate Adjunctive Therapy to Second-generation Antipsychotics and Metabolic Variables in Patients With Schizophrenia or Schizoaffective Disorder
Q55405731Long-term administration of olanzapine induces adiposity and increases hepatic fatty acid desaturation protein in female C57BL/6J mice.
Q47279555Long-term changes in weight and plasma lipids during maintenance treatment with ziprasidone
Q42601640Long-term improvement in efficacy and safety after switching to ziprasidone in stable outpatients with schizophrenia
Q36433993Long-term treatment with atypical antipsychotics and the risk of weight gain : a literature analysis
Q85278128Longitudinal examination of the skeletal effects of selective serotonin reuptake inhibitors and risperidone in boys
Q99402127Lurasidone and Risk for Metabolic Syndrome: Results from Short and Long-term Clinical Studies in Patients with Schizophrenia
Q57181189Macrophage migration inhibitory factor mediates metabolic dysfunction induced by atypical antipsychotic therapy
Q36987106Management of Medication-Related Cardiometabolic Risk in Patients with Severe Mental Illness.
Q37481134Management of Older Inpatients Who Refuse Nonpsychiatric Medication Within Birmingham and Solihull Mental Health NHS Foundation Trust: Audit
Q24610124Management of antipsychotic-related weight gain
Q37423313Management of patients presenting with acute psychotic episodes of schizophrenia.
Q37631787Mania and mortality: why the excess cardiovascular risk in bipolar disorder?
Q47753742Meal-induced insulin sensitization is preserved after acute olanzapine administration in female Sprague-Dawley rats
Q50156396Mechanisms underlying metabolic disturbances associated with psychosis and antipsychotic drug treatment
Q89329532Medical mimics: Differential diagnostic considerations for psychiatric symptoms
Q37722004Medication errors in psychiatry: a comprehensive review
Q34691850Metabolic Abnormality and Sleep Disturbance are Associated with Clinical Severity of Patients with Schizophrenia
Q89091008Metabolic Effects of Antipsychotics on Adiposity and Insulin Sensitivity in Youths: A Randomized Clinical Trial
Q37801922Metabolic Syndrome in Severe Mental Disorders
Q36474147Metabolic adverse events in patients with mental illness treated with antipsychotics: a primary care perspective
Q37947095Metabolic and cardiovascular adverse effects associated with antipsychotic drugs
Q37900615Metabolic and neurological complications of second-generation antipsychotic use in children: a systematic review and meta-analysis of randomized controlled trials
Q37496873Metabolic consequences of using low-dose quetiapine for insomnia in psychiatric patients
Q35330607Metabolic disturbances independent of body mass in patients with schizophrenia taking atypical antipsychotics
Q36703845Metabolic drug interactions with newer antipsychotics: a comparative review.
Q79829709Metabolic findings from the CATIE trial and their relation to tolerability
Q26783003Metabolic issues in patients affected by schizophrenia: clinical characteristics and medical management
Q36577861Metabolic monitoring for patients treated with antipsychotic medications
Q51391762Metabolic parameters in the short- and long-term treatment of schizophrenia with sertindole or risperidone
Q37189197Metabolic screening after the American Diabetes Association's consensus statement on antipsychotic drugs and diabetes
Q88808771Metabolic side effects of atypical antipsychotics in older adults
Q30459096Metabolic side-effects of the novel second-generation antipsychotic drugs asenapine and iloperidone: a comparison with olanzapine.
Q37738743Metabolic syndrome associated with schizophrenia and atypical antipsychotics
Q37129646Metabolic syndrome in people with schizophrenia: a review.
Q37102229Metabolic syndrome in schizophrenia: Differences between antipsychotic-naïve and treated patients
Q34037969Metabolic, endocrinologic and cardiac effects of amisulpride: a 24-week follow-up study
Q47351095Metformin for treatment of antipsychotic-induced weight gain in a South Asian population with schizophrenia or schizoaffective disorder: A double blind, randomized, placebo controlled study
Q36156730Metformin in prevention and treatment of antipsychotic induced weight gain: a systematic review and meta-analysis
Q39888640Mifepristone reduces weight gain and improves metabolic abnormalities associated with risperidone treatment in normal men.
Q41849512Modulation of conditioned avoidance response and quetiapine-induced metabolic syndrome by rosuvastatin and CDP-choline in rats
Q30558767Monitoring and managing metabolic effects of antipsychotics: a cluster randomized trial of an intervention combining evidence-based quality improvement and external facilitation
Q48015522Monitoring of Recommended Metabolic Laboratory Parameters Among Medicaid Recipients on Second-Generation Antipsychotics in Federally Qualified Health Centers
Q92001384Monitoring the physical health of individuals with serious mental illness
Q92168500Monthly Extended-Release Risperidone (RBP-7000) in the Treatment of Schizophrenia: Results From the Phase 3 Program
Q35586433Multiple risk-behavior profiles of smokers with serious mental illness and motivation for change
Q34111775Neuroprogressive effects of lifetime illness duration in older adults with bipolar disorder
Q38233857New approaches to the management of schizophrenia: focus on aberrant hippocampal drive of dopamine pathways
Q47305725No effect of dietary fat on short-term weight gain in mice treated with atypical antipsychotic drugs
Q35074667Obesity and coronary risk in patients treated with second-generation antipsychotics
Q37416376Off-label antipsychotic use and tardive dyskinesia in at-risk populations: new drugs with old side effects
Q64276340Olanzapine Induced Dysmetabolic Changes Involving Tissue Chromium Mobilization in Female Rats
Q37252495Olanzapine and fluoxetine combination therapy for treatment-resistant depression: review of efficacy, safety, and study design issues
Q37809849Olanzapine long-acting injection: a review of its use in the treatment of schizophrenia
Q43211028Olanzapine monotherapy for acute depression in patients with bipolar I or II disorder: results of an 8-week open label trial
Q33942644Olanzapine promotes fat accumulation in male rats by decreasing physical activity, repartitioning energy and increasing adipose tissue lipogenesis while impairing lipolysis.
Q37494988Olanzapine, weight change and metabolic effects: a naturalistic 12-month follow up
Q36390846Olanzapine/fluoxetine combination for bipolar depression
Q47242174Omega-3 fatty acids supplementation with lithium and aripiprazole for improving the balance of circulating hormones and brain neurotransmitters in manic mice model
Q89330644Overcoming barriers to monitoring patients taking second-generation antipsychotics
Q41541889Overexpression of Insig-2 inhibits atypical antipsychotic-induced adipogenic differentiation and lipid biosynthesis in adipose-derived stem cells
Q43260115P-glycoprotein inhibition potentiates the behavioural and neurochemical actions of risperidone in rats.
Q38163397Paliperidone extended-release: safety and tolerability from a metabolic profile perspective
Q37285348Pancreatitis and diabetic ketoacidosis with quetiapine use
Q34726953Past and Present Progress in the Pharmacologic Treatment of Schizophrenia
Q51910566Patient subpopulations with elevated cardiovascular risk pose unique treatment challenges.
Q34636572Patterns of initiation of second generation antipsychotics for bipolar disorder: a month-by-month analysis of provider behavior
Q36833921Patterns of psychotropic medication use in inpatient and outpatient psychiatric settings in Saudi Arabia
Q43042813Pharmacoeconomics of quetiapine for the management of acute mania in bipolar I disorder
Q38083647Pharmacogenetic Aspects of Antipsychotic Drug-induced Weight Gain - A Critical Review
Q37220366Pharmacogenetics of leptin in antipsychotic-associated weight gain and obesity-related complications
Q38217628Pharmacogenetics of second-generation antipsychotics
Q36577866Pharmacologic and nonpharmacologic strategies for weight gain and metabolic disturbance in patients treated with antipsychotic medications
Q33521748Pharmacological management in children and adolescents with pervasive developmental disorder
Q34985850Pharmacological modulation of dopamine receptor D2-mediated transmission alters the metabolic phenotype of diet induced obese and diet resistant C57Bl6 mice
Q34691376Pharmacological treatment of ambulatory schizophrenic patients in Belgium
Q37732209Pharmacologically-induced metabolic acidosis: a review.
Q38132160Physical complications in early clozapine treatment: a case report and implications for safe monitoring
Q37771647Physical health in schizophrenia: a challenge for antipsychotic therapy
Q37771645Physical health management in psychiatric settings
Q34623350Physical illness in patients with severe mental disorders. I. Prevalence, impact of medications and disparities in health care.
Q35575577Physiogenomic analysis of CYP450 drug metabolism correlates dyslipidemia with pharmacogenetic functional status in psychiatric patients
Q45319384Platform for systems medicine research and diagnostic applications in psychotic disorders-The METSY project
Q38047406Positioning mental health nursing practice within a positive health paradigm
Q30559039Positive predictive value of a case definition for diabetes mellitus using automated administrative health data in children and youth exposed to antipsychotic drugs or control medications: a Tennessee Medicaid study
Q34082230Positive predictive value of automated database records for diabetic ketoacidosis (DKA) in children and youth exposed to antipsychotic drugs or control medications: a Tennessee Medicaid Study
Q34995934Posttraumatic stress disorder is a risk factor for metabolic syndrome in an impoverished urban population
Q36506812Practical considerations for carbamazepine use in bipolar disorder
Q37206139Practical issues with amisulpride in the management of patients with schizophrenia.
Q30503523Predicting implementation from organizational readiness for change: a study protocol.
Q35997710Predicting the severity of everyday functional disability in people with schizophrenia: cognitive deficits, functional capacity, symptoms, and health status
Q36303695Prefrontal and Hippocampal Brain Volume Deficits: Role of Low Physical Activity on Brain Plasticity in First-Episode Schizophrenia Patients
Q37011220Pregnancy outcomes following maternal exposure to second-generation antipsychotics given with other psychotropic drugs: a cohort study.
Q34993531Preliminary Examination of Olanzapine and Diet Interactions On Metabolism in a Female Macaque
Q36159743Prevalence and appropriateness of psychotropic medication prescribing in a nationally representative cross-sectional survey of male and female prisoners in England
Q37053637Prevalence of Metabolic Syndrome in Patients with Schizophrenia Referred to Farabi Hospital, Kermanshah, Iran
Q34944648Prevalence of diabetes, metabolic syndrome and metabolic abnormalities in schizophrenia over the course of the illness: a cross-sectional study
Q37310164Principles of antipsychotic prescribing for policy makers, circa 2008. Translating knowledge to promote individualized treatment
Q37791558Promoting physical health in youth mental health services: ensuring routine monitoring of weight and metabolic indices in a first episode psychosis clinic.
Q38374033Psychotherapy Alone and Combined With Medication as Treatments for Bipolar II Depression: A Randomized Controlled Trial
Q40119718Psychotic disorder is an independent risk factor for increased fasting glucose and waist circumference
Q37190577Public-academic partnerships: a program to improve the quality of antipsychotic prescribing in a community mental health system
Q33159884QT interval duration and dispersion in children and adolescents treated with ziprasidone
Q33755431Quality of care for cardiometabolic disease: associations with mental disorder and rurality
Q36870523Quality of care for cardiovascular disease-related conditions in patients with and without mental disorders.
Q26863435Randomized controlled trials in schizophrenia: opportunities, limitations, and trial design alternatives
Q37425737Reasons and clinical outcomes of antipsychotic treatment switch in outpatients with schizophrenia in real-life clinical settings: the ETOS observational study
Q35886160Receipt of monitoring of diabetes mellitus in older adults with comorbid dementia
Q51838849Recent Swedish clinical practice guidelines for prevention and management of metabolic risk.
Q36063735Recent advances in understanding and mitigating adipogenic and metabolic effects of antipsychotic drugs
Q38154174Recent evidence and potential mechanisms underlying weight gain and insulin resistance due to atypical antipsychotics.
Q38132163Receptor mechanisms of antipsychotic drug action in bipolar disorder - focus on asenapine
Q37727085Regional differences in the action of antipsychotic drugs: implications for cognitive effects in schizophrenic patients
Q41587365Relationship Between Metabolic Syndrome and Clinical Features, and Its Personal-Social Performance in Patients with Schizophrenia
Q33662898Relationship between Serum Bilirubin Levels and Metabolic Syndrome in Patients with Schizophrenia Spectrum Disorders
Q60961783Relationship between mortality in people with mental disorders and suicide mortality in China during 2000 to 2014: An observational study
Q35744928Relative Risk of Acute Myocardial Infarction in People with Schizophrenia and Bipolar Disorder: A Population-Based Cohort Study.
Q35062881Repeated aripiprazole administration attenuates cocaine seeking in a rat model of relapse
Q47121019Reversal of olanzapine-induced weight gain in a patient with schizophrenia by switching to asenapine: a case report
Q92897789Reverse Integration Initiatives for Individuals With Serious Mental Illness
Q24657398Review of olanzapine in the management of bipolar disorders
Q38717462Risk of diabetes and dyslipidemia during clozapine and other antipsychotic drug treatment of schizophrenia in Iceland.
Q39652199Risperidone Added to Psychostimulant in Children with Severe Aggression and Attention-Deficit/Hyperactivity Disorder: Lack of Effect on Attention and Short-Term Memory
Q43145177Risperidone associated weight, leptin, and anthropometric changes in children and adolescents with psychotic disorders in early treatment
Q37079013Risperidone-induced acromegaly: a case report
Q36564507Role of Omega-3 fatty acids in preventing metabolic disturbances in patients on olanzapine plus either sodium valproate or lithium: a randomized double-blind placebo-controlled trial
Q35001376STRIDE: a randomized trial of a lifestyle intervention to promote weight loss among individuals taking antipsychotic medications
Q33587032Safety and Tolerability of Adjunctive Aripiprazole in Major Depressive Disorder: A Pooled Post Hoc Analysis (studies CN138-139 and CN138-163).
Q38099224Safety and pharmacokinetics of atypical antipsychotics in children and adolescents
Q35026487Safety and tolerability of antipsychotics: focus on amisulpride
Q37202889Safety of carbamazepine extended-release capsules used in combination with other psychotropic medications for the treatment of bipolar I disorder.
Q36936347Schizophrenia endophenotypes as treatment targets
Q98564310Schizophrenia patients with a metabolically abnormal obese phenotype have milder negative symptoms
Q34376884Second generation antipsychotic-induced type 2 diabetes: a role for the muscarinic M3 receptor
Q39353717Second-Generation Antipsychotics and Metabolic Side Effects: A Systematic Review of Population-Based Studies
Q37598227Second-generation antipsychotics cause a rapid switch to fat oxidation that is required for survival in C57BL/6J mice
Q24235758Second-generation antipsychotics for anxiety disorders
Q36523265Second-generation antipsychotics: is there evidence for sex differences in pharmacokinetic and adverse effect profiles?
Q37133664Secondary effects of antipsychotics: women at greater risk than men.
Q35549916Serum C-peptide assay of patients with hyperglycemic emergencies at the Lagos State University Teaching Hospital (LASUTH), Ikeja
Q35153031Serum levels of AgRP protein in patients with schizophrenia on clozapine monotherapy
Q55082720Serum levels of β-hydroxybutyrate and pyruvate, metabolic changes and cognitive function in patients with schizophrenia during antipsychotic treatment: a preliminary study.
Q33802927Sex Differences in Antipsychotic Related Metabolic Functioning in Schizophrenia Spectrum Disorders
Q37289300Should psychiatrists use atypical antipsychotics to treat nonpsychotic anxiety?
Q47173896Smoking and weight among patients using clozapine
Q51137100Subchronic olanzapine treatment decreases the expression of pancreatic glucose transporter 2 in rat pancreatic β cells.
Q53813141Synthesis of the olanzapine labeled by carbon-14.
Q37137008Systemic hypotheses for generalized cognitive deficits in schizophrenia: a new take on an old problem
Q36399716TARGETED TREATMENTS IN AUTISM AND FRAGILE X SYNDROME
Q89495962THE METABOLIC SYNDROME IN OUTPATIENTS WITH PSYCHOSIS: A COMPARATIVE STUDY BETWEEN LONG ACTING INJECTABLE OLANZAPINE AND RISPERIDONE
Q47361916Targeted intervention to improve monitoring of antipsychotic-induced weight gain and metabolic disturbance in first episode psychosis
Q36336524Targeting the fatty acid transport proteins (FATP) to understand the mechanisms linking fatty acid transport to metabolism
Q33566124The 2009 schizophrenia PORT psychopharmacological treatment recommendations and summary statements
Q37790906The Adjunctive Use of Metformin to Treat or Prevent Atypical Antipsychotic-Induced Weight Gain: A Review
Q36351299The Effects of Chlorpromazine on Reproductive System and Function in Female Rats.
Q84655745The METEOR study of diabetes and other metabolic disorders in patients with schizophrenia treated with antipsychotic drugs. I. Methodology
Q26748677The Treatment of Adult Bipolar Disorder with Aripiprazole: A Systematic Review
Q37030657The antipsychotic story: changes in prescriptions and overdose without better safety.
Q34331882The diagnosis and treatment of bipolar disorder: decision-making in primary care
Q28569990The distinct effects of subchronic antipsychotic drug treatment on macronutrient selection, body weight, adiposity, and metabolism in female rats
Q37719551The effect of serious mental illness on the risk of rehospitalization among patients with diabetes.
Q33609974The effectiveness and safety of amisulpride in Chinese patients with schizophrenia who switch from risperidone or olanzapine: a subgroup analysis of the ESCAPE study
Q64939436The effects of antipsychotic medications on microbiome and weight gain in children and adolescents.
Q38170310The effects of second-generation antipsychotics on food intake, resting energy expenditure and physical activity
Q34197980The impact of antipsychotic drugs on food intake and body weight and on leptin levels in blood and hypothalamic ob-r leptin receptor expression in wistar rats
Q38190416The interface of physical and mental health.
Q36919963The mental health clinic: a new model
Q36577856The metabolic effects of antipsychotic medications
Q46622979The metabolic side effects of 12 antipsychotic drugs used for the treatment of schizophrenia on glucose: a network meta-analysis
Q37999568The metabolic syndrome in schizophrenia: is inflammation a contributing cause?
Q36984231The pharmacology and safety of paliperidone extended-release in the treatment of schizophrenia
Q37079080The prevalence and mechanisms of metabolic syndrome in schizophrenia: a review
Q36908408The prevalence and risk factors of stroke in patients with chronic schizophrenia
Q33813264The prevalence and risk factors of young male schizophrenics with non-alcoholic fatty liver disease
Q89340368The relation of atypical antipsychotic use and stress with weight in individuals at clinical high risk for psychosis
Q39888212The return of fixed combinations in psychiatry: fluoxetine and olanzapine combination
Q35530114The treatment of autism with low-dose phenytoin: a case report
Q33718231The use of psychiatric drugs and worsening body mass index among inpatients with schizophrenia
Q58861808Thermal stability of aripiprazole monohydrate investigated by Raman spectroscopy
Q33765864Time-dependent changes and potential mechanisms of glucose-lipid metabolic disorders associated with chronic clozapine or olanzapine treatment in rats
Q36092635Topiramate versus Valproate Sodium as Adjunctive Therapies to a Combination of Lithium and Risperidone for Adolescents with Bipolar I Disorder: Effects on Weight and Serum Lipid Profiles
Q35680962Trabecular bone loss after administration of the second-generation antipsychotic risperidone is independent of weight gain.
Q37030481Translation of the diabetes prevention program into a community mental health organization for individuals with severe mental illness: a case study
Q34823805Treatment of bipolar disorders during pregnancy: maternal and fetal safety and challenges
Q30489980Treatment of clozapine-associated obesity and diabetes with exenatide (CODEX) in adults with schizophrenia: study protocol for a pilot randomised controlled trial
Q38334922Treatment of clozapine-associated weight gain: a systematic review.
Q36687060Treatment of psychosis: 30 years of progress.
Q58201746Understanding antipsychotic-induced weight gain and other metabolic issues
Q37896627Unmet treatment needs in schizophrenia patients: is asenapine a potential therapeutic option?
Q89027481Use of Academic Detailing With Audit and Feedback to Improve Antipsychotic Pharmacotherapy
Q26827756Use of atypical antipsychotics in the elderly: a clinical review
Q37356486Use of long-acting risperidone in psychiatric disorders: focus on efficacy, safety and cost-effectiveness
Q35049901Use of medications to reduce cardiovascular risk among individuals with psychotic disorders and Type 2 diabetes
Q30501289Using internet enabled mobile devices and social networking technologies to promote exercise as an intervention for young first episode psychosis patients
Q58778213Using motivational techniques to reduce cardiometabolic risk factors in long term psychiatric inpatients: a naturalistic interventional study
Q47141502Utilization of the Behavior Change Wheel framework to develop a model to improve cardiometabolic screening for people with severe mental illness
Q33865310Vagal nerve stimulation reverses aberrant dopamine system function in the methylazoxymethanol acetate rodent model of schizophrenia
Q37016538Validation of candidate genes associated with cardiovascular risk factors in psychiatric patients
Q36646810Warfarin-quetiapine interaction causing hemorrhage
Q34486175Weight change during long-term treatment with lurasidone: pooled analysis of studies in patients with schizophrenia
Q42682470Weight changes before and after lurasidone treatment: a real-world analysis using electronic health records
Q38151453Weight considerations in psychotropic drug prescribing and switching
Q37865505Weight gain and changes in metabolic variables following olanzapine treatment in schizophrenia and bipolar disorder.
Q34033259Weight gain and glucose dysregulation with second-generation antipsychotics and antidepressants: a review for primary care physicians
Q38504254Weight gain and obesity in schizophrenia: epidemiology, pathobiology, and management
Q36555343Weight gain, metabolic disturbances, and physical health care in a Brazilian sample of outpatients with schizophrenia
Q50139891What Works in a Nurse Led Self-Management Program for Patients with Serious Mental Illness (SMI) and Diabetes (DM).
Q28083481What can triumphs and tribulations from drug research in Alzheimer's disease tell us about the development of psychotropic drugs in general?
Q37801988Where to Position Clozapine: Re-Examining the Evidence
Q36553321Whole-organism screening for gluconeogenesis identifies activators of fasting metabolism.
Q34209287Ziprasidone and the corrected QT interval: a comprehensive summary of clinical data
Q34966022Ziprasidone in the treatment of mania in bipolar disorder
Q35577365Ziprasidone with adjunctive mood stabilizer in the maintenance treatment of bipolar I disorder: long-term changes in weight and metabolic profiles
Q40116422Zonisamide prevents olanzapine-associated hyperphagia, weight gain, and elevated blood glucose in rats
Q79776053[Antipsychotic drug-induced changes in metabolism]
Q80015079[Differences between men and women in side effects of second-generation antipsychotics]
Q87945859[Frontal brain volume reduction due to antipsychotic drugs?]
Q83130945[Metabolic disorders under antipsychotic treatment]
Q79327220[Pharmacotherapy for schizophrenia]